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Chemical Compound Review

Bromoadenosine     (2R,3R,4S,5R)-2-(6-amino-8- bromo-purin-9...

Synonyms: SureCN440925, CHEMBL1775009, B6272_SIGMA, AC1L3WOU, KB-46725, ...
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Disease relevance of NSC 79213


High impact information on NSC 79213


Biological context of NSC 79213

  • Transcriptional regulation of chorionic gonadotropin alpha- and beta-subunit gene expression by 8-bromo-adenosine 3',5'-monophosphate [8].
  • Interleukin-4 (IL-4) or 8-bromo-adenosine 3',5'-cyclic monophosphate (cAMP) also lowered the levels of these cell cycle regulatory proteins, although their effects were relatively weak, reflecting their only partial inhibition of HUASMC DNA synthesis [9].
  • METHODS: Changes in membrane potential induced either by the adenylcyclase activator forskolin (10 microM; n = 4) or the stable membrane permeable cAMP analog 8-bromo-adenosine 3',5'-cyclic monophosphothioate (8-br-cAMP; 30 microM; n = 4) were measured with intracellular microelectrodes [10].

Anatomical context of NSC 79213


Associations of NSC 79213 with other chemical compounds


Gene context of NSC 79213


  1. Bromo-adenosine stimulates choriogonadotropin production in JAr and cytotrophoblast cells: evidence for effects on two stages of differentiation. Sibley, C.P., Hochberg, A., Boime, I. Mol. Endocrinol. (1991) [Pubmed]
  2. Translocation of cytosol protein kinase into nuclei and the induction of tyrosine hydroxylase in NBD-2 neuroblastoma cells. Hollenbeck, R.A., Chuang, D.M., Costa, E. Brain Res. (1979) [Pubmed]
  3. Stimulation of amyloid precursor protein synthesis by adrenergic receptors coupled to cAMP formation. Lee, R.K., Araki, W., Wurtman, R.J. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  4. Human steroidogenic acute regulatory protein: functional activity in COS-1 cells, tissue-specific expression, and mapping of the structural gene to 8p11.2 and a pseudogene to chromosome 13. Sugawara, T., Holt, J.A., Driscoll, D., Strauss, J.F., Lin, D., Miller, W.L., Patterson, D., Clancy, K.P., Hart, I.M., Clark, B.J. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  5. Analysis of desmin and vimentin phosphopeptides in cultured avian myogenic cells and their modulation by 8-bromo-adenosine 3',5'-cyclic monophosphate. Gard, D.L., Lazarides, E. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  6. Modulation of rabbit ventricular cell volume and Na+/K+/2Cl- cotransport by cGMP and atrial natriuretic factor. Clemo, H.F., Feher, J.J., Baumgarten, C.M. J. Gen. Physiol. (1992) [Pubmed]
  7. 8-Bromo-adenosine 3',5'-monophosphate regulates expression of chorionic gonadotropin and fibronectin in human cytotrophoblasts. Ulloa-Aguirre, A., August, A.M., Golos, T.G., Kao, L.C., Sakuragi, N., Kliman, H.J., Strauss, J.F. J. Clin. Endocrinol. Metab. (1987) [Pubmed]
  8. Transcriptional regulation of chorionic gonadotropin alpha- and beta-subunit gene expression by 8-bromo-adenosine 3',5'-monophosphate. Jameson, J.L., Jaffe, R.C., Gleason, S.L., Habener, J.F. Endocrinology (1986) [Pubmed]
  9. G1 phase arrest of human smooth muscle cells by heparin, IL-4 and cAMP is linked to repression of cyclin D1 and cdk2. Vadiveloo, P.K., Filonzi, E.L., Stanton, H.R., Hamilton, J.A. Atherosclerosis (1997) [Pubmed]
  10. Cyclic AMP and anionic currents in porcine ciliary epithelium. Fleischhauer, J.C., Bény, J.L., Flammer, J., Haefliger, I.O. Klinische Monatsblätter für Augenheilkunde. (2001) [Pubmed]
  11. Enkephalin biosynthesis in adrenal medulla. Modulation of proenkephalin mRNA content of cultured chromaffin cells by 8-bromo-adenosine 3',5'-monophosphate. Quach, T.T., Tang, F., Kageyama, H., Mocchetti, I., Guidotti, A., Meek, J.L., Costa, E., Schwartz, J.P. Mol. Pharmacol. (1984) [Pubmed]
  12. 25-Hydroxycholesterol-supported and 8-bromo-adenosine 3',5'-monophosphate-stimulated testosterone production by primary cultures of two populations of rat Leydig cells. Georgiou, M., Payne, A.H. Endocrinology (1985) [Pubmed]
  13. Corticotropin increases protein tyrosine phosphatase activity by a cAMP-dependent mechanism in rat adrenal gland. Paz, C., Cornejo MacIel, F., Mendez, C., Podesta, E.J. Eur. J. Biochem. (1999) [Pubmed]
  14. Induction of meiotic maturation in mouse oocytes by adenosine analogs. Downs, S.M., Chen, J. Mol. Reprod. Dev. (2006) [Pubmed]
  15. Luteinizing hormone-induced intracellular calcium mobilization in granulosa cells: comparison with forskolin and 8-bromo-adenosine 3',5'-monophosphate. Asem, E.K., Molnar, M., Hertelendy, F. Endocrinology (1987) [Pubmed]
  16. The synthesis of several 8-substituted derivatives of adenosine 5'-monophosphate to study the effect of the nature of the spacer arm in affinity chromatography. Lowe, C.R. Eur. J. Biochem. (1977) [Pubmed]
  17. Depressed [Ca2+]i responses to isoproterenol and cAMP in isolated cardiomyocytes from experimental diabetic rats. Yu, Z., Quamme, G.A., McNeill, J.H. Am. J. Physiol. (1994) [Pubmed]
  18. 8-bromo-cAMP and 8-CPT-cAMP increase the density of beta-adrenoceptors in hepatocytes by a mechanism not mimicking the effect of cAMP. Sandnes, D., Jacobsen, F.W., Refsnes, M., Christoffersen, T. Pharmacol. Toxicol. (1996) [Pubmed]
  19. N-Methyl-D-aspartate receptors and p38 mitogen-activated protein kinase are required for cAMP-dependent cyclase response element binding protein and Elk-1 phosphorylation in the striatum. Choe, E.S., McGinty, J.F. Neuroscience (2000) [Pubmed]
  20. Stimulation of hepatocyte growth factor production in human fibroblasts by the protein phosphatase inhibitor okadaic acid. Gohda, E., Nagao, T., Yamamoto, I. Biochem. Pharmacol. (2000) [Pubmed]
  21. Testosterone suppresses 8-bromo-adenosine 3',5'-monophosphate and gonadotropin-releasing hormone-stimulated luteinizing hormone subunit synthesis. Muyan, M., Baldwin, D.M. Endocrinology (1992) [Pubmed]
  22. Progesterone and prostanoid production by bovine binucleate trophoblastic cells. Reimers, T.J., Ullmann, M.B., Hansel, W. Biol. Reprod. (1985) [Pubmed]
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