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Gene Review

CABIN1  -  calcineurin binding protein 1

Homo sapiens

Synonyms: CAIN, Calcineurin inhibitor, Calcineurin-binding protein cabin-1, KIAA0330, PPP3IN
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Disease relevance of CABIN1


Psychiatry related information on CABIN1

  • Recently, Olsson and Cain (2000, Chem. Senses, 25: 493) introduced a psychometric method which, for the first time, allows the standardized determination of odor quality discrimination (OQD) thresholds [6].
  • The review, which is largely based on presentations given by Dr. Richard Doty and Dr. William Cain, concludes by discussing the importance of the psychophysical approach, which considers physiochemical, subject, experimental, and cognitive/ psychological factors, for research in the chemical senses [7].

High impact information on CABIN1

  • Several MEF2 co-repressors, such as Cabin1/Cain and class II histone deacetylases (HDACs), have been identified [8].
  • Here we report a crystal structure of the MADS-box/MEF2S domain of human MEF2B bound to a motif of the transcriptional co-repressor Cabin1 and DNA at 2.2 A resolution [8].
  • Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2 [8].
  • TCR engagement led to an increase in intracellular calcium concentration and the dissociation of MEF2 from Cabin1, as a result of competitive binding of activated calmodulin to Cabin1 [9].
  • Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes [10].

