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Gene Review

CABP1  -  calcium binding protein 1

Homo sapiens

Synonyms: CALBRAIN, CaBP1, Calbrain, Calcium-binding protein 1, Caldendrin, ...
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Disease relevance of CABP1

  • Here we present data from NMR, microcalorimetry, and other biophysical studies that characterize Ca(2+) binding, Mg(2+) binding, and structural properties of recombinant CaBP1 purified from Escherichia coli [1].
  • In the present study we measured the content and determined the localization of a calcium-binding protein (CaBP) in the intestinal biopsy specimen of ten patients with severe renal insufficiency and in eight healthy individuals [2].
  • There was neither a correlation between the type and duration of renal insufficiency and the CaBP content of the specimens nor between the degree of renal osteodystrophy and CaBP content [2].
  • Because grafting procedures of fetal human neurons are increasingly used in the therapy of Parkinson's disease, it is important to study the development of DA neurons coexpressing CaBP [3].
  • The symptoms included reductions in body weight, plasma calcium and inorganic phosphorus, plasma and intestinal calcium-binding protein (CaBP), plasma 25-hydroxycholecalciferol [25(OH)D3], bone ash, and kidney 25(OH)D3-24-hydroxylase and a rise in kidney 25(OH)D3-1-hydroxylase activity [4].

Psychiatry related information on CABP1


High impact information on CABP1

  • We investigated the interaction of both naturally occurring long and short CaBP1 isoforms with InsP(3)Rs, and their functional effects on InsP(3)R-evoked Ca(2+) signals [6].
  • We also show that phosphorylation of CaBP1 at a casein kinase 2 consensus site regulates its inhibition of IICR [6].
  • Binding activates single-channel gating as efficaciously as InsP(3), dependent on functional EF-hands in CaBP [7].
  • Calcium-binding protein of chorioallantoic membrane: identification and development expression [8].
  • Expression of the CaBP occurs simultaneously with the onset of calcium absorption from the egg shell by the CAM, and the temporal increase in CaBP activity is coincident with calcium deposition in the embryo [8].

Chemical compound and disease context of CABP1

  • These findings suggest that the influence of the DA input on peptide expression varies from one striatal territory to the other, and that CaBP may protect midbrain DA neurons from MPTP toxicity [9].

Biological context of CABP1


Anatomical context of CABP1


Associations of CABP1 with chemical compounds

  • In the absence of Mg(2+) and Ca(2+), CaBP1 forms a flexible molten globule-like structure [1].
  • Calcium uptake was significantly stimulated in a dose-dependent manner by a 24-h treatment of the cells with 1,25-dihydroxy vitamin D3 (optimal dose approximately 0.5 nM); the CaBP level doubled whereas steady-state CaBP mRNA did not, suggesting that CaBP expression was regulated by 1,25-dihydroxy vitamin D3 [15].
  • In the primate neocortex, little is known about the possible associations between functional subclasses of GABA neurons, their morphological properties and calcium-binding protein (CaBP) content [16].
  • The X-ray structure of the quaternary complex of ribulose 1,5-bisphosphate carboxylase/oxygenase from spinach with CO2, Mg2+ and a reaction-intermediate analogue (CABP) has been determined and refined at 2.4 A resolution [17].
  • The association constant for the high-affinity Ca2+-binding sites of CaBP was estimated by gel filtration to be 0.1 X 10(6)M-1, and the protein displayed Ca2+-dependent electrophoretic mobility, with more rapid anodic migration in the presence of EDTA [13].

