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Gene Review

HNRNPA1  -  heterogeneous nuclear ribonucleoprotein A1

Homo sapiens

Synonyms: ALS19, ALS20, HNRPA1, HNRPA1L3, Helix-destabilizing protein, ...
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Disease relevance of HNRPA1


High impact information on HNRPA1


Biological context of HNRPA1


Anatomical context of HNRPA1


Associations of HNRPA1 with chemical compounds


Physical interactions of HNRPA1


Other interactions of HNRPA1


Analytical, diagnostic and therapeutic context of HNRPA1


  1. Assignment of the human heterogeneous nuclear ribonucleoprotein A1 gene (HNRPA1) to chromosome 12q13.1 by cDNA competitive in situ hybridization. Saccone, S., Biamonti, G., Maugeri, S., Bassi, M.T., Bunone, G., Riva, S., Della Valle, G. Genomics (1992) [Pubmed]
  2. SC35 and heterogeneous nuclear ribonucleoprotein A/B proteins bind to a juxtaposed exonic splicing enhancer/exonic splicing silencer element to regulate HIV-1 tat exon 2 splicing. Zahler, A.M., Damgaard, C.K., Kjems, J., Caputi, M. J. Biol. Chem. (2004) [Pubmed]
  3. Up-regulation of hnRNP A1 gene in sporadic human colorectal cancers. Ushigome, M., Ubagai, T., Fukuda, H., Tsuchiya, N., Sugimura, T., Takatsuka, J., Nakagama, H. Int. J. Oncol. (2005) [Pubmed]
  4. Heterogeneous nuclear ribonucleoprotein A1 binds to the transcription-regulatory region of mouse hepatitis virus RNA. Li, H.P., Zhang, X., Duncan, R., Comai, L., Lai, M.M. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  5. Identification of apoptosis-associated proteins in a human Burkitt lymphoma cell line. Cleavage of heterogeneous nuclear ribonucleoprotein A1 by caspase 3. Brockstedt, E., Rickers, A., Kostka, S., Laubersheimer, A., Dörken, B., Wittmann-Liebold, B., Bommert, K., Otto, A. J. Biol. Chem. (1998) [Pubmed]
  6. Alternative splicing in the human gene for the core protein A1 generates another hnRNP protein. Buvoli, M., Cobianchi, F., Bestagno, M.G., Mangiarotti, A., Bassi, M.T., Biamonti, G., Riva, S. EMBO J. (1990) [Pubmed]
  7. Mammalian single-stranded DNA binding protein UP I is derived from the hnRNP core protein A1. Riva, S., Morandi, C., Tsoulfas, P., Pandolfo, M., Biamonti, G., Merrill, B., Williams, K.R., Multhaup, G., Beyreuther, K., Werr, H. EMBO J. (1986) [Pubmed]
  8. Regulation of Ich-1 pre-mRNA alternative splicing and apoptosis by mammalian splicing factors. Jiang, Z.H., Zhang, W.J., Rao, Y., Wu, J.Y. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  9. DNA damage-inducible transcripts in mammalian cells. Fornace, A.J., Alamo, I., Hollander, M.C. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  10. Alternative splicing of the adenylyl cyclase stimulatory G-protein G alpha(s) is regulated by SF2/ASF and heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) and involves the use of an unusual TG 3'-splice Site. Pollard, A.J., Krainer, A.R., Robson, S.C., Europe-Finner, G.N. J. Biol. Chem. (2002) [Pubmed]
  11. Modulation of exon skipping and inclusion by heterogeneous nuclear ribonucleoprotein A1 and pre-mRNA splicing factor SF2/ASF. Mayeda, A., Helfman, D.M., Krainer, A.R. Mol. Cell. Biol. (1993) [Pubmed]
  12. Heterogeneous nuclear ribonucleoprotein A1 is a novel internal ribosome entry site trans-acting factor that modulates alternative initiation of translation of the fibroblast growth factor 2 mRNA. Bonnal, S., Pileur, F., Orsini, C., Parker, F., Pujol, F., Prats, A.C., Vagner, S. J. Biol. Chem. (2005) [Pubmed]