Chemical compound and disease context of CABIN1


Biological context of CABIN1


Anatomical context of CABIN1


Associations of CABIN1 with chemical compounds


Physical interactions of CABIN1


Regulatory relationships of CABIN1


Other interactions of CABIN1


Analytical, diagnostic and therapeutic context of CABIN1


  1. Oncogenic epidermal growth factor receptor mutants with tandem duplication: gene structure and effects on receptor function. Ciesielski, M.J., Fenstermaker, R.A. Oncogene (2000) [Pubmed]
  2. Oxidative stress in kidney transplant patients with calcineurin inhibitor-induced hypertension: effect of ramipril. Calò, L.A., Davis, P.A., Giacon, B., Pagnin, E., Sartori, M., Riegler, P., Antonello, A., Huber, W., Semplicini, A. J. Cardiovasc. Pharmacol. (2002) [Pubmed]
  3. Cytokine gene expression by alloactivated cells in SCID mice. Shoker, A.S., Lun, Z.R., Choudry, R. Transpl. Immunol. (2002) [Pubmed]
  4. Nephrotoxicity of immunosuppressive drugs: new insight and preventive strategies. Olyaei, A.J., de Mattos, A.M., Bennett, W.M. Current opinion in critical care. (2001) [Pubmed]
  5. Pimecrolimus in dermatology: atopic dermatitis and beyond. Gisondi, P., Ellis, C.N., Girolomoni, G. International journal of clinical practice. (2005) [Pubmed]
  6. SURE, why not? The SUbstitution-REciprocity method for measurement of odor quality discrimination thresholds: replication and extension to nonhuman primates. Laska, M., Grimm, N. Chem. Senses (2003) [Pubmed]
  7. Psychophysical methods in the study of olfaction and respiratory tract irritation. Dalton, P. AIHAJ : a journal for the science of occupational and environmental health and safety. (2001) [Pubmed]
  8. Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2. Han, A., Pan, F., Stroud, J.C., Youn, H.D., Liu, J.O., Chen, L. Nature (2003) [Pubmed]
  9. Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2. Youn, H.D., Sun, L., Prywes, R., Liu, J.O. Science (1999) [Pubmed]
  10. Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes. Sun, L., Youn, H.D., Loh, C., Stolow, M., He, W., Liu, J.O. Immunity (1998) [Pubmed]
  11. Mycophenolate mofetil monotherapy in liver transplantation. Stewart, S.F., Hudson, M., Talbot, D., Manas, D., Day, C.P. Lancet (2001) [Pubmed]
  12. The duration of nuclear residence of NFAT determines the pattern of cytokine expression in human SCID T cells. Feske, S., Draeger, R., Peter, H.H., Eichmann, K., Rao, A. J. Immunol. (2000) [Pubmed]
  13. Tacrolimus for the treatment of gout in renal transplantation: two case reports and review of the literature. Pilmore, H.L., Faire, B., Dittmer, I. Transplantation (2001) [Pubmed]
  14. The influence of immunomodulatory diets on transplant success and complications. Alexander, J.W., Metze, T.J., McIntosh, M.J., Goodman, H.R., First, M.R., Munda, R., Cardi, M.A., Austin, J.N., Goel, S., Safdar, S., Greenberg, N., Chen, X., Woodle, E.S. Transplantation (2005) [Pubmed]
  15. Kidney dysfunction in the recipients of liver transplants. Wilkinson, A., Pham, P.T. Liver Transpl. (2005) [Pubmed]
  16. The calcineurin-binding protein cain is a negative regulator of synaptic vesicle endocytosis. Lai, M.M., Luo, H.R., Burnett, P.E., Hong, J.J., Snyder, S.H. J. Biol. Chem. (2000) [Pubmed]
  17. Identification of genetic aberrations on chromosome 22 outside the NF2 locus in schwannomatosis and neurofibromatosis type 2. Buckley, P.G., Mantripragada, K.K., Díaz de Ståhl, T., Piotrowski, A., Hansson, C.M., Kiss, H., Vetrie, D., Ernberg, I.T., Nordenskjöld, M., Bolund, L., Sainio, M., Rouleau, G.A., Niimura, M., Wallace, A.J., Evans, D.G., Grigelionis, G., Menzel, U., Dumanski, J.P. Hum. Mutat. (2005) [Pubmed]
  18. Thapsigargin-induced apoptosis involves Cabin1-MEF2-mediated induction of Nur77. Liu, W., Youn, H.D., Liu, J.O. Eur. J. Immunol. (2001) [Pubmed]
  19. The challenge of renal function in heart transplant children. Di Filippo, S., Cochat, P., Bozio, A. Pediatr. Nephrol. (2007) [Pubmed]
  20. Apoptosis of allospecifically activated human helper T cells is blocked by calcineurin inhibition. Woodside, K.J., Hu, M., Liu, Y., Song, W., Hunter, G.C., Daller, J.A. Transpl. Immunol. (2006) [Pubmed]
  21. Calcineurin inhibitor effects on growth and phenotype of human airway epithelial cells in vitro. Neuringer, I.P., Sloan, J., Budd, S., Chalermskulrat, W., Park, R.C., Stonebraker, J.R., O'Neal, W.K., Aris, R.M., Randell, S.H. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. (2005) [Pubmed]
  22. Endotoxin-independent white cell cytokine production in haemodynamically stable patients with idiopathic dilated cardiomyopathy. Brooksbank, R., Woodiwiss, A.J., Sliwa, K., Badenhorst, D., Deftereos, D., Wadee, A.A., Essop, M.R., Sareli, P., Norton, G.R. Cardiovascular journal of South Africa : official journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners. (2005) [Pubmed]
  23. Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation. Pan, F., Means, A.R., Liu, J.O. EMBO J. (2005) [Pubmed]
  24. Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis. Shirane, M., Nakayama, K.I. Nat. Cell Biol. (2003) [Pubmed]
  25. Coadministration of either cyclosporine or steroids with humanized monoclonal antibodies against CD80 and CD86 successfully prolong allograft survival after life supporting renal transplantation in cynomolgus monkeys. Hausen, B., Klupp, J., Christians, U., Higgins, J.P., Baumgartner, R.E., Hook, L.E., Friedrich, S., Celnicker, A., Morris, R.E. Transplantation (2001) [Pubmed]
