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Gene Review

LARP1  -  La ribonucleoprotein domain family, member 1

Homo sapiens

Synonyms: KIAA0731, LARP, La ribonucleoprotein domain family member 1, La-related protein 1, MGC19556
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Disease relevance of LARP1

  • These data provide an immunological mechanism to explain HLA-related risk of progression to AIDS and emphasize the central role of viral evolution in the pathogenesis of HIV [1].
  • This impairment cannot be explained on the basis of HLA-related differences in phagocytosis among lupus patients [2].
  • This review examines the evidence for involvement of MHC-associated factors in host immune response to Mycobacterium leprae, by collating HLA studies of sporadic and familial leprosy and discussing possible HLA-related immunological mechanisms in determining host response [3].
  • Here, Christian Meyer and Peter Kremsner summarize current information on the involvement of HLA factors in P. falciparum malaria and O. volvulus infection, and briefly report on HLA-related immunological characteristics of various conditions in these infectious diseases [4].
  • Sex ratios in HLA related autoimmune disease [5].

High impact information on LARP1


Biological context of LARP1


Anatomical context of LARP1


Associations of LARP1 with chemical compounds

  • Seventy-seven of 139 patients (55.4%) with LA related to a variety of underlying diseases possessed anti-prothrombin antibodies (27 IgG, 35 IgM and 15 both isotypes), either isolated or more often associated with anti-beta 2 glycoprotein I (beta 2GPI) antibodies [19].
  • It does apply, however, to those tests that were performed in the absence of EDTA, and in connection to the study of HLA-related antigens [20].

Regulatory relationships of LARP1


Other interactions of LARP1

  • The surface expression of other HLA-related molecules, such as HLA-ABC (class I) and beta 2-microglobulin, was not influenced by TGF-beta 2 [22].
  • Until recently, the only genetic disorder with elevated serum ferritin levels known in Western countries was hereditary HLA-related HFE-related genetic haemochromatosis in Caucasians (HFE, OMIM 235200), and a high serum ferritin in apparently healthy persons was considered suggestive of this disease [23].
  • A detailed analysis of one donor (W6) indicated that measles-specific cytotoxicity was largely HLA-A and -B restricted; unexplained cross-reactive lysis was observed with some targets, but this lysis appeared to be HLA related, since all of the targets expressed HLA-B12 [24].
  • These results may indicate that HLA-related differences to specific and recall antigens are detectable in MS and these differences may have implications in the disease pathogenesis [25].
  • Knowing the mechanism of HLA-related dominant natural protection may help in designing novel treatment modalities for RA [26].

