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Gene Review

Aqp8  -  aquaporin 8

Mus musculus

Synonyms: AI255744, AQP-8, Aquaporin-8
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Disease relevance of Aqp8


High impact information on Aqp8


Biological context of Aqp8


Anatomical context of Aqp8


Associations of Aqp8 with chemical compounds

  • Mice lacking AQP7 and AQP8 can concentrate their urine fully, although AQP7 null mice manifest an interesting defect in glycerol reabsorption [10].
  • Normalization for oocyte plasma membrane expression using cMyc-tagged AQP8 indicated a single channel water permeability of 8.2 x 10(-14) cm3/s. AQP8 is unique among the water channels in terms of its urea permeability and its strong expression in gastrointestinal organs, placenta and heart [7].

Other interactions of Aqp8


Analytical, diagnostic and therapeutic context of Aqp8

  • Organ weight and serum/urine chemistries were similar in wild-type and AQP8-null mice, except for increased testicular weight in the null mice (4.8 +/- 0.7 vs. 7.3 +/- 0.3 mg/g body wt) [1].
  • Northern blotting showed strong AQP8 expression between fetal day 17 and birth as well as at weaning and thereafter [4].
  • AQP8-facilitated NH(3) transport was confirmed in mammalian cell cultures expressing rat or mouse AQP8, in which the fluorescence of a pH-sensing yellow fluorescent protein was measured in response to ammonia (NH(3)/NH(4)(+)) gradients [13].
  • Immunoblotting with subcellular membrane fractions of ANSCs showed predominant expression of AQP8 in the mitochondria-enriched fraction [14].
  • Immunohistochemistry and immunoblot analysis showed that aquaporin-8 was expressed in the basal component of fetal membranes, and that the protein level was significantly decreased to 60% at 20 GD compared with that at 14 GD [2].


  1. Phenotype analysis of aquaporin-8 null mice. Yang, B., Song, Y., Zhao, D., Verkman, A.S. Am. J. Physiol., Cell Physiol. (2005) [Pubmed]
  2. Reduction of aquaporin-8 on fetal membranes under oligohydramnios in mice lacking prostaglandin F2 alpha receptor. Shioji, M., Fukuda, H., Kanzaki, T., Wasada, K., Kanagawa, T., Shimoya, K., Mu, J., Sugimoto, Y., Murata, Y. J. Obstet. Gynaecol. Res. (2006) [Pubmed]
  3. Aquaporins in the kidney: from molecules to medicine. Nielsen, S., Frøkiaer, J., Marples, D., Kwon, T.H., Agre, P., Knepper, M.A. Physiol. Rev. (2002) [Pubmed]
  4. Ontogeny, distribution, and possible functional implications of an unusual aquaporin, AQP8, in mouse liver. Ferri, D., Mazzone, A., Liquori, G.E., Cassano, G., Svelto, M., Calamita, G. Hepatology (2003) [Pubmed]
  5. Evidence against functionally significant aquaporin expression in mitochondria. Yang, B., Zhao, D., Verkman, A.S. J. Biol. Chem. (2006) [Pubmed]
  6. Cloning, structural organization and chromosomal localization of the mouse aquaporin-8 water channel gene (Aqp8). Calamita, G., Spalluto, C., Mazzone, A., Rocchi, M., Svelto, M. Cytogenet. Cell Genet. (1999) [Pubmed]
  7. Cloning of a novel water and urea-permeable aquaporin from mouse expressed strongly in colon, placenta, liver, and heart. Ma, T., Yang, B., Verkman, A.S. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  8. Gallbladder histopathology during murine gallstone formation: relation to motility and concentrating function. van Erpecum, K.J., Wang, D.Q., Moschetta, A., Ferri, D., Svelto, M., Portincasa, P., Hendrickx, J.J., Schipper, M., Calamita, G. J. Lipid Res. (2006) [Pubmed]
  9. Aquaporin water channel genes are differentially expressed and regulated by ovarian steroids during the periimplantation period in the mouse. Richard, C., Gao, J., Brown, N., Reese, J. Endocrinology (2003) [Pubmed]
  10. Roles of aquaporins in kidney revealed by transgenic mice. Verkman, A.S. Semin. Nephrol. (2006) [Pubmed]
  11. Utilization of different aquaporin water channels in the mouse cervix during pregnancy and parturition and in models of preterm and delayed cervical ripening. Anderson, J., Brown, N., Mahendroo, M.S., Reese, J. Endocrinology (2006) [Pubmed]
  12. Estrogen regulation of aquaporins in the mouse uterus: potential roles in uterine water movement. Jablonski, E.M., McConnell, N.A., Hughes, F.M., Huet-Hudson, Y.M. Biol. Reprod. (2003) [Pubmed]
  13. Evidence from knockout mice against physiologically significant aquaporin 8-facilitated ammonia transport. Yang, B., Zhao, D., Solenov, E., Verkman, A.S. Am. J. Physiol., Cell Physiol. (2006) [Pubmed]
  14. Adult murine CNS stem cells express aquaporin channels. La Porta, C.A., Gena, P., Gritti, A., Fascio, U., Svelto, M., Calamita, G. Biol. Cell (2006) [Pubmed]
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