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Nr1i3  -  nuclear receptor subfamily 1, group I,...

Mus musculus

Synonyms: AA209988, AI551208, CAR, CAR-beta, CAR1, ...
 
 
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Disease relevance of Nr1i3

 

Psychiatry related information on Nr1i3

 

High impact information on Nr1i3

 

Biological context of Nr1i3

 

Anatomical context of Nr1i3

  • Mutations of the xenobiotic response sequence (XRS), which had been shown to block PB-dependent nuclear translocation of human CAR in mouse hepatocytes in vivo, also blocked GRIP1-mediated nuclear accumulation of mCAR in mouse hepatocytes in vivo and further blocked nuclear localization in cultured HepG2 cells [14].
  • Here, we have shown the presence of CAR at the cell membrane of mouse livers, using Car+/+ and Car-/- mice [15].
  • Furthermore, none of the mice in which macrophages were depleted by long-term treatment with silica and 10% of the mice treated with Car before virus infection became diabetic [16].
  • CAR2 protein was detected primarily in the endometrial epithelia and from PND 3 to PND 18 in the uteri of neonatal mice [17].
  • The modulation of NK activity in Car-treated mice is not due to the variation of the number of NK cells, since the frequency of target-binding cells (TBC) was not modified [18].
 

Associations of Nr1i3 with chemical compounds

 

Physical interactions of Nr1i3

 

Regulatory relationships of Nr1i3

 

Other interactions of Nr1i3

 

