Gene Review:
CDX1 - caudal type homeobox 1
Homo sapiens
Synonyms:
Caudal-type homeobox protein 1, Homeobox protein CDX-1
- Expression of the caudal-type homeodomain transcription factors CDX 1/2 and outcome in carcinomas of the ampulla of Vater. Hansel, D.E., Maitra, A., Lin, J.W., Goggins, M., Argani, P., Yeo, C.J., Piantadosi, S., Leach, S.D., Biankin, A.V. J. Clin. Oncol. (2005)
- Aberrant expression of CDX2 in Barrett's epithelium and inflammatory esophageal mucosa. Eda, A., Osawa, H., Satoh, K., Yanaka, I., Kihira, K., Ishino, Y., Mutoh, H., Sugano, K. J. Gastroenterol. (2003)
- Relationships between the expressions of CDX1 and CDX2 mRNA and clinicopathologic features in colorectal cancers. Kim, G.H., Lee, D.H., Kim, H.W., Cheong, J.Y., Seo, S.B., Heo, J., Kang, D.H., Song, G.A., Cho, M., Yang, U.S., Park, d.o. .Y., Yoo, M.A. Korean J. Intern. Med. (2005)
- CDX1 is an important molecular mediator of Barrett's metaplasia. Wong, N.A., Wilding, J., Bartlett, S., Liu, Y., Warren, B.F., Piris, J., Maynard, N., Marshall, R., Bodmer, W.F. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Isolation, characterization, and precise physical localization of human CDX1, a caudal-type homeobox gene. Bonner, C.A., Loftus, S.K., Wasmuth, J.J. Genomics (1995)
- CDX1 protein expression in normal, metaplastic, and neoplastic human alimentary tract epithelium. Silberg, D.G., Furth, E.E., Taylor, J.K., Schuck, T., Chiou, T., Traber, P.G. Gastroenterology (1997)
- DNA methylation down-regulates CDX1 gene expression in colorectal cancer cell lines. Suh, E.R., Ha, C.S., Rankin, E.B., Toyota, M., Traber, P.G. J. Biol. Chem. (2002)
- Expression of homeobox gene CDX2 precedes that of CDX1 during the progression of intestinal metaplasia. Eda, A., Osawa, H., Yanaka, I., Satoh, K., Mutoh, H., Kihira, K., Sugano, K. J. Gastroenterol. (2002)
- The caudal-related homeodomain protein CDX1 activates proliferating cell nuclear antigen expression in hepatocellular and colorectal carcinoma cells. Oh, E.J., Park, J.H., Cho, M., Lee, W.J., Choi, Y.H., Yoo, M.A. Int. J. Oncol. (2002)
- Loss of CDX1 expression in colorectal carcinoma: promoter methylation, mutation, and loss of heterozygosity analyses of 37 cell lines. Wong, N.A., Britton, M.P., Choi, G.S., Stanton, T.K., Bicknell, D.C., Wilding, J.L., Bodmer, W.F. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Putative intestine-specific enhancers located in 5' sequence of the CDX1 gene regulate CDX1 expression in the intestine. Rankin, E.B., Xu, W., Silberg, D.G., Suh, E. Am. J. Physiol. Gastrointest. Liver Physiol. (2004)
- Homeodomain protein CDX2 regulates goblet-specific MUC2 gene expression. Yamamoto, H., Bai, Y.Q., Yuasa, Y. Biochem. Biophys. Res. Commun. (2003)
- Functional interaction between the homeoprotein CDX1 and the transcriptional machinery containing the TATA-binding protein. Calon, A., Gross, I., Davidson, I., Kedinger, M., Duluc, I., Domon-Dell, C., Freund, J.N. Nucleic Acids Res. (2007)
- Expression of the Cdx1 and Cdx2 homeotic genes leads to reduced malignancy in colon cancer-derived cells. Mallo, G.V., Soubeyran, P., Lissitzky, J.C., André, F., Farnarier, C., Marvaldi, J., Dagorn, J.C., Iovanna, J.L. J. Biol. Chem. (1998)
- The homeobox gene Cdx1 belongs to the p53-p21(WAF)-Bcl-2 network in intestinal epithelial cells. Moucadel, V., Totaro, M.S., Dell, C.D., Soubeyran, P., Dagorn, J.C., Freund, J.N., Iovanna, J.L. Biochem. Biophys. Res. Commun. (2002)
- Stimulation of Cdx1 by oncogenic beta-catenin/Tcf4 in colon cancer cells; opposite effect of the CDX2 homeoprotein. Domon-Dell, C., Freund, J.N. FEBS Lett. (2002)
- Lewis type 1 antigen synthase (beta3Gal-T5) is transcriptionally regulated by homeoproteins. Isshiki, S., Kudo, T., Nishihara, S., Ikehara, Y., Togayachi, A., Furuya, A., Shitara, K., Kubota, T., Watanabe, M., Kitajima, M., Narimatsu, H. J. Biol. Chem. (2003)
- Differential regulation of intestinal alkaline phosphatase gene expression by Cdx1 and Cdx2. Alkhoury, F., Malo, M.S., Mozumder, M., Mostafa, G., Hodin, R.A. Am. J. Physiol. Gastrointest. Liver Physiol. (2005)
- Expression of CDX2 in normal and neoplastic human colon tissue and during differentiation of an in vitro model system. Qualtrough, D., Hinoi, T., Fearon, E., Paraskeva, C. Gut (2002)
- CDX1 expression is reduced in colorectal carcinoma and is associated with promoter hypermethylation. Pilozzi, E., Onelli, M.R., Ziparo, V., Mercantini, P., Ruco, L. J. Pathol. (2004)
- Cdx1 homeobox gene during human colon cancer progression. Domon-Dell, C., Schneider, A., Moucadel, V., Guerin, E., Guenot, D., Aguillon, S., Duluc, I., Martin, E., Iovanna, J., Launay, J.F., Duclos, B., Chenard, M.P., Meyer, C., Oudet, P., Kedinger, M., Gaub, M.P., Freund, J.N. Oncogene (2003)