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MeSH Review

Occult Blood

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Disease relevance of Occult Blood

  • Reducing mortality from colorectal cancer by screening for fecal occult blood. Minnesota Colon Cancer Control Study [1].
  • The stool DAF test was positive in a substantial portion of patients with colorectal cancer whose tumors were small ( < 2 cm), at an early TNM stage, or unassociated with fecal occult blood positivity [2].
  • After 7 weeks of daily intraperitoneal melatonin administration (150 micrograms/kg), rectal bleeding and occult blood was eliminated in all mice in which colitis was induced by DSS [3].
  • Recurrent episodes of severe abdominal pain and a positive fecal occult blood test in an 18-yr-old boy with mild mental retardation and slight dysmorphic features of the face, head, and skeletal system led to the diagnosis of FAP [4].
  • A study was undertaken to assess the impact of computer-generated reminders to adult patients, their physicians, or both patients and physicians on adherence to five recommended preventive services: cholesterol measurements, fecal occult blood testing, mammography, Papanicolaou smears, and tetanus immunization [5].

High impact information on Occult Blood


Chemical compound and disease context of Occult Blood

  • Indications for systemic toxicity were noticed in the high-dose group and included occult blood in urine, elevated protein/creatinine ratio concomitantly with an increased urine volume and increased relative kidney weight indicating a slight disturbance of the kidney function [11].
  • Mass screening for asymptomatic subjects and follow-up for high risk population are mainly used to find the early stage colorectal cancer in China. Fecal occult blood test is also widely made as primary screening test, galactose oxygenase test of rectal mucus (T antigen), fecal occult albumin test are also used [12].

Biological context of Occult Blood


Anatomical context of Occult Blood


Associations of Occult Blood with chemical compounds

  • The study focused on whether a Pap smear was performed and whether a breast examination, mammogram, rectal examination or stool occult blood test, or serum cholesterol testing was performed [21].
  • OBJECTIVE: To determine whether low-dose aspirin or warfarin induces fecal occult blood loss [22].
  • Fecal occult blood loss is increased in most regular aspirin users but not in those taking acetaminophen [23].
  • Even more alarming, 86% of the A lesions, 50% of the B1 lesions, 31% of the B2 lesions, and 14% of the C2 lesions were occult blood negative [24].
  • Rapid immunochemical detection of fecal occult blood by use of a latex-agglutination test [25].

