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Gene Review

GPBAR1  -  G protein-coupled bile acid receptor 1

Homo sapiens

Synonyms: BG37, G-protein coupled bile acid receptor 1, G-protein coupled receptor GPCR19, GPCR, GPCR19, ...
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Disease relevance of GPBAR1

  • When the temperature was at 5 degrees C and chamber pressure at 5 mbar respectively, the surface of the samples could be fully imaged without covering water or dehydration [1].
  • METHODS: Mechanical ventilation with peak inspiratory pressure limitation to 35 mbar, irrespective of hypercapnia and prone positioning to achieve adequate oxygenation [2].
  • For both 50 and 200 mbar suctions, the maximum distension (MD) and the biological elasticity (BE) of fasciae from direct hernias were significantly increased, compared with control fasciae [3].
  • Within 4 h after injection her arterial oxygen tension was 8.1 kPa (60 mm Hg) at an inspired oxygen fraction (F(IO2)) of 0.7 (P/F ratio: 85) despite a positive end expiratory pressure (PEEP) of 20 mbar, therefore meeting criteria for acute respiratory distress syndrome (ARDS) [4].
  • Repeated airway lavages (LAV) with normal saline or repeated instillations of a suspension of human meconium (MEC) were continued until both the a/A-ratio was < or =0.14 and a peak inspiratory pressure > or =22 mbar was needed to keep the tidal volume constant at 10 ml/kg of body weight [5].

Psychiatry related information on GPBAR1

  • The oxidation of the Rh(111) surface at oxygen pressures from 10(-10) mbar to 0.5 bar and temperatures between 300 and 900 K has been studied on the atomic scale using a multimethod approach of experimental and theoretical techniques [6].
  • When no airway obstruction was detected over a period of 30 min, the pressure was lowered once during the night in steps of 1 mbar at intervals of at least 10 min, until obstructive events reappeared, whereupon the pressure was again increased as described above, until, once more, no signs of airway obstruction and no arousals occurred [7].

High impact information on GPBAR1

  • The method involves transferring plasmas emanating from a region with a low magnetic field (0.14 T) and relatively high pressure (10(-9) mbar) into a 15 K Penning-Malmberg trap immersed in a 3 T magnetic field with a base pressure better than 10(-13) mbar [8].
  • EXAFS measurements of vanadium shocked to approximately 0.4 Mbar yield the compression and temperature in good agreement with hydrodynamic simulations and shock-speed measurements [9].
  • Reflectivities rise steadily with shock pressure up to 45% in sapphire at 20 Mbar and 20% in LiF at 13 Mbar [10].
  • Our electrical conductivity measurements of fluid oxygen under dynamic quasi-isentropic compression show that a nonmetal-metal transition occurs at 3.4 fold compression, 4500 K, and 1.2 Mbar [11].
  • An acetic acid/ammonia buffer (pH 10, ionic strength of 40 mM) was selected as running electrolyte, and the separation was performed by the simultaneous application of a CE voltage of +30 kV and an overimposed pressure of 28 mbar (0.4 psi) [12].

Chemical compound and disease context of GPBAR1

  • Slices to be treated with osmotic dehydration (OD) were first immersed in calcium, then placed in the osmotic solution (sucrose 65 degrees Bx, 30 degrees C) and 211 mbar vacuum was applied for 30 min [13].
  • RESULTS--After one hour of treatment compression with 193 mbar caused a significantly greater relief of symptoms of acute mountain sickness than dexamethasone (Lake Louise score: mean (SD) -4.6 (1.9) v -2.5 (1.8); clinical score: -4.0 (1.2) v -1.5 (1.4); AMS-C score: -1.24 (0.51) v -0.54 (0.59)) [14].

Biological context of GPBAR1

  • The throughput is about 2 samples/h using +20 kV voltage plus 5 mbar air pressure for separation [15].
  • Airway leak pressure in neutral head position (22.6 versus 18.5 mbar; P = 0.003), maximum flexion (37 versus 26.3 mbar; P < 0.001), maximum extension (15.2 versus 13 mbar; P = 0.045), and maximum tidal volume (1088 versus 949 mL; P = 0.002) were significantly better for the P-LMA [16].
  • The kinetics of the CH2CHO + O2 reaction was experimentally studied in two quasi-static reactors and a discharge flow-reactor at temperatures ranging from 298 to 660 K and pressures between 1 mbar and 46 bar with helium as the bath gas [17].
  • In AGS cells, siRNAs that target M-BAR suppress DC-induced phosphorylation of EGFR [18].
  • A fall in atmospheric pressure of at least 10 mbar within 24 h was followed by a statistically significant increase in the number of admissions 2 days later [19].

