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Chemical Compound Review

SureCN13123059     13-methyl- 6,7,8,9,11,12,14,15,16,17...

Synonyms: LS-64785, AR-1I7207, FT-0669583, AC1L1C53, 5976-61-4, ...
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  1. 4-Hydroxylation of estrogens as marker of human mammary tumors. Liehr, J.G., Ricci, M.J. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  2. Induction of uterine adenocarcinoma in CD-1 mice by catechol estrogens. Newbold, R.R., Liehr, J.G. Cancer Res. (2000) [Pubmed]
  3. Lack of association of CYP1 B1*3 polymorphism and ovarian cancer in a Caucasian population. Cecchin, E., Russo, A., Campagnutta, E., Martella, L., Toffoli, G. Int. J. Biol. Markers (2004) [Pubmed]
  4. Can estrogenic radicals, generated by lactoperoxidase, be involved in the molecular mechanism of breast carcinogenesis? Ghibaudi, E.M., Laurenti, E., Beltramo, P., Ferrari, R.P. Redox Rep. (2000) [Pubmed]
  5. Effect of various doses of catecholestrogens on uterine eosinophilia in the immature rat. Baumann, P., Tchernitchin, A.N., Grunert, G., Ball, P. Experientia (1986) [Pubmed]
  6. Is estradiol a genotoxic mutagenic carcinogen? Liehr, J.G. Endocr. Rev. (2000) [Pubmed]
  7. Is 2-methoxyestradiol an endogenous estrogen metabolite that inhibits mammary carcinogenesis? Zhu, B.T., Conney, A.H. Cancer Res. (1998) [Pubmed]
  8. An electron spin resonance study of o-semiquinones formed during the enzymatic and autoxidation of catechol estrogens. Kalyanaraman, B., Sealy, R.C., Sivarajah, K. J. Biol. Chem. (1984) [Pubmed]
  9. Double-Stranded RNA-Dependent Protein Kinase Is Involved in 2-Methoxyestradiol-Mediated Cell Death of Osteosarcoma Cells. Shogren, K.L., Turner, R.T., Yaszemski, M.J., Maran, A. J. Bone Miner. Res. (2007) [Pubmed]
  10. Thiols can either enhance or suppress DNA damage induction by catecholestrogens. Thibodeau, P.A., Kocsis-Bédard, S., Courteau, J., Niyonsenga, T., Paquette, B. Free Radic. Biol. Med. (2001) [Pubmed]
  11. Effect of frying-meat emission particulate on 17beta-estradiol 2- and 4-hydroxylation in human lung adenocarcinoma CL5 cells. Wang, H.W., Ueng, T.H., Chen, T.L., Yang, P.C. J. Toxicol. Environ. Health Part A (2003) [Pubmed]
  12. Inhibition of catechol O-methyltransferase-catalyzed O-methylation of 2- and 4-hydroxyestradiol by quercetin. Possible role in estradiol-induced tumorigenesis. Zhu, B.T., Liehr, J.G. J. Biol. Chem. (1996) [Pubmed]
  13. Synergistic induction of DNA strand breakage by catechol-estrogen and nitric oxide: implications for hormonal carcinogenesis. Yoshie, Y., Ohshima, H. Free Radic. Biol. Med. (1998) [Pubmed]
  14. Induction of cytosolic progestin binding sites by catecholestrogens in rat pituitary gland and uterus: different potencies of 2- and 4-hydroxyestradiol. Kirchhoff, J., Reinhardt, W., Grünke, W., Ghraf, R., Ball, P., Knuppen, R. J. Neurochem. (1983) [Pubmed]
  15. Polymorphisms in P450 CYP1B1 affect the conversion of estradiol to the potentially carcinogenic metabolite 4-hydroxyestradiol. Li, D.N., Seidel, A., Pritchard, M.P., Wolf, C.R., Friedberg, T. Pharmacogenetics (2000) [Pubmed]
  16. Mutagenic activity of 4-hydroxyestradiol, but not 2-hydroxyestradiol, in BB rat2 embryonic cells, and the mutational spectrum of 4-hydroxyestradiol. Zhao, Z., Kosinska, W., Khmelnitsky, M., Cavalieri, E.L., Rogan, E.G., Chakravarti, D., Sacks, P.G., Guttenplan, J.B. Chem. Res. Toxicol. (2006) [Pubmed]
