The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

SLC45A2  -  solute carrier family 45, member 2

Homo sapiens

Synonyms: 1A1, AIM-1, AIM1, MATP, Melanoma antigen AIM1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of SLC45A2


High impact information on SLC45A2

  • One of these, an orange-red variant, is a homozygote of a well-known and common allele, b, and has been bred for hundreds of years by the Japanese. Here, we report the first successful positional cloning of a medaka gene (AIM1): one that encodes a transporter that mediates melanin synthesis [6].
  • The antigen is no longer detectable in the fully emerged gamete. mAb 1A1 dramatically reduces the number of oocysts formed in P. falciparum gametocyte-fed mosquitoes [7].
  • Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes [8].
  • FINDINGS: mRNA for the cytochromes 1A1, 2B6/7, 2C8-19, 2D6, and 4B1 was predominantly expressed in the right ventricle; the unilateral expression of the 2D6 gene in right-venticular tissue is important because of its key role in the metabolism of beta-blockers [9].
  • We used a HD-Ad vector to achieve liver-restricted expression of human uridine diphospho-glucuronosyl transferase 1A1 in the Gunn rat, a model of the human disorder [5].

Chemical compound and disease context of SLC45A2


Biological context of SLC45A2

  • Single nucleotide polymorphisms in the MATP gene are associated with normal human pigmentation variation [15].
  • We investigated the role of two nonpathogenic nonsynonymous single nucleotide polymorphisms (SNPs) in the MATP gene to determine if they are associated with normal human skin, hair, and eye color variation [15].
  • The phenotypes of OCA4 were as various as the other types of OCA and probably depended on the mutation sites in the SLC45A2 gene [16].
  • The kinetics of induction for AIM-1 was similar to a mechanical strain-induced calmodulin (MBCaM-1) in V. radiata, whereas the kinetics of its decline from maximum was different [17].
  • Thus, these results suggest that the DNA adducts detected in human larynx are largely derived from metabolic activation of polycyclic aromatic hydrocarbons in cigarette smoke by P450 2C, 3A4, and/or 1A1 [18].

Anatomical context of SLC45A2

  • 7,8-Benzoflavone, an inhibitor of P-450s 1A1 and 1A2, had no effect on NNK metabolism in human lung microsomes but decreased the formation of keto alcohol by 47% in human liver microsomes [19].
  • MoAb SW1116-F2 1E3/1A1 reacted with four colon carcinoma cell lines, one gastric cancer line, MCF-7 cells, and a lung cancer line [20].
  • On the other hand, the enzyme activities in rat hepatocytes associated with cytochromes P-450 (CYPs) 1A1 and 2B1/2, namely ethoxyresorufin-O-deethylase and pentoxyresorufin-O-dealkylase, respectively, were decreased in a dose-dependent manner [21].
  • We also determined and compared these activities of P450 1B1 with those catalyzed by recombinant human P450s 1A1 and 1A2, which were purified from membranes of Escherichia coli [22].
  • Of greater interest is the observation that 1A1 is an antigen-specific helper T cell line [23].

Associations of SLC45A2 with chemical compounds

  • UDP-glucuronosyltransferase (UGT) 1A1 is involved in the inactivation of estradiol (E(2)) and its oxidized metabolites [24].
  • P450s 1A1, 1A2, and 2C10 had higher activities than the other enzymes for ring oxidation of 5-MeC and 6-MeC, whereas P450s 1A2 and 3A4 were more active than the other enzymes for methyl hydroxylation of 6-MeC [25].
  • The role of individual human recombinant p450s 1A1, 1A2, 1B1, 2A6, 2B6, 2D6, 2C9, 2E1, and 3A4 and of NADPH: p450 reductase in the metabolic activation of 3-NBA, catalyzing DNA adduct formation, was also examined using microsomes of baculovirus-transfected insect cells containing the recombinant enzymes (Supersomes) [26].
  • We investigated the effects of natural and xenoestrogens on basal and 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced cytochrome P450 (CYP) 1A1 and 1B1 [10].
  • The results of the correlation analysis indicated that P450s 1A1 and 1A2 were active in the formation of 5-MeC-1,2-diol and 6-MeC-1,2-diol, as well as several other metabolites resulting from ring oxidation [25].

Other interactions of SLC45A2

  • Our data confirm the earlier results and furthermore demonstrate that the SLC45A2 allele is a more specific AIM than the SLC24A5 allele because the former clearly distinguishes the Sri Lankans from the Europeans [27].