Anatomical context of GPBAR1

  • METHODS: Thirty-four consecutive patients underwent either bilateral ECC (n = 24, additional cannulation of pulmonary artery and left atrium and lungs perfused and ventilated during bypass) or conventional CPB (n = 10, right atrial and aortic cannulation, lungs statically inflated to 4 mbar (0.41 cm H(2)O) with oxygen, 500 mL/min) [20].
  • Stable fluxes of up to 80l m(-2)h(-1) were achieved with the ceramic flat-sheet multi-channel membranes applied at low transmembrane pressure (<100 mbar) [21].
  • It was demonstrated by using the pressure probe technique that a pressure gradient (cell turgor pressure) of several 100 mbar is built up when the immobilized cells were transferred to hypotonic solution [22].
  • We studied whether a PEEP of 10 mbar may negatively influence flow-dependent liver function (indocyanine green plasma disappearance rate, ICG-PDR) and splanchnic microcirculation as estimated by gastric mucosal PCO2 (PRCO2) [23].
  • It was demonstrated in vitro that it is possible to achieve obturation of the root canal system with a system utilizing a reduced pressure of 15 hPa (15 mbar) [24].

Associations of GPBAR1 with chemical compounds

  • Shock compression of sapphire (Al2O3) and lithium fluoride (LiF) to pressures above 5 Mbar has been observed to transform these transparent, wide band-gap insulators into partially degenerate liquid semiconductors with optical reflectivities of several percent [10].
  • The detection limit of each alkaloid dissolved in methanol was found to be 850 ng/mL (morphine), 450 ng/mL (thebaine), 500 ng/mL (codeine), 550 ng/mL (papaverine), and 500 ng/mL (narcotine) at an injection pressure of 300 mbar (injection volume, 4 nL) with a signal-to-noise ratio of 3:1 [25].
  • However, a reduction in sodium excretion was observed in the placebo group at -20 mbar, whereas no change was detected in the metoprolol group [26].
  • At -20 mbar, the 3-hour cumulative sodium excretion was + 4.6 +/- 1.4 mmol in the candesartan group (P= 0.02 vs. placebo) [27].
  • In order to increase sensitivity, the flow rate of the sheath liquid was diminished from 0.5 to 0.2 microL.min(-1) by increasing the content in water from 0 to 50% and the formic acid from 0.5 to 1.5% in this liquid and by applying an overimposed pressure of 5 mbar during the electrophoretic separation [28].

Analytical, diagnostic and therapeutic context of GPBAR1

  • In 11 healthy volunteers 44 measurements with near-infrared spectroscopy (NIRS) and perfusion-weighted MRI without and with a mean continuous positive airway pressure (CPAP) of 10 mbar were carried out [29].
  • METHODS: Twenty healthy men were submitted to three levels of LBNP (0, -10, and -20 mbar or 0, -7.5, and -15 mm Hg) for 1 hour according to a crossover design with a minimum of 2 days between each level of LBNP [27].
  • Twenty-four hours later rats were anesthetized, tracheotomized, and mechanically ventilated (peak airway pressure = 20 mbar; positive end-expiratory pressure = 6 mbar; inspiration time = expiration time = 0.6 sec; Fio2 = 50%) [30].
  • The difference was neutralized with both types of EVITA ventilator by adding 2 mbar of pressure support during CPAP in order to achieve comparable conditions [31].
  • In the hips managed with the bone vacuum, suction (-800 mbar) was applied to a drainage cannula placed along the linea aspera of the femur in order to prevent an increase in intramedullary pressure during the insertion of the stem [32].


