Gene Review:
Dck - deoxycytidine kinase
Rattus norvegicus
Synonyms:
Deoxycytidine kinase, dCK
- Viral vector transduction of the human deoxycytidine kinase cDNA sensitizes glioma cells to the cytotoxic effects of cytosine arabinoside in vitro and in vivo. Manome, Y., Wen, P.Y., Dong, Y., Tanaka, T., Mitchell, B.S., Kufe, D.W., Fine, H.A. Nat. Med. (1996)
- Detection of an alternatively spliced form of deoxycytidine kinase mRNA in the 2'-2'-difluorodeoxycytidine (gemcitabine)-resistant human ovarian cancer cell line AG6000. Al-Madhoun, A.S., van der Wilt, C.L., Loves, W.J., Padron, J.M., Eriksson, S., Talianidis, I., Peters, G.J. Biochem. Pharmacol. (2004)
- Regulation of deoxycytidine kinase activity and inhibition by DFDC. Weber, G., Singhal, R.L., Abonyi, M., Prajda, N., Hata, Y., Szekeres, T., Yeh, A., Look, K.Y. Adv. Enzyme Regul. (1993)
- Increased deoxycytidine kinase activity in cancer cells and inhibition by difluorodeoxycytidine. Singhal, R.L., Yeh, Y.A., Szekeres, T., Weber, G. Oncol. Res. (1992)
- High incidence of alternatively spliced forms of deoxycytidine kinase in patients with resistant acute myeloid leukemia. Veuger, M.J., Honders, M.W., Landegent, J.E., Willemze, R., Barge, R.M. Blood (2000)
- Cloning of the Dck gene encoding rat deoxycytidine kinase. Stegmann, A.P., Honders, M.W., Willemze, R., Landegent, J.E. Gene (1994)
- Transfection of wild-type deoxycytidine kinase (dck) cDNA into an AraC- and DAC-resistant rat leukemic cell line of clonal origin fully restores drug sensitivity. Stegmann, A.P., Honders, W.H., Willemze, R., Ruiz van Haperen, V.W., Landegent, J.E. Blood (1995)
- Modifications of deoxycytidine kinase and deaminase activities by docosahexaenoic acid in normal and transformed rat fibroblasts. Cha, M.C., Meckling-Gill, K.A. Biochem. Pharmacol. (2002)
- Substrate-specific deoxycytidine kinase deficiency in 1-beta-D-arabinofuranosylcytosine-resistant leukemic cells. Richel, D.J., Colly, L.P., Arkesteijn, G.J., Arentsen-Honders, M.W., Kerster, M.G., ter Riet, P.M., Willemze, R. Cancer Res. (1990)
- Role of deoxycytidine kinase in an in vitro model for AraC- and DAC-resistance: substrate-enzyme interactions with deoxycytidine, 1-beta-D-arabinofuranosylcytosine and 5-aza-2'-deoxycytidine. Stegmann, A.P., Honders, M.W., Kester, M.G., Landegent, J.E., Willemze, R. Leukemia (1993)
- Deoxycytidine kinase and thymidine kinase activities in rat brain. Singhal, R.L., Weber, G. Oncol. Res. (1993)
- In vitro-induced resistance to the deoxycytidine analogues cytarabine (AraC) and 5-aza-2'-deoxycytidine (DAC) in a rat model for acute myeloid leukemia is mediated by mutations in the deoxycytidine kinase (dck) gene. Stegmann, A.P., Honders, M.W., Hagemeijer, A., Hoebee, B., Willemze, R., Landegent, J.E. Ann. Hematol. (1995)
- A novel RT-PCR-based protein activity truncation assay for direct assessment of deoxycytidine kinase in small numbers of purified leukemic cells. Veuger, M.J., Honders, M.W., Landegent, J.E., Willemze, R., Barge, R.M. Leukemia (2000)