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Gene Review

lectin-24Db  -  CG2958 gene product from transcript CG2958-RA

Drosophila melanogaster

Synonyms: AC 004371A, AC004371a, CG2958, Dmel\CG2958
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Disease relevance of lectin-24Db


High impact information on lectin-24Db


Chemical compound and disease context of lectin-24Db


Biological context of lectin-24Db


Anatomical context of lectin-24Db

  • The lectin-producing hepatic cells were identified by immunostaining; in the gill, exocrine mucous cells were stained, suggesting that serum fucolectins derive from the liver [13].
  • This lectin agglutinated trypsinized and glutaraldehyde-fixed bovine red blood cells in the presence of calcium or magnesium [14].
  • Calnexin is a membrane-bound lectin of the endoplasmic reticulum (ER) that binds transiently to newly synthesized glycoproteins [15].
  • At low concentrations of the lectin (5-10 mug/ml), cells spread against the glass surface and fused to form syncytia [16].
  • Epitopes restricted to proteins from th-forming spermatocytes reacted with lectin Con A (specific for D-Man and/or D-Glc) and antibodies directed against mouse immunoglobulins (AIA) [17].

Associations of lectin-24Db with chemical compounds

  • Competition binding studies using monosaccharides demonstrate that CG2958 interacts specifically with fucose and mannose [18].
  • The hapten sugar of this lectin was galactose [14].
  • The protein product of the CHI3L1 gene, human cartilage 39-kDa glycoprotein (HC-gp39), is a tissue-restricted, chitin-binding lectin and member of glycosyl hydrolase family 18 [19].
  • The protein was solubilized with 1% Triton X-100 and 0.5 M sodium chloride and then purified using an alpha-cobratoxin column followed by a lentil lectin affinity column [20].
  • The coalescence of cells and morphologic disotrtion induced by wheat germ agglutinin were not inhibited by N-acetylglucosamine, the hapten inhibitor of the lectin, under the conditions utilized in this study [16].

Physical interactions of lectin-24Db

  • The amino acid composition and lectin-binding properties of Drosophila laminin are given [21].

Other interactions of lectin-24Db

  • The cloned lectin, designated 'gliolectin', possesses a novel protein sequence with a calculated molecular mass of 24,993 [9].
  • Helix pomatia lectin, an inducer of Drosophila immune response, binds to hemomucin, a novel surface mucin [22].
  • Some of the family members contain other modules for protein-protein interactions, including disulphide-stabilized structures (LDL(r)A, SRCR, frizzled, kringle, Sushi, Wonton and Pan/apple), carbohydrate-recognition domains (C-type lectin and chitin-binding), and other modules (such as zinc finger, CUB, coiled coil and Sina) [23].