  1. Environmental scanning electron microscopy observation of the ultrastructure of Demodex. Jing, X., Shuling, G., Ying, L. Microsc. Res. Tech. (2005) [Pubmed]
  2. Prone postioning and low-volume pressure-limited ventilation improve survival in patients with severe ARDS. Stocker, R., Neff, T., Stein, S., Ecknauer, E., Trentz, O., Russi, E. Chest (1997) [Pubmed]
  3. Adult groin hernias: new insight into their biomechanical characteristics. Pans, A., Pierard, G.E., Albert, A., Desaive, C. Eur. J. Clin. Invest. (1997) [Pubmed]
  4. Acute lung injury after peppermint oil injection. Behrends, M., Beiderlinden, M., Peters, J. Anesth. Analg. (2005) [Pubmed]
  5. Effect of inhaled nitric oxide on intrapulmonary right-to-left-shunting in two rabbit models of saline lavage induced surfactant deficiency and meconium instillation. Krause, M.F., Lienhart, H.G., Haberstroh, J., Hoehn, T., Schulte-Mönting, J., Leititis, J.U. Eur. J. Pediatr. (1998) [Pubmed]
  6. Self-limited growth of a thin oxide layer on Rh(111). Gustafson, J., Mikkelsen, A., Borg, M., Lundgren, E., Köhler, L., Kresse, G., Schmid, M., Varga, P., Yuhara, J., Torrelles, X., Quirós, C., Andersen, J.N. Phys. Rev. Lett. (2004) [Pubmed]
  7. Reproducibility of a standardized titration procedure for the initiation of continuous positive airway pressure therapy in patients with obstructive sleep apnoea. Wiest, G.H., Fuchs, F.S., Harsch, I.A., Pour Schahin, S., Lampert, S., Brueckl, W.M., Hahn, E.G., Ficker, J.H. Respiration; international review of thoracic diseases. (2001) [Pubmed]
  8. New source of dense, cryogenic positron plasmas. Jørgensen, L.V., Amoretti, M., Bonomi, G., Bowe, P.D., Canali, C., Carraro, C., Cesar, C.L., Charlton, M., Doser, M., Fontana, A., Fujiwara, M.C., Funakoshi, R., Genova, P., Hangst, J.S., Hayano, R.S., Kellerbauer, A., Lagomarsino, V., Landua, R., Lodi Rizzini, E., Macrì, M., Madsen, N., Mitchard, D., Montagna, P., Rotondi, A., Testera, G., Variola, A., Venturelli, L., van der Werf, D.P., Yamazaki, Y. Phys. Rev. Lett. (2005) [Pubmed]
  9. Extended X-ray absorption fine structure measurements of laser-shocked V and Ti and crystal phase transformation in Ti. Yaakobi, B., Meyerhofer, D.D., Boehly, T.R., Rehr, J.J., Remington, B.A., Allen, P.G., Pollaine, S.M., Albers, R.C. Phys. Rev. Lett. (2004) [Pubmed]
  10. Shock-induced transformation of Al2O3 and LiF into semiconducting liquids. Hicks, D.G., Celliers, P.M., Collins, G.W., Eggert, J.H., Moon, S.J. Phys. Rev. Lett. (2003) [Pubmed]
  11. High pressure insulator-metal transition in molecular fluid oxygen. Bastea, M., Mitchell, A.C., Nellis, W.J. Phys. Rev. Lett. (2001) [Pubmed]
  12. Analysis and validation of the phosphorylated metabolites of two anti-human immunodeficiency virus nucleotides (stavudine and didanosine) by pressure-assisted CE-ESI-MS/MS in cell extracts: sensitivity enhancement by the use of perfluorinated acids and alcohols as coaxial sheath-liquid make-up constituents. Bezy, V., Chaimbault, P., Morin, P., Unger, S.E., Bernard, M.C., Agrofoglio, L.A. Electrophoresis (2006) [Pubmed]
  13. Evolution of carbohydrates of pre-cut mango slices subjected to osmotic dehydration. Tovar, B., García, H.S., Mata, M. Plant foods for human nutrition (Dordrecht, Netherlands) (2005) [Pubmed]
  14. Simulated descent v dexamethasone in treatment of acute mountain sickness: a randomised trial. Keller, H.R., Maggiorini, M., Bärtsch, P., Oelz, O. BMJ (1995) [Pubmed]
  15. Screening of octanol-water partition coefficients for pharmaceuticals by pressure-assisted microemulsion electrokinetic chromatography. Jia, Z., Mei, L., Lin, F., Huang, S., Killion, R.B. Journal of chromatography. A. (2003) [Pubmed]
  16. A randomized crossover comparison of the size 2 1/2 laryngeal mask airway ProSeal versus laryngeal mask airway-Classic in pediatric patients. Goldmann, K., Jakob, C. Anesth. Analg. (2005) [Pubmed]
