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Gene Review

LOC548260  -  oxalate oxidase

Hordeum vulgare

 
 
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Disease relevance of LOC548260

  • Although a considerable part of the heterologous protein was produced in an insoluble and inactive form, this strain, E. coli Origami B(DE3), in addition yielded soluble and active barley and wheat oxalate oxidase [1].
  • The function of root border cells (RBC) during aluminum (Al) stress and the involvement of oxalate oxidase, peroxidase and H(2)O(2) generation in Al toxicity were studied in barley roots [2].
  • The degradation of endogenous oxalate in rat by immobilized oxalate oxidase has opened a new vistas in enzyme therapy of hyperoxaluria [3].
  • So far, a membrane bound oxalate oxidase from Pseudomonas sp. OX-53 and a soluble oxalate oxidase from seedling plants of barley and grain sorghum has been purified to homogeneity by conventional purification methods [3].
 

Psychiatry related information on LOC548260

 

High impact information on LOC548260

  • Germin with oxalate oxidase and superoxide dismutase activity is a homohexamer of six manganese-containing interlocked beta-jellyroll monomers with extreme resistance to heat and proteolytic degradation [Woo, E.-J., Dunwell, J. M., Goodenough, P. W., Marvier, A. C. & Pickersill, R. W. (2000) Nat. Struct. Biol. 7, 1036-1038] [5].
  • Based on evidence that oxalic acid is involved in the pathogenicity of many Sclerotinia species, our objectives were to recover transgenic peanut plants expressing an oxalic acid-degrading oxalate oxidase and to evaluate them for increased resistance to S. minor [6].
  • In this paper we show that the N terminus of the major pathogen-response oxalate oxidase has a high degree of sequence identity to previously characterized germin-like oxalate oxidases [7].
  • The oxalate oxidase is found exclusively in the leaf mesophyll, where it is cell wall located [7].
  • A model for a signal transduction pathway in which oxalate oxidase plays a central role is proposed for the regulation of the hypersensitive response [7].
 

Biological context of LOC548260

  • Our data suggest the presence of only two oxalate oxidase genes in the barley genome, i.e. a gene encoding HvOxOa, which possibly exists in several copies, and a single-copy gene encoding HvOxOb [7].
  • The results demonstrate that the Rar1 and Rar2 gene products, which are control elements of R-gene-mediated programmed cell death, also control accumulation of reactive oxygen intermediates but not the pathogenesis-related expression of oxalate oxidase [8].
  • An artificial gene for barley oxalate oxidase has been used to produce functional recombinant enzyme in a Pichia pastoris heterologous expression system, yielding 250 mg of purified oxalate oxidase from 5 L of fermentation medium [9].
  • Aluminum-induced cell death of barley-root border cells is correlated with peroxidase- and oxalate oxidase-mediated hydrogen peroxide production [2].
 

Associations of LOC548260 with chemical compounds

  • The involvement of Mn and neither flavin, Cu nor Fe in the direct conversion of dioxygen to H(2)O(2) makes oxalate oxidase unique [10].
  • The recombinant oxalate oxidase was expressed as a soluble, hexameric 140 kDa glycoprotein containing 0.2 g-atom Mn/monomer with a specific activity of 10 U/mg, similar to the properties reported for enzyme isolated from barley [9].
  • The deduced protein sequence of GhGLP1 is similar to Prunus persica auxin-binding proteins, a barley ADP-glucose pyrophosphatase/phosphodiesterase and two different classes of hydrogen peroxide-producing enzymes: wheat germin oxalate oxidase and moss extracellular Mn-superoxide dismutase [11].
  • EPR spectra indicate that the majority of the manganese in the protein is present as Mn(II), and are consistent with the six-coordinate metal center reported in the recent X-ray crystal structure for barley oxalate oxidase [9].
  • Blast QTL also were associated with aldose reductase, oxalate oxidase, JAMyb (a jasmonic acid-induced Myb transcription factor), and peroxidase markers [12].
 

