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Gene Review

Aifm1  -  apoptosis-inducing factor, mitochondrion...

Mus musculus

Synonyms: AIF, AIFsh2, Aif, Apoptosis-inducing factor 1, mitochondrial, Hq, ...
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Disease relevance of Aifm1


High impact information on Aifm1


Chemical compound and disease context of Aifm1


Biological context of Aifm1


Anatomical context of Aifm1


Associations of Aifm1 with chemical compounds


Physical interactions of Aifm1


Enzymatic interactions of Aifm1

  • Both precursor and mature forms of recombinant AIF were cleaved near the amino terminus by calpain I in vitro [1].

Regulatory relationships of Aifm1


Other interactions of Aifm1


Analytical, diagnostic and therapeutic context of Aifm1


  1. Calpain I induces cleavage and release of apoptosis-inducing factor from isolated mitochondria. Polster, B.M., Basañez, G., Etxebarria, A., Hardwick, J.M., Nicholls, D.G. J. Biol. Chem. (2005) [Pubmed]
  2. Apoptosis inducing factor mediates caspase-independent 1-methyl-4-phenylpyridinium toxicity in dopaminergic cells. Chu, C.T., Zhu, J.H., Cao, G., Signore, A., Wang, S., Chen, J. J. Neurochem. (2005) [Pubmed]
  3. Apoptosis inducing factor and PARP-mediated injury in the MPTP mouse model of Parkinson's disease. Wang, H., Shimoji, M., Yu, S.W., Dawson, T.M., Dawson, V.L. Ann. N. Y. Acad. Sci. (2003) [Pubmed]
  4. AIF deficiency compromises oxidative phosphorylation. Vahsen, N., Candé, C., Brière, J.J., Bénit, P., Joza, N., Larochette, N., Mastroberardino, P.G., Pequignot, M.O., Casares, N., Lazar, V., Feraud, O., Debili, N., Wissing, S., Engelhardt, S., Madeo, F., Piacentini, M., Penninger, J.M., Schägger, H., Rustin, P., Kroemer, G. EMBO J. (2004) [Pubmed]
  5. Muscle-specific loss of apoptosis-inducing factor leads to mitochondrial dysfunction, skeletal muscle atrophy, and dilated cardiomyopathy. Joza, N., Oudit, G.Y., Brown, D., Bénit, P., Kassiri, Z., Vahsen, N., Benoit, L., Patel, M.M., Nowikovsky, K., Vassault, A., Backx, P.H., Wada, T., Kroemer, G., Rustin, P., Penninger, J.M. Mol. Cell. Biol. (2005) [Pubmed]
  6. Dueling activities of AIF in cell death versus survival: DNA binding and redox activity. Lipton, S.A., Bossy-Wetzel, E. Cell (2002) [Pubmed]
  7. The harlequin mouse mutation downregulates apoptosis-inducing factor. Klein, J.A., Longo-Guess, C.M., Rossmann, M.P., Seburn, K.L., Hurd, R.E., Frankel, W.N., Bronson, R.T., Ackerman, S.L. Nature (2002) [Pubmed]
  8. Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death. Joza, N., Susin, S.A., Daugas, E., Stanford, W.L., Cho, S.K., Li, C.Y., Sasaki, T., Elia, A.J., Cheng, H.Y., Ravagnan, L., Ferri, K.F., Zamzami, N., Wakeham, A., Hakem, R., Yoshida, H., Kong, Y.Y., Mak, T.W., Zúñiga-Pflücker, J.C., Kroemer, G., Penninger, J.M. Nature (2001) [Pubmed]
  9. Genistein-induced apoptosis of p815 mastocytoma cells is mediated by Bax and augmented by a proteasome inhibitor, lactacystin. Park, B.S., Baek, S.J., Song, K.H., Kim, K.H., Jeong, S.J., Jeong, M.H., Seo, S.Y., Lee, S.W., Yoo, K.S., Yoo, Y.H. Nutrition and cancer. (2002) [Pubmed]
  10. Relocalization of apoptosis-inducing factor in photoreceptor apoptosis induced by retinal detachment in vivo. Hisatomi, T., Sakamoto, T., Murata, T., Yamanaka, I., Oshima, Y., Hata, Y., Ishibashi, T., Inomata, H., Susin, S.A., Kroemer, G. Am. J. Pathol. (2001) [Pubmed]
  11. Selective proapoptotic activity of a secreted recombinant antibody/AIF fusion protein in carcinomas overexpressing HER2. Yu, C.J., Jia, L.T., Meng, Y.L., Zhao, J., Zhang, Y., Qiu, X.C., Xu, Y.M., Wen, W.H., Yao, L.B., Fan, D.M., Jin, B.Q., Chen, S.Y., Yang, A.G. Gene Ther. (2006) [Pubmed]
  12. Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death. Cregan, S.P., Fortin, A., MacLaurin, J.G., Callaghan, S.M., Cecconi, F., Yu, S.W., Dawson, T.M., Dawson, V.L., Park, D.S., Kroemer, G., Slack, R.S. J. Cell Biol. (2002) [Pubmed]
