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Gene Review

PLCD1  -  phospholipase C, delta 1

Homo sapiens

Synonyms: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1, NDNC3, PLC-III, PLC-delta-1, Phosphoinositide phospholipase C-delta-1, ...
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Disease relevance of PLCD1


Psychiatry related information on PLCD1


High impact information on PLCD1

  • Here we discuss how the family of PLCs elaborates a minimal catalytic core typified by PLC-delta to confer multiple modes of regulation on their phospholipase activities [6].
  • The best characterized of the intranuclear lipids are the inositol lipids that form the components of a phosphoinositide-phospholipase C cycle [7].
  • Also, Galphaq(GTP[gammaS]) failed to associate with the C2 domain of PLC-delta, an isozyme that is not activated by Galphaq [8].
  • G16 alpha did not activate PLC-gamma 1 or PLC-delta 1 [9].
  • Also, the peptide was able to inhibit PI(4,5)P2 and G beta gamma activation of the PH-PLC delta 1 PH-PLC beta 2 enzymes in a concentration-dependent manner, suggesting that this is the region responsible for PH domain-mediated activation of the catalytic core [10].

Chemical compound and disease context of PLCD1


Biological context of PLCD1


Anatomical context of PLCD1

  • PLD and PI-PLC activities in these four transfected cell lines as well as in nontransfected cells were measured by the formation of [3H]phosphatidylethanol [( 3H]PEt) and [3H]inositol phosphates [( 3H]IP) after labeling cellular phospholipids with [3H]oleic acid and [3H]inositol [15].
  • Immunostaining of a specific antibody against the PLC isozyme, PLC-delta, demonstrated that this enzyme was abnormally accumulated in neurofibrillary tangles (NFT), the neurites surrounding senile plaque (SP) cores, and neuropil threads in AD brains [16].
  • The activity of PLC-delta 1 in the aortas of 12-week-old SHR is significantly higher at low Ca2+ concentration than that of normotensive WKY [17].
  • Our PI-(4,5)P2 binding results support the hypothesis that the intact PH domain, serving as a specific tether, directs PLC-delta 1 to membranes enriched in PI(4,5)P2 and permits the active site, located elsewhere in the protein, to hydrolyze multiple substrate molecules before this enzyme dissociates from the membrane surface [18].
  • In erythrocytes, activation of the phosphoinositide phospholipase C (PLC) or a 20 h ATP depletion, which both led to a reduction in the PIP2 content by 40-60%, did not affect Ca(2+)-induced phospholipid scrambling [19].

Associations of PLCD1 with chemical compounds


Physical interactions of PLCD1


Regulatory relationships of PLCD1

  • The activity of PLC delta 3 was stimulated by polyamines and by basic proteins such as protamine, histone and mellitin [21].

