Disease relevance of LARP1

• These data provide an immunological mechanism to explain HLA-related risk of progression to AIDS and emphasize the central role of viral evolution in the pathogenesis of HIV [1].
• This impairment cannot be explained on the basis of HLA-related differences in phagocytosis among lupus patients [2].
• This review examines the evidence for involvement of MHC-associated factors in host immune response to Mycobacterium leprae, by collating HLA studies of sporadic and familial leprosy and discussing possible HLA-related immunological mechanisms in determining host response [3].
• Here, Christian Meyer and Peter Kremsner summarize current information on the involvement of HLA factors in P. falciparum malaria and O. volvulus infection, and briefly report on HLA-related immunological characteristics of various conditions in these infectious diseases [4].
• Sex ratios in HLA related autoimmune disease [5].

High impact information on LARP1

• Quantifiable cytotoxic T lymphocyte responses and HLA-related risk of progression to AIDS [1].
• Mapping of the genes encoding the HLA-DR alpha chain and the HLA-related antigens to a chromosome 6 deletion by using genomic blotting [6].
• Juvenile genetic hemochromatosis is clinically and genetically distinct from the classical HLA-related disorder [7].
• Absorption of the antibody with these cultured polyclonal B cells did not affect the anti-CLL activity, which suggests that the cCLLa is not HLA related [8].
• These data suggest that the antigen detected on E-ALL blasts by anti-E-ALL serum is neither a HLA-related nor a cell differentiation antigen [9].

Biological context of LARP1

• Occurrence of thyroid and gastric autoantibodies in 404 siblings of patients with IDDM was not affected by their degree of HLA-haplotype sharing with their diabetic sibling, suggesting that the inherited predisposition to thyroid and gastric autoimmunity is not HLA-related [10].
• This distribution is inconsistent with simple dominant inheritance, but is consistent with simple recessive inheritance of HLA-related susceptibility over a range of gene frequencies (0.2-0.4) [11].
• The mechanism of platelet aggregation induced by HLA-related antibodies [12].
• These results indicate that complement activation is involved in the aggregation response to HLA-related antibodies [12].
• This defect may result from abnormal antigen presentation to T lymphocytes via an aberrant antigen-specific HLA-related gene [13].

Anatomical context of LARP1

• In contrast, a large number of HLA-related molecules were repressed at both the RNA and the protein levels in stimulated monocytes, whereas secretion of IL-10 and TNF-alpha was strongly induced [14].
• After treatments, the HLA-A*0201(+) tumor cell line KATO III was exposed for 24 hr to allogeneic, HLA-related GM-CSF, IL-4-driven immature (i) DC [15].
• This illustrates that the granulocyte reactivity of anti-6B is not granulocyte specific but is HLA related [16].
• MICA, a new polymorphic HLA-related antigen, is expressed mainly by keratinocytes, endothelial cells, and monocytes [17].
• ATG as part of the conditioning regimen leads to a significant reduction in GVHD without increase of relapse in patients with myeloid leukemia after stem cell transplantation from HLA-related donors [18].

Associations of LARP1 with chemical compounds

• Seventy-seven of 139 patients (55.4%) with LA related to a variety of underlying diseases possessed anti-prothrombin antibodies (27 IgG, 35 IgM and 15 both isotypes), either isolated or more often associated with anti-beta 2 glycoprotein I (beta 2GPI) antibodies [19].
• It does apply, however, to those tests that were performed in the absence of EDTA, and in connection to the study of HLA-related antigens [20].

Regulatory relationships of LARP1

• MICA is an HLA-related cell stress-regulated antigen recognized by cytotoxic cells expressing the NKG2D molecule [21].
• Antibody to platelet Fc gamma RIIa failed to block platelet aggregation with 8/9 samples, indicating that engagement of platelet Fc gamma RIIa is not necessary for the platelet aggregation induced by HLA-related antibodies [12].

Other interactions of LARP1

• The surface expression of other HLA-related molecules, such as HLA-ABC (class I) and beta 2-microglobulin, was not influenced by TGF-beta 2 [22].
• Until recently, the only genetic disorder with elevated serum ferritin levels known in Western countries was hereditary HLA-related HFE-related genetic haemochromatosis in Caucasians (HFE, OMIM 235200), and a high serum ferritin in apparently healthy persons was considered suggestive of this disease [23].
• A detailed analysis of one donor (W6) indicated that measles-specific cytotoxicity was largely HLA-A and -B restricted; unexplained cross-reactive lysis was observed with some targets, but this lysis appeared to be HLA related, since all of the targets expressed HLA-B12 [24].
• These results may indicate that HLA-related differences to specific and recall antigens are detectable in MS and these differences may have implications in the disease pathogenesis [25].
• Knowing the mechanism of HLA-related dominant natural protection may help in designing novel treatment modalities for RA [26].

Analytical, diagnostic and therapeutic context of LARP1

• This paper consists of: (1) significance of La-related variables, (2) longitudinal studies, (3) comments, and (4) conclusion [27].
• HLA related genetic control of natural killer activity and aflatoxin B1 suppression of lymphocytic blastogenesis [28].
• BACKGROUND/AIMS: Radical surgery with extended lymph node dissection (D2-LA) is the treatment of choice for gastric cancer patients in Japan. In Western countries results after D2-LA are controversially discussed, as increased D2-LA related complications are reported [29].

References