  26. Sensitivity of whole-blood T lymphocytes in individual patients to tacrolimus (FK 506): impact of interleukin-2 mRNA expression as surrogate measure of immunosuppressive effect. Härtel, C., Schumacher, N., Fricke, L., Ebel, B., Kirchner, H., Müller-Steinhardt, M. Clin. Chem. (2004) [Pubmed]
  27. Captopril enhances transforming growth factor (TGF)-beta1 expression in peripheral blood mononuclear cells: a mechanism independent from angiotensin converting enzyme inhibition? A study in cyclosporine-treated kidney-transplanted patients. Di Paolo, S., Schena, A., Stallone, G., Grandaliano, G., Soccio, M., Cerullo, G., Gesualdo, L., Paolo Schena, F. Transplantation (2002) [Pubmed]
  28. Enhanced interleukin-4 production in CD4+ T cells and elevated immunoglobulin E levels in antigen-primed mice by bisphenol A and nonylphenol, endocrine disruptors: involvement of nuclear factor-AT and Ca2+. Lee, M.H., Chung, S.W., Kang, B.Y., Park, J., Lee, C.H., Hwang, S.Y., Kim, T.S. Immunology (2003) [Pubmed]
  29. Efficacy of Daclizumab in an African-American and Hispanic renal transplant population. Meier-Kriesche, H.U., Palenkar, S.S., Friedman, G.S., Mulgaonkar, S.P., Goldblat, M.V., Kaplan, B. Transpl. Int. (2000) [Pubmed]
  30. Mechanism of recruitment of class II histone deacetylases by myocyte enhancer factor-2. Han, A., He, J., Wu, Y., Liu, J.O., Chen, L. J. Mol. Biol. (2005) [Pubmed]
  31. Use of cyclosporine in lung transplantation. Parekh, K., Trulock, E., Patterson, G.A. Transplant. Proc. (2004) [Pubmed]
  32. Cabin1 represses MEF2-dependent Nur77 expression and T cell apoptosis by controlling association of histone deacetylases and acetylases with MEF2. Youn, H.D., Liu, J.O. Immunity (2000) [Pubmed]
  33. Use of sirolimus and low-dose calcineurin inhibitor in lung transplant recipients with renal impairment: results of a controlled pilot study. Shitrit, D., Rahamimov, R., Gidon, S., Bakal, I., Bargil-Shitrit, A., Milton, S., Kramer, M.R. Kidney Int. (2005) [Pubmed]
  34. Calcineurin inhibitor-induced nephrotoxicity and renal expression of P-glycoprotein. Joy, M.S., Nickeleit, V., Hogan, S.L., Thompson, B.D., Finn, W.F. Pharmacotherapy (2005) [Pubmed]
  35. Calcineurin inhibitor-induced irreversible neuropathic pain after allogeneic hematopoietic stem cell transplantation. Fujii, N., Ikeda, K., Koyama, M., Aoyama, K., Masunari, T., Kondo, E., Matsuzaki, T., Mizobuchi, S., Hiraki, A., Teshima, T., Shinagawa, K., Ishimaru, F., Tanimoto, M. Int. J. Hematol. (2006) [Pubmed]
  36. Reconstruction of ureteral necrosis in kidney transplantation using an ileum interposition. Wolters, H.H., Palmes, D., Krieglstein, C.F., Suwelack, B., Hertle, L., Senninger, N., Brinkmann, O. Transplant. Proc. (2006) [Pubmed]
  37. Inhibitors of ADAMTS13: a potential factor in the cause of thrombotic microangiopathy in a renal allograft recipient. Pham, P.T., Danovitch, G.M., Wilkinson, A.H., Gritsch, H.A., Pham, P.C., Eric, T.M., Kendrick, E., Charles, L.R., Tsai, H.M. Transplantation (2002) [Pubmed]
  38. Down-regulation of cell surface CXCR6 expression during T cell activation is predominantly mediated by calcineurin. Koprak, S., Matheravidathu, S., Springer, M., Gould, S., Dumont, F.J. Cell. Immunol. (2003) [Pubmed]
  39. Obesity, adiponectin and inflammation as predictors of new-onset diabetes mellitus after kidney transplantation. Bayés, B., Granada, M.L., Pastor, M.C., Lauzurica, R., Salinas, I., Sanmartí, A., Espinal, A., Serra, A., Navarro, M., Bonal, J., Romero, R. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (2007) [Pubmed]
  40. Cabin1 represses MEF2 transcriptional activity by association with a methyltransferase, SUV39H1. Jang, H., Choi, D.E., Kim, H., Cho, E.J., Youn, H.D. J. Biol. Chem. (2007) [Pubmed]
  41. Molecular comparison of calcineurin inhibitor-induced fibrogenic responses in protocol renal transplant biopsies. Roos-van Groningen, M.C., Scholten, E.M., Lelieveld, P.M., Rowshani, A.T., Baelde, H.J., Bajema, I.M., Florquin, S., Bemelman, F.J., de Heer, E., de Fijter, J.W., Bruijn, J.A., Eikmans, M. J. Am. Soc. Nephrol. (2006) [Pubmed]
  42. The relationship of transforming growth factor-beta1 gene polymorphism, its plasma level, and gingival overgrowth in renal transplant recipients receiving different immunosuppressive regimens. Radwan-Oczko, M., Boratyńska, M., Zietek, M., Zołedziewska, M., Jonkisz, A. J. Periodontol. (2006) [Pubmed]
  43. Excellent results with calcineurin inhibitor-free initial immunosuppression in old recipients of old kidneys. Bösmüller, C., Ollinger, R., Mark, W., Brandacher, G., Schneeberger, S., Cakar, F., Bonatti, H., Margreiter, R. Transplant. Proc. (2005) [Pubmed]
  44. Rational development of LEA29Y (belatacept), a high-affinity variant of CTLA4-Ig with potent immunosuppressive properties. Larsen, C.P., Pearson, T.C., Adams, A.B., Tso, P., Shirasugi, N., Strobertm, E., Anderson, D., Cowan, S., Price, K., Naemura, J., Emswiler, J., Greene, J., Turk, L.A., Bajorath, J., Townsend, R., Hagerty, D., Linsley, P.S., Peach, R.J. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. (2005) [Pubmed]
  45. Listeria meningitis in transplant recipients. Wiesmayr, S., Tabarelli, W., Stelzmueller, I., Nachbaur, D., Boesmueller, C., Wykypiel, H., Pfausler, B., Margreiter, R., Allerberger, F., Bonatti, H. Wien. Klin. Wochenschr. (2005) [Pubmed]
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