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Gene Review

FBLN1  -  fibulin 1

Homo sapiens

Synonyms: FBLN, FIBL-1, FIBL1, Fibulin-1, PP213
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Disease relevance of FBLN1


High impact information on FBLN1


Biological context of FBLN1


Anatomical context of FBLN1


Associations of FBLN1 with chemical compounds

  • Fibulin binds to itself and to the carboxyl-terminal heparin-binding region of fibronectin [10].
  • Additional studies found that the mechanism for the motility-suppressive effects of fibulin-1 does not involve perturbations of interactions between alpha5beta1 or alpha4 integrins, or heparan sulfate proteoglycans with FN [11].
  • Using a modified Boyden-chamber assay, we have evaluated the respective roles of estradiol and fibulin-1 on cell motility, one of the earlier steps of tumor invasion [2].
  • Fibulin is a newly described extracellular matrix (ECM) glycoprotein whose function has not been elucidated [14].
  • The amino-terminal portion of fibulin contains a repeated element with potential disulfide loop structure resembling that of the complement component anaphylatoxins C3a, C4a, and C5a as well as proteins of the albumin gene family [7].

Physical interactions of FBLN1


Regulatory relationships of FBLN1

  • Fibulin-1 was found to inhibit haptotactic migration of MDA-MB231 cells to FN in a dose-dependent manner [2].
  • The C-terminal domain of the regulatory protein NOVH is sufficient to promote interaction with fibulin 1C: a clue for a role of NOVH in cell-adhesion signaling [15].

Other interactions of FBLN1


Analytical, diagnostic and therapeutic context of FBLN1


  1. The interaction of fibulin-1 with fibrinogen. A potential role in hemostasis and thrombosis. Tran, H., Tanaka, A., Litvinovich, S.V., Medved, L.V., Haudenschild, C.C., Argraves, W.S. J. Biol. Chem. (1995) [Pubmed]
  2. Estradiol and fibulin-1 inhibit motility of human ovarian- and breast-cancer cells induced by fibronectin. Hayashido, Y., Lucas, A., Rougeot, C., Godyna, S., Argraves, W.S., Rochefort, H. Int. J. Cancer (1998) [Pubmed]
  3. Estrogens increase the expression of fibulin-1, an extracellular matrix protein secreted by human ovarian cancer cells. Clinton, G.M., Rougeot, C., Derancourt, J., Roger, P., Defrenne, A., Godyna, S., Argraves, W.S., Rochefort, H. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  4. Increased immunostaining of fibulin-1, an estrogen-regulated protein in the stroma of human ovarian epithelial tumors. Roger, P., Pujol, P., Lucas, A., Baldet, P., Rochefort, H. Am. J. Pathol. (1998) [Pubmed]
  5. Fibulin, a novel protein that interacts with the fibronectin receptor beta subunit cytoplasmic domain. Argraves, W.S., Dickerson, K., Burgess, W.H., Ruoslahti, E. Cell (1989) [Pubmed]
  6. Structural basis and potential role of heparin/heparan sulfate binding to the angiogenesis inhibitor endostatin. Sasaki, T., Larsson, H., Kreuger, J., Salmivirta, M., Claesson-Welsh, L., Lindahl, U., Hohenester, E., Timpl, R. EMBO J. (1999) [Pubmed]
  7. Fibulin is an extracellular matrix and plasma glycoprotein with repeated domain structure. Argraves, W.S., Tran, H., Burgess, W.H., Dickerson, K. J. Cell Biol. (1990) [Pubmed]
  8. The fibulin-1 gene (FBLN1) is located on human chromosome 22 and on mouse chromosome 15. Mattei, M.G., Pan, T.C., Zhang, R.Z., Timpl, R., Chu, M.L. Genomics (1994) [Pubmed]
  9. Genomewide homozygosity mapping and molecular analysis of a candidate gene located on 22q13 (fibulin-1) in a previously undescribed vitreoretinal dystrophy. Weigell-Weber, M., Sarra, G.M., Kotzot, D., Sandkuijl, L., Messmer, E., Hergersberg, M. Arch. Ophthalmol. (2003) [Pubmed]
  10. Fibulin binds to itself and to the carboxyl-terminal heparin-binding region of fibronectin. Balbona, K., Tran, H., Godyna, S., Ingham, K.C., Strickland, D.K., Argraves, W.S. J. Biol. Chem. (1992) [Pubmed]
  11. Fibulin-1 suppression of fibronectin-regulated cell adhesion and motility. Twal, W.O., Czirok, A., Hegedus, B., Knaak, C., Chintalapudi, M.R., Okagawa, H., Sugi, Y., Argraves, W.S. J. Cell. Sci. (2001) [Pubmed]
  12. Human fibulin-1D: molecular cloning, expression and similarity with S1-5 protein, a new member of the fibulin gene family. Tran, H., Mattei, M., Godyna, S., Argraves, W.S. Matrix Biol. (1997) [Pubmed]
  13. The extracellular matrix proteins fibulin-1 and fibulin-2 in the early human embryo. Miosge, N., Götz, W., Sasaki, T., Chu, M.L., Timpl, R., Herken, R. Histochem. J. (1996) [Pubmed]
  14. Fibulin's organization into the extracellular matrix of fetal lung fibroblasts is dependent on fibronectin matrix assembly. Roman, J., McDonald, J.A. Am. J. Respir. Cell Mol. Biol. (1993) [Pubmed]
  15. The C-terminal domain of the regulatory protein NOVH is sufficient to promote interaction with fibulin 1C: a clue for a role of NOVH in cell-adhesion signaling. Perbal, B., Martinerie, C., Sainson, R., Werner, M., He, B., Roizman, B. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  16. Estrogen induction and overexpression of fibulin-1C mRNA in ovarian cancer cells. Moll, F., Katsaros, D., Lazennec, G., Hellio, N., Roger, P., Giacalone, P.L., Chalbos, D., Maudelonde, T., Rochefort, H., Pujol, P. Oncogene (2002) [Pubmed]
  17. Evidence that fibulin family members contribute to the steroid-dependent extravascular sequestration of sex hormone-binding globulin. Ng, K.M., Catalano, M.G., Pinós, T., Selva, D.M., Avvakumov, G.V., Munell, F., Hammond, G.L. J. Biol. Chem. (2006) [Pubmed]
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