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Gene Review

IL13RA2  -  interleukin 13 receptor, alpha 2

Homo sapiens

Synonyms: CD213A2, CD213a2, CT19, IL-13 receptor subunit alpha-2, IL-13R, ...
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Disease relevance of IL13RA2

  • We report here that human renal cell carcinoma (RCC) cells express large numbers of functional IL-13R [1].
  • Furthermore, cytotoxins targeted to this more restrictive IL-13R produced cures in animals bearing xenografts of human high-grade gliomas [2].
  • These results suggest that IL-13R-targeted cytotoxin therapy of prostate cancer may be dramatically enhanced by gene transfer of IL-13Ralpha2 chain and this strategy, the combination of gene therapy and cytotoxin therapy, may be utilized in the treatment of localized prostate cancer [3].
  • These results demonstrate that by using a combination approach of gene transfer and systemic or locoregional cytotoxin therapy, the IL-13R represents a new potent target for head and neck cancer therapy [4].
  • A restricted receptor for interleukin 13 (IL-13R alpha2) is over-expressed in high-grade astrocytoma (HGA), but not in normal organs [5].

High impact information on IL13RA2


Biological context of IL13RA2


Anatomical context of IL13RA2


Regulatory relationships of IL13RA2


Other interactions of IL13RA2

  • These data suggest that the interaction of IL-13 with IL-4R does not involve gamma c and IL-13R itself may be a novel subunit of the IL-4R [1].
  • IL-4, on the other hand, cross-linked with two major proteins, the smaller of which appears to be similar in size to IL-13R and gamma c, but (like the IL-13R) it did not react with anti-gamma c antibody [1].
  • Induction of cell signaling by IL-4 involves interaction with its cognate receptors, a complex of IL-4Ralpha with either the common gamma-chain or the IL-13R chain alpha1 (IL-13Ralpha1) [19].
  • Cloning of the human IL-13R alpha1 chain and reconstitution with the IL4R alpha of a functional IL-4/IL-13 receptor complex [20].
  • Interleukin (IL)-13 and IL-4 inhibit proliferation and stimulate IL-6 formation in human osteoblasts: evidence for involvement of receptor subunits IL-13R, IL-13Ralpha, and IL-4Ralpha [21].

Analytical, diagnostic and therapeutic context of IL13RA2

  • These characteristics of the G-26-IL-13R alpha2(+) tumors allowed us to test molecularly defined anti-glioma passive immunotherapy [5].
  • Indirect immunofluorescence analysis for four different receptor chains confirmed RT-PCR results and showed pronounced expression of IL-13Ralpha2 protein in three high IL-13R expressing cell lines [22].
  • In the search for a biomarker for early diagnosis and a target for therapy, the issue of whether interleukin-13 receptor (IL-13R), shown to be expressed on a variety of human cancers, is expressed in ovarian tumor samples was explored [23].
  • As IL-13R targeting for brain tumor therapy offers an exciting treatment option, optimization of production of IL-13PE will enhance production of clinical grade material for Phase III clinical trials [24].
  • With IL-13R-targeted cytotoxin (IL13-PE38QQR, comprising IL-13 and a mutated form of Pseudomonas exotoxin [PE]) being tested in three Phase I/II clinical trials for the treatment of adult human glioma, and with pediatric studies being planned, the authors set out to analyze pediatric brain tumor tissue specimens for the expression of IL-13R [25].


