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SSNA1  -  Sjogren syndrome nuclear autoantigen 1

Homo sapiens

Synonyms: N14, NA-14, NA14, Nuclear autoantigen of 14 kDa, Sjoegren syndrome nuclear autoantigen 1
 
 
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Disease relevance of SSNA1

  • The absolute delay of peak N14 and N20 in median and P40 in tibial nerve-evoked potentials was probably due to an impaired conduction in the peripheral branch of the bipolar ganglion cell [1].
  • The final identification revealed that D6, D14 and N14 were Lactobacillus paracasei subsp. paracasei, and L17 and N8 were Lact. rhamnosus [2].
  • The cephalic referenced 'N14' decreased in amplitude and increased in latency after the clinical brain death syndrome was observed, while N13 in the posterior to anterior neck montage remained unchanged [3].
  • After nystagmus, the SSNA increased to 166 +/- 7 and 168 +/- 6%, respectively, and the degree of motion sickness symptoms was correlated with this SSNA increase [4].
  • In addition to the known increase in peak latencies, hypothermia gave rise to the appearance of peaks ('P13,' 'N14') inconsistently recognized at normothermia; moreover, profound hypothermia is associated with the disappearance of cortical activities around 20 degrees, of subcortical waves at lower temperatures [5].
 

Psychiatry related information on SSNA1

  • The MSNA burst evolution time (interval between initiation of the burst and its peak) became longer with a transition to deeper non-REM sleep stages, whereas the SSNA burst evolution times remained constant [6].
  • In humans, muscle and skin sympathetic nerve activities (MSNA, SSNA) have been reported to discharge independently according to a regional differentiation of SNA during wakefulness [7].
 

High impact information on SSNA1

 

Biological context of SSNA1

  • 6. These findings indicate that there is a minimum force necessary to elicit peak levels of MSNA and SSNA during sustained isometric contractions in humans [11].
  • 2. In twelve healthy subjects, arterial blood pressure, heart rate, and MSNA (n = 6) or SSNA (n = 6) (peroneal microneurography) were recorded before and during isometric handgrip contractions sustained to exhaustion at 20, 40 and 60% of maximal force [11].
  • As expected, both S37 and Q67 are located at the active site, but in the consensus structure they are not within hydrogen bonding distance of N14 [12].
  • Since the plot of N14 along a chain shows a good correlation with the corresponding amino acid sequence, the N14 profile obtained from the X-ray structure is predictable from the sequence [13].
  • The subcortical generated somatosensory evoked potentials in non-cephalic, cephalic, and anterior neck referenced recordings in a patient with a cervico-medullary lesion: a clue to the identification of the P14/N14 and N13 generators [14].
 

Anatomical context of SSNA1

  • 1. Our purpose was to test the hypothesis that efferent sympathetic nerve activity to non-active skeletal muscle (MSNA) and skin (SSNA) is independent of the level of force during sustained submaximal isometric contractions in humans [11].
  • Increased N14 potential was associated with an increase in N19 and P22 potentials, and either a decrease (base) or no change (train) in the brachial plexus potential [15].
  • The central conduction time (CCT), the time between the N14 peak (recorded at C-2) and the N20 peak (recorded at the cortex) in response to median nerve stimulation, has been found to be increased by administration of halothane, by brain retraction, and by temporary vascular occlusion in some instances [16].
  • Focal stimulation posterior to the motor cortex elicited extinguishable SSNA responses [17].
  • In 10 subjects, we tested whether motor cortical stimulation could also elicit skin sympathetic nerve activity (SSNA; n = 8) and muscle sympathetic nerve activity (MSNA; n = 5) in the peroneal nerve [17].
 

Associations of SSNA1 with chemical compounds

  • Thiopental increased the latency of N10, N14, and N20 [18].
  • The backbone conformation of the TPTP phosphate binding loop is nearly superimposable with that of other tyrosine phosphatases, with N14 existing in a strained, left-handed conformation that is a hallmark of the active site hydrogen bonding network in the LMW PTPs [12].
  • In the phosphatase from the bovine parasite Tritrichomonas foetus (TPTP), both the conserved serine (S37) and asparagine (N14) are present, but the conserved histidine has been replaced by a glutamine residue (Q67) [12].
  • N14 is homologous to N16, recently found in the nacreous layer of P. fucata (2) and is characterized by high proportions of Gly, Tyr, and Asn together with NG repeat sequences [19].
  • The in vitro crystallization experiments revealed that the mixture of N66 and N14 could induce platy aragonite layers highly similar to the nacreous layer, once adsorbed onto the membrane of the water-insoluble matrix [19].
 

Other interactions of SSNA1

  • The 9q34 amplification may lead to elevated expression of various genes, and MRLP41, SSNA1 and PHPT1 were found significantly expressed at higher levels [20].
 

Analytical, diagnostic and therapeutic context of SSNA1

  • In a separate control group (n = 6), even high-intensity static handgrip was not accompanied by sustained elevation of SSNA during PHG-CA [21].
  • In order to acquire more effective control of PTNANBH, the HCV core-related antigen (GOR, N14) and second-generation Elisa (Ortho2, Abbott2) and second-generation antigen agglutination (PA, PHA) tests have been employed [22].

