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Chemical Compound Review

BSPBio_001403     [(2S)-2-acetyloxy-3-hydroxy- propyl] (Z)...

Synonyms: O6754_SIGMA, AC1O5MXE, BML2-F08, HMS1361G05, HMS1791G05, ...
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Disease relevance of Oleoylacetylglycerol


High impact information on Oleoylacetylglycerol


Chemical compound and disease context of Oleoylacetylglycerol


Biological context of Oleoylacetylglycerol


Anatomical context of Oleoylacetylglycerol

  • We report here that addition of the synthetic diacylglycerol 1-oleoyl-2-acetylglycerol (OAG) to quiescent cultures of Swiss 3T3 cells caused a marked increase in the rate of ouabain-sensitive 86Rb+ uptake, a measure of the activity of the Na+/K+ pump [18].
  • As judged by indirect immunofluorescence, phorbol 12,13-dibutyrate and 1-oleoyl-2-acetylglycerol induced a rapid, concentration-dependent decrease of about 50% in the surface expression of the T3 antigen on human T lymphoblasts, and of T3 and the T-cell antigen receptor on HPB-ALL cells [19].
  • The treatment of HL-60 and U-937 cell lines with 1-oleoyl-2-acetylglycerol, a synthetic analog of diacylglycerol that, like TPA, stimulates protein kinase C activity, was followed by early and transient induction of c-fos mRNA in the absence of terminal macrophage differentiation [20].
  • The addition of 1-oleoyl-2-acetylglycerol (OAG), or phorbol-12-myristate-13-acetate (PMA) to platelets induced the phosphorylation of a 47,000 dalton protein (47 Kd), fusion of granule membranes with membranes of the surface connected canalicular system, the formation of large vesicles and the secretion of serotonin [21].
  • We compared the effect of pretreating intact monoblastoid U937 cells with TPA or the diacylglycerol derivative, 1-oleoyl-2-acetylglycerol (OAG), by studying the protein kinase C dependent and independent histone phosphotransferase activity, the phosphorylation of endogenous substrates, and the ability to stimulate differentiation [22].

