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Gene Review

ANPEP  -  alanyl (membrane) aminopeptidase

Sus scrofa

Synonyms: APN, PEPN
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Disease relevance of ANPEP


High impact information on ANPEP


Biological context of ANPEP


Anatomical context of ANPEP


Associations of ANPEP with chemical compounds


Regulatory relationships of ANPEP


Other interactions of ANPEP


Analytical, diagnostic and therapeutic context of ANPEP


  1. Determinants essential for the transmissible gastroenteritis virus-receptor interaction reside within a domain of aminopeptidase-N that is distinct from the enzymatic site. Delmas, B., Gelfi, J., Kut, E., Sjöström, H., Noren, O., Laude, H. J. Virol. (1994) [Pubmed]
  2. Aminopeptidase N is a major receptor for the entero-pathogenic coronavirus TGEV. Delmas, B., Gelfi, J., L'Haridon, R., Vogel, L.K., Sjöström, H., Norén, O., Laude, H. Nature (1992) [Pubmed]
  3. Evidence for a putative second receptor for porcine transmissible gastroenteritis virus on the villous enterocytes of newborn pigs. Weingartl, H.M., Derbyshire, J.B. J. Virol. (1994) [Pubmed]
  4. Cellular reorganisation of membrane peptidases in Wallerian degeneration of pig peripheral nerve. Kenny, A.J., Bourne, A. J. Neurocytol. (1991) [Pubmed]
  5. Localization and biosynthesis of aminopeptidase N in pig fetal small intestine. Danielsen, E.M., Hansen, G.H., Niels-Christiansen, L.L. Gastroenterology (1995) [Pubmed]
  6. Assignment of the porcine aminopeptidase N (PEPN) gene to chromosome 7cen----q21. Poulsen, P.H., Thomsen, P.D., Olsen, J. Cytogenet. Cell Genet. (1991) [Pubmed]
  7. Alanyl aminopeptidase N (ANPEP) microsatellite: now a framework marker on porcine chromosome 7 map. Zhang, W., Brown, S.C., Moran, C. Anim. Genet. (1996) [Pubmed]
  8. Perturbation of intestinal microvillar enzyme biosynthesis by amino acid analogs. Evidence that dimerization is required for the transport of aminopeptidase N out of the endoplasmic reticulum. Danielsen, E.M. J. Biol. Chem. (1990) [Pubmed]
  9. Polarized distribution and delivery of plasma membrane proteins in thyroid follicular epithelial cells. Kuliawat, R., Lisanti, M.P., Arvan, P. J. Biol. Chem. (1995) [Pubmed]
  10. Metallopeptidase inhibitors induce an up-regulation of endothelin-converting enzyme levels and its redistribution from the plasma membrane to an intracellular compartment. Barnes, K., Shimada, K., Takahashi, M., Tanzawa, K., Turner, A.J. J. Cell. Sci. (1996) [Pubmed]
  11. Biosynthesis of intestinal microvillar proteins. Processing of aminopeptidase N by microsomal membranes. Danielsen, E.M., Norén, O., Sjöström, H. Biochem. J. (1983) [Pubmed]
  12. The metabolism of neuropeptides. Phase separation of synaptic membrane preparations with Triton X-114 reveals the presence of aminopeptidase N. Matsas, R., Stephenson, S.L., Hryszko, J., Kenny, A.J., Turner, A.J. Biochem. J. (1985) [Pubmed]
  13. Biosynthesis of intestinal microvillar proteins. The effect of swainsonine on post-translational processing of aminopeptidase N. Danielsen, E.M., Cowell, G.M., Norén, O., Sjöström, H., Dorling, P.R. Biochem. J. (1983) [Pubmed]
  14. Reorganization of porcine thyroid cells into functional follicles in a chemically defined, serum- and thyrotropin-free medium. Fayet, G., Hovsépian, S., Dickson, J.G., Lissitzky, S. J. Cell Biol. (1982) [Pubmed]
  15. Post-translational suppression of expression of intestinal brush border enzymes by fructose. Danielsen, E.M. J. Biol. Chem. (1989) [Pubmed]
  16. Cholesterol depletion of enterocytes. Effect on the Golgi complex and apical membrane trafficking. Hansen, G.H., Niels-Christiansen, L.L., Thorsen, E., Immerdal, L., Danielsen, E.M. J. Biol. Chem. (2000) [Pubmed]
  17. Biosynthesis of intestinal microvillar proteins. Processing of N-linked carbohydrate is not required for surface expression. Danielsen, E.M., Cowell, G.M. Biochem. J. (1986) [Pubmed]
  18. Tyrosine sulphation is not required for microvillar expression of intestinal aminopeptidase N. Danielsen, E.M. Biochem. J. (1988) [Pubmed]
  19. Early weaning stimulates intestinal brush border enzyme activities in piglets, mainly at the posttranscriptional level. Marion, J., Petersen, Y.M., Romé, V., Thomas, F., Sangild, P.T., Le Dividich, J., Le Huërou-Luron, I. J. Pediatr. Gastroenterol. Nutr. (2005) [Pubmed]
  20. Tyrosine sulfation, a post-translational modification of microvillar enzymes in the small intestinal enterocyte. Danielsen, E.M. EMBO J. (1987) [Pubmed]
  21. Is there a tripeptidyl peptidase in the renal brush-border membrane? Kenny, A.J., Ingram, J. Biochem. J. (1988) [Pubmed]
  22. Membrane peptidases in the pig choroid plexus and on other cell surfaces in contact with the cerebrospinal fluid. Bourne, A., Barnes, K., Taylor, B.A., Turner, A.J., Kenny, A.J. Biochem. J. (1989) [Pubmed]
  23. Localization of aminopeptidase N and dipeptidyl peptidase IV in pig striatum and in neuronal and glial cell cultures. Barnes, K., Kenny, A.J., Turner, A.J. Eur. J. Neurosci. (1994) [Pubmed]
  24. Lenten cell: ultrastructure, absorptive properties, and enzyme expression of a novel type of cell in the newborn and suckling pig intestinal epithelium. Heath, J.P., Kömüves, L.G., Nichols, B.L. Anat. Rec. (1996) [Pubmed]
  25. Entry and release of transmissible gastroenteritis coronavirus are restricted to apical surfaces of polarized epithelial cells. Rossen, J.W., Bekker, C.P., Voorhout, W.F., Strous, G.J., van der Ende, A., Rottier, P.J. J. Virol. (1994) [Pubmed]
  26. Biosynthesis of intestinal microvillar proteins. Pulse-chase labelling studies on aminopeptidase N and sucrase-isomaltase. Danielsen, E.M. Biochem. J. (1982) [Pubmed]
  27. Characterization of Glu350 as a critical residue involved in the N-terminal amine binding site of aminopeptidase N (EC insights into its mechanism of action. Luciani, N., Marie-Claire, C., Ruffet, E., Beaumont, A., Roques, B.P., Fournié-Zaluski, M.C. Biochemistry (1998) [Pubmed]
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