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CUX1  -  cut-like homeobox 1

Homo sapiens

Synonyms: CASP, CDP, CDP/Cut, CDP/Cux, CDP1, ...
 
 
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Disease relevance of CUTL1

 

Psychiatry related information on CUTL1

 

High impact information on CUTL1

  • Cells expressing a noncleavable mutant of p75 sustain DeltaPsim and ATP levels during apoptosis, and ROS production in response to apoptotic stimuli is dampened [7].
  • While cytochrome c release and DNA fragmentation are unaffected by the noncleavable p75 mutant, mitochondrial morphology of dying cells is maintained, and loss of plasma membrane integrity is delayed [7].
  • Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chain [7].
  • Human CCAAT displacement protein (CDP), a putative repressor of developmentally regulated gene expression, was purified from HeLa cells by DNA binding-site affinity chromatography. cDNA encoding CDP was obtained by immunoscreening a lambda gt11 library with antibody raised against purified protein [8].
  • A 70 kd protein can be identified in lymphoid cells using antibodies raised against the C-terminal region of p110 NF-kappa B. Comparison of the two-dimensional tryptic peptide maps of the 70 kd protein expressed in cells and the in vitro translated product encoded by the cDNA display extensive homology [9].
 

Chemical compound and disease context of CUTL1

  • The p75 proteins coprecipitated from cells infected with two different strains of human cytomegalovirus, AD169 and Towne, had different mobilities. p75 was detected as early as 6 h and as late as 72 h after infection, but it was not synthesized in cells released from a cycloheximide block [10].
  • Penta-acetyl geniposide induce apoptosis in C6 glioma cells by modulating the activation of neutral sphingomyelinase-induced p75 nerve growth factor receptor and protein kinase Cdelta pathway [11].
  • The low-affinity p75 neurotrophin receptor (p75NTR), a cysteine-rich transmembrane glycoprotein, is frequently expressed in advanced stages of human melanoma, but the biological consequences of this expression are unknown. p75NTR can enhance the invasive potential of brain-metastatic melanoma cells in vitro [12].
  • Parallel decrease in neurotoxin quinolinic acid and soluble tumor necrosis factor receptor p75 in serum during highly active antiretroviral therapy of HIV type 1 disease [13].
  • Exposure of SN56 cholinergic neuroblastoma cells to dibutyryl cAMP and retinoic acid for 3 days caused their morphologic differentiation along with the increase in choline acetyltransferase activity, acetylcholine content and release, calcium content, and the expression of p75 neurotrophin receptors [14].
 

Biological context of CUTL1

 

Anatomical context of CUTL1

 

Associations of CUTL1 with chemical compounds

 

Physical interactions of CUTL1

  • The p200 proteins have been implicated in cell cycle regulation and differentiation based on their ability to interact with and modulate the activities of multiple transcriptional factors such as Rb and p53, and there are significant findings that link mutations in their genetic loci to the incidence of cancer [25].
  • The deletion of the distal CCAAT box region of the A gamma-globin gene in black HPFH abolishes the binding of the erythroid specific protein NFE3 and of the CCAAT displacement protein [26].
  • CCAAT displacement protein competes with multiple transcriptional activators for binding to four sites in the proximal gp91phox promoter [27].
 

Enzymatic interactions of CUTL1

 

Regulatory relationships of CUTL1

  • Previous studies have shown that Abeta peptide can damage neurons by activating the p75 neurotrophin receptor (p75NTR) [30].
 

Other interactions of CUTL1

 