References

  1. Peripheral and central conduction times in hereditary pressure-sensitive neuropathy. Ebner, A., Dengler, R., Meier, C. J. Neurol. (1981) [Pubmed]
  2. Lactic acid bacteria from healthy oral cavity of Thai volunteers: inhibition of oral pathogens. Sookkhee, S., Chulasiri, M., Prachyabrued, W. J. Appl. Microbiol. (2001) [Pubmed]
  3. Serial recording of median nerve stimulated subcortical somatosensory evoked potentials (SEPs) in developing brain death. Buchner, H., Ferbert, A., Hacke, W. Electroencephalography and clinical neurophysiology. (1988) [Pubmed]
  4. Responses of sympathetic outflow to skin during caloric stimulation in humans. Cui, J., Iwase, S., Mano, T., Kitazawa, H. Am. J. Physiol. (1999) [Pubmed]
  5. Median nerve somatosensory evoked potentials in profound hypothermia for ascending aorta repair. Guérit, J.M., Soveges, L., Baele, P., Dion, R. Electroencephalography and clinical neurophysiology. (1990) [Pubmed]
  6. Sleep-related changes in human muscle and skin sympathetic nerve activities. Takeuchi, S., Iwase, S., Mano, T., Okada, H., Sugiyama, Y., Watanabe, T. J. Auton. Nerv. Syst. (1994) [Pubmed]
  7. Attenuation of regional differentiation of sympathetic nerve activity during sleep in humans. Kodama, Y., Iwase, S., Mano, T., Cui, J., Kitazawa, H., Okada, H., Takeuchi, S., Sobue, G. J. Auton. Nerv. Syst. (1998) [Pubmed]
  8. NA14 is a novel nuclear autoantigen with a coiled-coil domain. Ramos-Morales, F., Infante, C., Fedriani, C., Bornens, M., Rios, R.M. J. Biol. Chem. (1998) [Pubmed]
  9. Central nervous system modifications in patients with lesion of the anterior cruciate ligament of the knee. Valeriani, M., Restuccia, D., DiLazzaro, V., Franceschi, F., Fabbriciani, C., Tonali, P. Brain (1996) [Pubmed]
  10. Chlamydomonas DIP13 and human NA14: a new class of proteins associated with microtubule structures is involved in cell division. Pfannenschmid, F., Wimmer, V.C., Rios, R.M., Geimer, S., Kröckel, U., Leiherer, A., Haller, K., Nemcová, Y., Mages, W. J. Cell. Sci. (2003) [Pubmed]
  11. Influence of force on muscle and skin sympathetic nerve activity during sustained isometric contractions in humans. Seals, D.R. J. Physiol. (Lond.) (1993) [Pubmed]
  12. Solution structure of the low-molecular-weight protein tyrosine phosphatase from Tritrichomonas foetus reveals a flexible phosphate binding loop. Gustafson, C.L., Stauffacher, C.V., Hallenga, K., Van Etten, R.L. Protein Sci. (2005) [Pubmed]
  13. A geometrical constraint approach for reproducing the native backbone conformation of a protein. Saitoh, S., Nakai, T., Nishikawa, K. Proteins (1993) [Pubmed]
  14. The subcortical generated somatosensory evoked potentials in non-cephalic, cephalic, and anterior neck referenced recordings in a patient with a cervico-medullary lesion: a clue to the identification of the P14/N14 and N13 generators. Buchner, H., Ferbert, A., Brückmann, H., Hacke, W. J. Neurol. (1987) [Pubmed]
  15. Operant conditioning of the short-latency cervical somatosensory evoked potential in quadriplegics. Finley, W.W. Exp. Neurol. (1983) [Pubmed]
  16. Perioperative use of somatosensory evoked responses in aneurysm surgery. Symon, L., Wang, A.D., Costa e Silva, I.E., Gentili, F. J. Neurosurg. (1984) [Pubmed]
  17. Magnetic stimulation of the human motor cortex evokes skin sympathetic nerve activity. Silber, D.H., Sinoway, L.I., Leuenberger, U.A., Amassian, V.E. J. Appl. Physiol. (2000) [Pubmed]
  18. Effects of thiopental, fentanyl, and etomidate on upper extremity somatosensory evoked potentials in humans. McPherson, R.W., Sell, B., Traystman, R.J. Anesthesiology (1986) [Pubmed]
  19. Molecular mechanism of the nacreous layer formation in Pinctada maxima. Kono, M., Hayashi, N., Samata, T. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  20. A new recurrent 9q34 duplication in pediatric T-cell acute lymphoblastic leukemia. van Vlierberghe, P., Meijerink, J.P., Lee, C., Ferrando, A.A., Look, A.T., van Wering, E.R., Beverloo, H.B., Aster, J.C., Pieters, R. Leukemia (2006) [Pubmed]
  21. Altered mechanisms of sympathetic activation during rhythmic forearm exercise in heart failure. Silber, D.H., Sutliff, G., Yang, Q.X., Smith, M.B., Sinoway, L.I., Leuenberger, U.A. J. Appl. Physiol. (1998) [Pubmed]
  22. Predictive value of screening tests for persistent hepatitis C virus infection evidenced by viraemia. Japanese experience. Watanabe, J., Matsumoto, C., Fujimura, K., Shimada, T., Yoshizawa, H., Okamoto, H., Iizuka, H., Tango, T., Ikeda, H., Endo, N. Vox Sang. (1993) [Pubmed]
 
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