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Gene Review

NECAB1  -  N-terminal EF-hand calcium binding protein 1

Homo sapiens

Synonyms: EF-hand calcium-binding protein 1, EFCBP1, N-terminal EF-hand calcium-binding protein 1, Neuronal calcium-binding protein 1, STIP-1
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Disease relevance of EFCBP1


High impact information on EFCBP1


Biological context of EFCBP1


Anatomical context of EFCBP1


Associations of EFCBP1 with chemical compounds


Physical interactions of EFCBP1

  • The crystal structure of human EF-hand calcium-binding protein S100A12 in its calcium-bound form has been determined to 1.95 A resolution by molecular replacement using the structure of the S100B protein [19].

Other interactions of EFCBP1


Analytical, diagnostic and therapeutic context of EFCBP1


  1. High level expression in Escherichia coli and characterization of the EF-hand calcium-binding protein caltractin. Weber, C., Lee, V.D., Chazin, W.J., Huang, B. J. Biol. Chem. (1994) [Pubmed]
  2. The calcium-binding protein S100A2 interacts with p53 and modulates its transcriptional activity. Mueller, A., Schäfer, B.W., Ferrari, S., Weibel, M., Makek, M., Höchli, M., Heizmann, C.W. J. Biol. Chem. (2005) [Pubmed]
  3. Profilin (Che a 2) and polcalcin (Che a 3) are relevant allergens of Chenopodium album pollen: isolation, amino acid sequences, and immunologic properties. Barderas, R., Villalba, M., Pascual, C.Y., Batanero, E., Rodríguez, R. J. Allergy Clin. Immunol. (2004) [Pubmed]
  4. NMR assignments, secondary structure, and global fold of calerythrin, an EF-hand calcium-binding protein from Saccharopolyspora erythraea. Aitio, H., Annila, A., Heikkinen, S., Thulin, E., Drakenberg, T., Kilpeläinen, I. Protein Sci. (1999) [Pubmed]
  5. S100A4 (p9Ka) protein in colon carcinoma and liver metastases: association with carcinoma cells and T-lymphocytes. Taylor, S., Herrington, S., Prime, W., Rudland, P.S., Barraclough, R. Br. J. Cancer (2002) [Pubmed]
  6. Isolation and characterization of a downstream target of Pax6 in the mammalian retinal primordium. Bernier, G., Vukovich, W., Neidhardt, L., Herrmann, B.G., Gruss, P. Development (2001) [Pubmed]
  7. Human S100B protein interacts with the Escherichia coli division protein FtsZ in a calcium-sensitive manner. Ferguson, P.L., Shaw, G.S. J. Biol. Chem. (2004) [Pubmed]
  8. Calbrain, a novel two EF-hand calcium-binding protein that suppresses Ca2+/calmodulin-dependent protein kinase II activity in the brain. Yamaguchi, K., Yamaguchi, F., Miyamoto, O., Sugimoto, K., Konishi, R., Hatase, O., Tokuda, M. J. Biol. Chem. (1999) [Pubmed]
  9. Molecular cloning and characterization of grancalcin, a novel EF-hand calcium-binding protein abundant in neutrophils and monocytes. Boyhan, A., Casimir, C.M., French, J.K., Teahan, C.G., Segal, A.W. J. Biol. Chem. (1992) [Pubmed]
  10. Purification, biochemical, and immunological characterisation of a major food allergen: different immunoglobulin E recognition of the apo- and calcium-bound forms of carp parvalbumin. Bugajska-Schretter, A., Grote, M., Vangelista, L., Valent, P., Sperr, W.R., Rumpold, H., Pastore, A., Reichelt, R., Valenta, R., Spitzauer, S. Gut (2000) [Pubmed]
