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Gene Review

Ppp5c  -  protein phosphatase 5, catalytic subunit

Mus musculus

Synonyms: ANP receptor, AU020526, PP5, PPT, Protein phosphatase T, ...
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Disease relevance of Ppp5c


Psychiatry related information on Ppp5c


High impact information on Ppp5c

  • The ANP receptor/guanylate cyclase represents a new class of mammalian cell-surface receptors which contain an extracellular ligand-binding domain and an intracellular guanylate cyclase catalytic domain [6].
  • The activity but not the protein level of PP5 was found to be decreased by approximately 20% in AD neocortex [5].
  • A recombinant adenovirus vector with the PPT sequence, shielded from interfering adenoviral sequences by the mouse H19 insulator, yields high and prostate-specific transgene expression both in cell cultures and when prostate cancer, PC-346C, tumors were grown orthotopically in nude mice [3].
  • The membrane fraction of the whole brain in cocaine-sensitized mice showed that OA-sensitive activity levels rise after mice are subjected to restraint, and this is concomitant with an increase in expression levels of PP2A and PP5, but not PP1gamma [7].
  • We used okadaic acid (OA), a potent preferential inhibitor of PP2A and PP5 but not PP1 (PP subfamilies), to examine the involvement of serine/threonine protein phosphatase (PP) in behavioral sensitization stimulated by treatment with cocaine in mice [7].

Chemical compound and disease context of Ppp5c


Biological context of Ppp5c


Anatomical context of Ppp5c


Associations of Ppp5c with chemical compounds

  • In the xenograph model a modest two fold increase in PP5 protein levels significantly enhanced the growth rate of estrogen-dependent tumors, suggesting PP5 plays a positive role in tumor development [10].

Other interactions of Ppp5c

  • PP5-underexpressing cells released significantly more ir-ACTH (10-12-fold) relative to baseline levels and promoted POMC release into the media [15].

Analytical, diagnostic and therapeutic context of Ppp5c


  1. Expression in hepatomas and chromosomal localization of rat protein phosphatase 5 gene. Shirato, H., Shima, H., Nakagama, H., Fukuda, H., Watanabe, Y., Ogawa, K., Matsuda, Y., Kikuchi, K. Int. J. Oncol. (2000) [Pubmed]
  2. Pressure-independent cardiac hypertrophy in mice with cardiomyocyte-restricted inactivation of the atrial natriuretic peptide receptor guanylyl cyclase-A. Holtwick, R., van Eickels, M., Skryabin, B.V., Baba, H.A., Bubikat, A., Begrow, F., Schneider, M.D., Garbers, D.L., Kuhn, M. J. Clin. Invest. (2003) [Pubmed]
  3. A novel TARP-promoter-based adenovirus against hormone-dependent and hormone-refractory prostate cancer. Cheng, W.S., Kraaij, R., Nilsson, B., van der Weel, L., de Ridder, C.M., Tötterman, T.H., Essand, M. Mol. Ther. (2004) [Pubmed]
  4. Hypotension and bradycardia during caloric restriction in mice are independent of salt balance and do not require ANP receptor. Hunt, L.M., Hogeland, E.W., Henry, M.K., Swoap, S.J. Am. J. Physiol. Heart Circ. Physiol. (2004) [Pubmed]
  5. Dephosphorylation of tau by protein phosphatase 5: impairment in Alzheimer's disease. Liu, F., Iqbal, K., Grundke-Iqbal, I., Rossie, S., Gong, C.X. J. Biol. Chem. (2005) [Pubmed]
  6. A membrane form of guanylate cyclase is an atrial natriuretic peptide receptor. Chinkers, M., Garbers, D.L., Chang, M.S., Lowe, D.G., Chin, H.M., Goeddel, D.V., Schulz, S. Nature (1989) [Pubmed]
  7. Involvement of serine/threonine protein phosphatases sensitive to okadaic acid in restraint stress-induced hyperlocomotion in cocaine-sensitized mice. Maeda, T., Yoshimatsu, T., Hamabe, W., Fukazawa, Y., Kumamoto, K., Ozaki, M., Kishioka, S. Br. J. Pharmacol. (2006) [Pubmed]
  8. Prokaryotic expression, purification, and reconstitution of biological activities (Antiprotease, antitumor, and heparin-binding) for tissue factor pathway inhibitor-2. Rao, C.N., Reddy, P., Reeder, D.J., Liu, Y., Stack, S.M., Kisiel, W., Woodley, D.T. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  9. Mapping of Ppp5c, the gene encoding protein phosphatase 5, to mouse chromosome 7. Chinkers, M. Mamm. Genome (1997) [Pubmed]
  10. Constitutive over expression of serine/threonine protein phosphatase 5 (PP5) augments estrogen-dependent tumor growth in mice. Golden, T., Aragon, I.V., Zhou, G., Cooper, S.R., Dean, N.M., Honkanen, R.E. Cancer Lett. (2004) [Pubmed]
  11. Ventricular arrhythmias, increased cardiac calmodulin kinase II expression, and altered repolarization kinetics in ANP receptor deficient mice. Kirchhof, P., Fabritz, L., Kilić, A., Begrow, F., Breithardt, G., Kuhn, M. J. Mol. Cell. Cardiol. (2004) [Pubmed]
  12. Identification and biochemical characterisation of a protein phosphatase 5 homologue from Plasmodium falciparum. Lindenthal, C., Klinkert, M.Q. Mol. Biochem. Parasitol. (2002) [Pubmed]
  13. Morphine has an antinociceptive effect through activation of the okadaic-acid-sensitive Ser/Thr protein phosphatases PP 2 A and PP5 estimated by tail-pinch test in mice. Maeda, T., Hamabe, W., Gao, Y., Fukazawa, Y., Kumamoto, K., Ozaki, M., Kishioka, S. Brain Res. (2005) [Pubmed]
  14. 20(S)-Protopanaxatriol, one of ginsenoside metabolites, inhibits inducible nitric oxide synthase and cyclooxygenase-2 expressions through inactivation of nuclear factor-kappaB in RAW 264.7 macrophages stimulated with lipopolysaccharide. Oh, G.S., Pae, H.O., Choi, B.M., Seo, E.A., Kim, D.H., Shin, M.K., Kim, J.D., Kim, J.B., Chung, H.T. Cancer Lett. (2004) [Pubmed]
  15. Basal adrenocorticotropin (ACTH) secretion is negatively modulated by protein phosphatase 5 in mouse pituitary corticotropin AtT20 cells. Liu, F., Khawaja, X. Regul. Pept. (2005) [Pubmed]
  16. The tetratricopeptide repeat domain of protein phosphatase 5 mediates binding to glucocorticoid receptor heterocomplexes and acts as a dominant negative mutant. Chen, M.S., Silverstein, A.M., Pratt, W.B., Chinkers, M. J. Biol. Chem. (1996) [Pubmed]
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