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Gene Review

ERV3-1  -  endogenous retrovirus group 3, member 1

Homo sapiens

Synonyms: ERV-3 envelope protein, ERV-R, ERV-R envelope protein, ERV3, ERV3 envelope protein, ...
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Disease relevance of ERV3


High impact information on ERV3


Chemical compound and disease context of ERV3


Biological context of ERV3

  • DNA sequence analysis of this clone revealed that it is identical to the ERV3 genomic clone in the 1110 nucleotides that were sequenced [8].
  • The ERV3 genome was determined to reside at a single locus on human chromosome 7 using a panel of rodent X human somatic cell hybrids [2].
  • DNA sequencing within the clone and comparisons with other retroviruses revealed that ERV3 contains gag and pol gene sequences that are significantly related to those of mammalian type C retroviruses and previously described human endogenous proviruses [2].
  • It appears that ERV3 is expressed in an organ-specific way during embryogenesis and might suggest a possible role in the development and differentiation of human tissues [1].
  • A full-length human endogenous provirus termed ERV3 was isolated from a human fetal recombinant DNA library by low stringency hybridization with two probes: baboon endogenous virus LTR; and a pol-env subclone from the endogenous chimpanzee provirus, CH2 [2].

Anatomical context of ERV3


Associations of ERV3 with chemical compounds

  • A rabbit antiserum against synthetic peptides corresponding with the HERV-R env gene sequence led to detection of an 85 kDa product as a glycoprotein in the Harderian glands [10].
  • This high-level expression of HERV-R in the adrenal cortex may possibly relate to differentiation and/or steroid production by adrenocortical cells [11].

Regulatory relationships of ERV3


Other interactions of ERV3

  • The nucleotide sequence of the env gene of a previously described human provirus (ERV3) has been determined beginning near the 3'-end of the pol gene and continuing through the 3'-LTR [8].
  • By Northern blot analysis using fresh synovial tissues, cultured synovial cells, and peripheral blood mononuclear cells (PBMC) from patients with RA, we noted two molecular species of ERV3 mRNAs of 3.5 kb and 9.0 kb sizes, and one single molecular species of lambda 4-1 mRNAs of 4.2 kb size [3].
  • Using an enzymatic amplification technique, we found expression of the endogenous retroviral sequences, HRES-1, HERV-K10 and ERV3 in most samples of peripheral blood mononuclear cells from MS patients and controls without obvious differences between these two groups [13].
  • A possible association between the endogenous retrovirus, ERV3, and multiple sclerosis (MS) was examined [14].

Analytical, diagnostic and therapeutic context of ERV3


  1. Developmental expression of HERV-R (ERV3) and HERV-K in human tissue. Andersson, A.C., Venables, P.J., Tönjes, R.R., Scherer, J., Eriksson, L., Larsson, E. Virology (2002) [Pubmed]
  2. ERV3, a full-length human endogenous provirus: chromosomal localization and evolutionary relationships. O'Connell, C., O'Brien, S., Nash, W.G., Cohen, M. Virology (1984) [Pubmed]
  3. Expression of endogenous retroviruses, ERV3 and lambda 4-1, in synovial tissues from patients with rheumatoid arthritis. Takeuchi, K., Katsumata, K., Ikeda, H., Minami, M., Wakisaka, A., Yoshiki, T. Clin. Exp. Immunol. (1995) [Pubmed]
  4. ERV3 and related sequences in humans: structure and RNA expression. Andersson, A.C., Yun, Z., Sperber, G.O., Larsson, E., Blomberg, J. J. Virol. (2005) [Pubmed]
  5. Expression of human endogenous retrovirus k envelope transcripts in human breast cancer. Wang-Johanning, F., Frost, A.R., Johanning, G.L., Khazaeli, M.B., LoBuglio, A.F., Shaw, D.R., Strong, T.V. Clin. Cancer Res. (2001) [Pubmed]
  6. Human proviral mRNAs down regulated in choriocarcinoma encode a zinc finger protein related to Krüppel. Kato, N., Shimotohno, K., VanLeeuwen, D., Cohen, M. Mol. Cell. Biol. (1990) [Pubmed]
  7. Absence of expression of a human endogenous retrovirus is correlated with choriocarcinoma. Kato, N., Larsson, E., Cohen, M. Int. J. Cancer (1988) [Pubmed]
  8. The nucleotide sequence of the env gene from the human provirus ERV3 and isolation and characterization of an ERV3-specific cDNA. Cohen, M., Powers, M., O'Connell, C., Kato, N. Virology (1985) [Pubmed]
  9. Demethylation of ERV3, an endogenous retrovirus regulating the Krüppel-related zinc finger gene H-plk, in several human cell lines arrested during early monocyte development. Abrink, M., Larsson, E., Hellman, L. DNA Cell Biol. (1998) [Pubmed]
  10. Tissue specific high level expression of a full length human endogenous retrovirus genome transgene, HERV-R, under control of its own promoter in rats. Tanaka, S., Ikeda, H., Otsuka, N., Yamamoto, Y., Sugaya, T., Yoshiki, T. Transgenic Res. (2003) [Pubmed]
  11. Tissue-specific high-level expression of human endogenous retrovirus-R in the human adrenal cortex. Katsumata, K., Ikeda, H., Sato, M., Harada, H., Wakisaka, A., Shibata, M., Yoshiki, T. Pathobiology (1998) [Pubmed]
  12. Human endogenous retroviruses: expression in various organs in vivo and its regulation in vitro. Sibata, M., Ikeda, H., Katumata, K., Takeuchi, K., Wakisaka, A., Yoshoki, T. Leukemia (1997) [Pubmed]
  13. Expression of endogenous retroviruses in blood mononuclear cells and brain tissue from multiple sclerosis patients. Rasmussen, H.B., Geny, C., Deforges, L., Perron, H., Tourtelotte, W., Heltberg, A., Clausen, J. Mult. Scler. (1995) [Pubmed]
  14. Three allelic forms of the human endogenous retrovirus, ERV3, and their frequencies in multiple sclerosis patients and healthy individuals. Rasmussen, H.B., Heltberg, A., Lisby, G., Clausen, J. Autoimmunity (1996) [Pubmed]
  15. Human Endogenous Retrovirus (HERV)-R family in primates: Chromosomal location, gene expression, and evolution. Kim, H.S., Yi, J.M., Hirai, H., Huh, J.W., Jeong, M.S., Jang, S.B., Kim, C.G., Saitou, N., Hyun, B.H., Lee, W.H. Gene (2006) [Pubmed]
  16. Assignment of the endogenous retrovirus HERV-R (ERV3) to human chromosome 7q11.2 by radiation hybrid mapping. Kim, H., Crow, T.J., Hyun, B.H. Cytogenet. Cell Genet. (2000) [Pubmed]
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