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GFAP  -  glial fibrillary acidic protein

Sus scrofa

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Disease relevance of GFAP


High impact information on GFAP


Chemical compound and disease context of GFAP


Biological context of GFAP

  • 3. The phosphorylation of GFAP was dependent on Ca2+ in the incubation medium in adult animals [10].
  • As a consequence, the resulting human GFAPkappa protein harbors a nonconserved C-terminal tail sequence distinct from the tails of GFAPalpha, the predominant GFAP isoform, and GFAPepsilon, an isoform which also results from alternative splicing [8].

Anatomical context of GFAP


Associations of GFAP with chemical compounds


Other interactions of GFAP


Analytical, diagnostic and therapeutic context of GFAP


  1. Immunocytochemical localization of intermediate filaments in the guinea pig vestibular periphery with special reference to their alteration after ototoxic drug administration. Usami, S., Hozawa, J., Shinkawa, H., Saito, S., Matsubara, A., Fujita, S. Acta oto-laryngologica. Supplementum. (1993) [Pubmed]
  2. Immunocytochemical staining for glial fibrillary acidic protein and the metabolism of cytoskeletal proteins in experimental allergic encephalomyelitis. Smith, M.E., Somera, F.P., Eng, L.F. Brain Res. (1983) [Pubmed]
  3. Cellular and cytoskeletal dynamics within organ cultures of porcine neuroretina. Winkler, J., Hagelstein, S., Rohde, M., Laqua, H. Exp. Eye Res. (2002) [Pubmed]
  4. Immunocytochemical study of myelin-associated glycoprotein (MAG), basic protein (BP), and glial fibrillary acidic protein (GFAP) in chronic relapsing experimental allergic encephalomyelitis (EAE). Webster, H.D., Shii, H., Lassmann, H. Acta Neuropathol. (1985) [Pubmed]
  5. Efficient degradation in vitro of all intermediate filament subunit proteins by the Ca2+-activated neutral thiol proteinase from Ehrlich ascites tumor cells and porcine kidney. Vorgias, C.E., Traub, P. Biosci. Rep. (1986) [Pubmed]
  6. Amino acid sequence data on glial fibrillary acidic protein (GFA); implications for the subdivision of intermediate filaments into epithelial and non-epithelial members. Geisler, N., Weber, K. EMBO J. (1983) [Pubmed]
  7. Astrocytes express insulin-like growth factor-I (IGF-I) and its binding protein, IGFBP-2, during demyelination induced by experimental autoimmune encephalomyelitis. Liu, X., Yao, D.L., Bondy, C.A., Brenner, M., Hudson, L.D., Zhou, J., Webster, H.D. Mol. Cell. Neurosci. (1994) [Pubmed]
  8. Identification and characterization of GFAPkappa, a novel glial fibrillary acidic protein isoform. Blechingberg, J., Holm, I.E., Nielsen, K.B., Jensen, T.H., Jørgensen, A.L., Nielsen, A.L. Glia (2007) [Pubmed]
  9. Modified ultrafiltration may not improve neurologic outcome following deep hypothermic circulatory arrest. Myung, R.J., Kirshbom, P.M., Petko, M., Golden, J.A., Judkins, A.R., Ittenbach, R.F., Spray, T.L., Gaynor, J.W. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. (2003) [Pubmed]
  10. Properties of phosphorylated glial fibrillary acidic protein in brain slices of guinea pig, mouse and rat. Gonçalves, C.A., Salbego, C.G., Rodnight, R. Braz. J. Med. Biol. Res. (1994) [Pubmed]
  11. Astrocytes in the guinea pig, horse, and monkey retina: their occurrence coincides with the presence of blood vessels. Schnitzer, J. Glia (1988) [Pubmed]
  12. Intermediate filaments in the inner ear of normal and experimentally damaged guinea pigs. Oesterle, E.C., Sarthy, P.V., Rubel, E.W. Hear. Res. (1990) [Pubmed]
  13. Neurodegenerative changes in the guinea pig brainstem after intratympanic injection of gentamicin. Rosen, J.H., Thompson, G.C., Hill Britton, B., Thompson, A.M. Brain Res. (1998) [Pubmed]
  14. Cerebrospinal fluid biomarkers in experimental spinal nerve root injury. Cornefjord, M., Nyberg, F., Rosengren, L., Brisby, H. Spine. (2004) [Pubmed]
  15. Immunocytochemical localization of endopeptidase-24.11 in cultured neurons from pig striatum. Matsas, R., Kenny, A.J. Neuroscience (1989) [Pubmed]
  16. Protein markers in cerebrospinal fluid in experimental nerve root injury. A study of slow-onset chronic compression effects or the biochemical effects of nucleus pulposus on sacral nerve roots. Skouen, J.S., Brisby, H., Otani, K., Olmarker, K., Rosengren, L., Rydevik, B. Spine. (1999) [Pubmed]
  17. Glial fibrillary acidic protein in the fish optic nerve. Blaugrund, E., Cohen, I., Shani, Y., Schwartz, M. Glia (1991) [Pubmed]
  18. Focal brain damage enhances experimental allergic encephalomyelitis in brain and spinal cord. Phillips, M.J., Weller, R.O., Kida, S., Iannotti, F. Neuropathol. Appl. Neurobiol. (1995) [Pubmed]
  19. Collaborative trial for validation of a real-time reverse transcriptase-polymerase chain reaction assay for detection of central nervous system tissues as bovine spongiform encephalopathy risk material: part 1. Abdulmawjood, A., Sch??nenbr??cher, H., B??lte, M. Journal of AOAC International. (2006) [Pubmed]
  20. Membrane peptidases in the peripheral nervous system of the pig: their localization by immunohistochemistry at light and electron microscopic levels. Barnes, K., Bourne, A., Cook, P.A., Turner, A.J., Kenny, A.J. Neuroscience (1991) [Pubmed]
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