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Gene Review

CD70  -  CD70 molecule

Homo sapiens

Synonyms: CD27 ligand, CD27-L, CD27L, CD27LG, CD70 antigen, ...
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Disease relevance of CD70


High impact information on CD70


Chemical compound and disease context of CD70


Biological context of CD70


Anatomical context of CD70

  • Based on these observations, we hypothesized that a ligand for CD27L is expressed on B cell lines and that ligand interaction would result in down-modulation of the molecule from the T cell surface [8].
  • CD70 is a surface Ag found on activated but not resting T and B lymphocytes [12].
  • Phenotypical analyses showed that freshly isolated lymphocytes lacked CD27L expression, but that expression of the molecule could be induced after in vitro stimulation of T and B cells [8].
  • Enhancement of allospecific CTL generation was also observed when CD27L/CD70-expressing membranes were added only during the last 24 to 48 h of 5-day MLC [13].
  • To study the role of CD27-CD27 ligand (CD27L)/CD70 interactions in the generation of murine allospecific T cell responses, SF9 cells or cell membranes expressing recombinant human CD70 were added to in vitro MLC containing C57BL/6 (H-2b) responder cells and class I and II MHC disparate H-2b/d stimulator cells [13].

Associations of CD70 with chemical compounds

  • Human CD70 (CD27 ligand) is a type II transmembrane glycoprotein belonging to the TNF family [14].
  • Lipopolysaccharide stimulation converts vigorously washed dendritic cells (DCs) to nonexhausted DCs expressing CD70 and evoking long-lasting type 1 T cell responses [15].
  • CD70, CD27 ligand, is a TNF related trans-membrane protein induced upon activation on T and B cells [16].
  • PMA + Ionomycin induced CD70 on the large majority of CD8+ cells, but only on a minority of CD4+ cells (P < 0.002), and among these, preferentially on the CD45R0+ subset compared with the CD45RA+ [17].
  • Anti-CD70 antibody-drug conjugates (ADC) consisting of auristatin phenylalanine phenylenediamine (AFP) or monomethyl auristatin phenylalanine (MMAF), two novel derivatives of the anti-tubulin agent auristatin, mediated potent antigen-dependent cytotoxicity in CD70-expressing RCC cells [18].

Regulatory relationships of CD70


Other interactions of CD70

  • Among induced genes, four (TNFR1, TNFSF7, caspase-8, and DAPK1) were associated with the tumor necrosis factor ligand-receptor death pathway [22].
  • The cloning of CD70 and its identification as the ligand for CD27 [12].
  • Induction of TNFR1, TNFSF7, and caspase-8 were confirmed by Northern and Western analyses [22].
  • Interestingly, only the molecules CD25, CD70 and CD86, all relevant in cognate T-B interaction, showed a significantly lower expression in naive B cells from CVID patients compared to controls [1].
  • Characterization of the human CD27 ligand, a novel member of the TNF gene family [8].

