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ABCC11  -  ATP-binding cassette, sub-family C...

Homo sapiens

Synonyms: ATP-binding cassette sub-family C member 11, EWWD, MRP8, Multidrug resistance-associated protein 8, WW
 
 
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Disease relevance of ABCC11

  • To test whether ABCC11 directly confers 5-fluorouracil (5-FU) resistance, we used the 5-FU-resistant subline PC-6/FU23-26 selected from PC-6 human small-cell lung cancer cells by 5-FU and found that it increases the resistance by approximately 25-fold [1].
  • MRP8, a new member of ABC transporter superfamily, identified by EST database mining and gene prediction program, is highly expressed in breast cancer [2].
  • A rapid increase in serum levels occurred in response to bacterial infections (MRP8/14 up to 6,230 ng/ml; PCT up to 297 ng/ml) [3].
  • The myeloic related protein MRP8/14 (27E10 antigen)--usefulness as a potential marker for disease activity in ulcerative colitis and putative biological function [4].
  • In contrast, MRP8 expression is weak or absent in mononuclear phagocytes of sarcoidosis and tuberculosis [5].
 

Psychiatry related information on ABCC11

 

High impact information on ABCC11

  • Exploiting the basis of proline recognition by SH3 and WW domains: design of N-substituted inhibitors [7].
  • A WW domain protein TAZ is a critical coactivator for TBX5, a transcription factor implicated in Holt-Oram syndrome [8].
  • Myeloid-related protein 8 (MRP8) and MRP14, S100 proteins secreted by activated phagocytes, bind specifically to endothelial cells [9].
  • We demonstrated that the expression of MRP8/MRP14 closely correlated with the inflammatory activity in systemic vasculitis, confirming the important role of these proteins for distinct inflammatory reactions in endothelia [9].
  • This phosphorylation inhibits MRP8/MRP14-induced tubulin polymerization [10].
 

Biological context of ABCC11

 

Anatomical context of ABCC11

 

Associations of ABCC11 with chemical compounds

 

Regulatory relationships of ABCC11

 

Other interactions of ABCC11

 

Analytical, diagnostic and therapeutic context of ABCC11

  • Antibodies raised against ABCC11 served to detect the protein in brain by immunoblotting and immunofluorescence microscopy [15].
  • MRP8/14 levels were measured by ELISA (BMA Biomed), PCT by a sensitive immunoluminiscent assay ILMA (Brahms Diagn.) RESULTS: Both parameters showed very low basal levels in healthy subjects (range 303-1,660 ng/ml of MRP8/14; less than 0.08 ng/ml of PCT) [3].
  • Serum PCT concentration remained low in the presence of kidney allograft rejection, where MRP8/14 levels were increased [3].
  • An uncomplicated outcome of kidney or heart transplantation did not change basal serum MRP8/14 and PCT levels [3].
  • MRP 8/14 and procalcitonin serum levels in organ transplantations [3].

