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Gene Review

SELP  -  selectin P (granule membrane protein...

Sus scrofa

 
 
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Disease relevance of SELP

 

High impact information on SELP

  • Thus, patients undergoing heparin therapy for other reasons may be experiencing clinically significant inhibition of L- and P-selectin function, and the current switchover to low-molecular weight heparins may come at some loss of this effect [5].
  • Porcine intestinal mucosal (mast cell-derived) heparin (PIM-heparin) shows similar properties, with no binding to E-selectin, calcium-dependent binding of a subfraction to L-selectin and to P-selectin, and calcium-independent binding of a larger fraction to P-selectin, the latter being disrupted by high EDTA concentrations [5].
  • Despite this, HS chains bound to P-selectin are eluted by ethylenediamine tetraacetic acid (EDTA), but only at high concentrations [5].
  • Here, using biochemical as well as morphological approaches, we demonstrate that a P-selectin ligand is expressed in the porcine zona pellucida [6].
  • Taken together, our findings implicate a potential role for the oocyte P-selectin ligand and the sperm P-selectin in porcine sperm-egg interactions [6].
 

Chemical compound and disease context of SELP

  • Accumulating evidence indicates that the formation of tumor cell platelet emboli complexes in the blood stream is a very important step during metastases and that the anti-metastasis effects of heparin are partially due to a blockade of P-selectin on platelets [1].
 

Biological context of SELP

 

Anatomical context of SELP

 

Associations of SELP with chemical compounds

  • Heparan sulfate-like proteoglycans on these tumor cell surfaces are implicated in adhesion of the tumor cells to P-selectin [1].
  • Our findings suggested that the 6-O-sulfate group of glucosamine units in heparin is critical for the inhibition of P-selectin-mediated tumor cell adhesion [1].
  • OBJECTIVES: The role of P-selectin in the process of restenosis was evaluated using a recombinant immunoglobulin (Ig) chimera form of its ligand, soluble P-selectin glycoprotein ligand-Ig (rPSGL-Ig), as a competitive inhibitor for the natural ligand on leukocytes [2].
  • Lamifiban did not modify platelet P-selectin expression in additional studies [12].
  • Consistent with this finding, LB30057 showed concentration-dependent inhibitory effects on serotonin secretion and P-selectin expression induced by thrombin in platelets [13].
 

Regulatory relationships of SELP

 

Other interactions of SELP

 

