Gene Review:
Ugcg - UDP-glucose ceramide glucosyltransferase
Rattus norvegicus
Synonyms:
Ceramide glucosyltransferase, GCS, GLCT-1, Glucosylceramide synthase, UDP-glucose:N-acylsphingosine D-glucosyltransferase
- Glucosylceramide synthase activity and ceramide levels are modulated during cerebral ischemia after ischemic preconditioning. Takahashi, K., Ginis, I., Nishioka, R., Klimanis, D., Barone, F.C., White, R.F., Chen, Y., Hallenbeck, J.M. J. Cereb. Blood Flow Metab. (2004)
- Retrograde labeling, enrichment, and characterization of retinal ganglion cells from the neonatal rat. Sarthy, P.V., Curtis, B.M., Catterall, W.A. J. Neurosci. (1983)
- Glycine cleavage system in neurogenic regions. Ichinohe, A., Kure, S., Mikawa, S., Ueki, T., Kojima, K., Fujiwara, K., Iinuma, K., Matsubara, Y., Sato, K. Eur. J. Neurosci. (2004)
- Anoxia and reoxygenation of human endothelial cells decrease ceramide glucosyltransferase expression and activates caspases. Zhao, H., Miller, M., Pfeiffer, K., Buras, J.A., Stahl, G.L. FASEB J. (2003)
- Dexamethasone modulates rat renal brush border membrane phosphate transporter mRNA and protein abundance and glycosphingolipid composition. Levi, M., Shayman, J.A., Abe, A., Gross, S.K., McCluer, R.H., Biber, J., Murer, H., Lötscher, M., Cronin, R.E. J. Clin. Invest. (1995)
- A novel role of lactosylceramide in the regulation of tumor necrosis factor alpha-mediated proliferation of rat primary astrocytes. Implications for astrogliosis following neurotrauma. Pannu, R., Singh, A.K., Singh, I. J. Biol. Chem. (2005)
- Trafficking of ganglioside GD3 to mitochondria by tumor necrosis factor-alpha. García-Ruiz, C., Colell, A., Morales, A., Calvo, M., Enrich, C., Fernández-Checa, J.C. J. Biol. Chem. (2002)
- Identification of active site residues in glucosylceramide synthase. A nucleotide-binding catalytic motif conserved with processive beta-glycosyltransferases. Marks, D.L., Dominguez, M., Wu, K., Pagano, R.E. J. Biol. Chem. (2001)
- Structure and expression of the glycine cleavage system in rat central nervous system. Sakata, Y., Owada, Y., Sato, K., Kojima, K., Hisanaga, K., Shinka, T., Suzuki, Y., Aoki, Y., Satoh, J., Kondo, H., Matsubara, Y., Kure, S. Brain Res. Mol. Brain Res. (2001)
- Histidine-193 of rat glucosylceramide synthase resides in a UDP-glucose- and inhibitor (D-threo-1-phenyl-2-decanoylamino-3-morpholinopropan-1-ol)-binding region: a biochemical and mutational study. Wu, K., Marks, D.L., Watanabe, R., Paul, P., Rajan, N., Pagano, R.E. Biochem. J. (1999)
- Quinone-induced oxidative stress elevates glutathione and induces gamma-glutamylcysteine synthetase activity in rat lung epithelial L2 cells. Shi, M.M., Kugelman, A., Iwamoto, T., Tian, L., Forman, H.J. J. Biol. Chem. (1994)
- Regulation of gamma-glutamylcysteine synthetase by protein phosphorylation. Sun, W.M., Huang, Z.Z., Lu, S.C. Biochem. J. (1996)
- Stimulation of glycine catabolism in isolated perfused rat liver by calcium mobilizing hormones and in isolated rat liver mitochondria by submicromolar concentrations of calcium. Jois, M., Hall, B., Brosnan, J.T. J. Biol. Chem. (1990)
- Oligomerization and topology of the Golgi membrane protein glucosylceramide synthase. Marks, D.L., Wu, K., Paul, P., Kamisaka, Y., Watanabe, R., Pagano, R.E. J. Biol. Chem. (1999)
- Glucosylceramide synthase inhibitor inhibits the action of nerve growth factor in PC12 cells. Mutoh, T., Tokuda, A., Inokuchi, J., Kuriyama, M. J. Biol. Chem. (1998)
- The mitochondria-associated endoplasmic-reticulum subcompartment (MAM fraction) of rat liver contains highly active sphingolipid-specific glycosyltransferases. Ardail, D., Popa, I., Bodennec, J., Louisot, P., Schmitt, D., Portoukalian, J. Biochem. J. (2003)
- Depletion of cerebral D-serine in non-ketotic hyperglycinemia: possible involvement of glycine cleavage system in control of endogenous D-serine. Iwama, H., Takahashi, K., Kure, S., Hayashi, F., Narisawa, K., Tada, K., Mizoguchi, M., Takashima, S., Tomita, U., Nishikawa, T. Biochem. Biophys. Res. Commun. (1997)
- Rationales for cancer chemotherapy with PDMP, a specific inhibitor of glucosylceramide synthase. Radin, N.S. Mol. Chem. Neuropathol. (1994)
- Preparation, quality control and application of 99mTc-gluco-ene-diolate for renal scanning. Shafiq, Y.F., Al-Janabi, M.A. Nuklearmedizin. (1985)