References

  1. MRP8/ABCC11 directly confers resistance to 5-fluorouracil. Oguri, T., Bessho, Y., Achiwa, H., Ozasa, H., Maeno, K., Maeda, H., Sato, S., Ueda, R. Mol. Cancer Ther. (2007) [Pubmed]
  2. MRP8, a new member of ABC transporter superfamily, identified by EST database mining and gene prediction program, is highly expressed in breast cancer. Bera, T.K., Lee, S., Salvatore, G., Lee, B., Pastan, I. Mol. Med. (2001) [Pubmed]
  3. MRP 8/14 and procalcitonin serum levels in organ transplantations. Stríz, I., Jaresová, M., Lácha, J., Sedlácek, J., Vítko, S. Ann. Transplant. (2001) [Pubmed]
  4. The myeloic related protein MRP8/14 (27E10 antigen)--usefulness as a potential marker for disease activity in ulcerative colitis and putative biological function. Lügering, N., Stoll, R., Schmid, K.W., Kucharzik, T., Stein, H., Burmeister, G., Sorg, C., Domschke, W. Eur. J. Clin. Invest. (1995) [Pubmed]
  5. Differential expression of the calcium-binding proteins MRP8 and MRP14 in granulomatous conditions: an immunohistochemical study. Delabie, J., de Wolf-Peeters, C., van den Oord, J.J., Desmet, V.J. Clin. Exp. Immunol. (1990) [Pubmed]
  6. Huntingtin's WW domain partners in Huntington's disease post-mortem brain fulfill genetic criteria for direct involvement in Huntington's disease pathogenesis. Passani, L.A., Bedford, M.T., Faber, P.W., McGinnis, K.M., Sharp, A.H., Gusella, J.F., Vonsattel, J.P., MacDonald, M.E. Hum. Mol. Genet. (2000) [Pubmed]
  7. Exploiting the basis of proline recognition by SH3 and WW domains: design of N-substituted inhibitors. Nguyen, J.T., Turck, C.W., Cohen, F.E., Zuckermann, R.N., Lim, W.A. Science (1998) [Pubmed]
  8. A WW domain protein TAZ is a critical coactivator for TBX5, a transcription factor implicated in Holt-Oram syndrome. Murakami, M., Nakagawa, M., Olson, E.N., Nakagawa, O. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  9. Myeloid-related proteins 8 and 14 induce a specific inflammatory response in human microvascular endothelial cells. Viemann, D., Strey, A., Janning, A., Jurk, K., Klimmek, K., Vogl, T., Hirono, K., Ichida, F., Foell, D., Kehrel, B., Gerke, V., Sorg, C., Roth, J. Blood (2005) [Pubmed]
  10. MRP8 and MRP14 control microtubule reorganization during transendothelial migration of phagocytes. Vogl, T., Ludwig, S., Goebeler, M., Strey, A., Thorey, I.S., Reichelt, R., Foell, D., Gerke, V., Manitz, M.P., Nacken, W., Werner, S., Sorg, C., Roth, J. Blood (2004) [Pubmed]
  11. Impaired 2',3'-dideoxy-3'-thiacytidine accumulation in T-lymphoblastoid cells as a mechanism of acquired resistance independent of multidrug resistant protein 4 with a possible role for ATP-binding cassette C11. Turriziani, O., Schuetz, J.D., Focher, F., Scagnolari, C., Sampath, J., Adachi, M., Bambacioni, F., Riva, E., Antonelli, G. Biochem. J. (2002) [Pubmed]
  12. Two new genes from the human ATP-binding cassette transporter superfamily, ABCC11 and ABCC12, tandemly duplicated on chromosome 16q12. Tammur, J., Prades, C., Arnould, I., Rzhetsky, A., Hutchinson, A., Adachi, M., Schuetz, J.D., Swoboda, K.J., Ptácek, L.J., Rosier, M., Dean, M., Allikmets, R. Gene (2001) [Pubmed]
  13. Characterization of the mouse Abcc12 gene and its transcript encoding an ATP-binding cassette transporter, an orthologue of human ABCC12. Shimizu, H., Taniguchi, H., Hippo, Y., Hayashizaki, Y., Aburatani, H., Ishikawa, T. Gene (2003) [Pubmed]
  14. Multiple splicing variants of two new human ATP-binding cassette transporters, ABCC11 and ABCC12. Yabuuchi, H., Shimizu, H., Takayanagi, S., Ishikawa, T. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  15. Human multidrug resistance protein 8 (MRP8/ABCC11), an apical efflux pump for steroid sulfates, is an axonal protein of the CNS and peripheral nervous system. Bortfeld, M., Rius, M., König, J., Herold-Mende, C., Nies, A.T., Keppler, D. Neuroscience (2006) [Pubmed]
  16. Increased serum levels of MRP-8/14 in type 1 diabetes induce an increased expression of CD11b and an enhanced adhesion of circulating monocytes to fibronectin. Bouma, G., Lam-Tse, W.K., Wierenga-Wolf, A.F., Drexhage, H.A., Versnel, M.A. Diabetes (2004) [Pubmed]
  17. Transport of bile acids, sulfated steroids, estradiol 17-beta-D-glucuronide, and leukotriene C4 by human multidrug resistance protein 8 (ABCC11). Chen, Z.S., Guo, Y., Belinsky, M.G., Kotova, E., Kruh, G.D. Mol. Pharmacol. (2005) [Pubmed]
  18. MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2',3'-dideoxycytidine and 9'-(2'-phosphonylmethoxyethyl)adenine. Guo, Y., Kotova, E., Chen, Z.S., Lee, K., Hopper-Borge, E., Belinsky, M.G., Kruh, G.D. J. Biol. Chem. (2003) [Pubmed]
  19. ABCC10, ABCC11, and ABCC12. Kruh, G.D., Guo, Y., Hopper-Borge, E., Belinsky, M.G., Chen, Z.S. Pflugers Arch. (2007) [Pubmed]
 
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