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Gene Review

IL13RA1  -  interleukin 13 receptor, alpha 1

Homo sapiens

Synonyms: CD213A1, CD213a1, CT19, Cancer/testis antigen 19, IL-13 receptor subunit alpha-1, ...
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Disease relevance of IL13RA1

  • The purpose of the current study was to investigate IL-13 receptor components and sensitivity in a series of glial cell lines derived from adult human non-neoplastic cerebral cortex, low-grade astrocytoma, anaplastic astrocytoma, and glioblastoma multiforme [1].
  • Our findings make IL13R alpha even more attractive as a target for variety of approaches in glioma molecular management [2].
  • Moreover, the gene for IL13R alpha resides on chromosome X. Since IL13R alpha is (1) a cancer-associated protein, (2) virtually restricted to testes among normal tissues, and (3) its gene is on chromosome X, IL13R alpha is unexpectedly categorized as a cancer/testis antigen [2].
  • Finally, we demonstrate that the glioma-associated IL13 receptor is truly more restrictive in nature also due to its selective representation among brain tumors of glial origin [3].
  • Here, we show that IL-13 receptor (R)alpha2 is a critical down-regulatory factor of IL-13-mediated tissue fibrosis induced by the parasitic helminth Schistosoma mansoni [4].

High impact information on IL13RA1

  • IL-13 receptor alpha2 promotes epithelial cell regeneration from radiation-induced small intestinal injury in mice [5].
  • In order to achieve specific targeting of the IL13R in gliomas, we have mutagenized human (h) IL13 [6].
  • IL-13 receptor alpha 2 down-modulates granulomatous inflammation and prolongs host survival in schistosomiasis [7].
  • For a functional IL-13 receptor, the IL-13Ralpha1 chain forms a productive complex with the primary IL-4 binding protein (IL-4Ralpha also known as IL-4Rbeta) [8].
  • Moreover, B-CLL may be an interesting model to study the regulation of the expression of IL-13 receptor and/or signal transduction pathways [9].

Chemical compound and disease context of IL13RA1

  • Based on these findings, in our previous study we transiently transfected four cancer cell lines that do not express IL-13Ralpha2 chain and demonstrated that these cells acquired increased sensitivity to IL-13 receptor-targeted recombinant cytotoxin, IL13-PE38QQR, which is composed of IL-13 and a mutated form of a Pseudomonas exotoxin [10].