Analytical, diagnostic and therapeutic context of CD70


  1. Impaired up-regulation of CD70 and CD86 in naive (CD27-) B cells from patients with common variable immunodeficiency (CVID). Groth, C., Drager, R., Warnatz, K., Wolff-Vorbeck, G., Schmidt, S., Eibel, H., Schlesier, M., Peter, H.H. Clin. Exp. Immunol. (2002) [Pubmed]
  2. Identification of CD70-mediated apoptosis of immune effector cells as a novel immune escape pathway of human glioblastoma. Wischhusen, J., Jung, G., Radovanovic, I., Beier, C., Steinbach, J.P., Rimner, A., Huang, H., Schulz, J.B., Ohgaki, H., Aguzzi, A., Rammensee, H.G., Weller, M. Cancer Res. (2002) [Pubmed]
  3. Receptor-specific signaling for both the alternative and the canonical NF-kappaB activation pathways by NF-kappaB-inducing kinase. Ramakrishnan, P., Wang, W., Wallach, D. Immunity (2004) [Pubmed]
  4. Constitutive CD27/CD70 interaction induces expansion of effector-type T cells and results in IFNgamma-mediated B cell depletion. Arens, R., Tesselaar, K., Baars, P.A., van Schijndel, G.M., Hendriks, J., Pals, S.T., Krimpenfort, P., Borst, J., van Oers, M.H., van Lier, R.A. Immunity (2001) [Pubmed]
  5. Lethal T cell immunodeficiency induced by chronic costimulation via CD27-CD70 interactions. Tesselaar, K., Arens, R., van Schijndel, G.M., Baars, P.A., van der Valk, M.A., Borst, J., van Oers, M.H., van Lier, R.A. Nat. Immunol. (2003) [Pubmed]
  6. CD27 and CD70 in T cell and B cell activation. Borst, J., Hendriks, J., Xiao, Y. Curr. Opin. Immunol. (2005) [Pubmed]
  7. Demethylation of the same promoter sequence increases CD70 expression in lupus T cells and T cells treated with lupus-inducing drugs. Lu, Q., Wu, A., Richardson, B.C. J. Immunol. (2005) [Pubmed]
  8. Characterization of the human CD27 ligand, a novel member of the TNF gene family. Hintzen, R.Q., Lens, S.M., Beckmann, M.P., Goodwin, R.G., Lynch, D., van Lier, R.A. J. Immunol. (1994) [Pubmed]
  9. CD27 but not CD70 and 4-1BB intragraft gene expression is a risk factor for acute cardiac allograft rejection in humans. Shulzhenko, N., Morgun, A., Chinellato, A.P., Rampim, G.F., Diniz, R.V., Almeida, D.R., Gerbase-DeLima, M. Transplant. Proc. (2002) [Pubmed]
  10. Overexpression of CD70 and overstimulation of IgG synthesis by lupus T cells and T cells treated with DNA methylation inhibitors. Oelke, K., Lu, Q., Richardson, D., Wu, A., Deng, C., Hanash, S., Richardson, B. Arthritis Rheum. (2004) [Pubmed]
  11. The price of the CD27-CD70 costimulatory axis: you can't have it all. Nolte, M.A., van Lier, R.A. J. Exp. Med. (2006) [Pubmed]
  12. The cloning of CD70 and its identification as the ligand for CD27. Bowman, M.R., Crimmins, M.A., Yetz-Aldape, J., Kriz, R., Kelleher, K., Herrmann, S. J. Immunol. (1994) [Pubmed]
  13. CD27-CD27 ligand/CD70 interactions enhance alloantigen-induced proliferation and cytolytic activity in CD8+ T lymphocytes. Brown, G.R., Meek, K., Nishioka, Y., Thiele, D.L. J. Immunol. (1995) [Pubmed]
  14. Characterization of murine CD70, the ligand of the TNF receptor family member CD27. Tesselaar, K., Gravestein, L.A., van Schijndel, G.M., Borst, J., van Lier, R.A. J. Immunol. (1997) [Pubmed]
  15. Lipopolysaccharide stimulation converts vigorously washed dendritic cells (DCs) to nonexhausted DCs expressing CD70 and evoking long-lasting type 1 T cell responses. Iwamoto, S., Ishida, M., Takahashi, K., Takeda, K., Miyazaki, A. J. Leukoc. Biol. (2005) [Pubmed]
  16. CD27/CD70 interactions regulate T dependent B cell differentiation. Jacquot, S. Immunol. Res. (2000) [Pubmed]
  17. CD70 expression on T-cell subpopulations: study of normal individuals and patients with chronic immune activation. Brugnoni, D., Airò, P., Marino, R., Notarangelo, L.D., van Lier, R.A., Cattaneo, R. Immunol. Lett. (1997) [Pubmed]
  18. Lymphocyte activation antigen CD70 expressed by renal cell carcinoma is a potential therapeutic target for anti-CD70 antibody-drug conjugates. Law, C.L., Gordon, K.A., Toki, B.E., Yamane, A.K., Hering, M.A., Cerveny, C.G., Petroziello, J.M., Ryan, M.C., Smith, L., Simon, R., Sauter, G., Oflazoglu, E., Doronina, S.O., Meyer, D.L., Francisco, J.A., Carter, P., Senter, P.D., Copland, J.A., Wood, C.G., Wahl, A.F. Cancer Res. (2006) [Pubmed]
  19. CD27-CD70 interactions regulate B-cell activation by T cells. Kobata, T., Jacquot, S., Kozlowski, S., Agematsu, K., Schlossman, S.F., Morimoto, C. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  20. Direct cellular communications between CD45R0 and CD45RA T cell subsets via CD27/CD70. Agematsu, K., Kobata, T., Sugita, K., Hirose, T., Schlossman, S.F., Morimoto, C. J. Immunol. (1995) [Pubmed]
  21. A human Langerhans cell-like cell line, ELD-1, promotes CD8 T cells to produce IFN-gamma through CD70-dependent alternative pathway. Iwamoto, S., Ishida, M., Tamaoki, S., Hagiwara, T., Sueki, H., Miyazaki, A. Cell. Immunol. (2004) [Pubmed]
  22. Histone deacetylase 5 is not a p53 target gene, but its overexpression inhibits tumor cell growth and induces apoptosis. Huang, Y., Tan, M., Gosink, M., Wang, K.K., Sun, Y. Cancer Res. (2002) [Pubmed]
  23. CD27/CD70 interaction directly induces natural killer cell killing activity. Yang, F.C., Agematsu, K., Nakazawa, T., Mori, T., Ito, S., Kobata, T., Morimoto, C., Komiyama, A. Immunology (1996) [Pubmed]
  24. Proliferation response of leukemic cells to CD70 ligation oscillates with recurrent remission and relapse in a low-grade lymphoma. Kaufmann, Y., Amariglio, N., Rosenthal, E., Hirsch, Y.J., Many, A., Rechavi, G. J. Immunol. (2005) [Pubmed]
  25. Modulation by IL-2 of CD70 and CD27 expression on CD8+ T cells: importance for the therapeutic effectiveness of cell transfer immunotherapy. Huang, J., Kerstann, K.W., Ahmadzadeh, M., Li, Y.F., El-Gamil, M., Rosenberg, S.A., Robbins, P.F. J. Immunol. (2006) [Pubmed]
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