Analytical, diagnostic and therapeutic context of CUTL1

References

  1. Expression of N-terminally truncated isoforms of CDP/CUX is increased in human uterine leiomyomas. Moon, N.S., Rong Zeng, W., Premdas, P., Santaguida, M., Bérubé, G., Nepveu, A. Int. J. Cancer (2002) [Pubmed]
  2. CUTL1 is a target of TGF(beta) signaling that enhances cancer cell motility and invasiveness. Michl, P., Ramjaun, A.R., Pardo, O.E., Warne, P.H., Wagner, M., Poulsom, R., D'Arrigo, C., Ryder, K., Menke, A., Gress, T., Downward, J. Cancer Cell (2005) [Pubmed]
  3. Characterization of a tissue-specific CDP/Cux isoform, p75, activated in breast tumor cells. Goulet, B., Watson, P., Poirier, M., Leduy, L., Bérubé, G., Meterissian, S., Jolicoeur, P., Nepveu, A. Cancer Res. (2002) [Pubmed]
  4. Binding of CCAAT displacement protein CDP to adenovirus packaging sequences. Erturk, E., Ostapchuk, P., Wells, S.I., Yang, J., Gregg, K., Nepveu, A., Dudley, J.P., Hearing, P. J. Virol. (2003) [Pubmed]
  5. The p75 neurotrophin receptor in human development and disease. Schor, N.F. Prog. Neurobiol. (2005) [Pubmed]
  6. Does the p75 neurotrophin receptor mediate Abeta-induced toxicity in Alzheimer's disease? Coulson, E.J. J. Neurochem. (2006) [Pubmed]
  7. Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chain. Ricci, J.E., Muñoz-Pinedo, C., Fitzgerald, P., Bailly-Maitre, B., Perkins, G.A., Yadava, N., Scheffler, I.E., Ellisman, M.H., Green, D.R. Cell (2004) [Pubmed]
  8. Human CCAAT displacement protein is homologous to the Drosophila homeoprotein, cut. Neufeld, E.J., Skalnik, D.G., Lievens, P.M., Orkin, S.H. Nat. Genet. (1992) [Pubmed]
  9. I kappa B gamma, a 70 kd protein identical to the C-terminal half of p110 NF-kappa B: a new member of the I kappa B family. Inoue, J., Kerr, L.D., Kakizuka, A., Verma, I.M. Cell (1992) [Pubmed]
  10. The human cytomegalovirus 86-kilodalton immediate-early 2 protein: synthesis as a precursor polypeptide and interaction with a 75-kilodalton protein of probable viral origin. Samaniego, L.A., Tevethia, M.J., Spector, D.J. J. Virol. (1994) [Pubmed]
  11. Penta-acetyl geniposide induce apoptosis in C6 glioma cells by modulating the activation of neutral sphingomyelinase-induced p75 nerve growth factor receptor and protein kinase Cdelta pathway. Peng, C.H., Huang, C.N., Hsu, S.P., Wang, C.J. Mol. Pharmacol. (2006) [Pubmed]
  12. Correlation of overexpression of the low-affinity p75 neurotrophin receptor with augmented invasion and heparanase production in human malignant melanoma cells. Walch, E.T., Albino, A.P., Marchetti, D. Int. J. Cancer (1999) [Pubmed]
  13. Parallel decrease in neurotoxin quinolinic acid and soluble tumor necrosis factor receptor p75 in serum during highly active antiretroviral therapy of HIV type 1 disease. Look, M.P., Altfeld, M., Kreuzer, K.A., Riezler, R., Stabler, S.P., Allen, R.H., Sauerbruch, T., Rockstroh, J.K. AIDS Res. Hum. Retroviruses (2000) [Pubmed]
  14. Phenotype-dependent susceptibility of cholinergic neuroblastoma cells to neurotoxic inputs. Szutowicz, A., Bielarczyk, H., Gul, S., Ronowska, A., Pawe??czyk, T., Jankowska-Kulawy, A. Metabolic brain disease (2006) [Pubmed]
  15. Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes. Glöckner, G., Scherer, S., Schattevoy, R., Boright, A., Weber, J., Tsui, L.C., Rosenthal, A. Genome Res. (1998) [Pubmed]
  16. Exon/intron structure and alternative transcripts of the CUTL1 gene. Rong Zeng, W., Soucie, E., Sung Moon, N., Martin-Soudant, N., Bérubé, G., Leduy, L., Nepveu, A. Gene (2000) [Pubmed]
  17. Regional localization of the CCAAT displacement protein gene (CUTL1) to 7q22 by analysis of somatic cell hybrids. Scherer, S.W., Neufeld, E.J., Lievens, P.M., Orkin, S.H., Kim, J., Tsui, L.C. Genomics (1993) [Pubmed]
  18. CASP, a novel, highly conserved alternative-splicing product of the CDP/cut/cux gene, lacks cut-repeat and homeo DNA-binding domains, and interacts with full-length CDP in vitro. Lievens, P.M., Tufarelli, C., Donady, J.J., Stagg, A., Neufeld, E.J. Gene (1997) [Pubmed]
