The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

Igh-VS107  -  immunoglobulin heavy chain (S107 family)

Mus musculus

Synonyms: IgG, IgH, VhNZA6
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Igh-VS107


High impact information on Igh-VS107


Biological context of Igh-VS107

  • Somatic point mutations are usually found in the coding and flanking regions of functionally and aberrantly rearranged immunoglobulin variable region gene segments [10].
  • Sequence analysis of three of the VH7183-containing restriction fragments indicate that all are pseudogenes which contain interruptions at either the 5' and/or 3' ends of the VH coding region [11].
  • To better understand the molecular basis of the antibody response, the heavy- and light-chain immunoglobulin variable region (VH and VL, respectively) sequences of seven monoclonal antibodies (MAbs) to GXM were determined [12].
  • Many immunoglobulin variable region (IgV) genes are present in the vertebrate genome and provide a basis for antibody diversity [13].
  • The Igh locus is controlled by cis-acting elements, including Emu and the 3' IgH regulatory region which flank the C region genes within the well-studied 3' part of the locus [14].

Anatomical context of Igh-VS107

  • The molecular analysis of 12 such hybridomas revealed that all IgH loci were rearranged into DJH or productive or nonproductive VHDJH complexes [15].
  • Cell mixing experiments with genetically marked cells indicated that each colony is derived from a single progenitor cell not yet committed to the expression of either IgH locus [15].
  • Evidence for the presence of idiotype-bearing regulatory T cells in which idiotype expression does not show linkage to either IgH alleles or the MHC [16].
  • Immunoglobulin variable region gene sequencing, and 5-bromo-2'-deoxyuridine pulse-chase studies indicate that long-lived splenic plasma cells are a mixture of cells derived from the extrafollicular and germinal center responses and cells derived from virgin and memory B cells [17].
  • Immunoglobulin variable region hypermutation in hybrids derived from a pre-B- and a myeloma cell line [18].

