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Gene Review

LINC01554  -  long intergenic non-protein coding RNA 1554

Homo sapiens

Synonyms: C5orf27, FIS, FLJ38821, Protein FIS
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Disease relevance of C5orf27

  • FIS belongs to the group of small abundant DNA-binding proteins of Escherichia coli [1].
  • In the human enteropathogen Shigella transcription of virF, the primary regulator of the invasion functions, is strictly temperature-dependent and is antagonistically mediated by H-NS and FIS, which bind to specific sites on the virF promoter [2].
  • FIS, the factor for inversion stimulation, from Escherichia coli and other enteric bacteria, is an interwined alpha-helical homodimer [3].
  • As controls, two woodchucks chronically infected with woodchuck hepatitis virus were immunized: one with FIS only and the other with surface antigen only [4].
  • The results showed that carrageenan-induced thermal and mechanical allodynia and hyperalgesia were greater in FIS than in LEW [5].

High impact information on C5orf27

  • FIS genes are targets of imprinting, and the genes they control in developing endosperm are also regulated by DNA methylation and chromatin remodeling genes [6].
  • Individually FIS and RNA polymerase wrap approximately 80 and 150 bp of promoter DNA, respectively [7].
  • Two CRP- and several FIS-binding sites with different affinities are located in the crp promoter region, one of them overlapping the downstream transcription initiation sites [1].
  • During a 3-year period (June 1981-July 1984), 70 patients who presented with an endoscopically proven variceal bleed were randomized to receive either fiberoptic injection sclerotherapy (FIS, 36 patients) or a rigid scope technique (RIS, 34 patients), using ethanolamine oleate as the sclerosing agent [8].
  • The folding and unfolding of FIS were studied with both equilibrium and kinetic methods by circular dichroism using urea and guanidinium chloride (GdmCl) as the perturbants [3].

Biological context of C5orf27

  • We computed mean inbreeding coefficients (FIT, FIS, and FST) based on approximately 2,700 ascending pedigrees of contemporary people from Saguenay Lac-St-Jean (Québec, Canada) [9].
  • Expression of the FIS genes in turn is modulated by parent specific expression or genomic imprinting which in turn is controlled by DNA methylation [10].
  • Band-shift assays of FIS protein binding revealed facilitated interaction with inosine-containing DNA and markedly reduced binding to DAP-containing DNA, attributable to altered bendability [11].
  • We have identified mutants of the FIS protein resulting in reduced rrnB P1 transcription activation that nevertheless retain the ability to bind DNA in vivo [12].
  • The requirement for this sequence was strictly correlated with Benham's theoretical stress-induced DNA duplex destabilization. oriC mutations at DnaA, FIS, or IHF binding sites showed normal HIR activation, but DnaA was required for HIR [13].

Anatomical context of C5orf27

  • METHODS: Seven woodchucks chronically infected with woodchuck hepatitis virus were immunized with surface antigen from this virus, purified from plasma, in conjunction with a peptide named FIS (encompassing amino acids 106-118: FISEAIIHVLHSR from sperm whale myoglobin), which is recognized by T helper lymphocytes [4].
  • It is found that the theory for random mating populations holds if the effective population number is Ne = N'/(1 + FIS), where FIS is the inbreeding coefficient at equilibrium when N is infinite and N' is the reciprocal of the probability that two gametes contributing to random separate adults come from the same parent [14].
  • Similarly, FIS showed more carrageenan-induced hindpaw swelling and higher levels of myeloperoxidase (a measure of neutrophils) in the carrageenan-inflamed hindpaw [5].
  • In the present study, LEW and FIS were used to determine the relationship between HPA axis function and acute inflammatory pain (carrageenan-induced hindpaw inflammation) and neuropathic pain (partial sciatic nerve ligation; PSNL) [5].
  • The FIS score included age; cardiac signs; chest radiograph; respiratory history; blood pressure; pulse; Glasgow coma score; determinations of hemoglobin, leukocyte, urea, sodium, and potassium levels; and electrocardiogram [15].

Associations of C5orf27 with chemical compounds

  • DNase footprinting experiments confirmed that fewer sites would bind FIS in DAP-containing DNA at a given protein concentration, whereas higher levels of binding occurred with inosine-containing molecules [11].
  • The difference between the median changes in FIS scores (mexiletine = 5.5, placebo = 2) was not statistically significant [16].
  • They then describe in detail the development and implementation of one of these systems, The Johns Hopkins University School of Medicine Faculty Information System (FIS), which uses Web publishing technologies, collecting and making available information about the clinical, teaching, and research activities of faculty members [17].
  • We present a detailed glucose regulation model using fuzzy inference system (FIS) descriptions of hormonal control action and the familiar Michaelis-Menten (M-M) kinetic description for glucose transport [18].
  • The flexible part of the new FIS has been made as pliable as the Cantor tube or the Miller-Abbott tube so that the tip of the new FIS is carried on into the small intestine by peristaltic activity along its natural configuration [19].

Other interactions of C5orf27

  • One of the best-characterised examples of this class of proteins is the pleiotropic regulator of metabolism FIS, which reduces the activity of DNA gyrase and counteracts the increase of the overall superhelicity of DNA during early exponential growth phase [20].

Analytical, diagnostic and therapeutic context of C5orf27

  • The combined treatment compared with radiotherapy alone led to a longer survival (p = 0.04) and a longer FIS (p = 0.06) [21].
  • With the exception of four patients who underwent transplantation between 2000 and 2004, all of whom showed significant improvement in fatigue severity as assessed by FIS, fatigue severity was unchanged over four years of follow up [22].
  • Size exclusion chromatography and static light scattering measurements demonstrated that FIS is predominately a stable dimer at the concentrations (1-10 microM monomer) and buffer conditions employed in this study [3].
  • METHODS: 442 consecutive patients admitted with first-ever ischemic stroke (FIS) were assessed by the Unified Neurological Stroke Scale (UNSS) at admission, on hospitalization days 1, 2 and 3 and before discharge [23].
  • A four-item symptom score (FIS), which rated pain, dysesthesias, paresthesias, and nightly exacerbations of symptoms, and a 100-mm visual analog scale (VAS), which rated pain intensity, were completed by patients before and after treatment [16].


