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Gene Review

ACSL5  -  acyl-CoA synthetase long-chain family...

Homo sapiens

Synonyms: ACS2, ACS5, FACL5, LACS 5, Long-chain acyl-CoA synthetase 5, ...
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Disease relevance of ACSL5


High impact information on ACSL5


Chemical compound and disease context of ACSL5

  • The results suggest the involvement of ACS5 in the early genesis of colorectal cancer, most likely by modification of the transport and pool formation of long-chain acyl-CoA thioesters, as recently demonstrated for other isoforms of the ACS family [3].

Biological context of ACSL5


Anatomical context of ACSL5


Associations of ACSL5 with chemical compounds

  • Taken as a whole, these features suggest that in liver, ACS1 and ACS5 may provide acyl-CoA destined primarily for triacylglycerol synthesis or for mitochondrial oxidation, respectively [9].
  • In cultured hepatocytes, insulin and a high glucose concentration induce ACS-5 mRNA [10].
  • In conclusion, OS-ACS5 is involved in the rapid elongation growth of deepwater rice by contributing to the initial and long-term increase in ethylene levels [11].
  • Gibberellin up-regulated and abscisic acid down-regulated OS-ACS5 mRNA accumulation [11].
  • Homology modeling of ACS2 with docking of 1,3-dihydroxy-N-methylacridone suggested that the starter substrates for CHS or ACS reaction are placed in different topographies in the active site pocket [12].

Analytical, diagnostic and therapeutic context of ACSL5


  1. Fatty acid induced glioma cell growth is mediated by the acyl-CoA synthetase 5 gene located on chromosome 10q25.1-q25.2, a region frequently deleted in malignant gliomas. Yamashita, Y., Kumabe, T., Cho, Y.Y., Watanabe, M., Kawagishi, J., Yoshimoto, T., Fujino, T., Kang, M.J., Yamamoto, T.T. Oncogene (2000) [Pubmed]
  2. Characterization of metaplastic and heterotopic epithelia in the human gastrointestinal tract by the expression pattern of acyl-CoA synthetase 5. Gassler, N., Obermüller, N., Keith, M., Schirmacher, P., Autschbach, F. Histol. Histopathol. (2005) [Pubmed]
  3. Impaired expression of acyl-CoA synthetase 5 in sporadic colorectal adenocarcinomas. Gassler, N., Herr, I., Schneider, A., Penzel, R., Langbein, L., Schirmacher, P., Kopitz, J. J. Pathol. (2005) [Pubmed]
  4. Nucleocytosolic acetyl-coenzyme a synthetase is required for histone acetylation and global transcription. Takahashi, H., McCaffery, J.M., Irizarry, R.A., Boeke, J.D. Mol. Cell (2006) [Pubmed]
  5. Phosphorylation of tomato 1-aminocyclopropane-1-carboxylic acid synthase, LE-ACS2, at the C-terminal region. Tatsuki, M., Mori, H. J. Biol. Chem. (2001) [Pubmed]
  6. p53-defective tumors with a functional apoptosome-mediated pathway: a new therapeutic target. Mashima, T., Oh-hara, T., Sato, S., Mochizuki, M., Sugimoto, Y., Yamazaki, K., Hamada, J., Tada, M., Moriuchi, T., Ishikawa, Y., Kato, Y., Tomoda, H., Yamori, T., Tsuruo, T. J. Natl. Cancer Inst. (2005) [Pubmed]
  7. The role of long-chain fatty-acid-CoA ligase 3 in vitamin D3 and androgen control of prostate cancer LNCaP cell growth. Qiao, S., Tuohimaa, P. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  8. Expression of acyl-CoA synthetase 5 in human endometrium and in endometrioid adenocarcinomas. Gassler, N., Yang, S.H., Keith, M., Helmke, B.M., Schirmacher, P., Obermüller, N. Histopathology (2005) [Pubmed]
  9. Do long-chain acyl-CoA synthetases regulate fatty acid entry into synthetic versus degradative pathways? Coleman, R.A., Lewin, T.M., Van Horn, C.G., Gonzalez-Baró, M.R. J. Nutr. (2002) [Pubmed]
  10. Long chain fatty acyl-CoA synthetase 5 expression is induced by insulin and glucose: involvement of sterol regulatory element-binding protein-1c. Achouri, Y., Hegarty, B.D., Allanic, D., Bécard, D., Hainault, I., Ferré, P., Foufelle, F. Biochimie (2005) [Pubmed]
  11. A comparative molecular-physiological study of submergence response in lowland and deepwater rice. Van Der Straeten, D., Zhou, Z., Prinsen, E., Van Onckelen, H.A., Van Montagu, M.C. Plant Physiol. (2001) [Pubmed]
  12. Starter substrate specificities of wild-type and mutant polyketide synthases from Rutaceae. Lukacin, R., Schreiner, S., Silber, K., Matern, U. Phytochemistry (2005) [Pubmed]
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