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Gene Review

Mmp7  -  matrix metallopeptidase 7

Rattus norvegicus

Synonyms: MMP-7, Matrilysin, Matrin, Matrix metalloproteinase-7, Mmp-7, ...
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Disease relevance of Mmp7

  • This study suggests that inhibition of MMP-7 will have therapeutic benefit in the treatment of prostate cancer-induced osteolysis [1].
  • Matrix metalloproteinases MMP-9 and MMP-7 are expressed in experimental autoimmune neuritis and the Guillain-Barré syndrome [2].
  • CONCLUSIONS: Hemodynamic overload of the atria is an important pathogenic factor of fibrosis; MMP-7 appears to be involved in the early stage of this tissue remodeling process [3].
  • Increased expression of TRPM-2 and MMP-7 was observed in both premalignant and malignant tissues after sex hormone treatment, indicating their role in the early stages of hormone response and prostate cancer development [4].

High impact information on Mmp7


Biological context of Mmp7


Anatomical context of Mmp7


Associations of Mmp7 with chemical compounds

  • These findings suggest a previously unknown mechanism of vasoregulation whereby agonists of certain GPCRs (such as adrenoceptors and angiotensin receptors) activate MMPs (such as MMP-7) that shed EGFR ligands (such as HB-EGF), which then activate the EGFR, thereby promoting vasoconstriction as well as growth [7].
  • E2 treatment also induced an activity in casein gels of about 27 kDa with properties of MMP-7; that is, molecular mass, inhibition by EDTA, stimulation by heparin sulfate in casein and carboxymethylated transferrin gels [11].
  • In rats treated at pro-oestrus with 0.4 mg progesterone, there was a 70% increase in latent MMP-7, but no change in the active form [12].
  • Two other clones with higher mRNA on the n-cholesterol diet were matrin F/G protein and the NMDA receptor glutamate-binding subunit [13].

Other interactions of Mmp7

  • In the medulla, MMP-9 and MMP-7 were increased, but there was no change in MMP-2 [14].
  • Levels of MMP-7 and MMP-9 were unchanged in developing skin [15].
  • MMP-7 and TIMP-2 expression did not change in response to injury [15].
  • In the DTH lesions, significant increases in the level of mRNA expression were observed for MMP-7, MMP-8, MMP-12, and TNFalpha [16].
  • The remaining eight major proteins termed the nuclear matrins consisted of matrin 3 (125 kDa, slightly acidic), matrin 4 (105 kDa, basic), matrins D-G (60-75 kDa, basic), and matrins 12 and 13 (42-48 kDa, acidic) [17].

Analytical, diagnostic and therapeutic context of Mmp7

  • By using immunohistochemistry, positive immunoreactivity against MMP-9 and MMP-7 was noted and corroborated by demonstrating augmented mRNA expression in comparison with noninflammatory neuropathies [2].


  1. MMP-7 promotes prostate cancer-induced osteolysis via the solubilization of RANKL. Lynch, C.C., Hikosaka, A., Acuff, H.B., Martin, M.D., Kawai, N., Singh, R.K., Vargo-Gogola, T.C., Begtrup, J.L., Peterson, T.E., Fingleton, B., Shirai, T., Matrisian, L.M., Futakuchi, M. Cancer Cell (2005) [Pubmed]
  2. Matrix metalloproteinases MMP-9 and MMP-7 are expressed in experimental autoimmune neuritis and the Guillain-Barré syndrome. Kieseier, B.C., Clements, J.M., Pischel, H.B., Wells, G.M., Miller, K., Gearing, A.J., Hartung, H.P. Ann. Neurol. (1998) [Pubmed]
  3. Fibrosis of the left atria during progression of heart failure is associated with increased matrix metalloproteinases in the rat. Boixel, C., Fontaine, V., Rücker-Martin, C., Milliez, P., Louedec, L., Michel, J.B., Jacob, M.P., Hatem, S.N. J. Am. Coll. Cardiol. (2003) [Pubmed]
  4. Up-regulation of TRPM-2, MMP-7 and ID-1 during sex hormone-induced prostate carcinogenesis in the Noble rat. Ouyang, X.S., Wang, X., Lee, D.T., Tsao, S.W., Wong, Y.C. Carcinogenesis (2001) [Pubmed]
  5. Identification and characterization of a prostaglandin transporter. Kanai, N., Lu, R., Satriano, J.A., Bao, Y., Wolkoff, A.W., Schuster, V.L. Science (1995) [Pubmed]
  6. Dietary zinc modulates gene expression in murine thymus: results from a comprehensive differential display screening. Moore, J.B., Blanchard, R.K., Cousins, R.J. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  7. Agonist-induced activation of matrix metalloproteinase-7 promotes vasoconstriction through the epidermal growth factor-receptor pathway. Hao, L., Du, M., Lopez-Campistrous, A., Fernandez-Patron, C. Circ. Res. (2004) [Pubmed]
  8. Molecular cloning of matrin F/G: A DNA binding protein of the nuclear matrix that contains putative zinc finger motifs. Hakes, D.J., Berezney, R. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  9. Messenger ribonucleic acid levels of collagenase (MMP-13) and matrilysin (MMP-7) in virgin, pregnant, and postpartum uterus and cervix of rat. Wolf, K., Sandner, P., Kurtz, A., Moll, W. Endocrinology (1996) [Pubmed]
  10. The matrix metalloproteinase inhibitor BB-1101 prevents experimental autoimmune uveoretinitis (EAU). Wallace, G.R., Whiston, R.A., Stanford, M.R., Wells, G.M., Gearing, A.J., Clements, J.M. Clin. Exp. Immunol. (1999) [Pubmed]
  11. Matrix metalloproteinases in the pathogenesis of estradiol-induced nonbacterial prostatitis in the lateral prostate lobe of the Wistar rat. Wilson, M.J., Woodson, M., Wiehr, C., Reddy, A., Sinha, A.A. Exp. Mol. Pathol. (2004) [Pubmed]
  12. Matrilysin activity in the rat uterus during the oestrous cycle and implantation. Feng, J., Woessner, J.F., Zhu, C. J. Reprod. Fertil. (1998) [Pubmed]
  13. Application of the random arbitrary primed polymerase chain reaction differential display method to isolate genes of cholesterol metabolism-related proteins from rat liver. Sato, M., Yoshida, S., Nagao, K., Nishizono, S., Kusaba, M., Hung, M.C., Ikeda, I., Imaizumi, K. Biosci. Biotechnol. Biochem. (2000) [Pubmed]
  14. Mechanism of matrix accumulation and glomerulosclerosis in spontaneously hypertensive rats. Camp, T.M., Smiley, L.M., Hayden, M.R., Tyagi, S.C. J. Hypertens. (2003) [Pubmed]
  15. Scarless fetal wounds are associated with an increased matrix metalloproteinase-to-tissue-derived inhibitor of metalloproteinase ratio. Dang, C.M., Beanes, S.R., Lee, H., Zhang, X., Soo, C., Ting, K. Plast. Reconstr. Surg. (2003) [Pubmed]
  16. Matrix metalloproteinase expression in an experimentally-induced DTH model of multiple sclerosis in the rat CNS. Anthony, D.C., Miller, K.M., Fearn, S., Townsend, M.J., Opdenakker, G., Wells, G.M., Clements, J.M., Chandler, S., Gearing, A.J., Perry, V.H. J. Neuroimmunol. (1998) [Pubmed]
  17. Nuclear matrins: identification of the major nuclear matrix proteins. Nakayasu, H., Berezney, R. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
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