Analytical, diagnostic and therapeutic context of LOC548260

References

  1. Heterologous expression of barley and wheat oxalate oxidase in an E. coli trxB gor double mutant. Cassland, P., Larsson, S., Nilvebrant, N.O., Jönsson, L.J. J. Biotechnol. (2004) [Pubmed]
  2. Aluminum-induced cell death of barley-root border cells is correlated with peroxidase- and oxalate oxidase-mediated hydrogen peroxide production. Tamás, L., Budíková, S., Huttová, J., Mistrík, I., Simonovicová, M., Siroká, B. Plant Cell Rep. (2005) [Pubmed]
  3. Isolation, purification, immobilization of oxalate oxidase and its clinical applications. Pundir, C.S., Verma, U. Hindustan antibiotics bulletin. (1993) [Pubmed]
  4. Enzyme electrode based on oxalate oxidase immobilized in gelatin for specific determination of oxalate. Dinckaya, E., Telefoncu, A. Indian J. Biochem. Biophys. (1993) [Pubmed]
  5. Physical and genetic mapping of barley (Hordeum vulgare) germin-like cDNAs. Druka, A., Kudrna, D., Kannangara, C.G., von Wettstein, D., Kleinhofs, A. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  6. Enhancing resistance to Sclerotinia minor in peanut by expressing a barley oxalate oxidase gene. Livingstone, D.M., Hampton, J.L., Phipps, P.M., Grabau, E.A. Plant Physiol. (2005) [Pubmed]
  7. Molecular characterization of the oxalate oxidase involved in the response of barley to the powdery mildew fungus. Zhou, F., Zhang, Z., Gregersen, P.L., Mikkelsen, J.D., de Neergaard, E., Collinge, D.B., Thordal-Christensen, H. Plant Physiol. (1998) [Pubmed]
  8. Barley Mla and Rar mutants compromised in the hypersensitive cell death response against Blumeria graminis f.sp. hordei are modified in their ability to accumulate reactive oxygen intermediates at sites of fungal invasion. Hückelhoven, R., Fodor, J., Trujillo, M., Kogel, K.H. Planta (2000) [Pubmed]
  9. Characterization of recombinant barley oxalate oxidase expressed by Pichia pastoris. Whittaker, M.M., Whittaker, J.W. J. Biol. Inorg. Chem. (2002) [Pubmed]
  10. Barley (Hordeum vulgare) oxalate oxidase is a manganese-containing enzyme. Requena, L., Bornemann, S. Biochem. J. (1999) [Pubmed]
  11. Cotton fiber germin-like protein. I. Molecular cloning and gene expression. Kim, H.J., Triplett, B.A. Planta (2004) [Pubmed]
  12. Candidate defense genes from rice, barley, and maize and their association with qualitative and quantitative resistance in rice. Ramalingam, J., Vera Cruz, C.M., Kukreja, K., Chittoor, J.M., Wu, J.L., Lee, S.W., Baraoidan, M., George, M.L., Cohen, M.B., Hulbert, S.H., Leach, J.E., Leung, H. Mol. Plant Microbe Interact. (2003) [Pubmed]
  13. Barley oxalate oxidase is a hexameric protein related to seed storage proteins: evidence from X-ray crystallography. Woo, E.J., Dunwell, J.M., Goodenough, P.W., Pickersgill, R.W. FEBS Lett. (1998) [Pubmed]
  14. Chemical modification of barley root oxalate oxidase shows the presence of a lysine, a carboxylate, and disulfides, essential for enzyme activity. Kotsira, V.P., Clonis, Y.D. Arch. Biochem. Biophys. (1998) [Pubmed]
  15. Determination of urinary oxalate with oxalate oxidase and peroxidase immobilized on to glass beads. Pundir, C.S., Kuchhal, N.K., Bhargava, A.K. Biotechnol. Appl. Biochem. (1998) [Pubmed]
 
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