Analytical, diagnostic and therapeutic context of SLC45A2

  • The sequences of M2 dsRNA and of PCR products generated from Rhs 1A1 total DNA were found to be identical [28].
  • MATERIALS AND METHODS: Osteosarcoma tissue microarray blocks containing biopsies from 18 primary tumors were used to analyze the expression of P450s 1A1/2, 1B1, 2B6, 2D6, and 3A4/5 by enzyme-linked avidin-biotin complexed immunohistochemistry [29].
  • Thus, by utilizing ELISA systems to quantitate class-specific immunoglobulin and antigen-specific antibody, it was determined that co-culture of autologous B cells, 1A1 cells, and a low concentration (1 to 10 ng/ml) of TT results in an IgG response that is predominantly, if not exclusively, antigen-specific antibody [23].
  • The expression of CYP 1A1, 2B6, 2E1, 3A4, and GST-Pi was quantified by immunoblotting [30].
  • The purpose of this study was to compare the expression of GST-Pi and CYPs 1A1, 2B6, 2E1, and 3A4 in paired samples of normal and malignant breast tissue from patients with breast cancer and women undergoing reduction mammoplasty [30].


  1. A Korean case of oculocutaneous albinism type IV caused by a D157N mutation in the MATP gene. Suzuki, T., Inagaki, K., Fukai, K., Obana, A., Lee, S.T., Tomita, Y. Br. J. Dermatol. (2005) [Pubmed]
  2. Mutations in the MATP gene in five German patients affected by oculocutaneous albinism type 4. Rundshagen, U., Zühlke, C., Opitz, S., Schwinger, E., Käsmann-Kellner, B. Hum. Mutat. (2004) [Pubmed]
  3. Respiratory tract uptake of inhalants and metabolism of xenobiotics. Dahl, A.R., Lewis, J.L. Annu. Rev. Pharmacol. Toxicol. (1993) [Pubmed]
  4. Glucose-6-phosphate dehydrogenase deficiency, the UDP-glucuronosyl transferase 1A1 gene, and neonatal hyperbilirubinemia. Huang, C.S., Chang, P.F., Huang, M.J., Chen, E.S., Chen, W.C. Gastroenterology (2002) [Pubmed]
  5. Lifelong elimination of hyperbilirubinemia in the Gunn rat with a single injection of helper-dependent adenoviral vector. Toietta, G., Mane, V.P., Norona, W.S., Finegold, M.J., Ng, P., McDonagh, A.F., Beaudet, A.L., Lee, B. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  6. Mutations in the gene encoding B, a novel transporter protein, reduce melanin content in medaka. Fukamachi, S., Shimada, A., Shima, A. Nat. Genet. (2001) [Pubmed]
  7. Pfs2400 can mediate antibody-dependent malaria transmission inhibition and may be the Plasmodium falciparum 11.1 gene product. Feng, Z., Hoffmann, R.N., Nussenzweig, R.S., Tsuji, M., Fujioka, H., Aikawa, M., Lensen, T.H., Ponnudurai, T., Pologe, L.G. J. Exp. Med. (1993) [Pubmed]
  8. Genetic predisposition to the metabolism of irinotecan (CPT-11). Role of uridine diphosphate glucuronosyltransferase isoform 1A1 in the glucuronidation of its active metabolite (SN-38) in human liver microsomes. Iyer, L., King, C.D., Whitington, P.F., Green, M.D., Roy, S.K., Tephly, T.R., Coffman, B.L., Ratain, M.J. J. Clin. Invest. (1998) [Pubmed]
  9. Gene expression in distinct regions of the heart. Thum, T., Borlak, J. Lancet (2000) [Pubmed]
  10. Differential regulation of cytochrome P450 1A1 and 1B1 by a combination of dioxin and pesticides in the breast tumor cell line MCF-7. Coumoul, X., Diry, M., Robillot, C., Barouki, R. Cancer Res. (2001) [Pubmed]
  11. Relationship between bilirubin UDP-glucuronosyl transferase 1A1 gene and neonatal hyperbilirubinemia. Huang, C.S., Chang, P.F., Huang, M.J., Chen, E.S., Hung, K.L., Tsou, K.I. Pediatr. Res. (2002) [Pubmed]
  12. Inhibition of human cytochrome P450 1A1-, 1A2-, and 1B1-mediated activation of procarcinogens to genotoxic metabolites by polycyclic aromatic hydrocarbons. Shimada, T., Guengerich, F.P. Chem. Res. Toxicol. (2006) [Pubmed]
  13. Induction of cytochromes P450 1A1 and 1B1 by emodin in human lung adenocarcinoma cell line CL5. Wang, H.W., Chen, T.L., Yang, P.C., Ueng, T.H. Drug Metab. Dispos. (2001) [Pubmed]