Analytical, diagnostic and therapeutic context of SELP

References

  1. Modified heparin inhibits P-selectin-mediated cell adhesion of human colon carcinoma cells to immobilized platelets under dynamic flow conditions. Wei, M., Tai, G., Gao, Y., Li, N., Huang, B., Zhou, Y., Hao, S., Zeng, X. J. Biol. Chem. (2004) [Pubmed]
  2. Prevention of intimal hyperplasia with recombinant soluble P-selectin glycoprotein ligand-immunoglobulin in the porcine coronary artery balloon injury model. Wang, K., Zhou, Z., Zhou, X., Tarakji, K., Topol, E.J., Lincoff, A.M. J. Am. Coll. Cardiol. (2001) [Pubmed]
  3. Evaluation of cardioprotective effects of recombinant soluble P-selectin glycoprotein ligand-immunoglobulin in myocardial ischemia-reperfusion injury by real-time myocardial contrast echocardiography. Hansen, A., Kumar, A., Wolf, D., Frankenbergerova, K., Filusch, A., Gross, M.L., Mueller, S., Katus, H., Kuecherer, H. J. Am. Coll. Cardiol. (2004) [Pubmed]
  4. Activation of porcine endothelium in response to xenogeneic serum causes thrombosis independently of platelet activation. Galbusera, M., Buelli, S., Gastoldi, S., Macconi, D., Angioletti, S., Testa, C., Remuzzi, G., Morigi, M. Xenotransplantation (2005) [Pubmed]
  5. Differential interactions of heparin and heparan sulfate glycosaminoglycans with the selectins. Implications for the use of unfractionated and low molecular weight heparins as therapeutic agents. Koenig, A., Norgard-Sumnicht, K., Linhardt, R., Varki, A. J. Clin. Invest. (1998) [Pubmed]
  6. Expression of a P-selectin ligand in zona pellucida of porcine oocytes and P-selectin on acrosomal membrane of porcine sperm cells. Potential implications for their involvement in sperm-egg interactions. Geng, J.G., Raub, T.J., Baker, C.A., Sawada, G.A., Ma, L., Elhammer, A.P. J. Cell Biol. (1997) [Pubmed]
  7. Inhibition of platelet integrin GPIIbIIIa prolongs survival of discordant cardiac xenografts. Candinas, D., Lesnikoski, B.A., Hancock, W.W., Otsu, I., Koyamada, N., Dalmasso, A.P., Robson, S.C., Bach, F.H. Transplantation (1996) [Pubmed]
  8. Sex-specific changes in platelet aggregation and secretion with sexual maturity in pigs. Jayachandran, M., Okano, H., Chatrath, R., Owen, W.G., McConnell, J.P., Miller, V.M. J. Appl. Physiol. (2004) [Pubmed]
  9. Compstatin, a peptide inhibitor of C3, prolongs survival of ex vivo perfused pig xenografts. Fiane, A.E., Mollnes, T.E., Videm, V., Hovig, T., Høgåsen, K., Mellbye, O.J., Spruce, L., Moore, W.T., Sahu, A., Lambris, J.D. Xenotransplantation (1999) [Pubmed]
  10. Platelet and leukocyte activation and design consequences for thoracic artificial lungs. Cook, K.E., Maxhimer, J., Leonard, D.J., Mavroudis, C., Backer, C.L., Mockros, L.F. ASAIO journal (American Society for Artificial Internal Organs : 1992) (2002) [Pubmed]
  11. TNF-alpha, IL-4, and IFN-gamma regulate differential expression of P- and E-selectin expression by porcine aortic endothelial cells. Stocker, C.J., Sugars, K.L., Harari, O.A., Landis, R.C., Morley, B.J., Haskard, D.O. J. Immunol. (2000) [Pubmed]
  12. Lack of effect of glycoprotein IIb/IIIa blockade on myocardial platelet or polymorphonuclear leukocyte accumulation and on infarct size after transient coronary occlusion in pigs. Barrabés, J.A., Garcia-Dorado, D., Mirabet, M., Lidón, R.M., Soriano, B., Ruiz-Meana, M., Pizcueta, P., Blanco, J., Puigfel, Y., Soler-Soler, J. J. Am. Coll. Cardiol. (2002) [Pubmed]
  13. Antithrombotic activity of LB30057, a newly synthesized direct thrombin inhibitor. Kang, K.T., Jung, B.I., Bae, O.N., Lee, M.Y., Chung, S.M., Lee, J.Y., Lee, S.K., Kim, I.C., Chung, J.H. Thromb. Haemost. (2003) [Pubmed]
  14. P-selectin mRNA is expressed at a later phase of megakaryocyte maturation than mRNAs for von Willebrand factor and glycoprotein Ib-alpha. Schick, P.K., Konkle, B.A., He, X., Thornton, R.D. J. Lab. Clin. Med. (1993) [Pubmed]
  15. Aerosolized perfluorocarbon reduces adhesion molecule gene expression and neutrophil sequestration in acute respiratory distress. Schoof, E., von der Hardt, K., Kandler, M.A., Abendroth, F., Papadopoulos, T., Rascher, W., Dötsch, J. Eur. J. Pharmacol. (2002) [Pubmed]
  16. Effects of mechanical ventilation on platelet microparticles in bronchoalveolar lavage fluid. Mutschler, D.K., Larsson, A.O., Basu, S., Nordgren, A., Eriksson, M.B. Thromb. Res. (2002) [Pubmed]
  17. Relationship between platelets and neutrophil adhesion and neointimal growth after repeated arterial wall injury induced by angioplasty in pigs. Bienvenu, J.G., Tanguay, J.F., Chauvet, P., Merhi, Y. J. Vasc. Res. (2001) [Pubmed]
  18. Pharmacokinetics, pharmacodynamics, allometry, and dose selection of rPSGL-Ig for phase I trial. Khor, S.P., McCarthy, K., DuPont, M., Murray, K., Timony, G. J. Pharmacol. Exp. Ther. (2000) [Pubmed]
  19. Estrogenic regulation of tissue factor and tissue factor pathway inhibitor in platelets. Jayachandran, M., Sanzo, A., Owen, W.G., Miller, V.M. Am. J. Physiol. Heart Circ. Physiol. (2005) [Pubmed]
  20. Neutrophil recruitment by fetal porcine endothelial cells: implications in scarless fetal wound healing. Olutoye, O.O., Zhu, X., Cass, D.L., Smith, C.W. Pediatr. Res. (2005) [Pubmed]
  21. Effects of cryopreservation on the immunogenicity of porcine arterial allografts in early stages of transplant vasculopathy. Solanes, N., Rigol, M., Khabiri, E., Castellà, M., Ramírez, J., Roqué, M., Agustí, E., Roig, E., Pérez-Villa, F., Segalés, J., Pomar, J.L., Engel, P., Massaguer, A., Martorell, J., Rodríguez, J.A., Sanz, G., Heras, M. Cryobiology (2005) [Pubmed]
 
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