Gene context of Occult Blood


Analytical, diagnostic and therapeutic context of Occult Blood


  1. Reducing mortality from colorectal cancer by screening for fecal occult blood. Minnesota Colon Cancer Control Study. Mandel, J.S., Bond, J.H., Church, T.R., Snover, D.C., Bradley, G.M., Schuman, L.M., Ederer, F. N. Engl. J. Med. (1993) [Pubmed]
  2. Detection of decay-accelerating factor in stool specimens of patients with colorectal cancer. Mizuno, M., Nakagawa, M., Uesu, T., Inoue, H., Inaba, T., Ueki, T., Nasu, J., Okada, H., Fujita, T., Tsuji, T. Gastroenterology (1995) [Pubmed]
  3. Melatonin reduces the severity of dextran-induced colitis in mice. Pentney, P.T., Bubenik, G.A. J. Pineal Res. (1995) [Pubmed]
  4. A de novo deletion of chromosome 5q causing familial adenomatous polyposis, dysmorphic features, and mild mental retardation. Raedle, J., Friedl, W., Engels, H., Koenig, R., Trojan, J., Zeuzem, S. Am. J. Gastroenterol. (2001) [Pubmed]
  5. Computer-generated physician and patient reminders. Tools to improve population adherence to selected preventive services. Ornstein, S.M., Garr, D.R., Jenkins, R.G., Rust, P.F., Arnon, A. The Journal of family practice. (1991) [Pubmed]
  6. Contamination of urine with povidone-iodine. Cause of false-positive test for occult blood in urine. Said, R. JAMA (1979) [Pubmed]
  7. Guaifenesin effects on the guaiac test for occult blood. Brown, J.R., Self, T.H., Taylor, W.J., Stargel, W.W., Boswell, R.L. JAMA (1976) [Pubmed]
  8. False-positive stool occult blood tests caused by iron preparations. A controlled study and review of literature. Lifton, L.J., Kreiser, J. Gastroenterology (1982) [Pubmed]
  9. Vitamin C and guaiac occult blood tests. Nagengast, F.M. Lancet (1981) [Pubmed]
  10. Aspirin as an adjunct to screening for prevention of sporadic colorectal cancer. A cost-effectiveness analysis. Ladabaum, U., Chopra, C.L., Huang, G., Scheiman, J.M., Chernew, M.E., Fendrick, A.M. Ann. Intern. Med. (2001) [Pubmed]
  11. Subacute toxicity of Zwittergent administered intramuscularly. Speijers, G.J., Danse, L.H., Krajnc-Franken, M.A., van Leeuwen, F.X., Helleman, P.W., Beuvery, E.C., Vos, J.G., vd Heijden, C.A. Vaccine (1989) [Pubmed]
  12. Early diagnosis for colorectal cancer in China. Zhang, Y.L., Zhang, Z.S., Wu, B.P., Zhou, D.Y. World J. Gastroenterol. (2002) [Pubmed]
  13. Computerized protocol for preventive medicine: a controlled self-audit in family practice. Weingarten, M.A., Bazel, D., Shannon, H.S. Family practice. (1989) [Pubmed]
  14. Prevention of gut inflammation by Bifidobacterium in dextran sulfate-treated gnotobiotic mice associated with Bacteroides strains isolated from ulcerative colitis patients. Setoyama, H., Imaoka, A., Ishikawa, H., Umesaki, Y. Microbes Infect. (2003) [Pubmed]
  15. Defining and diagnosing irritable bowel syndrome. Schuster, M.M. The American journal of managed care. (2001) [Pubmed]
  16. Can the cost savings of eliminating urine microscopy in biochemically negative urines be extended to the pediatric population? Hamoudi, A.C., Bubis, S.C., Thompson, C. Am. J. Clin. Pathol. (1986) [Pubmed]
  17. Endothelin-1 in the gastric mucosa in stress ulcers of critically ill patients. Michida, T., Kawano, S., Masuda, E., Kobayashi, I., Nishimura, Y., Tsujii, M., Takei, Y., Tsuji, S., Nagano, K., Fusamoto, H., Kamada, T., Sugimoto, T. Am. J. Gastroenterol. (1997) [Pubmed]
  18. The etiology and management of diarrhea in the gynecologic oncology patient. Cirisano, F.D., Greenspoon, J.S., Stenson, R., Farias-Eisner, R., Karlan, B.Y., Lagasse, L.D. Gynecol. Oncol. (1993) [Pubmed]
  19. Screening for proteinuria in Japanese schoolchildren: a new approach. Pugia, M.J., Murakami, M., Lott, J.A., Ohta, Y., Kitagawa, T., Yamauchi, K., Suhara, Y., Kasjima, J. Clin. Chem. Lab. Med. (2000) [Pubmed]
  20. Effects of long-term oral administration of ketoprofen in clinically healthy beagle dogs. Narita, T., Tomizawa, N., Sato, R., Goryo, M., Hara, S. J. Vet. Med. Sci. (2005) [Pubmed]
  21. The Papanicolaou smear as a sentinel screening test for health screening in women. Hueston, W.J., Stiles, M.A. Arch. Intern. Med. (1994) [Pubmed]
  22. Asymptomatic chronic gastrointestinal blood loss in patients taking aspirin or warfarin for cardiovascular disease. Greenberg, P.D., Cello, J.P., Rockey, D.C. Am. J. Med. (1996) [Pubmed]
  23. Gastrointestinal effects of antipyretic analgesics. Ivey, K.J. Am. J. Med. (1983) [Pubmed]
  24. Colonoscopic detection of early colorectal cancers. Impact of a surgical endoscopy service. Longo, W.E., Ballantyne, G.H., Modlin, I.M. Ann. Surg. (1988) [Pubmed]
  25. Rapid immunochemical detection of fecal occult blood by use of a latex-agglutination test. Väänänen, P., Tenhunen, R. Clin. Chem. (1988) [Pubmed]
  26. Faecal elastase 1: a marker of exocrine pancreatic insufficiency in cystic fibrosis. Phillips, I.J., Rowe, D.J., Dewar, P., Connett, G.J. Ann. Clin. Biochem. (1999) [Pubmed]
  27. How to screen for colon cancer. Lieberman, D. Annu. Rev. Med. (1998) [Pubmed]
  28. Diagnostic value of a guaiac occult blood test and faecal alpha 1-antitrypsin. Moran, A., Husband, D., Jones, A.F., Asquith, P. Gut (1995) [Pubmed]
  29. Spectrophotometry of occult blood in feces. Welch, C.L., Young, D.S. Clin. Chem. (1983) [Pubmed]
  30. Immunological determination of fecal hemoglobin and transferrin levels: a comparison with other fecal occult blood tests. Miyoshi, H., Ohshiba, S., Asada, S., Hirata, I., Uchida, K. Am. J. Gastroenterol. (1992) [Pubmed]
  31. Opportunistic discovery of occult disease by use of test panels in new, symptomatic primary care outpatients: yield and cost of case finding. Takemura, Y., Ishida, H., Inoue, Y., Kobayashi, H., Beck, J.R. Clin. Chem. (2000) [Pubmed]
  32. Chemical and immunological testing for faecel occult blood: a comparison of two tests in symptomatic patients. Thomas, W.M., Hardcastle, J.D., Jackson, J., Pye, G. Br. J. Cancer (1992) [Pubmed]
  33. Delayed feedback of physician performance versus immediate reminders to perform preventive care. Effects on physician compliance. Tierney, W.M., Hui, S.L., McDonald, C.J. Medical care. (1986) [Pubmed]
  34. Practice patterns of testing waived under the clinical laboratory improvement amendments. Steindel, S.J., Granade, S., Lee, J., Avery, G., Clarke, L.M., Jenny, R.W., LaBeau, K.M. Arch. Pathol. Lab. Med. (2002) [Pubmed]
  35. Hosting a wellness day: promoting health in the old-old. Resnick, B. Clinical excellence for nurse practitioners : the international journal of NPACE. (2000) [Pubmed]
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