  1. Receptor for interleukin 13. Interaction with interleukin 4 by a mechanism that does not involve the common gamma chain shared by receptors for interleukins 2, 4, 7, 9, and 15. Obiri, N.I., Debinski, W., Leonard, W.J., Puri, R.K. J. Biol. Chem. (1995) [Pubmed]
  2. Receptor for interleukin 13 is a marker and therapeutic target for human high-grade gliomas. Debinski, W., Gibo, D.M., Hulet, S.W., Connor, J.R., Gillespie, G.Y. Clin. Cancer Res. (1999) [Pubmed]
  3. Gene transfer of interleukin 13 receptor alpha2 chain dramatically enhances the antitumor effect of IL-13 receptor-targeted cytotoxin in human prostate cancer xenografts. Kawakami, K., Husain, S.R., Bright, R.K., Puri, R.K. Cancer Gene Ther. (2001) [Pubmed]
  4. Interleukin-13 receptor-targeted cancer therapy in an immunodeficient animal model of human head and neck cancer. Kawakami, K., Kawakami, M., Joshi, B.H., Puri, R.K. Cancer Res. (2001) [Pubmed]
  5. Molecular targeting with recombinant cytotoxins of interleukin-13 receptor alpha2-expressing glioma. Mintz, A., Gibo, D.M., Madhankumar, A.B., Debinski, W. J. Neurooncol. (2003) [Pubmed]
  6. IL-13 receptor alpha2 promotes epithelial cell regeneration from radiation-induced small intestinal injury in mice. Kawashima, R., Kawamura, Y.I., Kato, R., Mizutani, N., Toyama-Sorimachi, N., Dohi, T. Gastroenterology (2006) [Pubmed]
  7. IL-4 and IL-13 receptors: are they one and the same? Callard, R.E., Matthews, D.J., Hibbert, L. Immunol. Today (1996) [Pubmed]
  8. Homodimerization of the human interleukin 4 receptor alpha chain induces Cepsilon germline transcripts in B cells in the absence of the interleukin 2 receptor gamma chain. Fujiwara, H., Hanissian, S.H., Tsytsykova, A., Geha, R.S. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  9. Genetic variants of IL-13 signalling and human asthma and atopy. Heinzmann, A., Mao, X.Q., Akaiwa, M., Kreomer, R.T., Gao, P.S., Ohshima, K., Umeshita, R., Abe, Y., Braun, S., Yamashita, T., Roberts, M.H., Sugimoto, R., Arima, K., Arinobu, Y., Yu, B., Kruse, S., Enomoto, T., Dake, Y., Kawai, M., Shimazu, S., Sasaki, S., Adra, C.N., Kitaichi, M., Inoue, H., Yamauchi, K., Tomichi, N., Kurimoto, F., Hamasaki, N., Hopkin, J.M., Izuhara, K., Shirakawa, T., Deichmann, K.A. Hum. Mol. Genet. (2000) [Pubmed]
  10. Targeting of interleukin-13 receptor on human renal cell carcinoma cells by a recombinant chimeric protein composed of interleukin-13 and a truncated form of Pseudomonas exotoxin A (PE38QQR). Puri, R.K., Leland, P., Obiri, N.I., Husain, S.R., Kreitman, R.J., Haas, G.P., Pastan, I., Debinski, W. Blood (1996) [Pubmed]
  11. The murine IL-13 receptor alpha 2: molecular cloning, characterization, and comparison with murine IL-13 receptor alpha 1. Donaldson, D.D., Whitters, M.J., Fitz, L.J., Neben, T.Y., Finnerty, H., Henderson, S.L., O'Hara, R.M., Beier, D.R., Turner, K.J., Wood, C.R., Collins, M. J. Immunol. (1998) [Pubmed]
  12. A novel 4-kb interleukin-13 receptor alpha mRNA expressed in human B, T, and endothelial cells encoding an alternate type-II interleukin-4/interleukin-13 receptor. Gauchat, J.F., Schlagenhauf, E., Feng, N.P., Moser, R., Yamage, M., Jeannin, P., Alouani, S., Elson, G., Notarangelo, L.D., Wells, T., Eugster, H.P., Bonnefoy, J.Y. Eur. J. Immunol. (1997) [Pubmed]
