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Gene Review

ERVE-1  -  endogenous retrovirus group E, member 1

Homo sapiens

Synonyms: ERVE1, HERV-E1, HERVE1, TCONS_00025599
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Disease relevance of ERVE1


High impact information on ERVE1

  • In contrast, stimulation of monocytes decreased or had no effect on HERV-E expression [5].
  • In this review, Pierre Ambroise-Thomas and Hervé Pelloux describe and compare the epidemiology, pathophysiology and clinical features of these three different forms of the disease [6].
  • In addition to elements closely related to ERV3, the group included the previously known retinoic acid-inducible element, RRHERVI, also referred to as HERV15, but was separate from the related HERV-E elements [7].
  • A characteristic brain-specific retroviral activity profile was found that consists of members of the class I families HERV-E, HERV-F, and ERV9 and members of HERV-K taxa [8].
  • These searches revealed a fusion transcript containing the LTR of an HERV-E element linked to the Opitz syndrome gene Mid1 [9].

Biological context of ERVE1

  • No significant influence of point mutation or DNA polymorphism on HERV-E 4-1 Env protein production was recognized [3].
  • Analysis of normal human DNA by Southern blot hybridization with three specific HERV-E molecular DNA probes revealed complex restriction-fragment length polymorphisms (RFLP), implying that the human genome contains diverse proviral structures and dispersed integration sites [10].
  • Finally, we performed FISH mapping, which revealed sites of integration of HERV-E not previously identified at the cytogenetic level [4].
  • HERV-E RNA expression was significantly higher in endometriotic tissue (average, SD) than in normal endometrium (average, SD), both measured as ratios versus control gene expression and as [11].
  • Those HERV-E sequences were extensively proliferated in the genome of humans and great apes [12].

Anatomical context of ERVE1


Associations of ERVE1 with chemical compounds

  • One was a hybrid HERV-H protease/HERV-E integrase ORF and the other was the HERV-E envelope surface glycoprotein ORF [14].
  • The inhibition by intracellular Ca2+ (0.2 microM) or by extracellularly added vanadate (50 microM) was reported (Seigneuret, M. and Devaux, P.F. (1984) Proc. Natl. Acad. Sci. USA 81, 3751-3755; Zachowski, A., Favre, E., Cribier, S., Hervé, P. and Devaux, P.F. (1986) Biochemistry 25, 2585-2590) [16].

Other interactions of ERVE1


Analytical, diagnostic and therapeutic context of ERVE1

  • In an RT-PCR study of HERV-H spliced subgenomic transcripts, we found transcripts with HERV-H leader and protease-encoding sequences spliced to HERV-E integrase-encoding sequences in lymphocytes from healthy blood donors [14].
  • BLAST analysis of the PCR products identified a subgroup that shows low identity (75%) to the original clone M10976 and slightly higher identity (80%) to a closely related HERV-E (Ac. n. K02166) [4].
  • CONCLUSIONS: The expression and distribution of multiple HERV-E endogenous retroviral elements in prostate carcinoma, but not in normal control specimens, suggests that they may serve as novel tumor markers for the early diagnosis and immunotherapy of patients with prostate carcinoma [17].
  • Here, we examined the expression pattern and their relationships of the HERV-E in Japanese monkey tissues by RT-PCR and sequence analysis [12].
  • Molecular cloning and phylogeny of HERV-E family that is expressed in Japanese monkey (Macaca fuscata) tissues [12].