  13. Polypyrimidine tract-binding protein and heterogeneous nuclear ribonucleoprotein A1 bind to human T-cell leukemia virus type 2 RNA regulatory elements. Black, A.C., Luo, J., Watanabe, C., Chun, S., Bakker, A., Fraser, J.K., Morgan, J.P., Rosenblatt, J.D. J. Virol. (1995) [Pubmed]
  14. Exposure of DNA bases induced by the interaction of DNA and calf thymus DNA helix-destabilizing protein. Kohwi-Shigematsu, T., Enomoto, T., Yamada, M.A., Nakanishi, M., Tsuboi, M. Proc. Natl. Acad. Sci. U.S.A. (1978) [Pubmed]
  15. Antibodies to hnRNP core protein A1 in connective tissue diseases. Astaldi Ricotti, G.C., Bestagno, M., Cerino, A., Negri, C., Caporali, R., Cobianchi, F., Longhi, M., Maurizio Montecucco, C. J. Cell. Biochem. (1989) [Pubmed]
  16. Modulation of AUUUA response element binding by heterogeneous nuclear ribonucleoprotein A1 in human T lymphocytes. The roles of cytoplasmic location, transcription, and phosphorylation. Hamilton, B.J., Burns, C.M., Nichols, R.C., Rigby, W.F. J. Biol. Chem. (1997) [Pubmed]
  17. Expression of mitochondrial genes and DNA-repair-related nuclear genes is altered in xeroderma pigmentosum fibroblasts. Xia, X., Werner, D., Popanda, O., Thielmann, H.W. J. Cancer Res. Clin. Oncol. (1994) [Pubmed]
  18. Identification of novel cellular genes transcriptionally suppressed by v-src. Frankfort, B.J., Gelman, I.H. Biochem. Biophys. Res. Commun. (1995) [Pubmed]
  19. Definition of a consensus transportin-specific nucleocytoplasmic transport signal. Bogerd, H.P., Benson, R.E., Truant, R., Herold, A., Phingbodhipakkiya, M., Cullen, B.R. J. Biol. Chem. (1999) [Pubmed]
  20. TDP-43 binds heterogeneous nuclear ribonucleoprotein A/B through its C-terminal tail: an important region for the inhibition of cystic fibrosis transmembrane conductance regulator exon 9 splicing. Buratti, E., Brindisi, A., Giombi, M., Tisminetzky, S., Ayala, Y.M., Baralle, F.E. J. Biol. Chem. (2005) [Pubmed]
  21. Antagonistic role of hnRNP A1 and KSRP in the regulation of let-7a biogenesis. Michlewski, G., Cáceres, J.F. Nat. Struct. Mol. Biol. (2010) [Pubmed]
  22. Interaction and stimulation of human FEN-1 nuclease activities by heterogeneous nuclear ribonucleoprotein A1 in alpha-segment processing during Okazaki fragment maturation. Chai, Q., Zheng, L., Zhou, M., Turchi, J.J., Shen, B. Biochemistry (2003) [Pubmed]
  23. Specific interaction of heterogeneous nuclear ribonucleoprotein A1 with the -219T allelic form modulates APOE promoter activity. Campillos, M., Lamas, J.R., García, M.A., Bullido, M.J., Valdivieso, F., Vázquez, J. Nucleic Acids Res. (2003) [Pubmed]
  24. Transportin is a major nuclear import receptor for c-Fos: a novel mode of cargo interaction. Arnold, M., Nath, A., Wohlwend, D., Kehlenbach, R.H. J. Biol. Chem. (2006) [Pubmed]
  25. Crystallization of preliminary electron diffraction study to 3.7 A of DNA helix-destabilizing protein gp32*I. Chiu, W., Hosoda, J. J. Mol. Biol. (1978) [Pubmed]
  26. Autoantibodies that recognize functional domains of hnRNPA1 implicate molecular mimicry in the pathogenesis of neurological disease. Lee, S.M., Dunnavant, F.D., Jang, H., Zunt, J., Levin, M.C. Neurosci. Lett. (2006) [Pubmed]
  27. Activity of helix: destabilizing protein in lymphocytes of patients with glomerulopathies and with chronic renal insufficiency. Prutis, K.B., Robak, M., Kopeć, W., Szewczyk, Z. Clin. Nephrol. (1985) [Pubmed]
  28. HnRNP-A1 binds directly to double-stranded DNA in vitro within a 36 bp sequence. Donev, R.M., Doneva, T.A., Bowen, W.R., Sheer, D. Mol. Cell. Biochem. (2002) [Pubmed]
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