Analytical, diagnostic and therapeutic context of lectin-24Db


  1. Modulation of a lectin insecticidal activity by carbohydrates. Triguéros, V., Wang, M., Père, D., Paquereau, L., Chavant, L., Fournier, D. Arch. Insect Biochem. Physiol. (2000) [Pubmed]
  2. Activation of the Sarcophaga lectin gene promoter in transgenic Drosophila. Tanji, T., Kobayashi, A., Natori, S. Arch. Insect Biochem. Physiol. (2002) [Pubmed]
  3. Glycoconjugate expression during Drosophila embryogenesis. Fredieu, J.R., Mahowald, A.P. Acta anatomica. (1994) [Pubmed]
  4. A clonal marker induced by mutation in mouse intestinal epithelium. Winton, D.J., Blount, M.A., Ponder, B.A. Nature (1988) [Pubmed]
  5. Basement membrane polarizes lectin binding sites of Drosophila larval fat body cells. Rizki, T.M., Rizki, R.M. Nature (1983) [Pubmed]
  6. Cell surface changes associated with cellular immune reactions in Drosophila. Nappi, A.J., Silvers, M. Science (1984) [Pubmed]
  7. A genetic approach to visualization of multisynaptic neural pathways using plant lectin transgene. Yoshihara, Y., Mizuno, T., Nakahira, M., Kawasaki, M., Watanabe, Y., Kagamiyama, H., Jishage, K., Ueda, O., Suzuki, H., Tabuchi, K., Sawamoto, K., Okano, H., Noda, T., Mori, K. Neuron (1999) [Pubmed]
  8. Insect glycobiology: a lectin multigene family in Drosophila melanogaster. Theopold, U., Rissler, M., Fabbri, M., Schmidt, O., Natori, S. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  9. Gliolectin is a novel carbohydrate-binding protein expressed by a subset of glia in the embryonic Drosophila nervous system. Tiemeyer, M., Goodman, C.S. Development (1996) [Pubmed]
  10. Gliolectin-mediated carbohydrate binding at the Drosophila midline ensures the fidelity of axon pathfinding. Sharrow, M., Tiemeyer, M. Development (2001) [Pubmed]
  11. A novel lectin from Sarcophaga. Its purification, characterization, and cDNA cloning. Fujita, Y., Kurata, S., Homma, K., Natori, S. J. Biol. Chem. (1998) [Pubmed]
  12. Drosophila insulin receptor: lectin-binding properties and a role for oxidation-reduction of receptor thiols in activation. Marin-Hincapie, M., Garofalo, R.S. Endocrinology (1995) [Pubmed]
  13. Multiplicity, structures, and endocrine and exocrine natures of eel fucose-binding lectins. Honda, S., Kashiwagi, M., Miyamoto, K., Takei, Y., Hirose, S. J. Biol. Chem. (2000) [Pubmed]
  14. Purification, characterization, and cDNA cloning of a galactose-specific C-type lectin from Drosophila melanogaster. Haq, S., Kubo, T., Kurata, S., Kobayashi, A., Natori, S. J. Biol. Chem. (1996) [Pubmed]
  15. Lectin-deficient calnexin is capable of binding class I histocompatibility molecules in vivo and preventing their degradation. Leach, M.R., Williams, D.B. J. Biol. Chem. (2004) [Pubmed]
  16. Drosophila cell fusion induced by wheat germ agglutinin. Rizki, R.M., Rizki, T.M., Andrews, C.A. J. Cell. Sci. (1975) [Pubmed]
  17. A group of non-Y encoded Drosophila hydei primary spermatocyte nuclear glycoproteins exhibits epitopes depending on formation of Y chromosomal giant lampbrush loops. Tischendorf, G., Liebrich, W., Trapitz, P., Wood, G., Schwochau, M. Chromosoma (1989) [Pubmed]
  18. An endogenous Drosophila receptor for glycans bearing alpha 1,3-linked core fucose residues. Bouyain, S., Silk, N.J., Fabini, G., Drickamer, K. J. Biol. Chem. (2002) [Pubmed]
  19. Transcriptional regulation of CHI3L1, a marker gene for late stages of macrophage differentiation. Rehli, M., Niller, H.H., Ammon, C., Langmann, S., Schwarzfischer, L., Andreesen, R., Krause, S.W. J. Biol. Chem. (2003) [Pubmed]
  20. The Drosophila acetylcholine receptor subunit D alpha5 is part of an alpha-bungarotoxin binding acetylcholine receptor. Wu, P., Ma, D., Pierzchala, M., Wu, J., Yang, L.C., Mai, X., Chang, X., Schmidt-Glenewinkel, T. J. Biol. Chem. (2005) [Pubmed]
  21. Drosophila laminin: characterization and localization. Fessler, L.I., Campbell, A.G., Duncan, K.G., Fessler, J.H. J. Cell Biol. (1987) [Pubmed]
  22. Helix pomatia lectin, an inducer of Drosophila immune response, binds to hemomucin, a novel surface mucin. Theopold, U., Samakovlis, C., Erdjument-Bromage, H., Dillon, N., Axelsson, B., Schmidt, O., Tempst, P., Hultmark, D. J. Biol. Chem. (1996) [Pubmed]
  23. Comparative analysis of serine protease-related genes in the honey bee genome: possible involvement in embryonic development and innate immunity. Zou, Z., Lopez, D.L., Kanost, M.R., Evans, J.D., Jiang, H. Insect Mol. Biol. (2006) [Pubmed]
  24. Cell surface proteins of Drosophila. II. A comparison of embryonic and ecdysone-induced proteins. Sater, A.K., Woods, D.F., Poodry, C.A. Dev. Biol. (1984) [Pubmed]
  25. Molecular cloning and characterization of a C-type lectin from Ancylostoma ceylanicum: Evidence for a role in hookworm reproductive physiology. Brown, A.C., Harrison, L.M., Kapulkin, W., Jones, B.F., Sinha, A., Savage, A., Villalon, N., Cappello, M. Mol. Biochem. Parasitol. (2007) [Pubmed]
  26. Xerocomus chrysenteron lectin: identification of a new pesticidal protein. Trigueros, V., Lougarre, A., Ali-Ahmed, D., Rahbé, Y., Guillot, J., Chavant, L., Fournier, D., Paquereau, L. Biochim. Biophys. Acta (2003) [Pubmed]
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