Analytical, diagnostic and therapeutic context of Nr1i3

References

  1. Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity. Guo, G.L., Lambert, G., Negishi, M., Ward, J.M., Brewer, H.B., Kliewer, S.A., Gonzalez, F.J., Sinal, C.J. J. Biol. Chem. (2003) [Pubmed]
  2. The orphan nuclear receptor constitutive active/androstane receptor is essential for liver tumor promotion by phenobarbital in mice. Yamamoto, Y., Moore, R., Goldsworthy, T.L., Negishi, M., Maronpot, R.R. Cancer Res. (2004) [Pubmed]
  3. The nuclear receptor CAR is a regulator of thyroid hormone metabolism during caloric restriction. Maglich, J.M., Watson, J., McMillen, P.J., Goodwin, B., Willson, T.M., Moore, J.T. J. Biol. Chem. (2004) [Pubmed]
  4. A locus for circadian period of locomotor activity on mouse proximal chromosome 3. Kernek, K.L., Trofatter, J.A., Mayeda, A.R., Hofstetter, J.R. Chronobiol. Int. (2004) [Pubmed]
  5. Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR. Xie, W., Barwick, J.L., Simon, C.M., Pierce, A.M., Safe, S., Blumberg, B., Guzelian, P.S., Evans, R.M. Genes Dev. (2000) [Pubmed]
  6. Structure of the murine constitutive androstane receptor complexed to androstenol: a molecular basis for inverse agonism. Shan, L., Vincent, J., Brunzelle, J.S., Dussault, I., Lin, M., Ianculescu, I., Sherman, M.A., Forman, B.M., Fernandez, E.J. Mol. Cell (2004) [Pubmed]
  7. The nuclear xenobiotic receptor CAR: structural determinants of constitutive activation and heterodimerization. Suino, K., Peng, L., Reynolds, R., Li, Y., Cha, J.Y., Repa, J.J., Kliewer, S.A., Xu, H.E. Mol. Cell (2004) [Pubmed]
  8. Transcription coactivator peroxisome proliferator-activated receptor-binding protein/mediator 1 deficiency abrogates acetaminophen hepatotoxicity. Jia, Y., Guo, G.L., Surapureddi, S., Sarkar, J., Qi, C., Guo, D., Xia, J., Kashireddi, P., Yu, S., Cho, Y.W., Rao, M.S., Kemper, B., Ge, K., Gonzalez, F.J., Reddy, J.K. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  9. Induction of bilirubin clearance by the constitutive androstane receptor (CAR). Huang, W., Zhang, J., Chua, S.S., Qatanani, M., Han, Y., Granata, R., Moore, D.D. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  10. Nuclear receptors constitutive androstane receptor and pregnane X receptor activate a drug-responsive enhancer of the murine 5-aminolevulinic acid synthase gene. Fraser, D.J., Zumsteg, A., Meyer, U.A. J. Biol. Chem. (2003) [Pubmed]
  11. Residue threonine 350 confers steroid hormone responsiveness to the mouse nuclear orphan receptor CAR. Ueda, A., Kakizaki, S., Negishi, M., Sueyoshi, T. Mol. Pharmacol. (2002) [Pubmed]
  12. Differential transactivation by two isoforms of the orphan nuclear hormone receptor CAR. Choi, H.S., Chung, M., Tzameli, I., Simha, D., Lee, Y.K., Seol, W., Moore, D.D. J. Biol. Chem. (1997) [Pubmed]
  13. Functional inhibitory cross-talk between constitutive androstane receptor and hepatic nuclear factor-4 in hepatic lipid/glucose metabolism is mediated by competition for binding to the DR1 motif and to the common coactivators, GRIP-1 and PGC-1alpha. Miao, J., Fang, S., Bae, Y., Kemper, J.K. J. Biol. Chem. (2006) [Pubmed]
  14. Structural determinants of constitutive androstane receptor required for its glucocorticoid receptor interacting protein-1-mediated nuclear accumulation. Xia, J., Kemper, B. J. Biol. Chem. (2005) [Pubmed]
  15. Localization of the nuclear receptor CAR at the cell membrane of mouse liver. Koike, C., Moore, R., Negishi, M. FEBS Lett. (2005) [Pubmed]
  16. Direct involvement of macrophages in destruction of beta-cells leading to development of diabetes in virus-infected mice. Baek, H.S., Yoon, J.W. Diabetes (1991) [Pubmed]
  17. Carbonic anhydrase regulate endometrial gland development in the neonatal uterus. Hu, J., Spencer, T.E. Biol. Reprod. (2005) [Pubmed]
  18. NK activity in carrageenan-treated mice. Quan, P.C., Kolb, J.P., Lespinats, G. Immunology (1980) [Pubmed]
  19. Phenobarbital regulates nuclear expression of HNF-4alpha in mouse and rat hepatocytes independent of CAR and PXR. Bell, A.W., Michalopoulos, G.K. Hepatology (2006) [Pubmed]
  20. Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for human CAR. Huang, W., Zhang, J., Wei, P., Schrader, W.T., Moore, D.D. Mol. Endocrinol. (2004) [Pubmed]
  21. Transcriptional analysis in vivo of the hepatic genes, Cyp2b9 and Cyp2b10, by intravenous administration of plasmid DNA in mice. Rivera-Rivera, I., Kim, J., Kemper, B. Biochim. Biophys. Acta (2003) [Pubmed]
  22. Peroxisome proliferator-activated receptor (PPAR)-binding protein (PBP) but not PPAR-interacting protein (PRIP) is required for nuclear translocation of constitutive androstane receptor in mouse liver. Guo, D., Sarkar, J., Ahmed, M.R., Viswakarma, N., Jia, Y., Yu, S., Sambasiva Rao, M., Reddy, J.K. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  23. Antagonist- and inverse agonist-driven interactions of the vitamin D receptor and the constitutive androstane receptor with corepressor protein. Lempiäinen, H., Molnár, F., Macias Gonzalez, M., Peräkylä, M., Carlberg, C. Mol. Endocrinol. (2005) [Pubmed]
  24. The ratio of constitutive androstane receptor to pregnane X receptor determines the activity of guggulsterone against the Cyp2b10 promoter. Ding, X., Staudinger, J.L. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
  25. Peroxisome proliferator-activated receptor-alpha mice show enhanced hepatocyte proliferation in response to the hepatomitogen 1,4-bis [2-(3,5-dichloropyridyloxy)] benzene, a ligand of constitutive androstane receptor. Columbano, A., Ledda-Columbano, G.M., Pibiri, M., Concas, D., Reddy, J.K., Rao, M.S. Hepatology (2001) [Pubmed]
  26. A common set of immediate-early response genes in liver regeneration and hyperplasia. Locker, J., Tian, J., Carver, R., Concas, D., Cossu, C., Ledda-Columbano, G.M., Columbano, A. Hepatology (2003) [Pubmed]
  27. Endogenous Hepatic Expression of the Hepatitis B Virus X-Associated Protein 2 Is Adequate for Maximal Association with Aryl Hydrocarbon Receptor-90-kDa Heat Shock Protein Complexes. Hollingshead, B.D., Patel, R.D., Perdew, G.H. Mol. Pharmacol. (2006) [Pubmed]
  28. Dual action of oestrogens on the mouse constitutive androstane receptor. Mäkinen, J., Reinisalo, M., Niemi, K., Viitala, P., Jyrkkärinne, J., Chung, H., Pelkonen, O., Honkakoski, P. Biochem. J. (2003) [Pubmed]
  29. The immunological relationship of epitopes on major tree pollen allergens. Rohac, M., Birkner, T., Reimitzer, I., Bohle, B., Steiner, R., Breitenbach, M., Kraft, D., Scheiner, O., Gabl, F., Rumpold, H. Mol. Immunol. (1991) [Pubmed]
  30. Depletion of intercalated cells from collecting ducts of carbonic anhydrase II-deficient (CAR2 null) mice. Breton, S., Alper, S.L., Gluck, S.L., Sly, W.S., Barker, J.E., Brown, D. Am. J. Physiol. (1995) [Pubmed]
 
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