  1. Regulation of crp transcription by oscillation between distinct nucleoprotein complexes. González-Gil, G., Kahmann, R., Muskhelishvili, G. EMBO J. (1998) [Pubmed]
  2. The virF promoter in Shigella: more than just a curved DNA stretch. Prosseda, G., Falconi, M., Giangrossi, M., Gualerzi, C.O., Micheli, G., Colonna, B. Mol. Microbiol. (2004) [Pubmed]
  3. Folding mechanism of FIS, the intertwined, dimeric factor for inversion stimulation. Topping, T.B., Hoch, D.A., Gloss, L.M. J. Mol. Biol. (2004) [Pubmed]
  4. Therapeutic vaccination of woodchucks against chronic woodchuck hepatitis virus infection. Hervás-Stubbs, S., Lasarte, J.J., Sarobe, P., Prieto, J., Cullen, J., Roggendorf, M., Borrás-Cuesta, F. J. Hepatol. (1997) [Pubmed]
  5. Acute inflammatory and neuropathic pain in Lewis and Fischer rats. Fecho, K., Valtschanoff, J.G. J. Neuroendocrinol. (2006) [Pubmed]
  6. Control of early seed development. Chaudhury, A.M., Koltunow, A., Payne, T., Luo, M., Tucker, M.R., Dennis, E.S., Peacock, W.J. Annu. Rev. Cell Dev. Biol. (2001) [Pubmed]
  7. RNA polymerase and an activator form discrete subcomplexes in a transcription initiation complex. Maurer, S., Fritz, J., Muskhelishvili, G., Travers, A. EMBO J. (2006) [Pubmed]
  8. Rigid versus fiberoptic endoscopic injection sclerotherapy. A prospective randomized controlled trial in patients with bleeding esophageal varices. Bornman, P.C., Kahn, D., Terblanche, J., Worthley, C., Spence, R.A., Krige, J.J. Ann. Surg. (1988) [Pubmed]
  9. Evolution of inbreeding coefficients and effective size in the population of Saguenay Lac-St.-Jean (Quebec). Mourali-Chebil, S., Heyer, E. Hum. Biol. (2006) [Pubmed]
  10. Maternal control of seed development. Chaudhury, A.M., Berger, F. Semin. Cell Dev. Biol. (2001) [Pubmed]
  11. Effects of base substitutions on the binding of a DNA-bending protein. Bailly, C., Waring, M.J., Travers, A.A. J. Mol. Biol. (1995) [Pubmed]
  12. A positive control mutant of the transcription activator protein FIS. Gosink, K.K., Gaal, T., Bokal, A.J., Gourse, R.L. J. Bacteriol. (1996) [Pubmed]
  13. Initiation of Heat-Induced Replication Requires DnaA and the L-13-mer of oriC. Gonz??lez-Soltero, R., Botello, E., Jim??nez-S??nchez, A. J. Bacteriol. (2006) [Pubmed]
  14. On the theory of partially inbreeding finite populations. I. Partial selfing. Pollak, E. Genetics (1987) [Pubmed]
  15. Application of the POSSUM system in bariatric surgery. Cagigas, J.C., Escalante, C.F., Ingelmo, A., Hernandez-Estefania, R., Hernanz, F., Castillo, J., Fleitas, M.G. Obesity surgery : the official journal of the American Society for Bariatric Surgery and of the Obesity Surgery Society of Australia and New Zealand. (1999) [Pubmed]
  16. Mexiletine in the symptomatic treatment of diabetic peripheral neuropathy. Wright, J.M., Oki, J.C., Graves, L. The Annals of pharmacotherapy. (1997) [Pubmed]
  17. Using modern information technology to profile faculty activities. Lombardo, J., White, C., Wojcik, R. Academic medicine : journal of the Association of American Medical Colleges. (1998) [Pubmed]
  18. A fuzzy model of glucose regulation. Ward, E., Martin, T. Journal of medical systems. (2006) [Pubmed]
  19. A new fiberintestinoscope type FIS-T1 patterned after intestinal biopsy tube. Mita, M., Wong, T.F., Yamagata, R., Matsumoto, K., Tachikawa, H. Tohoku J. Exp. Med. (1976) [Pubmed]
  20. Transcription factor as a topological homeostat. Muskhelishvili, G., Travers, A. Front. Biosci. (2003) [Pubmed]
  21. Treatment of single brain metastasis: radiotherapy alone or combined with neurosurgery? Vecht, C.J., Haaxma-Reiche, H., Noordijk, E.M., Padberg, G.W., Voormolen, J.H., Hoekstra, F.H., Tans, J.T., Lambooij, N., Metsaars, J.A., Wattendorff, A.R. Ann. Neurol. (1993) [Pubmed]
  22. Four year follow up of fatigue in a geographically defined primary biliary cirrhosis patient cohort. Jones, D.E., Bhala, N., Burt, J., Goldblatt, J., Prince, M., Newton, J.L. Gut (2006) [Pubmed]
  23. Stroke-in-evolution: infarct-inherent mechanisms versus systemic causes. Karepov, V.G., Gur, A.Y., Bova, I., Aronovich, B.D., Bornstein, N.M. Cerebrovasc. Dis. (2006) [Pubmed]
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