Gene Review:
Wt1 - Wilms tumor 1 homolog
Mus musculus
Synonyms:
D630046I19Rik, Wilms tumor protein homolog, Wt-1
- Initial differentiation of the metanephric mesenchyme is independent of WT1 and the ureteric bud. Donovan, M.J., Natoli, T.A., Sainio, K., Amstutz, A., Jaenisch, R., Sariola, H., Kreidberg, J.A. Dev. Genet. (1999)
- The Wilms' tumor gene Wt1 is required for normal development of the retina. Wagner, K.D., Wagner, N., Vidal, V.P., Schley, G., Wilhelm, D., Schedl, A., Englert, C., Scholz, H. EMBO J. (2002)
- The Wt1+/R394W mouse displays glomerulosclerosis and early-onset renal failure characteristic of human Denys-Drash syndrome. Gao, F., Maiti, S., Sun, G., Ordonez, N.G., Udtha, M., Deng, J.M., Behringer, R.R., Huff, V. Mol. Cell. Biol. (2004)
- The major podocyte protein nephrin is transcriptionally activated by the Wilms' tumor suppressor WT1. Wagner, N., Wagner, K.D., Xing, Y., Scholz, H., Schedl, A. J. Am. Soc. Nephrol. (2004)
- Bone marrow transplantation can attenuate the progression of mesangial sclerosis. Guo, J.K., Schedl, A., Krause, D.S. Stem Cells (2006)
- Two splice variants of the Wilms' tumor 1 gene have distinct functions during sex determination and nephron formation. Hammes, A., Guo, J.K., Lutsch, G., Leheste, J.R., Landrock, D., Ziegler, U., Gubler, M.C., Schedl, A. Cell (2001)
- Coronary vessel development requires activation of the TrkB neurotrophin receptor by the Wilms' tumor transcription factor Wt1. Wagner, N., Wagner, K.D., Theres, H., Englert, C., Schedl, A., Scholz, H. Genes Dev. (2005)
- Implication of Wt1 in the pathogenesis of nephrogenic failure in a mouse model of retinoic acid-induced caudal regression syndrome. Tse, H.K., Leung, M.B., Woolf, A.S., Menke, A.L., Hastie, N.D., Gosling, J.A., Pang, C.P., Shum, A.S. Am. J. Pathol. (2005)
- The Wilms' tumor suppressor Wt1 is expressed in the coronary vasculature after myocardial infarction. Wagner, K.D., Wagner, N., Bondke, A., Nafz, B., Flemming, B., Theres, H., Scholz, H. FASEB J. (2002)
- Development of an siRNA-based method for repressing specific genes in renal organ culture and its use to show that the Wt1 tumour suppressor is required for nephron differentiation. Davies, J.A., Ladomery, M., Hohenstein, P., Michael, L., Shafe, A., Spraggon, L., Hastie, N. Hum. Mol. Genet. (2004)
- Gonadal effects of a mouse Denys-Drash syndrome mutation. Patek, C.E., Saunders, P.T., Miles, C.G., Berry, R.L., Hastie, N.D., Sharpe, R.M., Hooper, M.L. Transgenic Res. (2005)
- Modifications of the retina neuronal populations of the heterozygous mutant small eye mouse, the Sey(Dey). Curto, G.G., Lara, J.M., Parrilla, M., Aij??n, J., Velasco, A. Brain Res. (2007)
- Gonadal differentiation, sex determination and normal Sry expression in mice require direct interaction between transcription partners GATA4 and FOG2. Tevosian, S.G., Albrecht, K.H., Crispino, J.D., Fujiwara, Y., Eicher, E.M., Orkin, S.H. Development (2002)
- Murine Denys-Drash syndrome: evidence of podocyte de-differentiation and systemic mediation of glomerulosclerosis. Patek, C.E., Fleming, S., Miles, C.G., Bellamy, C.O., Ladomery, M., Spraggon, L., Mullins, J., Hastie, N.D., Hooper, M.L. Hum. Mol. Genet. (2003)
- An inducible mouse model for PAX2-dependent glomerular disease: insights into a complex pathogenesis. Wagner, K.D., Wagner, N., Guo, J.K., Elger, M., Dallman, M.J., Bugeon, L., Schedl, A. Curr. Biol. (2006)
- The Wilms' tumor suppressor Wt1 encodes a transcriptional activator of the class IV POU-domain factor Pou4f2 (Brn-3b). Wagner, K.D., Wagner, N., Schley, G., Theres, H., Scholz, H. Gene (2003)
- Down-regulation of endogenous Wt1 expression by Sry transgene in the murine embryonic mesonephros-derived M15 cell line. Ito, M., Miyagishi, M., Murata, C., Kawasaki, H., Baba, T., Tachi, C., Taira, K. J. Reprod. Dev. (2006)
- Hox11 paralogous genes are essential for metanephric kidney induction. Wellik, D.M., Hawkes, P.J., Capecchi, M.R. Genes Dev. (2002)
- The Wilms tumor suppressor WT1 regulates early gonad development by activation of Sf1. Wilhelm, D., Englert, C. Genes Dev. (2002)