  11. EFCBP1/NECAB1, a brain-specifically expressed gene with highest abundance in temporal lobe, encodes a protein containing EF-hand and antibiotic biosynthesis monooxygenase domains. Wu, H., Li, D., Shan, Y., Wan, B., Hexige, S., Guo, J., Wu, C., Yu, L. DNA Seq. (2007) [Pubmed]
  12. Solution structure and backbone dynamics of Calsensin, an invertebrate neuronal calcium-binding protein. Venkitaramani, D.V., Fulton, D.B., Andreotti, A.H., Johansen, K.M., Johansen, J. Protein Sci. (2005) [Pubmed]
  13. Prokaryotic calcium-binding protein of the calmodulin superfamily. Calcium binding to a Saccharopolyspora erythraea 20 kDa protein. Bylsma, N., Drakenberg, T., Andersson, I., Leadlay, P.F., Forsén, S. FEBS Lett. (1992) [Pubmed]
  14. Calcium- and magnesium-dependent interactions between calcium- and integrin-binding protein and the integrin alphaIIb cytoplasmic domain. Yamniuk, A.P., Vogel, H.J. Protein Sci. (2005) [Pubmed]
  15. Involvement of Iba1 in membrane ruffling and phagocytosis of macrophages/microglia. Ohsawa, K., Imai, Y., Kanazawa, H., Sasaki, Y., Kohsaka, S. J. Cell. Sci. (2000) [Pubmed]
  16. Somal size of immunolabeled pyramidal cells in the prefrontal cortex of subjects with schizophrenia. Maldonado-Avilés, J.G., Wu, Q., Sampson, A.R., Lewis, D.A. Biol. Psychiatry (2006) [Pubmed]
  17. The allergen profile of ash (Fraxinus excelsior) pollen: cross-reactivity with allergens from various plant species. Niederberger, V., Purohit, A., Oster, J.P., Spitzauer, S., Valenta, R., Pauli, G. Clin. Exp. Allergy (2002) [Pubmed]
  18. Identification of a putative calcium-binding protein as a dioxin-responsive gene in zebrafish and rainbow trout. Cao, Z., Tanguay, R.L., McKenzie, D., Peterson, R.E., Aiken, J.M. Aquat. Toxicol. (2003) [Pubmed]
  19. The three-dimensional structure of human S100A12. Moroz, O.V., Antson, A.A., Murshudov, G.N., Maitland, N.J., Dodson, G.G., Wilson, K.S., Skibshøj, I., Lukanidin, E.M., Bronstein, I.B. Acta Crystallogr. D Biol. Crystallogr. (2001) [Pubmed]
  20. Unmasking the annexin I interaction from the structure of Apo-S100A11. Dempsey, A.C., Walsh, M.P., Shaw, G.S. Structure (Camb.) (2003) [Pubmed]
  21. Metastasis-associated protein Mts1 (S100A4) inhibits CK2-mediated phosphorylation and self-assembly of the heavy chain of nonmuscle myosin. Kriajevska, M., Bronstein, I.B., Scott, D.J., Tarabykina, S., Fischer-Larsen, M., Issinger, O., Lukanidin, E. Biochim. Biophys. Acta (2000) [Pubmed]
  22. The biochemical effect of Ser167 phosphorylation on Chlamydomonas reinhardtii centrin. Meyn, S.M., Seda, C., Campbell, M., Weiss, K.L., Hu, H., Pastrana-Rios, B., Chazin, W.J. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  23. Calretinin-immunoreactive elements in the retina and optic tectum of the frog, Rana esculenta. Gábriel, R., Völgyi, B., Pollák, E. Brain Res. (1998) [Pubmed]
  24. S100P calcium-binding protein overexpression is associated with immortalization of human breast epithelial cells in vitro and early stages of breast cancer development in vivo. Guerreiro Da Silva, I.D., Hu, Y.F., Russo, I.H., Ao, X., Salicioni, A.M., Yang, X., Russo, J. Int. J. Oncol. (2000) [Pubmed]
  25. Differential expression of the EF-hand calcium-binding protein calsensin in the central nervous system of hirudinid leeches. Veldman, M., Huang, Y., Jellies, J., Johansen, K.M., Johansen, J. Cell Tissue Res. (1996) [Pubmed]
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