The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

OVGP1  -  oviductal glycoprotein 1, 120kDa

Homo sapiens

Synonyms: CHIT5, EGP, Estrogen-dependent oviduct protein, MUC9, Mucin-9, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of OVGP1

  • Gain of OGP, an estrogen-regulated oviduct-specific glycoprotein, is associated with the development of endometrial hyperplasia and endometrial cancer [1].
  • In intensively treated type 1 diabetes, despite some activation of counterregulation, hypoglycemia failed to stimulate hepatic glycogen breakdown or activation of EGP, factors that may contribute to the defective counterregulation seen in such patients [2].
  • The objective of the current study was to generate a polyclonal antibody toward a previously described 110- to 130-kilodalton (kDa) human oviductal glycoprotein and to use the antibody to detect the protein in tissue sections, tissue culture media, and oviductal flushings [3].
  • In this study, we have examined the cytotoxic role of EGP in primary endothelial cells by transduction with a replication-deficient recombinant adenovirus expressing EGP (Ad-EGP) [4].
  • Pronounced tissue eosinophilia, especially EGP deposition as the result of complete activation of eosinophils, is found in chronic AD and may be involved in the development or maintenance of chronicity [5].

High impact information on OVGP1

  • In summary, our data suggest that (a) acute changes in plasma FFA produce acute changes in GNG and reciprocal changes in GL; (b) the decrease in EGP between 16 and 24 hours of fasting is due to a fall in GL; and (c) NA has no direct effect on GNG [6].
  • EGP decreased during hypoglycemia with no recovery (1.3 +/- 0.5 vs. 1.2 +/- 0.3 mg x kg(-1) x min(-1) compared with euglycemia, P = NS), and hepatic glycogen concentration did not change significantly with hypoglycemia [2].
  • We conclude that glycogenolysis accounts for the majority of EGP during the first 90 min of hypoglycemia in nondiabetic subjects [2].
  • The amino acid sequence of YKL-39 is most closely related to YKL-40, followed by macrophage chitotriosidase, oviductal glycoprotein, and macrophage YM-1 [7].
  • NIDDM patients had increased lactate turnover rates (16.18+/-0.92 vs 12.14+/-0.60 micromol x kg(-1) x min(-1), p < 0.01) and a moderate rise in glucose production (EGP) (15.39+/-0.87 vs 12.52+/-0.28 micromol x kg(-1) x min(-1) , p = 0.047) [8].

Biological context of OVGP1


Anatomical context of OVGP1


Associations of OVGP1 with chemical compounds

  • A high degree of homology was found to the N-terminal sequence of hamster oviductin and the partial sequence of a homologous baboon and bovine oviduct glycoprotein [12].
  • Complementary deoxyribonucleic acid cloning and molecular characterization of an estrogen-dependent human oviductal glycoprotein [12].
  • The time course of insulin action showed an early (first week of treatment) decrease in EGP in the troglitazone group that was maintained throughout, whereas steady-state plasma glucose levels began to diverge toward the end of treatment [14].
  • The oviductal glycoprotein mRNA levels were lower in the early follicular stage and early luteal stage and were not detectable in the late luteal stage or in progesterone-treated baboons [15].
  • RESULT(S): There was a significant positive correlation between serum estradiol and luteinizing hormone concentrations and oviductin mRNA expression [16].