Associations of Igh-VS107 with chemical compounds


Other interactions of Igh-VS107


Analytical, diagnostic and therapeutic context of Igh-VS107


  1. Retention of an idiotypic determinant in a human B-cell lymphoma undergoing immunoglobulin variable-region mutation. Kon, S., Levy, S., Levy, R. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  2. Restricted immunoglobulin variable region (Ig V) gene expression accompanies secondary rearrangements of light chain Ig V genes in mouse plasmacytomas. Diaw, L., Siwarski, D., Coleman, A., Kim, J., Jones, G.M., Dighiero, G., Huppi, K. J. Exp. Med. (1999) [Pubmed]
  3. Biased utilization of immunoglobulin variable region heavy- and light-chain genes by the malignant CD5- B lymphocytes from patients with Burkitt's lymphoma. Moazzeni, M., Mosayyebi, G., Stevenson, F.K., Abbot, S., Mageed, R.A., Shokri, F. Int. J. Cancer (1994) [Pubmed]
  4. Gene conversion of immunoglobulin variable regions in mutagenesis cassettes by replacement PCR mutagenesis. Near, R.I. BioTechniques (1992) [Pubmed]
  5. Transcription-targeted DNA deamination by the AID antibody diversification enzyme. Chaudhuri, J., Tian, M., Khuong, C., Chua, K., Pinaud, E., Alt, F.W. Nature (2003) [Pubmed]
  6. Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase. Di Noia, J., Neuberger, M.S. Nature (2002) [Pubmed]
  7. Cell-cycle-regulated DNA double-stranded breaks in somatic hypermutation of immunoglobulin genes. Papavasiliou, F.N., Schatz, D.G. Nature (2000) [Pubmed]
  8. Establishment of idiotypic helper T-cell repertoires early in life. Martinez, C., Bernabé, R.R., de la Hera, A., Pereira, P., Cazenave, P.A., Coutinho, A. Nature (1985) [Pubmed]
  9. Influence of clonal selection on the expression of immunoglobulin variable region genes. Manser, T., Huang, S.Y., Gefter, M.L. Science (1984) [Pubmed]
  10. Somatic point mutations in unrearranged immunoglobulin gene segments encoding the variable region of lambda light chains. Weiss, S., Wu, G.E. EMBO J. (1987) [Pubmed]
  11. Interspersion of the VHQ52 and VH7183 gene families in the NFS/N mouse. Kleinfield, R.W., Weigert, M.G. J. Immunol. (1989) [Pubmed]
  12. Molecular and idiotypic analysis of antibodies to Cryptococcus neoformans glucuronoxylomannan. Casadevall, A., DeShaw, M., Fan, M., Dromer, F., Kozel, T.R., Pirofski, L.A. Infect. Immun. (1994) [Pubmed]
  13. Evolution of immunoglobulin heavy chain variable region genes: a VH family can last for 150-200 million years or longer. Andersson, E., Matsunaga, T. Immunogenetics (1995) [Pubmed]
  14. Identification of a candidate regulatory element within the 5' flanking region of the mouse Igh locus defined by pro-B cell-specific hypersensitivity associated with binding of PU.1, Pax5, and E2A. Pawlitzky, I., Angeles, C.V., Siegel, A.M., Stanton, M.L., Riblet, R., Brodeur, P.H. J. Immunol. (2006) [Pubmed]
  15. Ig gene rearrangement and expression in the progeny of B-cell progenitors in the course of clonal expansion in bone marrow cultures. Yoshida, N., Radbruch, A., Rajewsky, K. EMBO J. (1987) [Pubmed]
  16. Evidence for the presence of idiotype-bearing regulatory T cells in which idiotype expression does not show linkage to either IgH alleles or the MHC. Singhai, R., Weaver, M., Sikora, L., Levy, J.G. Immunology (1984) [Pubmed]
  17. Intrinsic constraint on plasmablast growth and extrinsic limits of plasma cell survival. Sze, D.M., Toellner, K.M., García de Vinuesa, C., Taylor, D.R., MacLennan, I.C. J. Exp. Med. (2000) [Pubmed]
  18. Immunoglobulin variable region hypermutation in hybrids derived from a pre-B- and a myeloma cell line. Green, N.S., Rabinowitz, J.L., Zhu, M., Kobrin, B.J., Scharff, M.D. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  19. Restricted immunoglobulin variable region gene usage by normal Ly-1 (CD5+) B cells that recognize phosphatidyl choline. Mercolino, T.J., Locke, A.L., Afshari, A., Sasser, D., Travis, W.W., Arnold, L.W., Haughton, G. J. Exp. Med. (1989) [Pubmed]
  20. Molecular cloning of Lyt-3, a membrane glycoprotein marking a subset of mouse T lymphocytes: molecular homology to immunoglobulin and T-cell receptor variable and joining regions. Nakauchi, H., Shinkai, Y., Okumura, K. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  21. Molecular mechanisms resulting in pathogenic anti-mouse erythrocyte antibodies in New Zealand black mice. Scott, B.B., Sadigh, S., Stow, M., Mageed, R.A., Andrew, E.M., Maini, R.N. Clin. Exp. Immunol. (1993) [Pubmed]
  22. Formal proof that different-size Lyt-2 polypeptides arise from differential splicing and post-transcriptional regulation. Tagawa, M., Nakauchi, H., Herzenberg, L.A., Nolan, G.P. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  23. Molecular characterization of the murine cytotoxic T-cell membrane glycoprotein Ly-3 (CD8). Panaccio, M., Gillespie, M.T., Walker, I.D., Kirszbaum, L., Sharpe, J.A., Tobias, G.H., McKenzie, I.F., Deacon, N.J. Proc. Natl. Acad. Sci. U.S.A. (1987) [Pubmed]
  24. A carcinoembryonic antigen family cDNA from mouse placenta encoding a protein with a rare domain composition. Kataoka, K., Takata, Y., Nakajima, A., Saito, S., Huh, N. Placenta (2000) [Pubmed]
  25. A novel strategy for generating monoclonal antibodies from single, isolated lymphocytes producing antibodies of defined specificities. Babcook, J.S., Leslie, K.B., Olsen, O.A., Salmon, R.A., Schrader, J.W. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  26. Cloning and sequencing of immunoglobulin variable-region genes using degenerate oligodeoxyribonucleotides and polymerase chain reaction. LeBoeuf, R.D., Galin, F.S., Hollinger, S.K., Peiper, S.C., Blalock, J.E. Gene (1989) [Pubmed]
  27. Survival of long-lived plasma cells is independent of antigen. Manz, R.A., Löhning, M., Cassese, G., Thiel, A., Radbruch, A. Int. Immunol. (1998) [Pubmed]
WikiGenes - Universities