  14. Type I procollagen synthesis is regulated by steroids and related hormones in human osteosarcoma cells. Mahonen, A., Jukkola, A., Risteli, L., Risteli, J., Mäenpää, P.H. J. Cell. Biochem. (1998) [Pubmed]
  15. Single nucleotide polymorphisms in the MATP gene are associated with normal human pigmentation variation. Graf, J., Hodgson, R., van Daal, A. Hum. Mutat. (2005) [Pubmed]
  16. Oculocutaneous albinism type 4: six novel mutations in the membrane-associated transporter protein gene and their phenotypes. Inagaki, K., Suzuki, T., Ito, S., Suzuki, N., Adachi, K., Okuyama, T., Nakata, Y., Shimizu, H., Matsuura, H., Oono, T., Iwamatsu, H., Kono, M., Tomita, Y. Pigment Cell Res. (2006) [Pubmed]
  17. A mechanical strain-induced 1-aminocyclopropane-1-carboxylic acid synthase gene. Botella, J.R., Arteca, R.N., Frangos, J.A. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  18. Metabolic activation and carcinogen-DNA adduct detection in human larynx. Degawa, M., Stern, S.J., Martin, M.V., Guengerich, F.P., Fu, P.P., Ilett, K.F., Kaderlik, R.K., Kadlubar, F.F. Cancer Res. (1994) [Pubmed]
  19. Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human lung and liver microsomes and cytochromes P-450 expressed in hepatoma cells. Smith, T.J., Guo, Z., Gonzalez, F.J., Guengerich, F.P., Stoner, G.D., Yang, C.S. Cancer Res. (1992) [Pubmed]
  20. New monoclonal antibodies against colon cancer-associated antigens. Drewinko, B., Yang, L.Y., Chan, J., Trujillo, J.M. Cancer Res. (1986) [Pubmed]
  21. Inhibition of cytochromes P-450 and induction of glutathione S-transferases by sulforaphane in primary human and rat hepatocytes. Mahéo, K., Morel, F., Langouët, S., Kramer, H., Le Ferrec, E., Ketterer, B., Guillouzo, A. Cancer Res. (1997) [Pubmed]
  22. Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1. Shimada, T., Hayes, C.L., Yamazaki, H., Amin, S., Hecht, S.S., Guengerich, F.P., Sutter, T.R. Cancer Res. (1996) [Pubmed]
  23. Antigen-specific and polyclonal immunoglobulin production induced by a cloned tetanus toxoid-specific T cell line. Friedman, S.M., Principato, M.A., Thompson, G.S., Teichman, F. J. Immunol. (1983) [Pubmed]
  24. The functional UGT1A1 promoter polymorphism decreases endometrial cancer risk. Duguay, Y., McGrath, M., Lépine, J., Gagné, J.F., Hankinson, S.E., Colditz, G.A., Hunter, D.J., Plante, M., Têtu, B., Bélanger, A., Guillemette, C., De Vivo, I. Cancer Res. (2004) [Pubmed]
  25. Metabolism of 5-methylchrysene and 6-methylchrysene by human hepatic and pulmonary cytochrome P450 enzymes. Koehl, W., Amin, S., Staretz, M.E., Ueng, Y.F., Yamazaki, H., Tateishi, T., Guengerich, F.P., Hecht, S.S. Cancer Res. (1996) [Pubmed]
  26. Human enzymes involved in the metabolic activation of the environmental contaminant 3-nitrobenzanthrone: evidence for reductive activation by human NADPH:cytochrome p450 reductase. Arlt, V.M., Stiborova, M., Hewer, A., Schmeiser, H.H., Phillips, D.H. Cancer Res. (2003) [Pubmed]
  27. Population differences of two coding SNPs in pigmentation-related genes SLC24A5 and SLC45A2. Soejima, M., Koda, Y. Int. J. Legal Med. (2007) [Pubmed]
  28. A double-stranded RNA element from a hypovirulent strain of Rhizoctonia solani occurs in DNA form and is genetically related to the pentafunctional AROM protein of the shikimate pathway. Lakshman, D.K., Jian, J., Tavantzis, S.M. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  29. Cytochrome P450 CYP3A4/5 expression as a biomarker of outcome in osteosarcoma. Dhaini, H.R., Thomas, D.G., Giordano, T.J., Johnson, T.D., Biermann, J.S., Leu, K., Hollenberg, P.F., Baker, L.H. J. Clin. Oncol. (2003) [Pubmed]
  30. Cytochrome p450 and glutathione transferase expression in human breast cancer. El-Rayes, B.F., Ali, S., Heilbrun, L.K., Lababidi, S., Bouwman, D., Visscher, D., Philip, P.A. Clin. Cancer Res. (2003) [Pubmed]
WikiGenes - Universities