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Gene Review

Sgpp1  -  sphingosine-1-phosphate phosphatase 1

Mus musculus

Synonyms: AI463453, SPP, SPP1, SPPase1, Sphingosine-1-phosphatase 1, ...
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Disease relevance of Sgpp1


High impact information on Sgpp1


Chemical compound and disease context of Sgpp1

  • Consistent with the coupling of Edg receptors to G proteins, SPP- and SPC-induced Ca2+ signaling was inhibited by pretreatment of the cells with pertussis toxin (PTx) [9].
  • Moreover, this abrogation of caspase activation, which was prevented by the SPHK inhibitor N,N-dimethylsphingosine, was not affected by pertussis toxin treatment, indicating that the cytoprotective effect was likely not mediated by binding of SPP to cell surface G(i)-coupled SPP receptors [4].
  • Here the first evidence is provided that in C2C12 myoblasts sphingosine 1-phosphate (SPP) rapidly and transiently induced membrane association of Rho A in a pertussis toxin-insensitive manner [10].

Biological context of Sgpp1


Anatomical context of Sgpp1

  • Treatment of SPP-1 transfectants with S1P markedly increased ceramide levels, predominantly in the intracellular membranes, diminished survival, and enhanced apoptosis [8].
  • Enforced expression of mSPP1 in NIH 3T3 fibroblasts not only decreased SPP and enhanced ceramide levels, it also markedly diminished survival and induced the characteristic traits of apoptosis [11].
  • Activation of these channels occurred strictly when SPP was applied at the extracellular face of atrial myocyte plasma membrane as measured in cell-attached and inside-out patch clamp current recordings [3].
  • Thus, EDG receptors are expressed in pancreatic islet beta-cells and G(i) seems to mediate the inhibition by SPP of adenylyl cyclase and cAMP formation and inhibition of the stimulation of insulin secretion by GLP-1 [13].
  • In this report, pharmacological properties of the three G-protein-coupled receptors (GPCRs) for SPP, EDG-1, -3, and -5 are characterized using a Xenopus oocyte expression system, which lacks endogenous SPP receptors [14].

Associations of Sgpp1 with chemical compounds

  • Membrane fractions from human embryonic kidney HEK293 cells transfected with mSPP1 markedly degraded SPP but not lysophosphatidic acid, phosphatidic acid, or ceramide-1-phosphate [11].
  • 5. Similar to other LPPs, SPP1 activity was also independent of any cation requirements, including Mg(2+), and was not inhibited by EDTA but was markedly inhibited by NaF and Zn(2+) [12].
  • Edg-1 binds SPP with remarkable specificity as only sphinganine-1-phosphate displaced radiolabeled SPP, while other sphingolipids did not [1].
  • Sphingosine 1-phosphate (SPP) has recently emerged as an important lipid messenger and a ligand for the endothelial differentiation gene receptor family of proteins through which it mediates its biologic effects [15].
  • Sphingosine, a metabolic precursor of SPP, also produced a slight increase in tyrosine phosphorylation of Crk [16].