Other interactions of CABP1


Analytical, diagnostic and therapeutic context of CABP1


  1. Structural analysis of Mg2+ and Ca2+ binding to CaBP1, a neuron-specific regulator of calcium channels. Wingard, J.N., Chan, J., Bosanac, I., Haeseleer, F., Palczewski, K., Ikura, M., Ames, J.B. J. Biol. Chem. (2005) [Pubmed]
  2. Calcium-binding protein in the duodenal mucosa of uremic patients and normal subjects. Piazolo, P., Hotz, J., Helmke, K., Franz, H.E., Schleyer, M. Kidney Int. (1975) [Pubmed]
  3. Expression of calbindin D28K in the dopaminergic mesotelencephalic system in embryonic and fetal human brain. Verney, C., Zecevic, N., Ezan, P. J. Comp. Neurol. (2001) [Pubmed]
  4. Cholecalciferol requirements of young turkeys under normal conditions and during recovery from rickets. Bar, A., Edelstein, S., Eisner, U., Ben-Gal, I., Hurwitz, S. J. Nutr. (1982) [Pubmed]
  5. Calbindin-immunoreactive cholinergic neurones in the nucleus basalis of Meynert in Alzheimer-type dementia. Ichimiya, Y., Emson, P.C., Mountjoy, C.Q., Lawson, D.E., Iizuka, R. Brain Res. (1989) [Pubmed]
  6. Regulation of InsP3 receptor activity by neuronal Ca2+-binding proteins. Kasri, N.N., Holmes, A.M., Bultynck, G., Parys, J.B., Bootman, M.D., Rietdorf, K., Missiaen, L., McDonald, F., De Smedt, H., Conway, S.J., Holmes, A.B., Berridge, M.J., Roderick, H.L. EMBO J. (2004) [Pubmed]
  7. Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor Ca(2+) release channels. Yang, J., McBride, S., Mak, D.O., Vardi, N., Palczewski, K., Haeseleer, F., Foskett, J.K. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  8. Calcium-binding protein of chorioallantoic membrane: identification and development expression. Tuan, R.S., Scott, W.A. Proc. Natl. Acad. Sci. U.S.A. (1977) [Pubmed]
  9. Effects of dopamine denervation on striatal peptide expression in parkinsonian monkeys. Lavoie, B., Parent, A., Bédard, P.J. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques. (1991) [Pubmed]
  10. Calcium-binding protein 1 is an inhibitor of agonist-evoked, inositol 1,4,5-trisphosphate-mediated calcium signaling. Haynes, L.P., Tepikin, A.V., Burgoyne, R.D. J. Biol. Chem. (2004) [Pubmed]
  11. Calbrain, a novel two EF-hand calcium-binding protein that suppresses Ca2+/calmodulin-dependent protein kinase II activity in the brain. Yamaguchi, K., Yamaguchi, F., Miyamoto, O., Sugimoto, K., Konishi, R., Hatase, O., Tokuda, M. J. Biol. Chem. (1999) [Pubmed]
  12. Calcium binding protein in squid brain: biochemical similarity to the 28,000-Mr vitamin D-dependent calcium binding protein (calbindin-D28k). Christakos, S., Malkowitz, L., Sori, A., Sperduto, A., Feldman, S.C. J. Neurochem. (1987) [Pubmed]
  13. Ca2+-binding protein from human kidney. Purification and properties. Staun, M., Norén, O., Sjöström, H. Biochem. J. (1984) [Pubmed]
  14. Mechanism of S-nitrosation of recombinant human brain calbindin D28K. Tao, L., English, A.M. Biochemistry (2003) [Pubmed]
  15. In vitro study of placental trophoblast calcium uptake using JEG-3 human choriocarcinoma cells. Tuan, R.S., Moore, C.J., Brittingham, J.W., Kirwin, J.J., Akins, R.E., Wong, M. J. Cell. Sci. (1991) [Pubmed]
  16. Localization of calcium-binding proteins in physiologically and morphologically characterized interneurons of monkey dorsolateral prefrontal cortex. Zaitsev, A.V., Gonzalez-Burgos, G., Povysheva, N.V., Kröner, S., Lewis, D.A., Krimer, L.S. Cereb. Cortex (2005) [Pubmed]
  17. Crystallographic analysis of ribulose 1,5-bisphosphate carboxylase from spinach at 2.4 A resolution. Subunit interactions and active site. Knight, S., Andersson, I., Brändén, C.I. J. Mol. Biol. (1990) [Pubmed]
  18. Calcium-binding protein S100A7 and epidermal-type fatty acid-binding protein are associated in the cytosol of human keratinocytes. Hagens, G., Masouyé, I., Augsburger, E., Hotz, R., Saurat, J.H., Siegenthaler, G. Biochem. J. (1999) [Pubmed]
  19. Calcium binding protein (calbindin D28k) immunoreactivity in the hamster superior colliculus: ultrastructure and lack of co-localization with GABA. Behan, M., Jourdain, A., Bray, G.M. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (1992) [Pubmed]
  20. KDEL motif interacts with a specific sequence in mammalian erd2 receptor. Janson, I.M., Toomik, R., O'Farrell, F., Ek, P. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  21. Ca2+-binding protein-1 facilitates and forms a postsynaptic complex with Cav1.2 (L-type) Ca2+ channels. Zhou, H., Kim, S.A., Kirk, E.A., Tippens, A.L., Sun, H., Haeseleer, F., Lee, A. J. Neurosci. (2004) [Pubmed]
  22. The early time course of calcium-binding protein induction by 1,25-dihydroxyvitamin D3 as determined by computer analysis of two-dimensional electrophoresis gels. Bishop, C.W., Kendrick, N.C., DeLuca, H.F. J. Biol. Chem. (1984) [Pubmed]
  23. Ontogenesis of 28 kDa vitamin D-induced calcium-binding protein in human kidney. Mounier, F., Hinglais, N., Brehier, A., Thomasset, M., Lacoste, M., Sich, M., Gubler, M.C. Kidney Int. (1987) [Pubmed]
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