Other interactions of OVGP1


Analytical, diagnostic and therapeutic context of OVGP1


  1. Gain of OGP, an estrogen-regulated oviduct-specific glycoprotein, is associated with the development of endometrial hyperplasia and endometrial cancer. Woo, M.M., Alkushi, A., Verhage, H.G., Magliocco, A.M., Leung, P.C., Gilks, C.B., Auersperg, N. Clin. Cancer Res. (2004) [Pubmed]
  2. Role of hepatic glycogen breakdown in defective counterregulation of hypoglycemia in intensively treated type 1 diabetes. Kishore, P., Gabriely, I., Cui, M.H., Di Vito, J., Gajavelli, S., Hwang, J.H., Shamoon, H. Diabetes (2006) [Pubmed]
  3. Immunological characterization and immunocytochemical localization of an oviduct-specific glycoprotein in the human. Rapisarda, J.J., Mavrogianis, P.A., O'Day-Bowman, M.B., Fazleabas, A.T., Verhage, H.G. J. Clin. Endocrinol. Metab. (1993) [Pubmed]
  4. Ebola virus glycoprotein-mediated anoikis of primary human cardiac microvascular endothelial cells. Ray, R.B., Basu, A., Steele, R., Beyene, A., McHowat, J., Meyer, K., Ghosh, A.K., Ray, R. Virology (2004) [Pubmed]
  5. Tissue eosinophilia in acute and chronic atopic dermatitis: a morphometric approach using quantitative image analysis of immunostaining. Kiehl, P., Falkenberg, K., Vogelbruch, M., Kapp, A. Br. J. Dermatol. (2001) [Pubmed]
  6. The effects of free fatty acids on gluconeogenesis and glycogenolysis in normal subjects. Chen, X., Iqbal, N., Boden, G. J. Clin. Invest. (1999) [Pubmed]
  7. Isolation and sequence of a novel human chondrocyte protein related to mammalian members of the chitinase protein family. Hu, B., Trinh, K., Figueira, W.F., Price, P.A. J. Biol. Chem. (1996) [Pubmed]
  8. Non-invasive tracing of liver intermediary metabolism in normal subjects and in moderately hyperglycaemic NIDDM subjects. Evidence against increased gluconeogenesis and hepatic fatty acid oxidation in NIDDM. Diraison, F., Large, V., Brunengraber, H., Beylot, M. Diabetologia (1998) [Pubmed]
  9. Cloning and characterization of the human oviduct-specific glycoprotein (HuOGP) gene promoter. Agarwal, A., Yeung, W.S., Lee, K.F. Mol. Hum. Reprod. (2002) [Pubmed]
  10. Allelic polymorphism and chromosomal localization of the human oviductin gene (MUC9). Lapensée, L., Paquette, Y., Bleau, G. Fertil. Steril. (1997) [Pubmed]
  11. Variable expression of oviductin mRNA at different stages of human reproductive cycle. Lok, I.H., Briton-Jones, C.M., Yuen, P.M., Haines, C.J. J. Assist. Reprod. Genet. (2002) [Pubmed]
  12. Complementary deoxyribonucleic acid cloning and molecular characterization of an estrogen-dependent human oviductal glycoprotein. Arias, E.B., Verhage, H.G., Jaffe, R.C. Biol. Reprod. (1994) [Pubmed]
  13. Expression of human oviductin in an immortalized human oviductal cell line. Ling, L., Lee, Y.L., Lee, K.F., Tsao, S.W., Yeung, W.S., Kan, F.W. Fertil. Steril. (2005) [Pubmed]
  14. Effects of troglitazone on insulin action and cardiovascular risk factors in patients with non-insulin-dependent diabetes. Sironi, A.M., Vichi, S., Gastaldelli, A., Pecori, N., Anichini, R., Foot, E., Seghieri, G., Ferrannini, E. Clin. Pharmacol. Ther. (1997) [Pubmed]
  15. Regional distribution and hormonal control of estrogen-dependent oviduct-specific glycoprotein messenger ribonucleic acid in the baboon (Papio anubis). Jaffe, R.C., Arias, E.B., O'Day-Bowman, M.B., Donnelly, K.M., Mavrogianis, P.A., Verhage, H.G. Biol. Reprod. (1996) [Pubmed]
  16. Regulation of human oviductin mRNA expression in vivo. Briton-Jones, C., Lok, I.H., Yuen, P.M., Chiu, T.T., Cheung, L.P., Haines, C. Fertil. Steril. (2001) [Pubmed]
  17. Evidence for the regulation of glycosylation of golden hamster (Mesocricetus auratus) oviductin during the estrous cycle. McBride, D.S., Boisvert, C., Bleau, G., Kan, F.W. Biol. Reprod. (2004) [Pubmed]
  18. Allelic polymorphism in the hamster oviductin gene is due to a variable number of mucin-like tandem repeats. Paquette, Y., Merlen, Y., Malette, B., Bleau, G. Mol. Reprod. Dev. (1995) [Pubmed]
  19. Homology of primate DNA fragments for estrous-associated oviductal glycoprotein. Chen, Q., Zhang, J., Sweet, F. Hereditas (2003) [Pubmed]
  20. Cloning of a recombinant complementary DNA to a baboon (Papio anubis) estradiol-dependent oviduct-specific glycoprotein. Donnelly, K.M., Fazleabas, A.T., Verhage, H.G., Mavrogianis, P.A., Jaffe, R.C. Mol. Endocrinol. (1991) [Pubmed]
  21. Sustained reduction in plasma free fatty acid concentration improves insulin action without altering plasma adipocytokine levels in subjects with strong family history of type 2 diabetes. Bajaj, M., Suraamornkul, S., Kashyap, S., Cusi, K., Mandarino, L., DeFronzo, R.A. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
WikiGenes - Universities