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Gene Review

MED28  -  mediator complex subunit 28

Homo sapiens

Synonyms: 1500003D12Rik, DKFZP434N185, EG1, Endothelial-derived protein 1, FKSG20, ...
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Analytical, diagnostic and therapeutic context of MED28


  1. The novel gene EG-1 stimulates cellular proliferation. Lu, M., Zhang, L., Maul, R.S., Sartippour, M.R., Norris, A., Whitelegge, J., Rao, J.Y., Brooks, M.N. Cancer Res. (2005) [Pubmed]
  2. In vitro generation of endothelial microparticles and possible prothrombotic activity in patients with lupus anticoagulant. Combes, V., Simon, A.C., Grau, G.E., Arnoux, D., Camoin, L., Sabatier, F., Mutin, M., Sanmarco, M., Sampol, J., Dignat-George, F. J. Clin. Invest. (1999) [Pubmed]
  3. Increased plasma endothelin-1 in pulmonary hypertension: marker or mediator of disease? Stewart, D.J., Levy, R.D., Cernacek, P., Langleben, D. Ann. Intern. Med. (1991) [Pubmed]
  4. Chemoprevention of intestinal polyposis in the Apcdelta716 mouse by rofecoxib, a specific cyclooxygenase-2 inhibitor. Oshima, M., Murai, N., Kargman, S., Arguello, M., Luk, P., Kwong, E., Taketo, M.M., Evans, J.F. Cancer Res. (2001) [Pubmed]
  5. Ethanol increases endothelial nitric oxide production through modulation of nitric oxide synthase expression. Venkov, C.D., Myers, P.R., Tanner, M.A., Su, M., Vaughan, D.E. Thromb. Haemost. (1999) [Pubmed]
  6. Paracrine regulation of the renal microcirculation. Navar, L.G., Inscho, E.W., Majid, S.A., Imig, J.D., Harrison-Bernard, L.M., Mitchell, K.D. Physiol. Rev. (1996) [Pubmed]
  7. Cultured human endothelial cells express platelet-derived growth factor B chain: cDNA cloning and structural analysis. Collins, T., Ginsburg, D., Boss, J.M., Orkin, S.H., Pober, J.S. Nature (1985) [Pubmed]
  8. Nitric oxide in the nervous system. Zhang, J., Snyder, S.H. Annu. Rev. Pharmacol. Toxicol. (1995) [Pubmed]
  9. Suppression of apoptosis by nitric oxide via inhibition of interleukin-1beta-converting enzyme (ICE)-like and cysteine protease protein (CPP)-32-like proteases. Dimmeler, S., Haendeler, J., Nehls, M., Zeiher, A.M. J. Exp. Med. (1997) [Pubmed]
  10. Interleukin 15 is produced by endothelial cells and increases the transendothelial migration of T cells In vitro and in the SCID mouse-human rheumatoid arthritis model In vivo. Oppenheimer-Marks, N., Brezinschek, R.I., Mohamadzadeh, M., Vita, R., Lipsky, P.E. J. Clin. Invest. (1998) [Pubmed]
  11. Hydrogen peroxide restrains endothelium-derived nitric oxide bioactivity -- role for iron-dependent oxidative stress. Thomas, S.R., Schulz, E., Keaney, J.F. Free Radic. Biol. Med. (2006) [Pubmed]
  12. Influence of angiotensin-converting enzyme inhibitor enalaprilat on endothelial-derived substances in the critically ill. Boldt, J., Papsdorf, M., Kumle, B., Piper, S., Hempelmann, G. Crit. Care Med. (1998) [Pubmed]
  13. Activation of nitric oxide synthesis in human endothelial cells by red clover extracts. Simoncini, T., Fornari, L., Mannella, P., Caruso, A., Garibaldi, S., Baldacci, C., Genazzani, A.R. Menopause (New York, N.Y.) (2005) [Pubmed]
  14. Cytokine and adhesion molecule expression in primary human endothelial cells stimulated with fever-range hyperthermia. Shah, A., Unger, E., Bain, M.D., Bruce, R., Bodkin, J., Ginnetti, J., Wang, W.C., Seon, B., Stewart, C.C., Evans, S.S. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group. (2002) [Pubmed]
  15. The role of the vascular endothelium in the contractile responses of human chorionic plate artery in pre-eclampsia to prostaglandin F2 alpha, 5-hydroxytryptamine, and potassium chloride. Ezimokhai, M., Aloamaka, C.P., Osman, N.A., Mensah-Brown, E.P., Morrison, J. Research in experimental medicine. Zeitschrift für die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie. (1995) [Pubmed]
  16. Magicin associates with the Src-family kinases and is phosphorylated upon CD3 stimulation. Lee, M.F., Beauchamp, R.L., Beyer, K.S., Gusella, J.F., Ramesh, V. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  17. Liver sinusoidal endothelial cells are responsible for nitric oxide modulation of resistance in the hepatic sinusoids. Shah, V., Haddad, F.G., Garcia-Cardena, G., Frangos, J.A., Mennone, A., Groszmann, R.J., Sessa, W.C. J. Clin. Invest. (1997) [Pubmed]
