Gene Review:
IRF8 - interferon regulatory factor 8
Homo sapiens
Synonyms:
H-ICSBP, ICSBP, ICSBP1, IMD32A, IMD32B, ...
- Interferon consensus sequence-binding protein, a member of the interferon regulatory factor family, suppresses interferon-induced gene transcription. Nelson, N., Marks, M.S., Driggers, P.H., Ozato, K. Mol. Cell. Biol. (1993)
- Functional domain analysis of interferon consensus sequence binding protein (ICSBP) and its association with interferon regulatory factors. Sharf, R., Azriel, A., Lejbkowicz, F., Winograd, S.S., Ehrlich, R., Levi, B.Z. J. Biol. Chem. (1995)
- Expression of nuclear transcription factor interferon consensus sequence binding protein in chronic myeloid leukemia correlates with pretreatment risk features and cytogenetic response to interferon-alpha. Schmidt, M., Hochhaus, A., Nitsche, A., Hehlmann, R., Neubauer, A. Blood (2001)
- The interferon consensus sequence-binding protein activates transcription of the gene encoding neurofibromin 1. Zhu, C., Saberwal, G., Lu, Y., Platanias, L.C., Eklund, E.A. J. Biol. Chem. (2004)
- Transcriptional control of early B cell development. Busslinger, M. Annu. Rev. Immunol. (2004)
- Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene. Holtschke, T., Löhler, J., Kanno, Y., Fehr, T., Giese, N., Rosenbauer, F., Lou, J., Knobeloch, K.P., Gabriele, L., Waring, J.F., Bachmann, M.F., Zinkernagel, R.M., Morse, H.C., Ozato, K., Horak, I. Cell (1996)
- Regulation of the germinal center gene program by interferon (IFN) regulatory factor 8/IFN consensus sequence-binding protein. Lee, C.H., Melchers, M., Wang, H., Torrey, T.A., Slota, R., Qi, C.F., Kim, J.Y., Lugar, P., Kong, H.J., Farrington, L., van der Zouwen, B., Zhou, J.X., Lougaris, V., Lipsky, P.E., Grammer, A.C., Morse, H.C. J. Exp. Med. (2006)
- Molecular interactions between interferon consensus sequence binding protein and members of the interferon regulatory factor family. Bovolenta, C., Driggers, P.H., Marks, M.S., Medin, J.A., Politis, A.D., Vogel, S.N., Levy, D.E., Sakaguchi, K., Appella, E., Coligan, J.E. Proc. Natl. Acad. Sci. U.S.A. (1994)
- Human interferon consensus sequence binding protein is a negative regulator of enhancer elements common to interferon-inducible genes. Weisz, A., Marx, P., Sharf, R., Appella, E., Driggers, P.H., Ozato, K., Levi, B.Z. J. Biol. Chem. (1992)
- Interaction between interferon consensus sequence-binding protein and COP9/signalosome subunit CSN2 (Trip15). A possible link between interferon regulatory factor signaling and the COP9/signalosome. Cohen, H., Azriel, A., Cohen, T., Meraro, D., Hashmueli, S., Bech-Otschir, D., Kraft, R., Dubiel, W., Levi, B.Z. J. Biol. Chem. (2000)
- Synergistic activation of interleukin-12 p35 gene transcription by interferon regulatory factor-1 and interferon consensus sequence-binding protein. Liu, J., Guan, X., Tamura, T., Ozato, K., Ma, X. J. Biol. Chem. (2004)
- Chicken interferon consensus sequence-binding protein (ICSBP) and interferon regulatory factor (IRF) 1 genes reveal evolutionary conservation in the IRF gene family. Jungwirth, C., Rebbert, M., Ozato, K., Degen, H.J., Schultz, U., Dawid, I.B. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Regulation of IFN-gamma-induced nuclear expression of IFN consensus sequence binding protein in murine peritoneal macrophages. Politis, A.D., Ozato, K., Coligan, J.E., Vogel, S.N. J. Immunol. (1994)
- Phosphorylation events modulate the ability of interferon consensus sequence binding protein to interact with interferon regulatory factors and to bind DNA. Sharf, R., Meraro, D., Azriel, A., Thornton, A.M., Ozato, K., Petricoin, E.F., Larner, A.C., Schaper, F., Hauser, H., Levi, B.Z. J. Biol. Chem. (1997)
- Decitabine and Vitamin D3 differentially affect hematopoietic transcription factors to induce monocytic differentiation. Koschmieder, S., Agrawal, S., Radomska, H.S., Huettner, C.S., Tenen, D.G., Ottmann, O.G., Berdel, W.E., Serve, H.L., M??ller-Tidow, C. Int. J. Oncol. (2007)
- Proteasome inhibitor bortezomib modulates TLR4-induced dendritic cell activation. Nencioni, A., Schwarzenberg, K., Brauer, K.M., Schmidt, S.M., Ballestrero, A., Grünebach, F., Brossart, P. Blood (2006)
- IRF-8/interferon (IFN) consensus sequence-binding protein is involved in Toll-like receptor (TLR) signaling and contributes to the cross-talk between TLR and IFN-gamma signaling pathways. Zhao, J., Kong, H.J., Li, H., Huang, B., Yang, M., Zhu, C., Bogunovic, M., Zheng, F., Mayer, L., Ozato, K., Unkeless, J., Xiong, H. J. Biol. Chem. (2006)
- PU.1, interferon regulatory factor (IRF) 2, and the interferon consensus sequence-binding protein (ICSBP/IRF8) cooperate to activate NF1 transcription in differentiating myeloid cells. Huang, W., Horvath, E., Eklund, E.A. J. Biol. Chem. (2007)
- IFN consensus sequence binding protein (ICSBP) is a conditional repressor of IFN inducible promoters. Weisz, A., Kirchhoff, S., Levi, B.Z. Int. Immunol. (1994)
- JAK2 is necessary and sufficient for interferon-gamma-induced transcription of the gene encoding gp91PHOX. Kakar, R., Kautz, B., Eklund, E.A. J. Leukoc. Biol. (2005)
- PU.1/Interferon Regulatory Factor interactions: mechanisms of transcriptional regulation. Marecki, S., Fenton, M.J. Cell Biochem. Biophys. (2000)
- Ubiquitin-dependent degradation of interferon regulatory factor-8 mediated by Cbl down-regulates interleukin-12 expression. Xiong, H., Li, H., Kong, H.J., Chen, Y., Zhao, J., Xiong, S., Huang, B., Gu, H., Mayer, L., Ozato, K., Unkeless, J.C. J. Biol. Chem. (2005)
- Expression of interferon consensus sequence binding protein induces potent immunity against BCR/ABL-induced leukemia. Deng, M., Daley, G.Q. Blood (2001)