  13. p53-dependent caspase-2 activation in mitochondrial release of apoptosis-inducing factor and its role in renal tubular epithelial cell injury. Seth, R., Yang, C., Kaushal, V., Shah, S.V., Kaushal, G.P. J. Biol. Chem. (2005) [Pubmed]
  14. Two distinct pathways leading to nuclear apoptosis. Susin, S.A., Daugas, E., Ravagnan, L., Samejima, K., Zamzami, N., Loeffler, M., Costantini, P., Ferri, K.F., Irinopoulou, T., Prévost, M.C., Brothers, G., Mak, T.W., Penninger, J., Earnshaw, W.C., Kroemer, G. J. Exp. Med. (2000) [Pubmed]
  15. Identification and characterization of AIFsh2, a mitochondrial apoptosis-inducing factor (AIF) isoform with NADH oxidase activity. Delettre, C., Yuste, V.J., Moubarak, R.S., Bras, M., Robert, N., Susin, S.A. J. Biol. Chem. (2006) [Pubmed]
  16. Dexamethasone prevents podocyte apoptosis induced by puromycin aminonucleoside: role of p53 and Bcl-2-related family proteins. Wada, T., Pippin, J.W., Marshall, C.B., Griffin, S.V., Shankland, S.J. J. Am. Soc. Nephrol. (2005) [Pubmed]
  17. Apoptosis-inducing factor substitutes for caspase executioners in NMDA-triggered excitotoxic neuronal death. Wang, H., Yu, S.W., Koh, D.W., Lew, J., Coombs, C., Bowers, W., Federoff, H.J., Poirier, G.G., Dawson, T.M., Dawson, V.L. J. Neurosci. (2004) [Pubmed]
  18. Molecular characterization of mitochondrial apoptosis-inducing factor. Susin, S.A., Lorenzo, H.K., Zamzami, N., Marzo, I., Snow, B.E., Brothers, G.M., Mangion, J., Jacotot, E., Costantini, P., Loeffler, M., Larochette, N., Goodlett, D.R., Aebersold, R., Siderovski, D.P., Penninger, J.M., Kroemer, G. Nature (1999) [Pubmed]
  19. Apoptosis-inducing factor regulates death in peripheral T cells. Srivastava, S., Banerjee, H., Chaudhry, A., Khare, A., Sarin, A., George, A., Bal, V., Durdik, J.M., Rath, S. J. Immunol. (2007) [Pubmed]
  20. Heat shock protein 70 binding inhibits the nuclear import of apoptosis-inducing factor. Gurbuxani, S., Schmitt, E., Cande, C., Parcellier, A., Hammann, A., Daugas, E., Kouranti, I., Spahr, C., Pance, A., Kroemer, G., Garrido, C. Oncogene (2003) [Pubmed]
  21. Interleukin-4-triggered, STAT6-dependent production of a factor that induces mouse mast cell apoptosis. Hu, Z.Q., Zhao, W.H., Shimamura, T., Galli, S.J. Eur. J. Immunol. (2006) [Pubmed]
  22. Bid-induced release of AIF from mitochondria causes immediate neuronal cell death. Landshamer, S., Hoehn, M., Barth, N., Duvezin-Caubet, S., Schwake, G., Tobaben, S., Kazhdan, I., Becattini, B., Zahler, S., Vollmar, A., Pellecchia, M., Reichert, A., Plesnila, N., Wagner, E., Culmsee, C. Cell Death Differ. (2008) [Pubmed]
  23. Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor. Yu, S.W., Wang, H., Poitras, M.F., Coombs, C., Bowers, W.J., Federoff, H.J., Poirier, G.G., Dawson, T.M., Dawson, V.L. Science (2002) [Pubmed]
  24. Photoreceptor cell apoptosis in the retinal degeneration of Uchl3-deficient mice. Sano, Y., Furuta, A., Setsuie, R., Kikuchi, H., Wang, Y.L., Sakurai, M., Kwon, J., Noda, M., Wada, K. Am. J. Pathol. (2006) [Pubmed]
  25. Heat-shock protein 70 antagonizes apoptosis-inducing factor. Ravagnan, L., Gurbuxani, S., Susin, S.A., Maisse, C., Daugas, E., Zamzami, N., Mak, T., Jäättelä, M., Penninger, J.M., Garrido, C., Kroemer, G. Nat. Cell Biol. (2001) [Pubmed]
  26. Irradiation-induced progenitor cell death in the developing brain is resistant to erythropoietin treatment and caspase inhibition. Fukuda, H., Fukuda, A., Zhu, C., Korhonen, L., Swanpalmer, J., Hertzman, S., Leist, M., Lannering, B., Lindholm, D., Björk-Eriksson, T., Marky, I., Blomgren, K. Cell Death Differ. (2004) [Pubmed]
  27. Minocycline inhibits caspase-dependent and -independent cell death pathways and is neuroprotective against hippocampal damage after treatment with kainic acid in mice. Heo, K., Cho, Y.J., Cho, K.J., Kim, H.W., Kim, H.J., Shin, H.Y., Lee, B.I., Kim, G.W. Neurosci. Lett. (2006) [Pubmed]
  28. Nuclear Translocation of Endonuclease G and Apoptosis-Inducing Factor during Acetaminophen-Induced Liver Cell Injury. Bajt, M.L., Cover, C., Lemasters, J.J., Jaeschke, H. Toxicol. Sci. (2006) [Pubmed]
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