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MeSH Review

Nerve Degeneration

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Disease relevance of Nerve Degeneration


Psychiatry related information on Nerve Degeneration


High impact information on Nerve Degeneration


Chemical compound and disease context of Nerve Degeneration

  • In the present study, we tested the hypothesis that 17beta-estradiol (betaE2) is a neuroprotectant in the retina, using two experimental approaches: 1) hydrogen peroxide (H(2)O(2))-induced retinal neuron degeneration in vitro, and 2) light-induced photoreceptor degeneration in vivo [13].
  • We demonstrated that both betaE2 and 17alpha-estradiol (alphaE2) significantly protected against H(2)O(2)-induced retinal neuron degeneration; however, progesterone had no effect. betaE2 transiently increased the phosphoinositide 3-kinase (PI3K) activity, when phosphoinositide 4,5-bisphosphate and [(32)gammaATP] were used as substrate [13].
  • Because 6-hydroxydopamine (6-OHDA) is thought to induce nigrostriatal dopaminergic neuronal lesions via metal-catalyzed free radical formation, the effect of the iron chelator desferrioxamine was investigated on 6-OHDA-induced dopaminergic neuron degeneration in the rat [14].
  • During the interval of nerve degeneration, there was a significant reduction of bromodeoxyuridine incorporation from 24 h of nerve injury (39 +/- 7% of the control side, p 0.01) [15].
  • Reductions in muscimol binding to the gamma-aminobutyric acidA receptor had the closest relationship with neuron degeneration, whereas pirenzepine binding appeared to reflect a compensation in muscarinic receptors for changes in neuron densities [16].

Biological context of Nerve Degeneration


Anatomical context of Nerve Degeneration


Gene context of Nerve Degeneration


Analytical, diagnostic and therapeutic context of Nerve Degeneration


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  19. Sorbitol and myo-inositol levels and morphology of sural nerve in relation to peripheral nerve function and clinical neuropathy in men with diabetic, impaired, and normal glucose tolerance. Sundkvist, G., Dahlin, L.B., Nilsson, H., Eriksson, K.F., Lindgärde, F., Rosén, I., Lattimer, S.A., Sima, A.A., Sullivan, K., Greene, D.A. Diabet. Med. (2000) [Pubmed]
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