  17. Microsomal hydroxylation of 2- and 4-fluoroestradiol to catechol metabolites and their conversion to methyl ethers: catechol estrogens as possible mediators of hormonal carcinogenesis. Ashburn, S.P., Han, X., Liehr, J.G. Mol. Pharmacol. (1993) [Pubmed]
  18. Formation of 2- and 4-hydroxyestrogens by brain, pituitary, and liver of the human fetus. Ball, P., Knuppen, R. J. Clin. Endocrinol. Metab. (1978) [Pubmed]
  19. Conversion of estrone to 2- and 4-hydroxyestrone by hamster kidney and liver microsomes: implications for the mechanism of estrogen-induced carcinogenesis. Zhu, B.T., Bui, Q.D., Weisz, J., Liehr, J.G. Endocrinology (1994) [Pubmed]
  20. Estradiol and its metabolites 4-hydroxyestradiol and 2-hydroxyestradiol induce mutations in human breast epithelial cells. Fernandez, S.V., Russo, I.H., Russo, J. Int. J. Cancer (2006) [Pubmed]
  21. Metabolism and DNA binding studies of 4-hydroxyestradiol and estradiol-3,4-quinone in vitro and in female ACI rat mammary gland in vivo. Li, K.M., Todorovic, R., Devanesan, P., Higginbotham, S., Köfeler, H., Ramanathan, R., Gross, M.L., Rogan, E.G., Cavalieri, E.L. Carcinogenesis (2004) [Pubmed]
  22. Interactions of catecholestrogens with cytoplasmic and nuclear estrogen receptors in rat pituitary gland and hypothalamus. Kirchhoff, J., Hornung, E., Ghraf, R., Ball, P., Knuppen, R. J. Neurochem. (1981) [Pubmed]
  23. Inhibition of the catechol-O-methyltransferase-catalyzed O-methylation of 2- and 4-hydroxyestradiol by catecholamine: implications for the mechanism of estrogen-induced carcinogenesis. Zhu, B.T., Liehr, J.G. Arch. Biochem. Biophys. (1993) [Pubmed]
  24. Enzymatic O-methylation of catechol estrogens in red blood cells: differences in animal species and strains. Suzuki, E., Saegusa, K., Anjo, T., Matsuki, Y., Nambara, T. Steroids (1993) [Pubmed]
  25. Concentration dependence of prooxidant and antioxidant properties of catecholestrogens. Markides, C.S., Roy, D., Liehr, J.G. Arch. Biochem. Biophys. (1998) [Pubmed]
  26. Nrf2, not the estrogen receptor, mediates catechol estrogen-induced activation of the antioxidant responsive element. Lee, J.M., Anderson, P.C., Padgitt, J.K., Hanson, J.M., Waters, C.M., Johnson, J.A. Biochim. Biophys. Acta (2003) [Pubmed]
  27. 17 beta-estradiol metabolism by hamster hepatic microsomes: comparison of catechol estrogen O-methylation with catechol estrogen oxidation and glutathione conjugation. Butterworth, M., Lau, S.S., Monks, T.J. Chem. Res. Toxicol. (1996) [Pubmed]
  28. On the structures of hydroxylated metabolites of estradiol 17-sulfate by rat liver microsomes. Itoh, Y., Matsuda, N., Matsuura, K., Watanabe, K., Takanashi, K., Itoh, S., Takagi, H., Yoshizawa, I. Steroids (2002) [Pubmed]
  29. Effect of intraventricular administration of catechol estrogens on catecholamine content in various brain regions. Panek, D.U., Dixon, W.R. Brain Res. (1985) [Pubmed]
  30. A gas chromatography/mass spectrometry assay to measure estradiol, catecholestradiols, and methoxyestradiols in plasma. Zacharia, L.C., Dubey, R.K., Jackson, E.K. Steroids (2004) [Pubmed]
  31. Pattern and tissue distribution of catechol estrogen forming activity by pig conceptuses during the peri-implantation period. Chakraborty, C., Dey, S.K., Davis, D.L. J. Anim. Sci. (1989) [Pubmed]
  32. Binding of 2-hydroxyestradiol and 4-hydroxyestradiol to estrogen receptors from human breast cancers. Van Aswegen, C.H., Purdy, R.H., Wittliff, J.L. J. Steroid Biochem. (1989) [Pubmed]
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