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Gene Review

Mmp8  -  matrix metallopeptidase 8

Mus musculus

Synonyms: BB138268, Collagenase 2, Collagenase-2, MMP-8, Matrix metalloproteinase-8, ...
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Disease relevance of Mmp8


High impact information on Mmp8

  • Bone marrow transplantation experiments confirmed that Mmp8 supplied by neutrophils was sufficient to restore the natural protection against tumor development mediated by this protease in male mice [5].
  • Loss of Mmp8 did not cause abnormalities during embryonic development or in adult mice [5].
  • Loss of collagenase-2 confers increased skin tumor susceptibility to male mice [5].
  • MMP-8 deficiency was associated with increased levels of IL-4 and anti-OVA IgE and IgG1 in BALF and serum, respectively [1].
  • After allergen exposure, MMP-8(-/-) mice developed an airway inflammation characterized by an increased neutrophilic inflammation in BALF and an increased neutrophilic and eosinophilic infiltration in the airway walls [1].

Biological context of Mmp8


Anatomical context of Mmp8


Associations of Mmp8 with chemical compounds

  • PMN infiltration towards LPS is abrogated in Mmp8-null mice [7].

Other interactions of Mmp8

  • Similarly, the messages for MMP-2, MMP-3 and MMP-8 were elevated, indicating the potential for collagen degradation [12].
  • However, with biochemical redundancy between MMPs 1, 2, 9, and 13, which also cleave LIX at position 4 approximately 5, it was surprising to observe such a markedly reduced PMN infiltration towards LPS and LIX in Mmp8-/- mice [7].
  • Neither MMP8 nor TIMP1 mRNA was detected in murine cartilage [13].

Analytical, diagnostic and therapeutic context of Mmp8

  • Northern blot analysis of RNAs isolated from a variety of mouse tissues revealed that collagenase 2 is expressed at late stages during mouse embryogenesis, coinciding with the appearance of hematopoietic cells [6].
  • MMP-8, mainly produced by neutrophils, has recently been reported to be increased in the bronchoalveolar lavage fluid (BALF) from asthmatic patients [1].
  • When C57BL/6 wild-type (n=15) and MMP-8-deficient mice (n=17) were subjected to elastase perfusion, however, ADs at 14 days were no different in size (134+/-7.9% versus 154+/-9.9%; P=0.603), which suggests that MMP-8 serves only as a marker for the presence of neutrophils and is not critical for AAA formation [14].


  1. Matrix metalloproteinase-8 deficiency promotes granulocytic allergen-induced airway inflammation. Gueders, M.M., Balbin, M., Rocks, N., Foidart, J.M., Gosset, P., Louis, R., Shapiro, S., Lopez-Otin, C., Noël, A., Cataldo, D.D. J. Immunol. (2005) [Pubmed]
  2. Carvedilol improves left ventricular function in murine coxsackievirus-induced acute myocarditis association with reduced myocardial interleukin-1beta and MMP-8 expression and a modulated immune response. Pauschinger, M., Rutschow, S., Chandrasekharan, K., Westermann, D., Weitz, A., Peter Schwimmbeck, L., Zeichhardt, H., Poller, W., Noutsias, M., Li, J., Schultheiss, H.P., Tschope, C. Eur. J. Heart Fail. (2005) [Pubmed]
  3. Up-regulation of MMP-8 and MMP-9 activity in the BALB/c mouse spinal cord correlates with the severity of experimental autoimmune encephalomyelitis. Nygårdas, P.T., Hinkkanen, A.E. Clin. Exp. Immunol. (2002) [Pubmed]
  4. Resistance of collagenase-2 (matrix metalloproteinase-8)-deficient mice to TNF-induced lethal hepatitis. Van Lint, P., Wielockx, B., Puimège, L., Noël, A., López-Otin, C., Libert, C. J. Immunol. (2005) [Pubmed]
  5. Loss of collagenase-2 confers increased skin tumor susceptibility to male mice. Balbín, M., Fueyo, A., Tester, A.M., Pendás, A.M., Pitiot, A.S., Astudillo, A., Overall, C.M., Shapiro, S.D., López-Otín, C. Nat. Genet. (2003) [Pubmed]
  6. Collagenase 2 (MMP-8) expression in murine tissue-remodeling processes. Analysis of its potential role in postpartum involution of the uterus. Balbín, M., Fueyo, A., Knäuper, V., Pendás, A.M., López, J.M., Jiménez, M.G., Murphy, G., López-Otín, C. J. Biol. Chem. (1998) [Pubmed]
  7. LPS Responsiveness and Neutrophil Chemotaxis In Vivo Require PMN MMP-8 Activity. Tester, A.M., Cox, J.H., Connor, A.R., Starr, A.E., Dean, R.A., Puente, X.S., López-Otín, C., Overall, C.M. PLoS ONE (2007) [Pubmed]
  8. Epidermal development and wound healing in matrix metalloproteinase 13-deficient mice. Hartenstein, B., Dittrich, B.T., Stickens, D., Heyer, B., Vu, T.H., Teurich, S., Schorpp-Kistner, M., Werb, Z., Angel, P. J. Invest. Dermatol. (2006) [Pubmed]
  9. Matrix Metalloproteinase (MMP)-7 Activates MMP-8 But Not MMP-13. Dozier, S., Escobar, G.P., Lindsey, M.L. Medicinal chemistry (Sh???ariqah, United Arab Emirates) (2006) [Pubmed]
  10. Key metalloproteinases are expressed by specific cell types in experimental autoimmune encephalomyelitis. Toft-Hansen, H., Nuttall, R.K., Edwards, D.R., Owens, T. J. Immunol. (2004) [Pubmed]
  11. The enzymatic degradation of scaffolds and their replacement by vascularized extracellular matrix in the murine myocardium. van Amerongen, M.J., Harmsen, M.C., Petersen, A.H., Kors, G., van Luyn, M.J. Biomaterials (2006) [Pubmed]
  12. Differential expression of collagen, MMP, TIMP and fibrogenic-cytokine genes in the granulomatous colon of Schistosoma mansoni-infected mice. Singh, K.P., Gerard, H.C., Hudson, A.P., Boros, D.L. Ann. Trop. Med. Parasitol. (2006) [Pubmed]
  13. Metalloproteinase and tissue inhibitor of metalloproteinase expression in the murine STR/ort model of osteoarthritis. Flannelly, J., Chambers, M.G., Dudhia, J., Hembry, R.M., Murphy, G., Mason, R.M., Bayliss, M.T. Osteoarthr. Cartil. (2002) [Pubmed]
  14. Neutrophil depletion inhibits experimental abdominal aortic aneurysm formation. Eliason, J.L., Hannawa, K.K., Ailawadi, G., Sinha, I., Ford, J.W., Deogracias, M.P., Roelofs, K.J., Woodrum, D.T., Ennis, T.L., Henke, P.K., Stanley, J.C., Thompson, R.W., Upchurch, G.R. Circulation (2005) [Pubmed]
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