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Chemical Compound Review

FEDOTOZINE     (2R)-N,N-dimethyl-2-phenyl-1- [(3,4,5...

Synonyms: Fedotozina, Fedotozinum, SureCN1649900, AC1L1TVH, AC1Q56G3, ...
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Disease relevance of FEDOTOZINE


Psychiatry related information on FEDOTOZINE


High impact information on FEDOTOZINE


Chemical compound and disease context of FEDOTOZINE

  • Opiates, including morphine as well as compounds such as trimebutine or fedotozine designed for therapeutic use in irritable bowel syndrome, are effective in reducing visceral nociception [8].
  • The CRF effects were blocked by alpha-helical-CRF9-41 (10 nmol/rat) given i.c. but not i.v. Fedotozine (1-10 mg/kg s.c. but not 300 micrograms/rat i.c.v. or intrathecally) and (+/-)U-50,488H (0.3-3 mg/kg s.c. but not 100 micrograms/kg i.c.v.) reversed PI- but not CRF-induced ileus [9].

Biological context of FEDOTOZINE


Anatomical context of FEDOTOZINE


Associations of FEDOTOZINE with other chemical compounds


Gene context of FEDOTOZINE

  • The aims of this study were: to map, in conscious rats, central pathways activated by AA using Fos as a marker of neuronal activation; to characterize primary afferent fibres involved in this activation; and to investigate the effect of fedotozine on AA-induced Fos expression [16].
  • Since altered visceral perception is thought to play an important role in the genesis of abdominal pain and bloating in many patients with IBS, new drugs are targeted at modulating the sensitivity, such as 5HT3 antagonists (e.g. alosetron), kappa-agonists (e.g. fedotozine) and somatostatin analogues [17].

Analytical, diagnostic and therapeutic context of FEDOTOZINE


  1. The kappa agonist fedotozine relieves hypersensitivity to colonic distention in patients with irritable bowel syndrome. Delvaux, M., Louvel, D., Lagier, E., Scherrer, B., Abitbol, J.L., Frexinos, J. Gastroenterology (1999) [Pubmed]
  2. Fedotozine reverses ileus induced by surgery or peritonitis: action at peripheral kappa-opioid receptors. Rivière, P.J., Pascaud, X., Chevalier, E., Le Gallou, B., Junien, J.L. Gastroenterology (1993) [Pubmed]
  3. Efficacy and safety of the peripheral kappa agonist fedotozine versus placebo in the treatment of functional dyspepsia. Read, N.W., Abitbol, J.L., Bardhan, K.D., Whorwell, P.J., Fraitag, B. Gut (1997) [Pubmed]
  4. The discriminative stimulus properties of U50,488 and morphine are not shared by fedotozine. Broqua, P., Wettstein, J.G., Rocher, M.N., Rivière, P.J., Dahl, S.G. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. (1998) [Pubmed]
  5. Kappa opioid receptor agonists differentially inhibit two classes of rat spinal neurons excited by colorectal distention. Ness, T.J. Gastroenterology (1999) [Pubmed]
  6. Effects of fedotozine on gastric emptying and upper gastrointestinal symptoms in diabetic gastroparesis. Jones, K.L., Wishart, J.M., Berry, M.K., Abitbol, J.L., Horowitz, M. Aliment. Pharmacol. Ther. (2000) [Pubmed]
  7. Differential effects of fedotozine compared to other kappa agonists on diuresis in rats. Soulard, C.D., Guerif, S., Payne, A., Dahl, S.G. J. Pharmacol. Exp. Ther. (1996) [Pubmed]
  8. Centrally acting agents and visceral sensitivity. Fioramonti, J., Bueno, L. Gut (2002) [Pubmed]
  9. Fedotozine reversal of peritoneal-irritation-induced ileus in rats: possible peripheral action on sensory afferents. Riviere, P.J., Pascaud, X., Chevalier, E., Junien, J.L. J. Pharmacol. Exp. Ther. (1994) [Pubmed]
  10. Pharmacological characterization of the cloned kappa opioid receptor as a kappa 1b subtype. Lai, J., Ma, S.W., Zhu, R.H., Rothman, R.B., Lentes, K.U., Porreca, F. Neuroreport (1994) [Pubmed]
  11. Effects of fedotozine on gastrointestinal motility in dogs: mechanism of action and related pharmacokinetics. Pascaud, X., Honde, C., Le Gallou, B., Chanoine, F., Roman, F., Bueno, L., Junien, J.L. J. Pharm. Pharmacol. (1990) [Pubmed]
  12. Effect of the kappa agonist fedotozine on perception of gastric distension in healthy humans. Coffin, B., Bouhassira, D., Chollet, R., Fraitag, B., De Meynard, C., Geneve, J., Lemann, M., Willer, J.C., Jian, R. Aliment. Pharmacol. Ther. (1996) [Pubmed]
  13. The contractile effect of fedotozine on guinea pig isolated intestinal cells is not mediated by kappa opioid receptors. Coruzzi, G., Morini, G., Coppelli, G., Bertaccini, G. Pharmacology (1998) [Pubmed]
  14. Role of opioid ligands in the irritable bowel syndrome. Corazziari, E. Can. J. Gastroenterol. (1999) [Pubmed]
  15. Effect of fedotozine on human distal colon. Adami, M., Bertaccini, G., Roncoroni, L., Cobianchi, F. The Italian journal of gastroenterology. (1996) [Pubmed]
  16. Fedotozine, a kappa-opioid agonist, prevents spinal and supra-spinal Fos expression induced by a noxious visceral stimulus in the rat. Bonaz, B., Rivière, P.J., Sinniger, V., Pascaud, X., Junien, J.L., Fournet, J., Feuerstein, C. Neurogastroenterol. Motil. (2000) [Pubmed]
  17. New developments in the treatment of irritable bowel syndrome. De Schryver, A.M., Samsom, M. Scand. J. Gastroenterol. Suppl. (2000) [Pubmed]
  18. Effects of mu- and kappa-opioid receptors on postoperative ileus in rats. De Winter, B.Y., Boeckxstaens, G.E., De Man, J.G., Moreels, T.G., Herman, A.G., Pelckmans, P.A. Eur. J. Pharmacol. (1997) [Pubmed]
  19. Irritable bowel syndrome neuropharmacology. A review of approved and investigational compounds. Callahan, M.J. J. Clin. Gastroenterol. (2002) [Pubmed]
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