  18. Endothelium-dependent hyperpolarization: a role in the control of vascular tone. Garland, C.J., Plane, F., Kemp, B.K., Cocks, T.M. Trends Pharmacol. Sci. (1995) [Pubmed]
  19. Nitric oxide uptake by erythrocytes is primarily limited by extracellular diffusion not membrane resistance. Liu, X., Samouilov, A., Lancaster, J.R., Zweier, J.L. J. Biol. Chem. (2002) [Pubmed]
  20. Magicin, a novel cytoskeletal protein associates with the NF2 tumor suppressor merlin and Grb2. Wiederhold, T., Lee, M.F., James, M., Neujahr, R., Smith, N., Murthy, A., Hartwig, J., Gusella, J.F., Ramesh, V. Oncogene (2004) [Pubmed]
  21. Identification of a novel endothelial-derived gene EG-1. Liu, C., Zhang, L., Shao, Z.M., Beatty, P., Sartippour, M., Lane, T.F., Barsky, S.H., Livingston, E., Nguyen, M. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  22. Regulation of human aortic endothelial cell-derived mesenchymal growth factors by allogeneic lymphocytes in vitro. A potential mechanism for cardiac allograft vasculopathy. Wagner, C.R., Morris, T.E., Shipley, G.D., Hosenpud, J.D. J. Clin. Invest. (1993) [Pubmed]
  23. Role of circulating nitrite and S-nitrosohemoglobin in the regulation of regional blood flow in humans. Gladwin, M.T., Shelhamer, J.H., Schechter, A.N., Pease-Fye, M.E., Waclawiw, M.A., Panza, J.A., Ognibene, F.P., Cannon, R.O. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  24. Endothelial renin-angiotensin pathway: evidence for intracellular synthesis and secretion of angiotensins. Kifor, I., Dzau, V.J. Circ. Res. (1987) [Pubmed]
  25. Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites. Bredt, D.S., Ferris, C.D., Snyder, S.H. J. Biol. Chem. (1992) [Pubmed]
  26. Angiopoietin-regulated recruitment of vascular smooth muscle cells by endothelial-derived heparin binding EGF-like growth factor. Iivanainen, E., Nelimarkka, L., Elenius, V., Heikkinen, S.M., Junttila, T.T., Sihombing, L., Sundvall, M., Maatta, J.A., Laine, V.J., Yla-Herttuala, S., Higashiyama, S., Alitalo, K., Elenius, K. FASEB J. (2003) [Pubmed]
  27. Transcriptional regulation of the tissue-type plasminogen-activator gene in human endothelial cells: identification of nuclear factors that recognise functional elements in the tissue-type plasminogen-activator gene promoter. Costa, M., Shen, Y., Maurer, F., Medcalf, R.L. Eur. J. Biochem. (1998) [Pubmed]
  28. Nitric oxide attenuates normal and sickle red blood cell adherence to pulmonary endothelium. Space, S.L., Lane, P.A., Pickett, C.K., Weil, J.V. Am. J. Hematol. (2000) [Pubmed]
  29. TGF-beta 1, IL-10 and IL-4 differentially modulate the cytokine-induced expression of IL-6 and IL-8 in human endothelial cells. Chen, C.C., Manning, A.M. Cytokine (1996) [Pubmed]
  30. Variations among normal individuals in the cleavage of endothelial-derived ultra-large von Willebrand factor under flow. Dong, J.F., Whitelock, J., Bernardo, A., Ball, C., Cruz, M.A. J. Thromb. Haemost. (2004) [Pubmed]
  31. Perturbations in paracrine control of the circulation: role of the endothelial-derived vasomediators, endothelin-1 and nitric oxide. Mawji, I.A., Marsden, P.A. Microsc. Res. Tech. (2003) [Pubmed]
  32. Modulation of the endothelial procoagulant response to lipopolysaccharide and tumour necrosis factor-alpha in-vitro: the effects of dexamethasone, pentoxifylline, iloprost and a polyclonal anti-human IL-1 alpha antibody. Heyderman, R.S., Klein, N.J., Daramola, O.A., Levin, M. Inflamm. Res. (1995) [Pubmed]
  33. Cloning of a unique lipase from endothelial cells extends the lipase gene family. Hirata, K., Dichek, H.L., Cioffi, J.A., Choi, S.Y., Leeper, N.J., Quintana, L., Kronmal, G.S., Cooper, A.D., Quertermous, T. J. Biol. Chem. (1999) [Pubmed]
  34. Changes in the distribution of LFA-1, catenins, and F-actin during transendothelial migration of monocytes in culture. Sandig, M., Negrou, E., Rogers, K.A. J. Cell. Sci. (1997) [Pubmed]
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