Disease relevance of KALRN

• BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders [1].
• Adult respiratory distress syndrome and gram-negative sepsis: a deadly duo [2].
• Stem cells in unstable angina: the dynamic duo [3].
• A merging duo in melanoma formation [4].
• Chimerism testing and detection of minimal residual disease after allogeneic hematopoietic transplantation using the bioView (Duet) combined morphological and cytogenetical analysis [5].

High impact information on KALRN

• Overexpression of dominant-negative EphB receptor, catalytically inactive kalirin, or dominant-negative Rac1, or inhibition of PAK eliminates ephrin-induced spine development [6].
• A dynamic duo of microtubule modulators [7].
• PAM-CD interactor proteins include a protein kinase that phosphorylates PAM (P-CIP2) and Kalirin, a Rho family GDP/GTP exchange factor [8].
• Induction of lamellipodia by Kalirin does not require its guanine nucleotide exchange factor activity [9].
• Adolescents with PCOS (n = 32; age, approximately 15 yr; body mass index, approximately 22 kg/m(2)) were randomly assigned to receive the oral contraceptive (OC) ethinylestradiol-drospirenone, or the low-dose generic duo of flutamide (62.5 mg/d) plus metformin (850 mg/d) [10].

Chemical compound and disease context of KALRN

• Two fourth-generation assays, HIV DUO (Biomérieux) and HIV Combi (Boehringer Mannheim), for the combined detection of HIV antigen and antibody, were compared with a third-generation assay (HIV-1/HIV-2 3rd Generation Plus enzyme immunoassay [EIA]; Abbott) and a p24 antigen test (HIV-1 Ag monoclonal; Abbott) [11].
• Propylene glycol interference in the Vidas HIV DUO assay [12].

Biological context of KALRN

• For Kalirin, numerous isoforms containing different combinations of functional domains are generated through alternative splicing and use of alternative transcriptional start sites [13].
• The kinase domain of Duet shows a homology to that of DAP kinase that is involved in apoptosis, and Duet is autophosphorylated by an in-vitro kinase assay [14].
• Additionally, the vector duo allows co-propagation of different transgenes as well as mobilization of a third replication-defective vector [15].
• Two a priori probabilities were calculated for each VNTR locus separately and for all eight loci jointly: (i) the "power of exclusion" for an alleged father/mother/child trio and for an alleged parent/child duo, and (ii) the "probability of matching" when two unrelated individuals or two siblings are genotyped [16].
• This activation, which is spatially and temporally regulated, allows Kalirin to influence neurite initiation, axonal growth, and dendritic morphogenesis [17].

Anatomical context of KALRN

• Trad mRNA is specifically expressed in skeletal muscle [14].
• The cytosol was then fractionated on a duo-gel column of G-50 Sephadex over Bio-gel A 1.5m and fractions counted for 3H, assayed for protein and plotted graphically [18].
• A dangerous duo? A combination of common diet drugs (fen-phen) may lead to heart valve disease [19].
• A randomized trial comparing the hand-mounted JoStent with the premounted Multi-Link Duet stent in patients with coronary artery disease [20].
• The specific objective of this experiment was to investigate the possible interrelationship between RAW and human monocyte/macrophage cells at the biochemical and morphological level after being in contact with three different dental cement ionomers (Fuji Duet, Fuji IX, and GC-Fuji-Ortho, GC America Inc., Chicago IL) for 72 hours [21].

Associations of KALRN with chemical compounds

• We show here the identification of Duet, a novel molecule bearing serine/threonine kinase, Dbl-Homology (DH), and Pleckstrin-Homology (PH) domains [14].
• Dopamine and prolactin--an imperfect duo in circadian rhythmicity [22].
• Routine, formalin-fixed, paraffin-embedded tumour samples were used and sections were stained immunohistochemically using the Duet StreptABC method [23].
• L-type calcium channels and NMDA receptors: a determinant duo for short-term nociceptive plasticity [24].
• Four hundred and six patients underwent stent implantation for single discrete coronary artery lesion: 105 received a 16 mm Paragon stent, 112 an 18 mm Multilink Duet, 97 a 16 mm NIR Primo stent, and 92 a 15 or 18 mm NIR Royal Advance [25].
• KALRN is a protein with many functions, including the inhibition of inducible nitric oxide synthase and guanine-exchange-factor activity [26].

Physical interactions of KALRN

• RESULTS: iNOS interacts with the inhibitory molecules Kalirin and NOS-associated protein 1.10 kd (NAP110), which inhibit iNOS homodimerization, as well as activator proteins, the Rac-GTPases [27].

Other interactions of KALRN

• Kalirin isoforms are predominantly expressed in the brain, while Trio is expressed in a wider variety of tissues [13].
• Humans, like rats, express a large set of Kalirin isoform mRNAs, and we identified a novel Kalirin isoform, containing only the second GEF domain [13].
• Kalirin: a dual Rho guanine nucleotide exchange factor that is so much more than the sum of its many parts [17].

Analytical, diagnostic and therapeutic context of KALRN

• Ten seroconversions were detected an average of 8.1 days earlier with HIV DUO and 7.5 days earlier with HIV Combi than with the third-generation ELISA [11].
• In conclusion, VIDAS HIV DUO Ultra can replace single-antigen screening for laboratory diagnosis and screening of HIV infection in blood donors [28].
• HIV antigen was detected with HIV DUO and HIV Combi in all of the 15 cell culture supernatants infected with different HIV-1 subtypes, including subtype O [11].
• The VIDAS HIV DUO Ultra, a fourth-generation immunoassay under development for the simultaneous detection of human immunodeficiency virus type 1 (HIV-1) p24 antigen and antibodies to HIV-1 and HIV-2, was evaluated [29].
• The subjects practiced the procedure described, directed toward self-care and mutual aid facilitated and supported by the duo, in a series of ten 2-hour weekly sessions [30].

References