Other interactions of Sgpp1


Analytical, diagnostic and therapeutic context of Sgpp1


  1. Dual actions of sphingosine-1-phosphate: extracellular through the Gi-coupled receptor Edg-1 and intracellular to regulate proliferation and survival. Van Brocklyn, J.R., Lee, M.J., Menzeleev, R., Olivera, A., Edsall, L., Cuvillier, O., Thomas, D.M., Coopman, P.J., Thangada, S., Liu, C.H., Hla, T., Spiegel, S. J. Cell Biol. (1998) [Pubmed]
  2. The transcriptional coactivator FHL2 transmits Rho signals from the cell membrane into the nucleus. Müller, J.M., Metzger, E., Greschik, H., Bosserhoff, A.K., Mercep, L., Buettner, R., Schüle, R. EMBO J. (2002) [Pubmed]
  3. Activation of a high affinity Gi protein-coupled plasma membrane receptor by sphingosine-1-phosphate. van Koppen, C., Meyer zu Heringdorf, M., Laser, K.T., Zhang, C., Jakobs, K.H., Bünemann, M., Pott, L. J. Biol. Chem. (1996) [Pubmed]
  4. Sphingosine kinase expression regulates apoptosis and caspase activation in PC12 cells. Edsall, L.C., Cuvillier, O., Twitty, S., Spiegel, S., Milstien, S. J. Neurochem. (2001) [Pubmed]
  5. Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate. Lee, M.J., Thangada, S., Claffey, K.P., Ancellin, N., Liu, C.H., Kluk, M., Volpi, M., Sha'afi, R.I., Hla, T. Cell (1999) [Pubmed]
  6. Overexpression of acid ceramidase protects from tumor necrosis factor-induced cell death. Strelow, A., Bernardo, K., Adam-Klages, S., Linke, T., Sandhoff, K., Krönke, M., Adam, D. J. Exp. Med. (2000) [Pubmed]
  7. Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation. Liu, Y., Wada, R., Yamashita, T., Mi, Y., Deng, C.X., Hobson, J.P., Rosenfeldt, H.M., Nava, V.E., Chae, S.S., Lee, M.J., Liu, C.H., Hla, T., Spiegel, S., Proia, R.L. J. Clin. Invest. (2000) [Pubmed]
  8. Sphingosine-1-phosphate phosphohydrolase in regulation of sphingolipid metabolism and apoptosis. Le Stunff, H., Galve-Roperh, I., Peterson, C., Milstien, S., Spiegel, S. J. Cell Biol. (2002) [Pubmed]
  9. A role for G protein-coupled lysophospholipid receptors in sphingolipid-induced Ca2+ signaling in MC3T3-E1 osteoblastic cells. Lyons, J.M., Karin, N.J. J. Bone Miner. Res. (2001) [Pubmed]
  10. Permissive role of protein kinase C alpha but not protein kinase C delta in sphingosine 1-phosphate-induced Rho A activation in C2C12 myoblasts. Meacci, E., Donati, C., Cencetti, F., Romiti, E., Bruni, P. FEBS Lett. (2000) [Pubmed]
  11. Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death. Mandala, S.M., Thornton, R., Galve-Roperh, I., Poulton, S., Peterson, C., Olivera, A., Bergstrom, J., Kurtz, M.B., Spiegel, S. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  12. Characterization of murine sphingosine-1-phosphate phosphohydrolase. Le Stunff, H., Peterson, C., Thornton, R., Milstien, S., Mandala, S.M., Spiegel, S. J. Biol. Chem. (2002) [Pubmed]
  13. Endothelial differentiation gene receptors in pancreatic islets and INS-1 cells. Laychock, S.G., Tian, Y., Sessanna, S.M. Diabetes (2003) [Pubmed]
  14. Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5. Ancellin, N., Hla, T. J. Biol. Chem. (1999) [Pubmed]
  15. Cystic fibrosis transmembrane regulator regulates uptake of sphingoid base phosphates and lysophosphatidic acid: modulation of cellular activity of sphingosine 1-phosphate. Boujaoude, L.C., Bradshaw-Wilder, C., Mao, C., Cohn, J., Ogretmen, B., Hannun, Y.A., Obeid, L.M. J. Biol. Chem. (2001) [Pubmed]
  16. Sphingosine 1-phosphate stimulates tyrosine phosphorylation of Crk. Blakesley, V.A., Beitner-Johnson, D., Van Brocklyn, J.R., Rani, S., Shen-Orr, Z., Stannard, B.S., Spiegel, S., LeRoith, D. J. Biol. Chem. (1997) [Pubmed]
  17. Sphingosine-1-phosphate inhibits cell migration and endothelial to mesenchymal cell transformation during cardiac development. Wendler, C.C., Rivkees, S.A. Dev. Biol. (2006) [Pubmed]
  18. Difference and similarity of DNA sequence recognized by VDR homodimer and VDR/RXR heterodimer. Nishikawa, J., Kitaura, M., Matsumoto, M., Imagawa, M., Nishihara, T. Nucleic Acids Res. (1994) [Pubmed]
  19. Immunochemical comparison of transformation-associated protein and secreted phosphoprotein. Chan, J.C., Scanlon, M., Denhardt, D.T., Singh, K., Mukherjee, B.B., Farach-Carson, M.C., Butler, W.T. Int. J. Cancer (1990) [Pubmed]
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