Biological context of IL13RA1


Anatomical context of IL13RA1


Associations of IL13RA1 with chemical compounds


Other interactions of IL13RA1


Analytical, diagnostic and therapeutic context of IL13RA1


  1. Interleukin-13 sensitivity and receptor phenotypes of human glial cell lines: non-neoplastic glia and low-grade astrocytoma differ from malignant glioma. Liu, H., Jacobs, B.S., Liu, J., Prayson, R.A., Estes, M.L., Barnett, G.H., Barna, B.P. Cancer Immunol. Immunother. (2000) [Pubmed]
  2. Molecular expression analysis of restrictive receptor for interleukin 13, a brain tumor-associated cancer/testis antigen. Debinski, W., Gibo, D.M. Mol. Med. (2000) [Pubmed]
  3. Expression of a restrictive receptor for interleukin 13 is associated with glial transformation. Debinski, W., Slagle, B., Gibo, D.M., Powers, S.K., Gillespie, G.Y. J. Neurooncol. (2000) [Pubmed]
  4. Regulation and function of the interleukin 13 receptor alpha 2 during a T helper cell type 2-dominant immune response. Chiaramonte, M.G., Mentink-Kane, M., Jacobson, B.A., Cheever, A.W., Whitters, M.J., Goad, M.E., Wong, A., Collins, M., Donaldson, D.D., Grusby, M.J., Wynn, T.A. J. Exp. Med. (2003) [Pubmed]
  5. IL-13 receptor alpha2 promotes epithelial cell regeneration from radiation-induced small intestinal injury in mice. Kawashima, R., Kawamura, Y.I., Kato, R., Mizutani, N., Toyama-Sorimachi, N., Dohi, T. Gastroenterology (2006) [Pubmed]
  6. Novel anti-brain tumor cytotoxins specific for cancer cells. Debinski, W., Gibo, D.M., Obiri, N.I., Kealiher, A., Puri, R.K. Nat. Biotechnol. (1998) [Pubmed]
  7. IL-13 receptor alpha 2 down-modulates granulomatous inflammation and prolongs host survival in schistosomiasis. Mentink-Kane, M.M., Cheever, A.W., Thompson, R.W., Hari, D.M., Kabatereine, N.B., Vennervald, B.J., Ouma, J.H., Mwatha, J.K., Jones, F.M., Donaldson, D.D., Grusby, M.J., Dunne, D.W., Wynn, T.A. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  8. The interleukin-13 receptor alpha2 chain: an essential component for binding and internalization but not for interleukin-13-induced signal transduction through the STAT6 pathway. Kawakami, K., Taguchi, J., Murata, T., Puri, R.K. Blood (2001) [Pubmed]
  9. Interleukin-13 inhibits interleukin-2-induced proliferation and protects chronic lymphocytic leukemia B cells from in vitro apoptosis. Chaouchi, N., Wallon, C., Goujard, C., Tertian, G., Rudent, A., Caput, D., Ferrera, P., Minty, A., Vazquez, A., Delfraissy, J.F. Blood (1996) [Pubmed]
  10. Gene transfer of interleukin 13 receptor alpha2 chain dramatically enhances the antitumor effect of IL-13 receptor-targeted cytotoxin in human prostate cancer xenografts. Kawakami, K., Husain, S.R., Bright, R.K., Puri, R.K. Cancer Gene Ther. (2001) [Pubmed]
  11. IL-13 receptor alpha 2: A regulator of IL-13 and IL-4 signal transduction in primary human fibroblasts. Andrews, A.L., Nasir, T., Bucchieri, F., Holloway, J.W., Holgate, S.T., Davies, D.E. J. Allergy Clin. Immunol. (2006) [Pubmed]
  12. Chromosome mapping and expression of the human interleukin-13 receptor. Guo, J., Apiou, F., Mellerin, M.P., Lebeau, B., Jacques, Y., Minvielle, S. Genomics (1997) [Pubmed]
  13. Polymorphisms in the IL13, IL13RA1, and IL4RA genes and rate of decline in lung function in smokers. He, J.Q., Connett, J.E., Anthonisen, N.R., Sandford, A.J. Am. J. Respir. Cell Mol. Biol. (2003) [Pubmed]
  14. The murine IL-13 receptor alpha 2: molecular cloning, characterization, and comparison with murine IL-13 receptor alpha 1. Donaldson, D.D., Whitters, M.J., Fitz, L.J., Neben, T.Y., Finnerty, H., Henderson, S.L., O'Hara, R.M., Beier, D.R., Turner, K.J., Wood, C.R., Collins, M. J. Immunol. (1998) [Pubmed]
  15. Sensitization of cancer cells to interleukin 13-pseudomonas exotoxin-induced cell death by gene transfer of interleukin 13 receptor alpha chain. Kawakami, K., Joshi, B.H., Puri, R.K. Hum. Gene Ther. (2000) [Pubmed]
  16. Characterization of IL-4 and IL-13 signals dependent on the human IL-13 receptor alpha chain 1: redundancy of requirement of tyrosine residue for STAT3 activation. Umeshita-Suyama, R., Sugimoto, R., Akaiwa, M., Arima, K., Yu, B., Wada, M., Kuwano, M., Nakajima, K., Hamasaki, N., Izuhara, K. Int. Immunol. (2000) [Pubmed]
  17. Interleukin-13 and interleukin-13 receptor in Hodgkin's disease: possible autocrine mechanism and involvement in fibrosis. Ohshima, K., Akaiwa, M., Umeshita, R., Suzumiya, J., Izuhara, K., Kikuchi, M. Histopathology (2001) [Pubmed]
  18. Recombinant canine IL-13 receptor alpha2-Fc fusion protein inhibits canine allergen-specific-IgE production in vitro by peripheral blood mononuclear cells from allergic dogs. Tang, L., Boroughs, K.L., Morales, T., Stedman, K., Sellins, K., Clarke, K., McDermott, M., Yang, S., McCall, C. Vet. Immunol. Immunopathol. (2001) [Pubmed]
  19. Interactions between leukotriene C4 and interleukin 13 signaling pathways in a mouse model of airway disease. Chavez, J., Young, H.W., Corry, D.B., Lieberman, M.W. Arch. Pathol. Lab. Med. (2006) [Pubmed]
  20. Identification of distinct roles for a dileucine and a tyrosine internalization motif in the interleukin (IL)-13 binding component IL-13 receptor alpha 2 chain. Kawakami, K., Takeshita, F., Puri, R.K. J. Biol. Chem. (2001) [Pubmed]
  21. Structural and magnetic diversity in tetraalkylammonium salts of anionic M[N(CN)2]3(-) (M = Mn and Ni) three-dimensional coordination polymers. Schlueter, J.A., Manson, J.L., Geiser, U. Inorganic chemistry. (2005) [Pubmed]
  22. Microarray analysis of genes controlled by progesterone in human endometrial stromal cells in vitro. Okada, H., Nakajima, T., Yoshimura, T., Yasuda, K., Kanzaki, H. Gynecol. Endocrinol. (2003) [Pubmed]
  23. Binding of interleukin-13 and interleukin-4 to the interleukin (IL)-4/IL-13 receptor of human synovial fibroblasts. Lutz, R.A., Feng, N., Moser, R. J. Recept. Signal Transduct. Res. (1999) [Pubmed]
  24. Cloning of the human IL-13R alpha1 chain and reconstitution with the IL4R alpha of a functional IL-4/IL-13 receptor complex. Miloux, B., Laurent, P., Bonnin, O., Lupker, J., Caput, D., Vita, N., Ferrara, P. FEBS Lett. (1997) [Pubmed]
  25. Gene expression profiling identifies IL-13 receptor alpha 2 chain as a therapeutic target in prostate tumor cells overexpressing adrenomedullin. Gonzalez-Moreno, O., Calvo, A., Joshi, B.H., Abasolo, I., Leland, P., Wang, Z., Montuenga, L., Puri, R.K., Green, J.E. Int. J. Cancer (2005) [Pubmed]
  26. Structure of IL-13 receptor: analysis of subunit composition in cancer and immune cells. Murata, T., Obiri, N.I., Debinski, W., Puri, R.K. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  27. Protection of human conjunctival fibroblasts from NO-induced apoptosis by interleukin-4 or interleukin-13. Fujitsu, Y., Fukuda, K., Kimura, K., Seki, K., Kumagai, N., Nishida, T. Invest. Ophthalmol. Vis. Sci. (2005) [Pubmed]
  28. Expression and localization of the Th2-type cytokine interleukin-13 and its receptor in the placenta during human pregnancy. Dealtry, G.B., Clark, D.E., Sharkey, A., Charnock-Jones, D.S., Smith, S.K. Am. J. Reprod. Immunol. (1998) [Pubmed]
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