  1. Search for active endogenous retroviruses: identification and characterization of a HERV-E gene that is expressed in the pancreas and thyroid. Shiroma, T., Sugimoto, J., Oda, T., Jinno, Y., Kanaya, F. J. Hum. Genet. (2001) [Pubmed]
  2. Regulatory T cells and inflammatory bowel disease. Groux, H., Powrie, F. Immunol. Today (1999) [Pubmed]
  3. Alveolar macrophages produce the Env protein of a human endogenous retrovirus, HERV-E 4-1, in a subgroup of interstitial lung diseases. Tamura, N., Iwase, A., Suzuki, K., Maruyama, N., Kira, S. Am. J. Respir. Cell Mol. Biol. (1997) [Pubmed]
  4. Organization and integration sites in the human genome of endogenous retroviral sequences belonging to HERV-E family. Taruscio, D., Floridia, G., Zoraqi, G.K., Mantovani, A., Falbo, V. Mamm. Genome (2002) [Pubmed]
  5. Monocyte activation and differentiation augment human endogenous retrovirus expression: implications for inflammatory brain diseases. Johnston, J.B., Silva, C., Holden, J., Warren, K.G., Clark, A.W., Power, C. Ann. Neurol. (2001) [Pubmed]
  6. Toxoplasmosis - congenital and in immunocompromised patients: a parallel. Ambroise-Thomas, P., Pelloux, H. Parasitol. Today (Regul. Ed.) (1993) [Pubmed]
  7. ERV3 and related sequences in humans: structure and RNA expression. Andersson, A.C., Yun, Z., Sperber, G.O., Larsson, E., Blomberg, J. J. Virol. (2005) [Pubmed]
  8. Human endogenous retrovirus expression profiles in samples from brains of patients with schizophrenia and bipolar disorders. Frank, O., Giehl, M., Zheng, C., Hehlmann, R., Leib-Mösch, C., Seifarth, W. J. Virol. (2005) [Pubmed]
  9. The Opitz syndrome gene Mid1 is transcribed from a human endogenous retroviral promoter. Landry, J.R., Rouhi, A., Medstrand, P., Mager, D.L. Mol. Biol. Evol. (2002) [Pubmed]
  10. Cloning and characterization of the endogenous retroviral-tRNA(Glu) multigene family from human genomes of different racial backgrounds. Yeh, K.W., Yang, W.K., Huang, H.C., Feng, Y.N., Liu, J.C., Wu, F.Y., Wu, C.W. Gene (1995) [Pubmed]
  11. Expression of human endogenous gammaretroviral sequences in endometriosis and ovarian cancer. Hu, L., Hornung, D., Kurek, R., Helen, O., Blomberg, J., Bergqvist, A. AIDS Res. Hum. Retroviruses (2006) [Pubmed]
  12. Molecular cloning and phylogeny of HERV-E family that is expressed in Japanese monkey (Macaca fuscata) tissues. Yi, J.M., Takenaka, O., Kim, H.S. Arch. Virol. (2005) [Pubmed]
  13. Human endogenous retroviruses: expression in various organs in vivo and its regulation in vitro. Sibata, M., Ikeda, H., Katumata, K., Takeuchi, K., Wakisaka, A., Yoshoki, T. Leukemia (1997) [Pubmed]
  14. Coamplification and dispersion of adjacent human endogenous retroviral HERV-H and HERV-E elements; presence of spliced hybrid transcripts in normal leukocytes. Lindeskog, M., Medstrand, P., Cunningham, A.A., Blomberg, J. Virology (1998) [Pubmed]
  15. Differential expression of a human endogenous retrovirus E transmembrane envelope glycoprotein in normal, psoriatic and atopic dermatitis human skin. Bessis, D., Molès, J.P., Basset-Séguin, N., Tesniere, A., Arpin, C., Guilhou, J.J. Br. J. Dermatol. (2004) [Pubmed]
  16. Ion regulation of phosphatidylserine and phosphatidylethanolamine outside-inside translocation in human erythrocytes. Bitbol, M., Fellmann, P., Zachowski, A., Devaux, P.F. Biochim. Biophys. Acta (1987) [Pubmed]
  17. Detecting the expression of human endogenous retrovirus E envelope transcripts in human prostate adenocarcinoma. Wang-Johanning, F., Frost, A.R., Jian, B., Azerou, R., Lu, D.W., Chen, D.T., Johanning, G.L. Cancer (2003) [Pubmed]
  18. Expression of human endogenous retrovirus clone 4-1 may correlate with blood plasma concentration of anti-U1 RNP and anti-Sm nuclear antibodies. Piotrowski, P.C., Duriagin, S., Jagodzinski, P.P. Clin. Rheumatol. (2005) [Pubmed]
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