Gene Review:
PRDM16 - PR domain containing 16
Homo sapiens
Synonyms:
CMD1LL, KIAA1675, LVNC8, MDS1/EVI1-like gene 1, MEL1, ...
Lin,
Lindner,
Rodriguez-Vicente,
Baker,
Arduini,
Wen,
Chen,
Uchida,
Calderon-Rubiales,
Narumi,
Chen,
Hess,
Whitty,
Sakai,
Pellegrini,
Fujita,
Canteras-Jordana,
Gill,
Brickelmaier,
Tamura,
Petter,
Grant,
Yakushijin,
Lin,
Vicente-Ortega,
Pepinsky,
Yasukawa,
Hato,
- Insertional mutagenesis identifies genes that promote the immortalization of primary bone marrow progenitor cells. Du, Y., Jenkins, N.A., Copeland, N.G. Blood (2005)
- Overexpression of PRDM16 in the presence and absence of the RUNX1/PRDM16 fusion gene in myeloid leukemias. Hazourli, S., Chagnon, P., Sauvageau, M., Fetni, R., Busque, L., Hébert, J. Genes Chromosomes Cancer (2006)
- Informatic selection of a neural crest-melanocyte cDNA set for microarray analysis. Loftus, S.K., Chen, Y., Gooden, G., Ryan, J.F., Birznieks, G., Hilliard, M., Baxevanis, A.D., Bittner, M., Meltzer, P., Trent, J., Pavan, W. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Synergistic antitumor effects of a combination of interferons and retinoic acid on human tumor cells in vitro and in vivo. Lindner, D.J., Borden, E.C., Kalvakolanu, D.V. Clin. Cancer Res. (1997)
- Up-regulated expression of the beta3 integrin and the 92-kDa gelatinase in human HT-144 melanoma cell tumors grown in nude mice. Gouon, V., Tucker, G.C., Kraus-Berthier, L., Atassi, G., Kieffer, N. Int. J. Cancer (1996)
- SKI and MEL1 cooperate to inhibit transforming growth factor-beta signal in gastric cancer cells. Takahata, M., Inoue, Y., Tsuda, H., Imoto, I., Koinuma, D., Hayashi, M., Ichikura, T., Yamori, T., Nagasaki, K., Yoshida, M., Matsuoka, M., Morishita, K., Yuki, K., Hanyu, A., Miyazawa, K., Inazawa, J., Miyazono, K., Imamura, T. J. Biol. Chem. (2009)
- Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1. Ott, M.G., Schmidt, M., Schwarzwaelder, K., Stein, S., Siler, U., Koehl, U., Glimm, H., Kühlcke, K., Schilz, A., Kunkel, H., Naundorf, S., Brinkmann, A., Deichmann, A., Fischer, M., Ball, C., Pilz, I., Dunbar, C., Du, Y., Jenkins, N.A., Copeland, N.G., Lüthi, U., Hassan, M., Thrasher, A.J., Hoelzer, D., von Kalle, C., Seger, R., Grez, M. Nat. Med. (2006)
- Aberrant expression of the MEL1S gene identified in association with hypomethylation in adult T-cell leukemia cells. Yoshida, M., Nosaka, K., Yasunaga, J., Nishikata, I., Morishita, K., Matsuoka, M. Blood (2004)
- Molecular characterization of a t(1;3)(p36;q21) in a patient with MDS. MEL1 is widely expressed in normal tissues, including bone marrow, and it is not overexpressed in the t(1;3) cells. Lahortiga, I., Agirre, X., Belloni, E., Vázquez, I., Larrayoz, M.J., Gasparini, P., Lo Coco, F., Pelicci, P.G., Calasanz, M.J., Odero, M.D. Oncogene (2004)
- Induction of G(1) cell cycle arrest and p27(KIP1) increase by panaxydol isolated from Panax ginseng. Moon, J., Yu, S.J., Kim, H.S., Sohn, J. Biochem. Pharmacol. (2000)
- Azelaic acid was sensitizing effect in the chemotherapeutic treatment of several melanoma cell lines. Rodriguez-Vicente, J., Vicente-Ortega, V., Canteras-Jordana, n.u.l.l. Pigment Cell Res. (1996)
- Relationship between 4-hydroxyanisole toxicity and dopa oxidase activity for three melanoma cell lines. Rodriguez-Vicente, J., Vicente-Ortega, V., Canteras-Jordana, M., Calderon-Rubiales, F. Melanoma Res. (1997)
- The effects of different antineoplastic agents and of pretreatment by modulators on three melanoma lines. Rodriguez-Vicente, J., Vicente-Ortega, V., Canteras-Jordana, M. Cancer (1998)
- Immunohistochemical detection of melanoma-specific antigens in spontaneous canine melanoma. Sulaimon, S., Kitchell, B., Ehrhart, E. J. Comp. Pathol. (2002)
- Low expression of MDS1-EVI1-like-1 (MEL1) and EVI1-like-1 (EL1) genes in favorable-risk acute myeloid leukemia. Barjesteh van Waalwijk van Doorn-Khosrovani, S., Erpelinck, C., Löwenberg, B., Delwel, R. Exp. Hematol. (2003)
- Effects of several flavonoids on the growth of B16F10 and SK-MEL-1 melanoma cell lines: relationship between structure and activity. Rodriguez, J., Yáñez, J., Vicente, V., Alcaraz, M., Benavente-García, O., Castillo, J., Lorente, J., Lozano, J.A. Melanoma Res. (2002)
- N-terminally PEGylated human interferon-beta-1a with improved pharmacokinetic properties and in vivo efficacy in a melanoma angiogenesis model. Baker, D.P., Lin, E.Y., Lin, K., Pellegrini, M., Petter, R.C., Chen, L.L., Arduini, R.M., Brickelmaier, M., Wen, D., Hess, D.M., Chen, L., Grant, D., Whitty, A., Gill, A., Lindner, D.J., Pepinsky, R.B. Bioconjug. Chem. (2006)
- Binding characteristics and daily rhythms of melatonin receptors are distinct in the retina and the brain areas of the European sea bass retina (Dicentrarchus labrax). Bayarri, M.J., Iigo, M., Muñoz-Cueto, J.A., Isorna, E., Delgado, M.J., Madrid, J.A., Sánchez-Vázquez, F.J., Alonso-Gómez, A.L. Brain Res. (2004)
- Novel RUNX1-PRDM16 fusion transcripts in a patient with acute myeloid leukemia showing t(1;21)(p36;q22). Sakai, I., Tamura, T., Narumi, H., Uchida, N., Yakushijin, Y., Hato, T., Fujita, S., Yasukawa, M. Genes Chromosomes Cancer (2005)
- Breakpoints at 1p36.3 in three MDS/AML(M4) patients with t(1;3)(p36;q21) occur in the first intron and in the 5' region of MEL1. Xinh, P.T., Tri, N.K., Nagao, H., Nakazato, H., Taketazu, F., Fujisawa, S., Yagasaki, F., Chen, Y.Z., Hayashi, Y., Toyoda, A., Hattori, M., Sakaki, Y., Tokunaga, K., Sato, Y. Genes Chromosomes Cancer (2003)