Gene Review:
Map2k2 - mitogen-activated protein kinase kinase 2
Mus musculus
Synonyms:
AA589381, Dual specificity mitogen-activated protein kinase kinase 2, ERK activator kinase 2, MAP kinase kinase 2, MAP kinase/Erk kinase, ...
- Smooth muscle alpha-actin expression and myofibroblast differentiation by TGFbeta are dependent upon MK2. Sousa, A.M., Liu, T., Guevara, O., Stevens, J., Fanburg, B.L., Gaestel, M., Toksoz, D., Kayyali, U.S. J. Cell. Biochem. (2007)
- MAPK-activated protein kinase 2 deficiency in microglia inhibits pro-inflammatory mediator release and resultant neurotoxicity. Relevance to neuroinflammation in a transgenic mouse model of Alzheimer disease. Culbert, A.A., Skaper, S.D., Howlett, D.R., Evans, N.A., Facci, L., Soden, P.E., Seymour, Z.M., Guillot, F., Gaestel, M., Richardson, J.C. J. Biol. Chem. (2006)
- Gene deletion of MK2 inhibits TNF-alpha and IL-6 and protects against cerulein-induced pancreatitis. Tietz, A.B., Malo, A., Diebold, J., Kotlyarov, A., Herbst, A., Kolligs, F.T., Brandt-Nedelev, B., Halangk, W., Gaestel, M., Göke, B., Schäfer, C. Am. J. Physiol. Gastrointest. Liver Physiol. (2006)
- Phorbol ester-induced G1 arrest in BALB/MK-2 mouse keratinocytes is mediated by delta and eta isoforms of protein kinase C. Ishino, K., Ohba, M., Kashiwagi, M., Kawabe, S., Chida, K., Kuroki, T. Jpn. J. Cancer Res. (1998)
- Toxin-induced resistance in Bacillus anthracis lethal toxin-treated macrophages. Salles, I.I., Tucker, A.E., Voth, D.E., Ballard, J.D. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Mek2 is dispensable for mouse growth and development. Bélanger, L.F., Roy, S., Tremblay, M., Brott, B., Steff, A.M., Mourad, W., Hugo, P., Erikson, R., Charron, J. Mol. Cell. Biol. (2003)
- Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEK1-ERK complexes. Eblen, S.T., Slack, J.K., Weber, M.J., Catling, A.D. Mol. Cell. Biol. (2002)
- MEK2 is a kinase related to MEK1 and is differentially expressed in murine tissues. Brott, B.K., Alessandrini, A., Largaespada, D.A., Copeland, N.G., Jenkins, N.A., Crews, C.M., Erikson, R.L. Cell Growth Differ. (1993)
- Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2. Zheng, C.F., Guan, K.L. J. Biol. Chem. (1993)
- Distinct cellular functions of MK2. Kotlyarov, A., Yannoni, Y., Fritz, S., Laass, K., Telliez, J.B., Pitman, D., Lin, L.L., Gaestel, M. Mol. Cell. Biol. (2002)
- Preferential involvement of MEK1 in the tumor necrosis factor-alpha-induced activation of p42mapk/erk2 in mouse macrophages. Winston, B.W., Remigio, L.K., Riches, D.W. J. Biol. Chem. (1995)
- Mitogen-activated protein kinase dynamics during the meiotic G2/MI transition of mouse spermatocytes. Inselman, A., Handel, M.A. Biol. Reprod. (2004)
- Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta. Giroux, S., Tremblay, M., Bernard, D., Cardin-Girard, J.F., Aubry, S., Larouche, L., Rousseau, S., Huot, J., Landry, J., Jeannotte, L., Charron, J. Curr. Biol. (1999)
- Homologous regulation of the gonadotropin-releasing hormone receptor gene is partially mediated by protein kinase C activation of an activator protein-1 element. White, B.R., Duval, D.L., Mulvaney, J.M., Roberson, M.S., Clay, C.M. Mol. Endocrinol. (1999)
- GDNF-induced leukemia inhibitory factor can mediate differentiation via the MEK/ERK pathway in pheochromocytoma cells derived from nf1-heterozygous knockout mice. Park, J.I., Powers, J.F., Tischler, A.S., Strock, C.J., Ball, D.W., Nelkin, B.D. Exp. Cell Res. (2005)
- Estradiol-induced phosphorylation of ERK1/2 in explants of the mouse cerebral cortex: the roles of heat shock protein 90 (Hsp90) and MEK2. Sétáló, G., Singh, M., Guan, X., Toran-Allerand, C.D. J. Neurobiol. (2002)
- Abnormal migration phenotype of mitogen-activated protein kinase-activated protein kinase 2-/- neutrophils in Zigmond chambers containing formyl-methionyl-leucyl-phenylalanine gradients. Hannigan, M.O., Zhan, L., Ai, Y., Kotlyarov, A., Gaestel, M., Huang, C.K. J. Immunol. (2001)
- Regulation of Mouse Inducible Costimulator (ICOS) Expression by Fyn-NFATc2 and ERK Signaling in T Cells. Tan, A.H., Wong, S.C., Lam, K.P. J. Biol. Chem. (2006)
- Nerve growth factor regulates TNF-alpha production in mouse macrophages via MAP kinase activation. Barouch, R., Kazimirsky, G., Appel, E., Brodie, C. J. Leukoc. Biol. (2001)
- Differential expression of MEK1 and MEK2 during mouse development. Alessandrini, A., Brott, B.K., Erikson, R.L. Cell Growth Differ. (1997)
- Airway recruitment of leukocytes in mice is dependent on alpha4-integrins and vascular cell adhesion molecule-1. Chin, J.E., Hatfield, C.A., Winterrowd, G.E., Brashler, J.R., Vonderfecht, S.L., Fidler, S.F., Griffin, R.L., Kolbasa, K.P., Krzesicki, R.F., Sly, L.M., Staite, N.D., Richards, I.M. Am. J. Physiol. (1997)