Other interactions of PLCD1


Analytical, diagnostic and therapeutic context of PLCD1


  1. Overexpression of phospholipase C-gamma 1 in familial adenomatous polyposis. Park, J.G., Lee, Y.H., Kim, S.S., Park, K.J., Noh, D.Y., Ryu, S.H., Suh, P.G. Cancer Res. (1994) [Pubmed]
  2. Expression of phospholipases gamma 1, beta 1, and delta 1 in primary human colon carcinomas and colon carcinoma cell lines. Nomoto, K., Tomita, N., Miyake, M., Xhu, D.B., LoGerfo, P.R., Weinstein, I.B. Mol. Carcinog. (1995) [Pubmed]
  3. Expression, purification and characterisation of a functional phosphatidylinositol-specific phospholipase C-delta 1 protein in Escherichia coli. Ginger, R.S., Parker, P.J. Eur. J. Biochem. (1992) [Pubmed]
  4. Abnormal accumulation of phospholipase C-delta in filamentous inclusions of human neurodegenerative diseases. Shimohama, S., Perry, G., Richey, P., Takenawa, T., Whitehouse, P.J., Miyoshi, K., Suenaga, T., Matsumoto, S., Nishimura, M., Kimura, J. Neurosci. Lett. (1993) [Pubmed]
  5. Alteration of phospholipase C-delta protein level and specific activity in Alzheimer's disease. Shimohama, S., Fujimoto, S., Matsushima, H., Takenawa, T., Taniguchi, T., Perry, G., Whitehouse, P.J., Kimura, J. J. Neurochem. (1995) [Pubmed]
  6. Regulation of phospholipase C isozymes by ras superfamily GTPases. Harden, T.K., Sondek, J. Annu. Rev. Pharmacol. Toxicol. (2006) [Pubmed]
  7. Nuclear lipid signalling. Irvine, R.F. Nat. Rev. Mol. Cell Biol. (2003) [Pubmed]
  8. Selective interaction of the C2 domains of phospholipase C-beta1 and -beta2 with activated Galphaq subunits: an alternative function for C2-signaling modules. Wang, T., Pentyala, S., Elliott, J.T., Dowal, L., Gupta, E., Rebecchi, M.J., Scarlata, S. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  9. Purification and characterization of recombinant G16 alpha from Sf9 cells: activation of purified phospholipase C isozymes by G-protein alpha subunits. Kozasa, T., Hepler, J.R., Smrcka, A.V., Simon, M.I., Rhee, S.G., Sternweis, P.C., Gilman, A.G. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  10. The Pleckstrin homology domains of phospholipases C-beta and -delta confer activation through a common site. Guo, Y., Philip, F., Scarlata, S. J. Biol. Chem. (2003) [Pubmed]
  11. Cloning and identification of amino acid residues of human phospholipase C delta 1 essential for catalysis. Cheng, H.F., Jiang, M.J., Chen, C.L., Liu, S.M., Wong, L.P., Lomasney, J.W., King, K. J. Biol. Chem. (1995) [Pubmed]
  12. Mutation in the pleckstrin homology domain of the human phospholipase C-delta 1 gene is associated with loss of function. Shimohama, S., Kamiya, S., Fujii, M., Ogawa, T., Kanamori, M., Kawamata, J., Imura, T., Taniguchi, T., Yagisawa, H. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  13. Reconstitution of thromboxane A2 receptor-stimulated phosphoinositide hydrolysis in isolated platelet membranes: involvement of phosphoinositide-specific phospholipase C-beta and GTP-binding protein Gq. Baldassare, J.J., Tarver, A.P., Henderson, P.A., Mackin, W.M., Sahagan, B., Fisher, G.J. Biochem. J. (1993) [Pubmed]
  14. Mutations within a highly conserved sequence present in the X region of phosphoinositide-specific phospholipase C-delta 1. Ellis, M.V., U, S., Katan, M. Biochem. J. (1995) [Pubmed]
  15. Coupling of transfected muscarinic acetylcholine receptor subtypes to phospholipase D. Sandmann, J., Peralta, E.G., Wurtman, R.J. J. Biol. Chem. (1991) [Pubmed]
  16. Aberrant accumulation of phospholipase C-delta in Alzheimer brains. Shimohama, S., Homma, Y., Suenaga, T., Fujimoto, S., Taniguchi, T., Araki, W., Yamaoka, Y., Takenawa, T., Kimura, J. Am. J. Pathol. (1991) [Pubmed]
  17. Enhancement of phospholipase C delta 1 activity in the aortas of spontaneously hypertensive rats. Kato, H., Fukami, K., Shibasaki, F., Homma, Y., Takenawa, T. J. Biol. Chem. (1992) [Pubmed]
  18. The pleckstrin homology domain of phospholipase C-delta 1 binds with high affinity to phosphatidylinositol 4,5-bisphosphate in bilayer membranes. Garcia, P., Gupta, R., Shah, S., Morris, A.J., Rudge, S.A., Scarlata, S., Petrova, V., McLaughlin, S., Rebecchi, M.J. Biochemistry (1995) [Pubmed]
  19. Antagonist effects of Ca2+ and spermine on phosphatidylinositol 4,5-bisphosphate-mediated transmembrane redistribution of phospholipids in large unilamellar vesicles and in erythrocytes. Sulpice, J.C., Moreau, C., Devaux, P.F., Zachowski, A., Giraud, F. Biochemistry (1996) [Pubmed]
  20. Modulation of ERK 1/2 and p38 MAPK signaling pathways by ATP in osteoblasts: Involvement of mechanical stress-activated calcium influx, PKC and Src activation. Katz, S., Boland, R., Santillán, G. Int. J. Biochem. Cell Biol. (2006) [Pubmed]
  21. Expression, purification and kinetic properties of human recombinant phospholipase C delta 3. Pawełczyk, T., Matecki, A. Acta Biochim. Pol. (1997) [Pubmed]
  22. Distribution of phospholipase C isozymes in normal human lung tissue and their immunohistochemical localization. Hwang, S.C., Park, K.H., Ha, M.J., Noh, I.S., Park, T.B., Lee, Y.H. J. Korean Med. Sci. (1996) [Pubmed]
  23. The C2 domain calcium-binding motif: structural and functional diversity. Nalefski, E.A., Falke, J.J. Protein Sci. (1996) [Pubmed]
  24. Molecular cloning, splice variants, expression, and purification of phospholipase C-delta 4. Lee, S.B., Rhee, S.G. J. Biol. Chem. (1996) [Pubmed]
  25. Membrane targeting of C2 domains of phospholipase C-delta isoforms. Ananthanarayanan, B., Das, S., Rhee, S.G., Murray, D., Cho, W. J. Biol. Chem. (2002) [Pubmed]
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