  17. Rate coefficients and equilibrium constant for the CH2CHO + O2 reaction system. Delbos, E., Fittschen, C., Hippler, H., Krasteva, N., Olzmann, M., Viskolcz, B. The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment & general theory. (2006) [Pubmed]
  18. Involvement of membrane-type bile acid receptor M-BAR/TGR5 in bile acid-induced activation of epidermal growth factor receptor and mitogen-activated protein kinases in gastric carcinoma cells. Yasuda, H., Hirata, S., Inoue, K., Mashima, H., Ohnishi, H., Yoshiba, M. Biochem. Biophys. Res. Commun. (2007) [Pubmed]
  19. Spontaneous pneumothorax related to falls in atmospheric pressure. Bense, L. European journal of respiratory diseases. (1984) [Pubmed]
  20. Perfusing and ventilating the patient's lungs during bypass ameliorates the increase in extravascular thermal volume after coronary bypass grafting. Massoudy, P., Piotrowski, J.A., van de Wal, H.C., Giebler, R., Marggraf, G., Peters, J., Jakob, H.G. Ann. Thorac. Surg. (2003) [Pubmed]
  21. Hybrid flotation--membrane filtration process for the removal of heavy metal ions from wastewater. Blöcher, C., Dorda, J., Mavrov, V., Chmiel, H., Lazaridis, N.K., Matis, K.A. Water Res. (2003) [Pubmed]
  22. Immobilisation and mechanical, support of individual protoplasts. Scheurich, P., Schnabl, H., Zimmermann, U., Klein, J. Biochim. Biophys. Acta (1980) [Pubmed]
  23. Positive end-expiratory pressure does not affect indocyanine green plasma disappearance rate or gastric mucosal perfusion after cardiac surgery. Holland, A., Thuemer, O., Schelenz, C., van Hout, N., Sakka, S.G. European journal of anaesthesiology (2007) [Pubmed]
  24. Obturation of root canals in vivo with a new vacuum technique. Lussi, A., Suter, B., Grosrey, J. Journal of endodontics. (1997) [Pubmed]
  25. Application of capillary zone electrophoresis in the separation and determination of the principal gum opium alkaloids. Reddy, M.M., Suresh, V., Jayashanker, G., Rao, B.S., Sarin, R.K. Electrophoresis (2003) [Pubmed]
  26. Metoprolol prevents sodium retention induced by lower body negative pressure in healthy men. Wuerzner, G., Chiolero, A., Maillard, M., Nussberger, J., Burnier, M. Kidney Int. (2005) [Pubmed]
  27. Angiotensin II receptor blockade prevents acute renal sodium retention induced by low levels of orthostatic stress. Wuerzner, G., Chioléro, A., Maillard, M., Nussberger, J., Brunner, H.R., Burnier, M., Chiclero, A. Kidney Int. (2004) [Pubmed]
  28. Screening and analytical confirmation of sulfonamide residues in milk by capillary electrophoresis-mass spectrometry. Santos, B., Lista, A., Simonet, B.M., Ríos, A., Valcárcel, M. Electrophoresis (2005) [Pubmed]
  29. Noninvasive measurement of regional cerebral blood flow and regional cerebral blood volume by near-infrared spectroscopy and indocyanine green dye dilution. Keller, E., Nadler, A., Alkadhi, H., Kollias, S.S., Yonekawa, Y., Niederer, P. Neuroimage (2003) [Pubmed]
  30. In vitro and in vivo intrapulmonary distribution of fluorescently labeled surfactant. Diemel, R.V., Walch, M., Haagsman, H.P., Putz, G. Crit. Care Med. (2002) [Pubmed]
  31. Work of breathing, inspiratory flow response, and expiratory resistance during continuous positive airway pressure with the ventilators EVITA-2, EVITA-4 and SV 300. Calzia, E., Lindner, K.H., Stahl, W., Martin, A., Radermacher, P., Georgieff, M. Intensive care medicine. (1998) [Pubmed]
  32. Prophylaxis against fat and bone-marrow embolism during total hip arthroplasty reduces the incidence of postoperative deep-vein thrombosis: a controlled, randomized clinical trial. Pitto, R.P., Hamer, H., Fabiani, R., Radespiel-Troeger, M., Koessler, M. The Journal of bone and joint surgery. American volume. (2002) [Pubmed]
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