Disease relevance of 33240-95-8

• Mineralization of free and of humus-bound 3,4-dichloroaniline (DCA) by a Pseudomonas putida strain isolated by analog enrichment was greatly enhanced in the presence of aniline [1].
• Salicylanilide, salicylic acid, and 3,4-dichloroaniline failed to demonstrate photosensitization potential [2].
• The toxicity of 3,4-dichloroaniline was not significantly affected by food concentration [3].
• In this work we investigated the acute effects of 3,4-dichloroaniline (DCA) on the changes of specific biochemical and cellular blood parameters using male Wistar rats, 24 hours after the intraperitoneal administration of five different doses of DCA (0, 81, 162, 324, 486, and 568 mg/Kg of body weight) [4].
• Among the substrates of PANAT so far identified are the anti-tubercular drug isoniazid, 5-aminosalicylate (a drug used in the treatment of inflammatory bowel disease), as well as important environmental pollutants such as 3,4-dichloroaniline and 2-aminofluorene [5].

High impact information on 33240-95-8

• The myelotoxicity of the herbicide propanil (3,4-dichloroproprioanilide) and its metabolite 3,4-dichloroaniline (DCA) is well documented in mice, but evidence that pesticides may severely compromise hematopoiesis in humans is lacking [6].
• The phenylurea herbicide linuron and its derivative 3,4-dichloroaniline (3,4-DCA), which are found in sediments and surface waters, are known to displace bound testosterone from the rat androgen receptor [7].
• The survival of previously administered 51Cr-labeled erythrocytes in rats was reduced in a dose-dependent manner by ip administration of both propanil and its deacylated metabolite, 3,4-dichloroaniline (ED50 for both ca. 1.8 mmol/kg) [8].
• HPLC analysis of alkaline-treated hemoglobin from propanil-treated rats indicated the presence of one radiolabeled compound with the same HPLC retention time as 3,4-dichloraniline [9].
• The major pathway of propanil metabolism in microsomal incubations was acylamidase-catalyzed hydrolysis to 3,4-dichloroaniline [10].

Chemical compound and disease context of 33240-95-8

• The feeding activity of juvenile G. pulex was found to be a sensitive response criterion for use in assessing the sublethal toxicity of copper, lindane, and 3,4-dichloroaniline (3,4-DCA) [11].
• In this report we used the yield of PSII variable fluorescence of Lemna gibba affected by the DCMU derivatives DCPMU [1-(3,4-dichlorophenyl)-3-methylurea], DCPU [1-(3,4-dichlorophenyl)urea], and DCA [3,4-dichloroaniline] to calculate the fluorescence toxicity index [12].
• Propanil 3,4-dichloroaniline, and their N-OH derivatives were not mutagenic in the Salmonella typhimurium reversion assay using tester strains TA97, TA98, TA100, and TA104, in both the presence and absence of exogenous metabolic activation (S9) [13].
• Toxicity of sodium chromate and 3,4-dichloroaniline to crustaceans [14].

Biological context of 33240-95-8

• Acylamidase-catalyzed hydrolysis of propanil to 3,4-dichloroaniline was not induced by any of the pretreatments; however, hydroxylation of propanil at the 2'-position was induced by TCDD, TCAB, TCAOB, propanil, and 3,4-dichloroaniline pretreatments [15].
• The results indicate that 3,4-DCA might induce aneuploidy in mammalian cells by interaction with the mitotic apparatus [16].
• Cytogenetic effects of 3,4-dichloroaniline in human lymphocytes and V79 Chinese hamster cells [16].
• In the present study a preparation and staining technique has been used that allows a direct examination of the spindle apparatus and chromosome behaviour of 3,4-DCA-exposed V79 Chinese hamster cells [17].
• So the biotransformation of 3,4-dichloroaniline was then tested with four fungal strains: Aspergillus niger, Beauveria bassiana, Cunninghamella echinulata var. elegans and Mortierella isabellina [18].

Anatomical context of 33240-95-8

• The same N- and C-oxygenated derivatives of 4-chloro- and 3,4-dichloroaniline were also formed by hepatic microsomes, although at a 25- to 5000-fold higher rate [19].
• Degradation of 3,4-dichloroaniline (34DCA) in aqueous solution by undefined cultures of free and immobilized cells was examined [20].

Associations of 33240-95-8 with other chemical compounds

• The binary mixture of 2 micrograms/liter, 3,4-dichloroaniline and 40 micrograms/liter lindane in tap water had an influence on growth on the early life stages of zebrafish [21].
• The effects of 3,4-dichloroaniline (DCA) on various reproductive parameters of Daphnia magna, including r, net reproductive rate in 21 days (R21), age at first reproduction (AFR), adult survival, and egg viability, were measured simultaneously with gj [22].
• OBJECTIVE: In order to develop a screening test to detect human occupational exposure to aromatic amines such as 3,4-dichloroaniline (3,4-DCA) and 3,5-dichloroaniline (3,5-DCA), we first investigated the urinary excretion of these highly toxic compounds in the rat [23].
• The LC50 (96 h) values and the bioconcentration factors (BCF) for nine anilines (aniline; 2-, 3-, 4-chloroaniline; 2-, 3-, 4-nitroaniline; 2,4- and 3,4-dichloroaniline) in the zebrafish (Brachydanio rerio) were determined [24].
• The evaluated inhibition of growth to Cu2+, Cr6+, Zn2+, Hg2+, Cd2+, Pb2+, cetyl-trimethylammonium bromide, 3,4-dichloroaniline, acetone, dimethylsulfoxide, ethanol, nitrobenzene, methanol, and 3,5-dichlorophenol was compared with results from another investigation, where the inhibition was determined by bioluminescence [25].

Analytical, diagnostic and therapeutic context of 33240-95-8

• The urine samples were collected for a period of 24 hours after treatment and the excretion of 3,4-DCA, 3,5-DCA was studied using a GC-MS and an HPLC method after urine extraction [23].
• The filtration and ingestion rates of this rotifer decreased after an exposure of 5 hr to sublethal concentrations of copper, pentachlorophenolate, 3,4-dichloroaniline, and lindane [26].
• However, control group FT50 values were determined on each occasion the bioassay was performed, indicating that a substantial reduction in gammarid feeding activity had occurred in the majority of the 3,4-DCA treatment groups [11].

References