Disease relevance of Ppp5c

• The levels of PP5 mRNA were markedly elevated in rat highly malignant ascites hepatomas, while those in several rat primary hepatomas were slightly increased and those in the regenerating livers were not elevated at all compared to the control liver [1].
• Thus, a loss of function of the ANP receptor guanylyl cyclase-A (GC-A) might contribute to the increased propensity to cardiac hypertrophy, although a causative role in vivo has not been definitively demonstrated [2].
• Therefore, the PPT sequence may, in a gene therapy setting, be beneficial to prostate cancer patients that have been treated with androgen withdrawal [3].
• Therefore, we believe that an adenovirus with therapeutic gene expression controlled by an insulator-shielded PPT sequence is a promising candidate for gene therapy of prostate cancer [3].
• Hypotension and bradycardia during caloric restriction in mice are independent of salt balance and do not require ANP receptor [4].

Psychiatry related information on Ppp5c

• PP5 dephosphorylated tau at all 12 Alzheimer's disease (AD)-associated abnormal phosphorylation sites studied, with different efficiency toward each site [5].

High impact information on Ppp5c

• The ANP receptor/guanylate cyclase represents a new class of mammalian cell-surface receptors which contain an extracellular ligand-binding domain and an intracellular guanylate cyclase catalytic domain [6].
• The activity but not the protein level of PP5 was found to be decreased by approximately 20% in AD neocortex [5].
• A recombinant adenovirus vector with the PPT sequence, shielded from interfering adenoviral sequences by the mouse H19 insulator, yields high and prostate-specific transgene expression both in cell cultures and when prostate cancer, PC-346C, tumors were grown orthotopically in nude mice [3].
• The membrane fraction of the whole brain in cocaine-sensitized mice showed that OA-sensitive activity levels rise after mice are subjected to restraint, and this is concomitant with an increase in expression levels of PP2A and PP5, but not PP1gamma [7].
• We used okadaic acid (OA), a potent preferential inhibitor of PP2A and PP5 but not PP1 (PP subfamilies), to examine the involvement of serine/threonine protein phosphatase (PP) in behavioral sensitization stimulated by treatment with cocaine in mice [7].

Chemical compound and disease context of Ppp5c

• We report the expression of tissue factor pathway inhibitor-2 (TFPI-2) (also known as PP-5, placental protein-5; MSPI, matrix-associated serine protease inhibitor) in E. coli as a 25-kDa nonglycosylated protein with a glycine substituted for aspartic acid at the amino terminus [8].

Biological context of Ppp5c

• Mapping of Ppp5c, the gene encoding protein phosphatase 5, to mouse chromosome 7 [9].
• Serine/threonine protein phosphatase 5 (PP5) appears to play an underappreciated role in the regulation of cellular proliferation [10].
• To further explore the relationship between PP5 and the development of human cancer, here we tested the effect of elevated PP5 expression on tumor growth using a mouse xenograph model and a stable MCF-7 cell line in which the expression of wild-type PP5 was placed under the control of tetracycline-off regulated transactivator and operator plasmids [10].
• Ventricular arrhythmias, increased cardiac calmodulin kinase II expression, and altered repolarization kinetics in ANP receptor deficient mice [11].
• The deduced amino acid sequence shares 55% identity with a mouse protein, identified as Protein Phosphatase 5 (PP5) [12].

Anatomical context of Ppp5c

• Overexpression of PP5 in PC12 cells resulted in dephosphorylation of tau at multiple phosphorylation sites [5].
• On the seventh day of withdrawal, OA-sensitive PP activity and expression of PP2A and PP5, but not PP1gamma, were increased in whole-cell extract of the nucleus accumbens and the ventral tegmental area in cocaine-sensitized mice, compared to saline-treated mice [7].
• Pretreatment with AS-ODN against PP 2 A or PP5 via each route weakened the antinociceptive effect of morphine, accompanied by reduction of expression levels of PP in the periaqueductal gray (PAG) and the spinal cord [13].
• Here, we investigated whether PPT could modulate iNOS and COX-2 expressions in RAW 264.7 macrophages stimulated with the endotoxin lipopolysaccharide (LPS) [14].

Associations of Ppp5c with chemical compounds

• In the xenograph model a modest two fold increase in PP5 protein levels significantly enhanced the growth rate of estrogen-dependent tumors, suggesting PP5 plays a positive role in tumor development [10].

Other interactions of Ppp5c

• PP5-underexpressing cells released significantly more ir-ACTH (10-12-fold) relative to baseline levels and promoted POMC release into the media [15].

Analytical, diagnostic and therapeutic context of Ppp5c

• During gel filtration, PP5 and hsp90 comigrated in a high molecular weight complex [16].
• Thus, it may be possible to develop PPT as a useful agent for chemoprevention of cancer or inflammatory diseases [14].

References