  13. Cloning and characterization of a specific interleukin (IL)-13 binding protein structurally related to the IL-5 receptor alpha chain. Caput, D., Laurent, P., Kaghad, M., Lelias, J.M., Lefort, S., Vita, N., Ferrara, P. J. Biol. Chem. (1996) [Pubmed]
  14. IL-4 induces germ-line IgE heavy chain gene transcription in human fetal pre-B cells. Evidence for differential expression of functional IL-4 and IL-13 receptors during B cell ontogeny. Punnonen, J., Cocks, B.G., de Vries, J.E. J. Immunol. (1995) [Pubmed]
  15. Interleukin-13 receptors on human prostate carcinoma cell lines represent a novel target for a chimeric protein composed of IL-13 and a mutated form of Pseudomonas exotoxin. Maini, A., Hillman, G., Haas, G.P., Wang, C.Y., Montecillo, E., Hamzavi, F., Pontes, J.E., Leland, P., Pastan, I., Debinski, W., Puri, R.K. J. Urol. (1997) [Pubmed]
  16. Human pulmonary fibroblasts exhibit altered interleukin-4 and interleukin-13 receptor subunit expression in idiopathic interstitial pneumonia. Jakubzick, C., Choi, E.S., Carpenter, K.J., Kunkel, S.L., Evanoff, H., Martinez, F.J., Flaherty, K.R., Toews, G.B., Colby, T.V., Travis, W.D., Joshi, B.H., Puri, R.K., Hogaboam, C.M. Am. J. Pathol. (2004) [Pubmed]
  17. Differential responses of human monocytes and macrophages to IL-4 and IL-13. Hart, P.H., Bonder, C.S., Balogh, J., Dickensheets, H.L., Donnelly, R.P., Finlay-Jones, J.J. J. Leukoc. Biol. (1999) [Pubmed]
  18. Interleukin-13 responsiveness and interleukin-13 receptor expression in non-Hodgkin's lymphoma and reactive lymph node B cells. Modulation by CD40 activation. Billard, C., Caput, D., Vita, N., Ferrara, P., Orrico, M., Gaulard, P., Boumsell, L., Bensussan, A., Farcet, J.P. Eur. Cytokine Netw. (1997) [Pubmed]
  19. IL-4 receptor alpha is an important modulator of IL-4 and IL-13 receptor binding: implications for the development of therapeutic targets. Andrews, A.L., Holloway, J.W., Holgate, S.T., Davies, D.E. J. Immunol. (2006) [Pubmed]
  20. Cloning of the human IL-13R alpha1 chain and reconstitution with the IL4R alpha of a functional IL-4/IL-13 receptor complex. Miloux, B., Laurent, P., Bonnin, O., Lupker, J., Caput, D., Vita, N., Ferrara, P. FEBS Lett. (1997) [Pubmed]
  21. Interleukin (IL)-13 and IL-4 inhibit proliferation and stimulate IL-6 formation in human osteoblasts: evidence for involvement of receptor subunits IL-13R, IL-13Ralpha, and IL-4Ralpha. Frost, A., Jonsson, K.B., Brändström, H., Ljunghall, S., Nilsson, O., Ljunggren, O. Bone (2001) [Pubmed]
  22. Heterogeneity in interleukin-13 receptor expression and subunit structure in squamous cell carcinoma of head and neck: differential sensitivity to chimeric fusion proteins comprised of interleukin-13 and a mutated form of Pseudomonas exotoxin. Joshi, B.H., Kawakami, K., Leland, P., Puri, R.K. Clin. Cancer Res. (2002) [Pubmed]
  23. Interleukin-13 receptor alpha2 chain: a potential biomarker and molecular target for ovarian cancer therapy. Kioi, M., Kawakami, M., Shimamura, T., Husain, S.R., Puri, R.K. Cancer (2006) [Pubmed]
  24. Optimization of expression and purification of two biologically active chimeric fusion proteins that consist of human interleukin-13 and Pseudomonas exotoxin in Escherichia coli. Joshi, B.H., Puri, R.K. Protein Expr. Purif. (2005) [Pubmed]
  25. Analysis of interleukin-13 receptor alpha2 expression in human pediatric brain tumors. Kawakami, M., Kawakami, K., Takahashi, S., Abe, M., Puri, R.K. Cancer (2004) [Pubmed]
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