Associations of Oleoylacetylglycerol with other chemical compounds


Gene context of Oleoylacetylglycerol


Analytical, diagnostic and therapeutic context of Oleoylacetylglycerol


  1. Effects of 12-O-tetradecanoylphorbol-13-acetate on adhesiveness and lung-colonizing ability of Lewis lung carcinoma cells. Takenaga, K., Takahashi, K. Cancer Res. (1986) [Pubmed]
  2. Ultraviolet radiation-induced melanogenesis in human melanocytes. Effects of modulating protein kinase C. Carsberg, C.J., Warenius, H.M., Friedmann, P.S. J. Cell. Sci. (1994) [Pubmed]
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  5. Differential effect on inositol-phospholipid hydrolysis, cytosolic-free Ca2+ concentration, protein kinase C activity and protein phosphorylation of 1-oleoyl-2-acetyl-sn-glycerol growth-stimulated ascites tumor cells. Seibicke, S., Strosznajder, J.B., Haeffner, E.W. Eur. J. Cell Biol. (1988) [Pubmed]
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  8. Dopamine induces neurite retraction in retinal horizontal cells via diacylglycerol and protein kinase C. Rodrigues, P.d.o.s. .S., Dowling, J.E. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  9. Rapid enhancement of beta 2-interferon/B-cell differentiation factor BSF-2 gene expression in human fibroblasts by diacylglycerols and the calcium ionophore A23187. Sehgal, P.B., Walther, Z., Tamm, I. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  10. Activators of protein kinase C enhance acetylcholine receptor desensitization in sympathetic ganglion neurons. Downing, J.E., Role, L.W. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
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  12. Guanine nucleotides activate cytosolic phospholipase C of ascites tumour cells stimulated by 1-oleoyl-2-acetyl-sn-glycerol. Strosznajder, J., Haeffner, E.W. International journal of tissue reactions. (1988) [Pubmed]
  13. Phorbol ester, serum, and rous sarcoma virus transforming gene product induce similar phosphorylations of ribosomal protein S6. Blenis, J., Spivack, J.G., Erikson, R.L. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
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  15. R 59 022, a diacylglycerol kinase inhibitor. Its effect on diacylglycerol and thrombin-induced C kinase activation in the intact platelet. de Chaffoy de Courcelles, D.C., Roevens, P., Van Belle, H. J. Biol. Chem. (1985) [Pubmed]
  16. Modulation of human platelet-activating factor receptor gene expression by protein kinase C activation. Thivierge, M., Parent, J.L., Stankova, J., Rola-Pleszczynski, M. J. Immunol. (1996) [Pubmed]
  17. Sphingomyelin synthase as a potential target for D609-induced apoptosis in U937 human monocytic leukemia cells. Meng, A., Luberto, C., Meier, P., Bai, A., Yang, X., Hannun, Y.A., Zhou, D. Exp. Cell Res. (2004) [Pubmed]
  18. Ionic responses rapidly elicited by activation of protein kinase C in quiescent Swiss 3T3 cells. Vara, F., Schneider, J.A., Rozengurt, E. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  19. Activators of protein kinase C down-regulate and phosphorylate the T3/T-cell antigen receptor complex of human T lymphocytes. Cantrell, D.A., Davies, A.A., Crumpton, M.J. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  20. Dissociation of c-fos induction from macrophage differentiation in human myeloid leukemic cell lines. Calabretta, B. Mol. Cell. Biol. (1987) [Pubmed]
  21. A role for protein kinase C in the membrane fusion necessary for platelet granule secretion. Gerrard, J.M., Beattie, L.L., Park, J., Israels, S.J., McNicol, A., Lint, D., Cragoe, E.J. Blood (1989) [Pubmed]
  22. Dissimilar effects of phorbol ester and diacylglycerol derivative on protein kinase activity in the monoblastoid U937 cell. Ways, D.K., Dodd, R.C., Earp, H.S. Cancer Res. (1987) [Pubmed]
  23. Synergy between phorbol esters, 1-oleyl-2-acetylglycerol, urushiol, and calcium ionophore in eliciting aggregation of marine sponge cells. Weissmann, G., Azaroff, L., Davidson, S., Dunham, P. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  24. Diacylglycerol increases cytosolic free Ca2+ concentration in rat pituitary cells. Relationship to thyrotropin-releasing hormone action. Albert, P.R., Wolfson, G., Tashjian, A.H. J. Biol. Chem. (1987) [Pubmed]
  25. Phorbol ester and 1-oleoyl-2-acetylglycerol inhibit angiotensin activation of phospholipase C in cultured vascular smooth muscle cells. Brock, T.A., Rittenhouse, S.E., Powers, C.W., Ekstein, L.S., Gimbrone, M.A., Alexander, R.W. J. Biol. Chem. (1985) [Pubmed]
  26. Protein tyrosine phosphorylation and p56lck modification in IL-2 or phorbol ester-activated human natural killer cells. Einspahr, K.J., Abraham, R.T., Dick, C.J., Leibson, P.J. J. Immunol. (1990) [Pubmed]
  27. Differential effects of phorbol ester on phenylephrine and vasopressin-induced Ca2+ mobilization in isolated hepatocytes. Cooper, R.H., Coll, K.E., Williamson, J.R. J. Biol. Chem. (1985) [Pubmed]
  28. 1-Oleoyl-2-acetylglycerol stimulates 5-lipoxygenase activity via a putative (phospho)lipid binding site within the N-terminal C2-like domain. Hörnig, C., Albert, D., Fischer, L., Hörnig, M., Rådmark, O., Steinhilber, D., Werz, O. J. Biol. Chem. (2005) [Pubmed]
  29. Protein kinase C regulates Fas (CD95/APO-1) expression. Wang, R., Zhang, L., Yin, D., Mufson, R.A., Shi, Y. J. Immunol. (1998) [Pubmed]
  30. Unsaturated fatty acids phosphorylate and destabilize ABCA1 through a phospholipase D2 pathway. Wang, Y., Oram, J.F. J. Biol. Chem. (2005) [Pubmed]
  31. The canonical transient receptor potential 6 channel as a putative phosphatidylinositol 3,4,5-trisphosphate-sensitive calcium entry system. Tseng, P.H., Lin, H.P., Hu, H., Wang, C., Zhu, M.X., Chen, C.S. Biochemistry (2004) [Pubmed]
  32. Phosphatidylcholine-specific phospholipase C regulates activation of RAW264.7 macrophage-like cells by lipopeptide JBT3002. Zhang, F., Zhao, G., Dong, Z. J. Leukoc. Biol. (2001) [Pubmed]
  33. Inhibition by bradykinin of voltage-activated barium current in a rat dorsal root ganglion cell line: role of protein kinase C. Boland, L.M., Allen, A.C., Dingledine, R. J. Neurosci. (1991) [Pubmed]
  34. Regulation of calcium channels in aortic muscle cells by protein kinase C activators (diacylglycerol and phorbol esters) and by peptides (vasopressin and bombesin) that stimulate phosphoinositide breakdown. Galizzi, J.P., Qar, J., Fosset, M., Van Renterghem, C., Lazdunski, M. J. Biol. Chem. (1987) [Pubmed]
  35. Studies on the mechanism of phorbol ester-induced inhibition of intercellular junctional communication. Davidson, J.S., Baumgarten, I.M., Harley, E.H. Carcinogenesis (1985) [Pubmed]
  36. Growth hormone-releasing hormone immunoreactivity in mouse placenta, maternal blood, and amniotic fluid: molecular characterization and secretion from primary cell cultures in vitro. Mizobuchi, M., Downs, T.R., Frohman, L.A. Endocrinology (1995) [Pubmed]
  37. Inhibition of phorbol ester stimulated superoxide production by 1-oleoyl-2-acetyl-sn-glycerol (OAG); fact or artefact? Bonser, R.W., Dawson, J., Thompson, N.T., Hodson, H.F., Garland, L.G. FEBS Lett. (1986) [Pubmed]
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