  19. Transfection of keratinocytes abrogates detectable DNA-binding activity of CCAAT displacement protein. Narahari, J., Roman, A. DNA Cell Biol. (2002) [Pubmed]
  20. CUTL1 is phosphorylated by protein kinase A, modulating its effects on cell proliferation and motility. Michl, P., Knobel, B., Downward, J. J. Biol. Chem. (2006) [Pubmed]
  21. CCAAT displacement protein/cut homolog recruits G9a histone lysine methyltransferase to repress transcription. Nishio, H., Walsh, M.J. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  22. Erythropoietin rapidly induces tyrosine phosphorylation in the human erythropoietin-dependent cell line, UT-7. Komatsu, N., Adamson, J.W., Yamamoto, K., Altschuler, D., Torti, M., Marzocchini, R., Lapetina, E.G. Blood (1992) [Pubmed]
  23. Schwann cells secrete a novel collagen-like adhesive protein that binds N-syndecan. Chernousov, M.A., Stahl, R.C., Carey, D.J. J. Biol. Chem. (1996) [Pubmed]
  24. Retinoblastoma protein in non-small cell lung carcinoma, cells arrested for growth by retinoic acid. Maxwell, S.A. Anticancer Res. (1994) [Pubmed]
  25. The interferon-inducible p200 family of proteins: a perspective on their roles in cell cycle regulation and differentiation. Asefa, B., Klarmann, K.D., Copeland, N.G., Gilbert, D.J., Jenkins, N.A., Keller, J.R. Blood Cells Mol. Dis. (2004) [Pubmed]
  26. The deletion of the distal CCAAT box region of the A gamma-globin gene in black HPFH abolishes the binding of the erythroid specific protein NFE3 and of the CCAAT displacement protein. Mantovani, R., Superti-Furga, G., Gilman, J., Ottolenghi, S. Nucleic Acids Res. (1989) [Pubmed]
  27. CCAAT displacement protein competes with multiple transcriptional activators for binding to four sites in the proximal gp91phox promoter. Luo, W., Skalnik, D.G. J. Biol. Chem. (1996) [Pubmed]
  28. Identification of CCAAT displacement protein (CDP/cut) as a locus-specific repressor of major histocompatibility complex gene expression in human tumor cells. Snyder, S.R., Wang, J., Waring, J.F., Ginder, G.D. J. Biol. Chem. (2001) [Pubmed]
  29. CCAAT displacement protein (CDP/cut) recognizes a silencer element within the lactoferrin gene promoter. Khanna-Gupta, A., Zibello, T., Kolla, S., Neufeld, E.J., Berliner, N. Blood (1997) [Pubmed]
  30. Characterization of the signaling pathway downstream p75 neurotrophin receptor involved in beta-amyloid peptide-dependent cell death. Costantini, C., Rossi, F., Formaggio, E., Bernardoni, R., Cecconi, D., Della-Bianca, V. J. Mol. Neurosci. (2005) [Pubmed]
  31. Homeoproteins CDP and SATB1 interact: potential for tissue-specific regulation. Liu, J., Barnett, A., Neufeld, E.J., Dudley, J.P. Mol. Cell. Biol. (1999) [Pubmed]
  32. CASP, the alternatively spliced product of the gene encoding the CCAAT-displacement protein transcription factor, is a Golgi membrane protein related to giantin. Gillingham, A.K., Pfeifer, A.C., Munro, S. Mol. Biol. Cell (2002) [Pubmed]
  33. Rabies virus receptors. Lafon, M. J. Neurovirol. (2005) [Pubmed]
  34. Loss of heterozygosity and reduced expression of the CUTL1 gene in uterine leiomyomas. Zeng, W.R., Scherer, S.W., Koutsilieris, M., Huizenga, J.J., Filteau, F., Tsui, L.C., Nepveu, A. Oncogene (1997) [Pubmed]
  35. Baculovirus-mediated gene delivery into Mammalian cells does not alter their transcriptional and differentiating potential but is accompanied by early viral gene expression. Kenoutis, C., Efrose, R.C., Swevers, L., Lavdas, A.A., Gaitanou, M., Matsas, R., Iatrou, K. J. Virol. (2006) [Pubmed]
  36. Decreased mutation rate for cellular resistance to doxorubicin and suppression of mdr1 gene activation by the cyclosporin PSC 833. Beketic-Oreskovic, L., Durán, G.E., Chen, G., Dumontet, C., Sikic, B.I. J. Natl. Cancer Inst. (1995) [Pubmed]
  37. Identification of a zinc finger protein whose subcellular distribution is regulated by serum and nerve growth factor. Chittka, A., Chao, M.V. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
 
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