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Gene Review

Mmp8  -  matrix metallopeptidase 8

Rattus norvegicus

Synonyms: MMP-8, Matrix metalloproteinase-8, Neutrophil collagenase
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Disease relevance of Mmp8

  • Marked up-regulation of trypsin and MMP-8 early during hyperoxic lung injury suggests that these enzymes play a role in the pathogenesis of acute lung injury and may therefore be potential targets for therapy of lung injury [1].
  • Biliary decompression results in increased MMP-8 activity co-localized to areas of portal fibrosis and PMN accumulation [2].
  • We conclude that secretion of MMP-8 by neutrophils may play a critical role in resolving the fibrotic scar generated during cholestasis [2].
  • In the present time-course studies of pneumococcal meningitis in infant rats, MMP-8 and -9 were 100- to 1000-fold transcriptionally upregulated, both in CSF cells and in brain tissue [3].
  • RESULTS: LPS injection significantly (P<0.001) increased alveolar bone loss and increased collagenase (MMP-8), gelatinase (MMP-9), and elastase activities [4].

High impact information on Mmp8

  • Western blot data showed that all forms of MMP-8 and MMP-13 were clearly reduced in the CMT-8 treated group compared to OVX [5].
  • Our results show for the first time that MMP-8 mRNA and protein are expressed in rat wound epithelium [5].
  • Westerns were run on the MMPs known to cleave fibrillar collagen in the rat (MMP-8, -13, and -14) as well as TIMP-1, -2, and -4 [6].
  • MMP-8 and MMP-14 protein levels increased later during heart failure progression [6].
  • Up-Regulation of Trypsin and Mesenchymal MMP-8 During Development of Hyperoxic Lung Injury in the Rat [1].

Biological context of Mmp8


Anatomical context of Mmp8


Associations of Mmp8 with chemical compounds


Other interactions of Mmp8

  • In situ zymography was performed by using fluorogenic substrates for MMP-8 and MMP-2 to spatially localize enzymatic activity [2].
  • Because Mmp-8 and -13 expression overlapped with Col2a1 and Col10a1, chondrocytes could play a pivotal role in degradation as well as production of the cartilaginous matrix in MCC [12].
  • In the DTH lesions, significant increases in the level of mRNA expression were observed for MMP-7, MMP-8, MMP-12, and TNFalpha [13].

Analytical, diagnostic and therapeutic context of Mmp8


  1. Up-Regulation of Trypsin and Mesenchymal MMP-8 During Development of Hyperoxic Lung Injury in the Rat. Cederqvist, K., Janer, J., Tervahartiala, T., Sorsa, T., Haglund, C., Salmenkivi, K., Stenman, U.H., Andersson, S. Pediatr. Res. (2006) [Pubmed]
  2. Repair after cholestatic liver injury correlates with neutrophil infiltration and matrix metalloproteinase 8 activity. Harty, M.W., Huddleston, H.M., Papa, E.F., Puthawala, T., Tracy, A.P., Ramm, G.A., Gehring, S., Gregory, S.H., Tracy, T.F. Surgery (2005) [Pubmed]
  3. Inhibition of matrix metalloproteinases and tumour necrosis factor alpha converting enzyme as adjuvant therapy in pneumococcal meningitis. Leib, S.L., Clements, J.M., Lindberg, R.L., Heimgartner, C., Loeffler, J.M., Pfister, L.A., Täuber, M.G., Leppert, D. Brain (2001) [Pubmed]
  4. A combination of a chemically modified doxycycline and a bisphosphonate synergistically inhibits endotoxin-induced periodontal breakdown in rats. Llavaneras, A., Ramamurthy, N.S., Heikkilä, P., Teronen, O., Salo, T., Rifkin, B.R., Ryan, M.E., Golub, L.M., Sorsa, T. J. Periodontol. (2001) [Pubmed]
  5. Wound healing in ovariectomized rats: effects of chemically modified tetracycline (CMT-8) and estrogen on matrix metalloproteinases -8, -13 and type I collagen expression. Pirilä, E., Ramamurthy, N., Maisi, P., McClain, S., Kucine, A., Wahlgren, J., Golub, L., Salo, T., Sorsa, T. Current medicinal chemistry. (2001) [Pubmed]
  6. Evolution of matrix metalloprotease and tissue inhibitor expression during heart failure progression in the infarcted rat. Peterson, J.T., Li, H., Dillon, L., Bryant, J.W. Cardiovasc. Res. (2000) [Pubmed]
  7. Expression of MMP-8 and MMP-13 mRNAs in rat periodontium during tooth eruption. Tsubota, M., Sasano, Y., Takahashi, I., Kagayama, M., Shimauchi, H. J. Dent. Res. (2002) [Pubmed]
  8. Expression of MMP-8 and MMP-13 genes in the periodontal ligament during tooth movement in rats. Takahashi, I., Nishimura, M., Onodera, K., Bae, J.W., Mitani, H., Okazaki, M., Sasano, Y., Mitani, H. J. Dent. Res. (2003) [Pubmed]
  9. Gene expression of MMP8 and MMP13 during embryonic development of bone and cartilage in the rat mandible and hind limb. Sasano, Y., Zhu, J.X., Tsubota, M., Takahashi, I., Onodera, K., Mizoguchi, I., Kagayama, M. J. Histochem. Cytochem. (2002) [Pubmed]
  10. Effects of 17 beta-estradiol on the expression of interstitial collagenases-8 and -13 (MMP-8 and MMP-13) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in ovariectomized rat osteoblastic cells. Li, J., Liao, E.Y., Dai, R.C., Wei, Q.Y., Luo, X.H. J. Mol. Histol. (2004) [Pubmed]
  11. Effects of topical nonsteroidal antiinflammatory drugs on the expression of matrix metalloproteinases in the cornea. Reviglio, V.E., Rana, T.S., Li, Q.J., Ashraf, M.F., Daly, M.K., O'Brien, T.P. Journal of cataract and refractive surgery. (2003) [Pubmed]
  12. Age-related changes in gene expression patterns of matrix metalloproteinases and their collagenous substrates in mandibular condylar cartilage in rats. Bae, J.W., Takahashi, I., Sasano, Y., Onodera, K., Mitani, H., Kagayama, M., Mitani, H. J. Anat. (2003) [Pubmed]
  13. Matrix metalloproteinase expression in an experimentally-induced DTH model of multiple sclerosis in the rat CNS. Anthony, D.C., Miller, K.M., Fearn, S., Townsend, M.J., Opdenakker, G., Wells, G.M., Clements, J.M., Chandler, S., Gearing, A.J., Perry, V.H. J. Neuroimmunol. (1998) [Pubmed]
  14. Influence of pneumoperitoneum on small bowel anastomoses: a histological analysis in the rat model. Rosch, R., Stumpf, M., Junge, K., Drinjakovic, D., Schachtrupp, A., Afify, M., Schumpelick, V. Journal of investigative surgery : the official journal of the Academy of Surgical Research. (2005) [Pubmed]
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