Analytical, diagnostic and therapeutic context of LARP1


  1. Quantifiable cytotoxic T lymphocyte responses and HLA-related risk of progression to AIDS. Scherer, A., Frater, J., Oxenius, A., Agudelo, J., Price, D.A., Günthard, H.F., Barnardo, M., Perrin, L., Hirschel, B., Phillips, R.E., McLean, A.R. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  2. Defective mononuclear phagocyte function in systemic lupus erythematosus: dissociation of Fc receptor-ligand binding and internalization. Salmon, J.E., Kimberly, R.P., Gibofsky, A., Fotino, M. J. Immunol. (1984) [Pubmed]
  3. HLA and susceptibility to leprosy. Serjeantson, S.W. Immunol. Rev. (1983) [Pubmed]
  4. Malaria and onchocerciasis: On HLA and related matters. Meyer, C.G., Kremsner, P.G. Parasitol. Today (Regul. Ed.) (1996) [Pubmed]
  5. Sex ratios in HLA related autoimmune disease. Foster, H., Kelly, C., Griffiths, I. Ann. Rheum. Dis. (1991) [Pubmed]
  6. Mapping of the genes encoding the HLA-DR alpha chain and the HLA-related antigens to a chromosome 6 deletion by using genomic blotting. Erlich, H.A., Stetler, D., Saiki, R., Gladstone, P., Pious, D. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  7. Juvenile genetic hemochromatosis is clinically and genetically distinct from the classical HLA-related disorder. Cazzola, M., Cerani, P., Rovati, A., Iannone, A., Claudiani, G., Bergamaschi, G. Blood (1998) [Pubmed]
  8. An antigen common to chronic lymphocytic and hairy cell leukemia cells not shared by normal lymphocytes or by other leukemic cells. Agee, J.F., Garver, F.A., Faguet, G.B. Blood (1986) [Pubmed]
  9. Acute lymphoblastic leukemia (ALL) antigens detected with antisera to E rosette-froming and non-E rosette-forming ALL blasts. Borella, L., Sen, L., Casper, J.T. J. Immunol. (1977) [Pubmed]
  10. Thyroid, gastric, and adrenal autoimmunities associated with insulin-dependent diabetes mellitus. Maclaren, N.K., Riley, W.J. Diabetes Care (1985) [Pubmed]
  11. The genetics of Graves' disease: HLA and disease susceptibility. Stenszky, V., Kozma, L., Balázs, C., Rochlitz, S., Bear, J.C., Farid, N.R. J. Clin. Endocrinol. Metab. (1985) [Pubmed]
  12. The mechanism of platelet aggregation induced by HLA-related antibodies. Brandt, J.T., Julius, C.J., Osborne, J.M., Anderson, C.L. Thromb. Haemost. (1996) [Pubmed]
  13. Autoimmunity causing thyroid dysfunction. Volpé, R. Endocrinol. Metab. Clin. North Am. (1991) [Pubmed]
  14. Borrelia burgdorferi Induces TLR1 and TLR2 in human microglia and peripheral blood monocytes but differentially regulates HLA-class II expression. Cassiani-Ingoni, R., Cabral, E.S., Lünemann, J.D., Garza, Z., Magnus, T., Gelderblom, H., Munson, P.J., Marques, A., Martin, R. J. Neuropathol. Exp. Neurol. (2006) [Pubmed]
  15. Influence of drug-induced apoptotic death on processing and presentation of tumor antigens by dendritic cells. Buttiglieri, S., Galetto, A., Forno, S., De Andrea, M., Matera, L. Int. J. Cancer (2003) [Pubmed]
  16. The frequency of granulocyte-specific antibodies in postpartum sera and a family study of the 6B antigen. Clay, M., Kline, W., McCullough, J. Transfusion (1984) [Pubmed]
  17. MICA, a new polymorphic HLA-related antigen, is expressed mainly by keratinocytes, endothelial cells, and monocytes. Zwirner, N.W., Fernández-Viña, M.A., Stastny, P. Immunogenetics (1998) [Pubmed]
  18. In vivo T cell depletion with pretransplant anti-thymocyte globulin reduces graft-versus-host disease without increasing relapse in good risk myeloid leukemia patients after stem cell transplantation from matched related donors. Kröger, N., Zabelina, T., Krüger, W., Renges, H., Stute, N., Rischewski, J., Sonnenberg, S., Ayuk, F., Tögel, F., Schade, U., Fiegel, H., Erttmann, R., Löliger, C., Zander, A.R. Bone Marrow Transplant. (2002) [Pubmed]
  19. Development of an ELISA for autoantibodies to prothrombin showing their prevalence in patients with lupus anticoagulants. Arvieux, J., Darnige, L., Caron, C., Reber, G., Bensa, J.C., Colomb, M.G. Thromb. Haemost. (1995) [Pubmed]
  20. Neutrophil antigens: immunology and clinical implications. Lalezari, P. Prog. Clin. Biol. Res. (1977) [Pubmed]
  21. Activation-induced expression of MICA on T lymphocytes involves engagement of CD3 and CD28. Molinero, L.L., Fuertes, M.B., Rabinovich, G.A., Fainboim, L., Zwirner, N.W. J. Leukoc. Biol. (2002) [Pubmed]
  22. Transforming growth factor-beta 2 down-regulates HLA-DR antigen expression on human malignant glioma cells. Zuber, P., Kuppner, M.C., De Tribolet, N. Eur. J. Immunol. (1988) [Pubmed]
  23. Role of ferritin and ferroportin genes in unexplained hyperferritinaemia. Cazzola, M. Best practice & research. Clinical haematology. (2005) [Pubmed]
  24. Killing of measles virus-infected cells by human cytotoxic T cells. Lucas, C.J., Biddison, W.E., Nelson, D.L., Shaw, S. Infect. Immun. (1982) [Pubmed]
  25. Autoreactivity to myelin antigens related to HLA associations with multiple sclerosis. Yentür, S.P., Akman-Demir, G., Eraksoy, M., Saruhan-Direskeneli, G. Mult. Scler. (2002) [Pubmed]
  26. HLA-DQ-associated predisposition to and dominant HLA-DR-associated protection against rheumatoid arthritis. van der Horst-Bruinsma, I.E., Visser, H., Hazes, J.M., Breedveld, F.C., Verduyn, W., Schreuder, G.M., de Vries, R.R., Zanelli, E. Hum. Immunol. (1999) [Pubmed]
  27. Lactate-related factors as a critical determinant of endurance. Tanaka, K. The Annals of physiological anthropology = Seiri Jinruigaku Kenkyūkai kaishi. (1990) [Pubmed]
  28. HLA related genetic control of natural killer activity and aflatoxin B1 suppression of lymphocytic blastogenesis. Wang, C.Y., Yu, X.S., Hong, J.X., Lin, T.Z., Yang, Y.Q. Chin. Med. J. (1987) [Pubmed]
  29. Differential effects of radical D2-lymphadenectomy and splenectomy in surgically treated gastric cancer patients. Schmid, A., Thybusch, A., Kremer, B., Henne-Bruns, D. Hepatogastroenterology (2000) [Pubmed]
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